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Editing gene: TMEM198B (CAeditome ID:440104)

Gene summary for TMEM198B

Gene summary

Gene information	Gene symbol	TMEM198B
	Gene ID	440104
	Gene name	transmembrane protein 198B (pseudogene)
	Synonyms	-
	Cytomap	12q13.2
	Type of gene	pseudo
	Description	1110012D08Rik pseudogenetransmembrane protein 198, pseudogene
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for TMEM198B

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000182796.11

RNA A-to-I editing events in Cancer.

CAediting_895315(55833836, +), CAediting_895316(55833837, +), CAediting_895317(55833842, +), CAediting_895318(55833845, +), CAediting_895319(55833880, +), CAediting_895320(55833883, +), CAediting_895321(55833903, +), CAediting_895322(55833904, +), CAediting_895323(55833912, +), CAediting_895324(55833914, +), CAediting_895325(55833928, +), CAediting_895326(55833930, +), CAediting_895327(55833979, +), CAediting_895328(55833985, +), CAediting_895329(55833989, +), CAediting_895330(55834002, +), CAediting_895331(55834006, +), CAediting_895332(55834009, +), CAediting_895333(55834020, +), CAediting_895334(55834021, +), CAediting_895335(55834045, +), CAediting_895336(55834065, +), CAediting_895337(55834295, +), CAediting_895338(55834303, +), CAediting_895339(55834317, +), CAediting_895340(55834319, +), CAediting_895341(55834325, +), CAediting_895342(55834338, +), CAediting_895343(55834344, +), CAediting_895344(55834359, +), CAediting_895345(55834363, +), CAediting_895346(55834364, +), CAediting_895347(55834368, +), CAediting_895348(55834374, +), CAediting_895349(55834381, +), CAediting_895350(55834393, +), CAediting_895351(55834405, +), CAediting_895352(55834429, +), CAediting_895353(55834438, +), CAediting_895354(55834444, +), CAediting_895355(55834447, +), CAediting_895356(55834449, +), CAediting_895357(55834461, +), CAediting_895358(55834469, +), CAediting_895359(55834473, +), CAediting_895360(55834503, +), CAediting_895361(55834507, +), CAediting_895362(55834511, +), CAediting_895363(55834516, +), CAediting_895364(55834525, +), CAediting_895365(55834526, +), CAediting_895366(55834538, +), CAediting_895367(55834540, +), CAediting_895368(55834823, +), CAediting_895369(55835324, +), CAediting_895370(55835343, +), CAediting_895371(55835354, +), CAediting_895372(55835374, +), CAediting_895373(55835390, +), CAediting_895374(55835409, +), CAediting_895375(55835416, +), CAediting_895376(55835427, +),

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RNA editing positional annotations for TMEM198B using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_895315	chr12_55833836_+	ncRNA_intronic
CAediting_895316	chr12_55833837_+	ncRNA_intronic
CAediting_895317	chr12_55833842_+	ncRNA_intronic
CAediting_895318	chr12_55833845_+	ncRNA_intronic
CAediting_895319	chr12_55833880_+	ncRNA_intronic
CAediting_895320	chr12_55833883_+	ncRNA_intronic
CAediting_895321	chr12_55833903_+	ncRNA_intronic
CAediting_895322	chr12_55833904_+	ncRNA_intronic
CAediting_895323	chr12_55833912_+	ncRNA_intronic
CAediting_895324	chr12_55833914_+	ncRNA_intronic
CAediting_895325	chr12_55833928_+	ncRNA_intronic
CAediting_895326	chr12_55833930_+	ncRNA_intronic
CAediting_895327	chr12_55833979_+	ncRNA_intronic
CAediting_895328	chr12_55833985_+	ncRNA_intronic
CAediting_895329	chr12_55833989_+	ncRNA_intronic
CAediting_895330	chr12_55834002_+	ncRNA_intronic
CAediting_895331	chr12_55834006_+	ncRNA_intronic
CAediting_895332	chr12_55834009_+	ncRNA_intronic
CAediting_895333	chr12_55834020_+	ncRNA_intronic
CAediting_895334	chr12_55834021_+	ncRNA_intronic
CAediting_895335	chr12_55834045_+	ncRNA_intronic
CAediting_895336	chr12_55834065_+	ncRNA_intronic
CAediting_895337	chr12_55834295_+	ncRNA_intronic
CAediting_895338	chr12_55834303_+	ncRNA_intronic
CAediting_895339	chr12_55834317_+	ncRNA_intronic
CAediting_895340	chr12_55834319_+	ncRNA_intronic
CAediting_895341	chr12_55834325_+	ncRNA_intronic
CAediting_895342	chr12_55834338_+	ncRNA_intronic
CAediting_895343	chr12_55834344_+	ncRNA_intronic
CAediting_895344	chr12_55834359_+	ncRNA_intronic
CAediting_895345	chr12_55834363_+	ncRNA_intronic
CAediting_895346	chr12_55834364_+	ncRNA_intronic
CAediting_895347	chr12_55834368_+	ncRNA_intronic
CAediting_895348	chr12_55834374_+	ncRNA_intronic
CAediting_895349	chr12_55834381_+	ncRNA_intronic
CAediting_895350	chr12_55834393_+	ncRNA_intronic
CAediting_895351	chr12_55834405_+	ncRNA_intronic
CAediting_895352	chr12_55834429_+	ncRNA_intronic
CAediting_895353	chr12_55834438_+	ncRNA_intronic
CAediting_895354	chr12_55834444_+	ncRNA_intronic
CAediting_895355	chr12_55834447_+	ncRNA_intronic
CAediting_895356	chr12_55834449_+	ncRNA_intronic
CAediting_895357	chr12_55834461_+	ncRNA_intronic
CAediting_895358	chr12_55834469_+	ncRNA_intronic
CAediting_895359	chr12_55834473_+	ncRNA_intronic
CAediting_895360	chr12_55834503_+	ncRNA_intronic
CAediting_895361	chr12_55834507_+	ncRNA_intronic
CAediting_895362	chr12_55834511_+	ncRNA_intronic
CAediting_895363	chr12_55834516_+	ncRNA_intronic
CAediting_895364	chr12_55834525_+	ncRNA_intronic
CAediting_895365	chr12_55834526_+	ncRNA_intronic
CAediting_895366	chr12_55834538_+	ncRNA_intronic
CAediting_895367	chr12_55834540_+	ncRNA_intronic
CAediting_895368	chr12_55834823_+	ncRNA_intronic
CAediting_895369	chr12_55835324_+	ncRNA_exonic
CAediting_895370	chr12_55835343_+	ncRNA_exonic
CAediting_895371	chr12_55835354_+	ncRNA_exonic
CAediting_895372	chr12_55835374_+	ncRNA_exonic
CAediting_895373	chr12_55835390_+	ncRNA_exonic
CAediting_895374	chr12_55835409_+	ncRNA_exonic
CAediting_895375	chr12_55835416_+	ncRNA_exonic
CAediting_895376	chr12_55835427_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_895315	chr12_55833836_+	SINE	Alu	AluY
CAediting_895316	chr12_55833837_+	SINE	Alu	AluY
CAediting_895317	chr12_55833842_+	SINE	Alu	AluY
CAediting_895318	chr12_55833845_+	SINE	Alu	AluY
CAediting_895319	chr12_55833880_+	SINE	Alu	AluY
CAediting_895320	chr12_55833883_+	SINE	Alu	AluY
CAediting_895321	chr12_55833903_+	SINE	Alu	AluY
CAediting_895322	chr12_55833904_+	SINE	Alu	AluY
CAediting_895323	chr12_55833912_+	SINE	Alu	AluY
CAediting_895324	chr12_55833914_+	SINE	Alu	AluY
CAediting_895325	chr12_55833928_+	SINE	Alu	AluY
CAediting_895326	chr12_55833930_+	SINE	Alu	AluY
CAediting_895327	chr12_55833979_+	SINE	Alu	AluY
CAediting_895328	chr12_55833985_+	SINE	Alu	AluY
CAediting_895329	chr12_55833989_+	SINE	Alu	AluY
CAediting_895330	chr12_55834002_+	SINE	Alu	AluY
CAediting_895331	chr12_55834006_+	SINE	Alu	AluY
CAediting_895332	chr12_55834009_+	SINE	Alu	AluY
CAediting_895333	chr12_55834020_+	SINE	Alu	AluY
CAediting_895334	chr12_55834021_+	SINE	Alu	AluY
CAediting_895335	chr12_55834045_+	SINE	Alu	AluY
CAediting_895336	chr12_55834065_+	SINE	Alu	AluY
CAediting_895337	chr12_55834295_+	SINE	Alu	AluSz
CAediting_895338	chr12_55834303_+	SINE	Alu	AluSz
CAediting_895339	chr12_55834317_+	SINE	Alu	AluSz
CAediting_895340	chr12_55834319_+	SINE	Alu	AluSz
CAediting_895341	chr12_55834325_+	SINE	Alu	AluSz
CAediting_895342	chr12_55834338_+	SINE	Alu	AluSz
CAediting_895343	chr12_55834344_+	SINE	Alu	AluSz
CAediting_895344	chr12_55834359_+	SINE	Alu	AluSz
CAediting_895345	chr12_55834363_+	SINE	Alu	AluSz
CAediting_895346	chr12_55834364_+	SINE	Alu	AluSz
CAediting_895347	chr12_55834368_+	SINE	Alu	AluSz
CAediting_895348	chr12_55834374_+	SINE	Alu	AluSz
CAediting_895349	chr12_55834381_+	SINE	Alu	AluSz
CAediting_895350	chr12_55834393_+	SINE	Alu	AluSz
CAediting_895351	chr12_55834405_+	SINE	Alu	AluSz
CAediting_895352	chr12_55834429_+	SINE	Alu	AluSz
CAediting_895353	chr12_55834438_+	SINE	Alu	AluSz
CAediting_895354	chr12_55834444_+	SINE	Alu	AluSz
CAediting_895355	chr12_55834447_+	SINE	Alu	AluSz
CAediting_895356	chr12_55834449_+	SINE	Alu	AluSz
CAediting_895357	chr12_55834461_+	SINE	Alu	AluSz
CAediting_895358	chr12_55834469_+	SINE	Alu	AluSz
CAediting_895359	chr12_55834473_+	SINE	Alu	AluSz
CAediting_895360	chr12_55834503_+	SINE	Alu	AluSz
CAediting_895361	chr12_55834507_+	SINE	Alu	AluSz
CAediting_895362	chr12_55834511_+	SINE	Alu	AluSz
CAediting_895363	chr12_55834516_+	SINE	Alu	AluSz
CAediting_895364	chr12_55834525_+	SINE	Alu	AluSz
CAediting_895365	chr12_55834526_+	SINE	Alu	AluSz
CAediting_895366	chr12_55834538_+	SINE	Alu	AluSz
CAediting_895367	chr12_55834540_+	SINE	Alu	AluSz
CAediting_895369	chr12_55835324_+	SINE	Alu	AluJb
CAediting_895370	chr12_55835343_+	SINE	Alu	AluJb
CAediting_895371	chr12_55835354_+	SINE	Alu	AluJb
CAediting_895372	chr12_55835374_+	SINE	Alu	AluJb
CAediting_895373	chr12_55835390_+	SINE	Alu	AluJb
CAediting_895374	chr12_55835409_+	SINE	Alu	AluJb
CAediting_895375	chr12_55835416_+	SINE	Alu	AluJb
CAediting_895376	chr12_55835427_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for TMEM198B

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000182796.11.TMEM198B.

Correlation between RNA A-to-I editing and PSI for ENSG00000182796.11.TMEM198B.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM198B

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM198B

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM198B

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM198B

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for TMEM198B

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
GBM	CAediting_895349	chr12_55834381_+	.	.	.	.	0.0136588306365984	0.285545175703026
THCA	CAediting_895349	chr12_55834381_+	0.0221377448868383	0.323014011973723	.	.	.	.
OV	CAediting_895349	chr12_55834381_+	0.0254912067683691	0.188117999685291	.	.	.	.

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Relation with cancer stages for TMEM198B

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_895348	chr12_55834374_+	0.00221283898615752	0.393994917260566
KIRC	pathologic_stage	CAediting_895349	chr12_55834381_+	0.012407070379202	0.274993475751313

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Relation with survival for TMEM198B

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
OV	CAediting_895337	chr12_55834295_+	0.0198811865452461	0.00575764	0.0266395
OV	CAediting_895348	chr12_55834374_+	0.0478812681994781	0.0392773	5.52798

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RelatedDrugs for TMEM198B

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM198B

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene