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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: MMP17 (CAeditome ID:4326)

Gene summary for MMP17

check button Gene summary
Gene informationGene symbol

MMP17

Gene ID

4326

Gene namematrix metallopeptidase 17
SynonymsMMP-17|MT4-MMP|MT4MMP|MTMMP4
Cytomap

12q24.33

Type of geneprotein-coding
Descriptionmatrix metalloproteinase-17MT-MMP 4matrix metallopeptidase 17 (membrane-inserted)matrix metalloproteinase 17 (membrane-inserted)membrane-type matrix metalloproteinase 4membrane-type-4 matrix metalloproteinase
Modification date20210518
UniProtAcc

Q9ULZ9

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for MMP17

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000198598.5

check button RNA A-to-I editing events in Cancer.
CAediting_947835(131839336, +), CAediting_947836(131839344, +), CAediting_947837(131839387, +), CAediting_947838(131839412, +), CAediting_947839(131839416, +), CAediting_947840(131839417, +), CAediting_947841(131839501, +), CAediting_947842(131839538, +), CAediting_947843(131839932, +), CAediting_947844(131846396, +), CAediting_947845(131846398, +), CAediting_947846(131846400, +), CAediting_947847(131846401, +), CAediting_947848(131846402, +), CAediting_947849(131846408, +), CAediting_947850(131846428, +), CAediting_947851(131846433, +), CAediting_947852(131846441, +), CAediting_947853(131846446, +), CAediting_947854(131846478, +), CAediting_947855(131846491, +), CAediting_947856(131846503, +), CAediting_947857(131846513, +), CAediting_947858(131846541, +), CAediting_947859(131846549, +), CAediting_947860(131846555, +), CAediting_947861(131846564, +), CAediting_947862(131846572, +), CAediting_947863(131846575, +), CAediting_947864(131846584, +), CAediting_947865(131846604, +), CAediting_947866(131846609, +), CAediting_947867(131846618, +), CAediting_947868(131846636, +), CAediting_947869(131846637, +), CAediting_947870(131846643, +), CAediting_947871(131846644, +), CAediting_947872(131846649, +), CAediting_947873(131846989, +), CAediting_947874(131847002, +), CAediting_947875(131847015, +), CAediting_947876(131847019, +), CAediting_947877(131847099, +), CAediting_947878(131847149, +), CAediting_947879(131847163, +), CAediting_947880(131847196, +), CAediting_947881(131847201, +), CAediting_947882(131847206, +), CAediting_947883(131847212, +), CAediting_947884(131847225, +), CAediting_947885(131847233, +), CAediting_947886(131847234, +), CAediting_947887(131847253, +), CAediting_947888(131847254, +), CAediting_947889(131847256, +), CAediting_947890(131847258, +), CAediting_947891(131847259, +), CAediting_947892(131847260, +), CAediting_947893(131847261, +), CAediting_947894(131847262, +), CAediting_947895(131847298, +), CAediting_947896(131847302, +), CAediting_947897(131847315, +), CAediting_947898(131847319, +), CAediting_947899(131847322, +), CAediting_947900(131847341, +), CAediting_947901(131847358, +), CAediting_947902(131847363, +), CAediting_947903(131847378, +), CAediting_947904(131847383, +), CAediting_947905(131847513, +), CAediting_947906(131848105, +), CAediting_947907(131848109, +), CAediting_947908(131848117, +), CAediting_947909(131848129, +), CAediting_947910(131848155, +), CAediting_947911(131848160, +), CAediting_947912(131848172, +), CAediting_947913(131848185, +), CAediting_947914(131848186, +), CAediting_947915(131848215, +), CAediting_947916(131848220, +), CAediting_947917(131848225, +), CAediting_947918(131848235, +), CAediting_947919(131848250, +), CAediting_947920(131848251, +), CAediting_947921(131848252, +), CAediting_947922(131848261, +), CAediting_947923(131848272, +), CAediting_947924(131848276, +), CAediting_947925(131848329, +), CAediting_947926(131848333, +), CAediting_947927(131848347, +), CAediting_947928(131848360, +), CAediting_947929(131849222, +), CAediting_947930(131849228, +), CAediting_947931(131849229, +), CAediting_947932(131849234, +), CAediting_947933(131849274, +), CAediting_947934(131849369, +), CAediting_947935(131849373, +), CAediting_947936(131849470, +),

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RNA editing positional annotations for MMP17 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_947835chr12_131839336_+intronic
CAediting_947836chr12_131839344_+intronic
CAediting_947837chr12_131839387_+intronic
CAediting_947838chr12_131839412_+intronic
CAediting_947839chr12_131839416_+intronic
CAediting_947840chr12_131839417_+intronic
CAediting_947841chr12_131839501_+intronic
CAediting_947842chr12_131839538_+intronic
CAediting_947843chr12_131839932_+intronic
CAediting_947844chr12_131846396_+intronic
CAediting_947845chr12_131846398_+intronic
CAediting_947846chr12_131846400_+intronic
CAediting_947847chr12_131846401_+intronic
CAediting_947848chr12_131846402_+intronic
CAediting_947849chr12_131846408_+intronic
CAediting_947850chr12_131846428_+intronic
CAediting_947851chr12_131846433_+intronic
CAediting_947852chr12_131846441_+intronic
CAediting_947853chr12_131846446_+intronic
CAediting_947854chr12_131846478_+intronic
CAediting_947855chr12_131846491_+intronic
CAediting_947856chr12_131846503_+intronic
CAediting_947857chr12_131846513_+intronic
CAediting_947858chr12_131846541_+intronic
CAediting_947859chr12_131846549_+intronic
CAediting_947860chr12_131846555_+intronic
CAediting_947861chr12_131846564_+intronic
CAediting_947862chr12_131846572_+intronic
CAediting_947863chr12_131846575_+intronic
CAediting_947864chr12_131846584_+intronic
CAediting_947865chr12_131846604_+intronic
CAediting_947866chr12_131846609_+intronic
CAediting_947867chr12_131846618_+intronic
CAediting_947868chr12_131846636_+intronic
CAediting_947869chr12_131846637_+intronic
CAediting_947870chr12_131846643_+intronic
CAediting_947871chr12_131846644_+intronic
CAediting_947872chr12_131846649_+intronic
CAediting_947873chr12_131846989_+intronic
CAediting_947874chr12_131847002_+intronic
CAediting_947875chr12_131847015_+intronic
CAediting_947876chr12_131847019_+intronic
CAediting_947877chr12_131847099_+intronic
CAediting_947878chr12_131847149_+intronic
CAediting_947879chr12_131847163_+intronic
CAediting_947880chr12_131847196_+intronic
CAediting_947881chr12_131847201_+intronic
CAediting_947882chr12_131847206_+intronic
CAediting_947883chr12_131847212_+intronic
CAediting_947884chr12_131847225_+intronic
CAediting_947885chr12_131847233_+intronic
CAediting_947886chr12_131847234_+intronic
CAediting_947887chr12_131847253_+intronic
CAediting_947888chr12_131847254_+intronic
CAediting_947889chr12_131847256_+intronic
CAediting_947890chr12_131847258_+intronic
CAediting_947891chr12_131847259_+intronic
CAediting_947892chr12_131847260_+intronic
CAediting_947893chr12_131847261_+intronic
CAediting_947894chr12_131847262_+intronic
CAediting_947895chr12_131847298_+intronic
CAediting_947896chr12_131847302_+intronic
CAediting_947897chr12_131847315_+intronic
CAediting_947898chr12_131847319_+intronic
CAediting_947899chr12_131847322_+intronic
CAediting_947900chr12_131847341_+intronic
CAediting_947901chr12_131847358_+intronic
CAediting_947902chr12_131847363_+intronic
CAediting_947903chr12_131847378_+intronic
CAediting_947904chr12_131847383_+intronic
CAediting_947905chr12_131847513_+intronic
CAediting_947906chr12_131848105_+intronic
CAediting_947907chr12_131848109_+intronic
CAediting_947908chr12_131848117_+intronic
CAediting_947909chr12_131848129_+intronic
CAediting_947910chr12_131848155_+intronic
CAediting_947911chr12_131848160_+intronic
CAediting_947912chr12_131848172_+intronic
CAediting_947913chr12_131848185_+intronic
CAediting_947914chr12_131848186_+intronic
CAediting_947915chr12_131848215_+intronic
CAediting_947916chr12_131848220_+intronic
CAediting_947917chr12_131848225_+intronic
CAediting_947918chr12_131848235_+intronic
CAediting_947919chr12_131848250_+intronic
CAediting_947920chr12_131848251_+intronic
CAediting_947921chr12_131848252_+intronic
CAediting_947922chr12_131848261_+intronic
CAediting_947923chr12_131848272_+intronic
CAediting_947924chr12_131848276_+intronic
CAediting_947925chr12_131848329_+intronic
CAediting_947926chr12_131848333_+intronic
CAediting_947927chr12_131848347_+intronic
CAediting_947928chr12_131848360_+intronic
CAediting_947929chr12_131849222_+intronic
CAediting_947930chr12_131849228_+intronic
CAediting_947931chr12_131849229_+intronic
CAediting_947932chr12_131849234_+intronic
CAediting_947933chr12_131849274_+intronic
CAediting_947934chr12_131849369_+intronic
CAediting_947935chr12_131849373_+intronic
CAediting_947936chr12_131849470_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_947835chr12_131839336_+SINEAluAluJo
CAediting_947836chr12_131839344_+SINEAluAluJo
CAediting_947837chr12_131839387_+SINEAluAluJo
CAediting_947838chr12_131839412_+SINEAluAluJo
CAediting_947839chr12_131839416_+SINEAluAluJo
CAediting_947840chr12_131839417_+SINEAluAluJo
CAediting_947841chr12_131839501_+SINEAluAluJo
CAediting_947842chr12_131839538_+SINEAluAluJo
CAediting_947843chr12_131839932_+SINEAluAluSz
CAediting_947844chr12_131846396_+SINEAluAluSx1
CAediting_947845chr12_131846398_+SINEAluAluSx1
CAediting_947846chr12_131846400_+SINEAluAluSx1
CAediting_947847chr12_131846401_+SINEAluAluSx1
CAediting_947848chr12_131846402_+SINEAluAluSx1
CAediting_947849chr12_131846408_+SINEAluAluSx1
CAediting_947850chr12_131846428_+SINEAluAluSx1
CAediting_947851chr12_131846433_+SINEAluAluSx1
CAediting_947852chr12_131846441_+SINEAluAluSx1
CAediting_947853chr12_131846446_+SINEAluAluSx1
CAediting_947854chr12_131846478_+SINEAluAluSx1
CAediting_947855chr12_131846491_+SINEAluAluSx1
CAediting_947856chr12_131846503_+SINEAluAluSx1
CAediting_947857chr12_131846513_+SINEAluAluSx1
CAediting_947858chr12_131846541_+SINEAluAluSx1
CAediting_947859chr12_131846549_+SINEAluAluSx1
CAediting_947860chr12_131846555_+SINEAluAluSx1
CAediting_947861chr12_131846564_+SINEAluAluSx1
CAediting_947862chr12_131846572_+SINEAluAluSx1
CAediting_947863chr12_131846575_+SINEAluAluSx1
CAediting_947864chr12_131846584_+SINEAluAluSx1
CAediting_947865chr12_131846604_+SINEAluAluSx1
CAediting_947866chr12_131846609_+SINEAluAluSx1
CAediting_947867chr12_131846618_+SINEAluAluSx1
CAediting_947868chr12_131846636_+SINEAluAluSx1
CAediting_947869chr12_131846637_+SINEAluAluSx1
CAediting_947870chr12_131846643_+SINEAluAluSx1
CAediting_947871chr12_131846644_+SINEAluAluSx1
CAediting_947872chr12_131846649_+SINEAluAluSx1
CAediting_947874chr12_131847002_+SINEAluAluJb
CAediting_947875chr12_131847015_+SINEAluAluJb
CAediting_947876chr12_131847019_+SINEAluAluJb
CAediting_947877chr12_131847099_+SINEAluAluJb
CAediting_947878chr12_131847149_+SINEAluAluY
CAediting_947879chr12_131847163_+SINEAluAluY
CAediting_947880chr12_131847196_+SINEAluAluY
CAediting_947881chr12_131847201_+SINEAluAluY
CAediting_947882chr12_131847206_+SINEAluAluY
CAediting_947883chr12_131847212_+SINEAluAluY
CAediting_947884chr12_131847225_+SINEAluAluY
CAediting_947885chr12_131847233_+SINEAluAluY
CAediting_947886chr12_131847234_+SINEAluAluY
CAediting_947887chr12_131847253_+SINEAluAluY
CAediting_947888chr12_131847254_+SINEAluAluY
CAediting_947889chr12_131847256_+SINEAluAluY
CAediting_947890chr12_131847258_+SINEAluAluY
CAediting_947891chr12_131847259_+SINEAluAluY
CAediting_947892chr12_131847260_+SINEAluAluY
CAediting_947893chr12_131847261_+SINEAluAluY
CAediting_947894chr12_131847262_+SINEAluAluY
CAediting_947895chr12_131847298_+SINEAluAluY
CAediting_947896chr12_131847302_+SINEAluAluY
CAediting_947897chr12_131847315_+SINEAluAluY
CAediting_947898chr12_131847319_+SINEAluAluY
CAediting_947899chr12_131847322_+SINEAluAluY
CAediting_947900chr12_131847341_+SINEAluAluY
CAediting_947901chr12_131847358_+SINEAluAluY
CAediting_947902chr12_131847363_+SINEAluAluY
CAediting_947903chr12_131847378_+SINEAluAluY
CAediting_947904chr12_131847383_+SINEAluAluY
CAediting_947906chr12_131848105_+SINEAluAluSx1
CAediting_947907chr12_131848109_+SINEAluAluSx1
CAediting_947908chr12_131848117_+SINEAluAluSx1
CAediting_947909chr12_131848129_+SINEAluAluSx1
CAediting_947910chr12_131848155_+SINEAluAluSx1
CAediting_947911chr12_131848160_+SINEAluAluSx1
CAediting_947912chr12_131848172_+SINEAluAluSx1
CAediting_947913chr12_131848185_+SINEAluAluSx1
CAediting_947914chr12_131848186_+SINEAluAluSx1
CAediting_947915chr12_131848215_+SINEAluAluSx1
CAediting_947916chr12_131848220_+SINEAluAluSx1
CAediting_947917chr12_131848225_+SINEAluAluSx1
CAediting_947918chr12_131848235_+SINEAluAluSx1
CAediting_947919chr12_131848250_+SINEAluAluSx1
CAediting_947920chr12_131848251_+SINEAluAluSx1
CAediting_947921chr12_131848252_+SINEAluAluSx1
CAediting_947922chr12_131848261_+SINEAluAluSx1
CAediting_947923chr12_131848272_+SINEAluAluSx1
CAediting_947924chr12_131848276_+SINEAluAluSx1
CAediting_947925chr12_131848329_+SINEAluAluSx1
CAediting_947926chr12_131848333_+SINEAluAluSx1
CAediting_947927chr12_131848347_+SINEAluAluSx1
CAediting_947928chr12_131848360_+SINEAluAluSx1
CAediting_947929chr12_131849222_+SINEAluAluSx1
CAediting_947930chr12_131849228_+SINEAluAluSx1
CAediting_947931chr12_131849229_+SINEAluAluSx1
CAediting_947932chr12_131849234_+SINEAluAluSx1
CAediting_947933chr12_131849274_+SINEAluAluSx1
CAediting_947934chr12_131849369_+SINEAluAluSx1
CAediting_947935chr12_131849373_+SINEAluAluSx1
CAediting_947936chr12_131849470_+SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for MMP17

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_947835chr12_131839336_+131839317:1318393393SS0+1iCTTTTTTTTTTTTTGAGACAGGG-13.3CTTTTTTTTTTTTTGAGACGGGG-4.55
MEX_1CAediting_947835chr12_131839336_+131839317:1318393393SS0+1iCTTTTTTTTTTTTTGAGACAGGG-13.3CTTTTTTTTTTTTTGAGACGGGG-4.55
ESCAediting_947901chr12_131847358_+131847357:1318473655SS2+0iGAGGTGAGA7.66GGGGTGAGA4.74
IRCAediting_947901chr12_131847358_+131847357:1318473655SS2+0iGAGGTGAGA7.66GGGGTGAGA4.74
ESCAediting_947902chr12_131847363_+131847357:1318473655SS0+4iGAGGTGAGA7.66GAGGTGGGA4.3
IRCAediting_947902chr12_131847363_+131847357:1318473655SS0+4iGAGGTGAGA7.66GAGGTGGGA4.3

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198598.5.MMP17.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000198598.5.MMP17.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MMP17

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MMP17

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MMP17

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_77128chr1_85133844_+ENSG00000198598.5ENST00000360564hsa-miR-4423-3p1318515171318515237mer-m8131851504131851524145-17.65
CAediting_77128chr1_85133844_+ENSG00000198598.5ENST00000535291hsa-miR-4423-3p1318515171318515237mer-m8131851504131851524145-17.65
CAediting_468389chr6_31355314_-ENSG00000198598.5ENST00000360564hsa-miR-6891-5p1318515451318515517mer-m8131851533131851552144-23.19
CAediting_468389chr6_31355314_-ENSG00000198598.5ENST00000535291hsa-miR-6891-5p1318515451318515517mer-m8131851533131851552144-23.19

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MMP17

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for MMP17

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
SKCMCAediting_947846chr12_131846400_+1.21327973108414e-050.487588719752405....
SKCMCAediting_947847chr12_131846401_+7.3686654694329e-050.421084423559941....
SKCMCAediting_947848chr12_131846402_+0.0002915064246859950.394671974770171....
SKCMCAediting_947860chr12_131846555_+..3.26074309599484e-060.595179658827802..
SKCMCAediting_947861chr12_131846564_+..2.22590537495158e-060.576083457996039..
BRCACAediting_947869chr12_131846637_+0.04233323547179420.23829835485854....
SKCMCAediting_947869chr12_131846637_+1.45289307239118e-050.340542480221458....
BRCACAediting_947872chr12_131846649_+0.0119923371639890.327853791020421....
SKCMCAediting_947872chr12_131846649_+6.32635380928744e-050.316600311671984....
SKCMCAediting_947891chr12_131847259_+0.0007978934281618830.315157208940983....
SKCMCAediting_947896chr12_131847302_+0.0296562850820530.159936896147815....
SKCMCAediting_947915chr12_131848215_+0.04813502360995680.19242680033848....
LGGCAediting_947924chr12_131848276_+..0.02278492671432410.2843293823701050.003357169637058960.361274195911405
SKCMCAediting_947924chr12_131848276_+..2.34675632110941e-090.427713748952697..

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Relation with cancer stages for MMP17

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for MMP17

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for MMP17

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MMP17

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource