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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: MGAT3 (CAeditome ID:4248)

Gene summary for MGAT3

check button Gene summary
Gene informationGene symbol

MGAT3

Gene ID

4248

Gene namebeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
SynonymsGNT-III|GNT3
Cytomap

22q13.1

Type of geneprotein-coding
Descriptionbeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferaseGlcNAc-T IIIN-acetylglucosaminyltransferase IIIN-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IIImannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosami
Modification date20210518
UniProtAcc

Q09327

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MGAT3

GO:0030334

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

26801611


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RNA A-to-I events for MGAT3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000128268.11

check button RNA A-to-I editing events in Cancer.
CAediting_1483333(39459658, +), CAediting_1483334(39460542, +), CAediting_1483335(39460543, +), CAediting_1483336(39460736, +), CAediting_1483337(39462002, +), CAediting_1483338(39462031, +), CAediting_1483339(39462085, +), CAediting_1483340(39462160, +), CAediting_1483341(39462161, +), CAediting_1483342(39462173, +), CAediting_1483343(39463726, +), CAediting_1483344(39463730, +), CAediting_1483345(39463761, +), CAediting_1483346(39463769, +), CAediting_1483347(39463777, +), CAediting_1483348(39463795, +), CAediting_1483349(39463805, +), CAediting_1483350(39463825, +), CAediting_1483351(39463835, +), CAediting_1483352(39463840, +), CAediting_1483353(39463849, +), CAediting_1483354(39463872, +), CAediting_1483355(39463902, +), CAediting_1483356(39463903, +), CAediting_1483357(39464937, +), CAediting_1483358(39465029, +), CAediting_1483359(39465712, +), CAediting_1483360(39465717, +), CAediting_1483361(39465730, +), CAediting_1483362(39465736, +), CAediting_1483363(39465745, +), CAediting_1483364(39465746, +), CAediting_1483365(39465754, +), CAediting_1483366(39465755, +), CAediting_1483367(39465772, +), CAediting_1483368(39465781, +), CAediting_1483369(39465782, +), CAediting_1483370(39465785, +), CAediting_1483371(39465811, +), CAediting_1483372(39465812, +), CAediting_1483373(39465821, +), CAediting_1483374(39465864, +), CAediting_1483375(39465877, +), CAediting_1483376(39465884, +), CAediting_1483377(39467780, +), CAediting_1483378(39479218, +), CAediting_1483379(39479232, +), CAediting_1483380(39479254, +), CAediting_1483381(39481975, +), CAediting_1483382(39482053, +), CAediting_1483383(39482057, +), CAediting_1483384(39482071, +), CAediting_1483385(39482079, +), CAediting_1483386(39482087, +), CAediting_1483387(39482222, +), CAediting_1483388(39482234, +), CAediting_1483389(39483217, +), CAediting_1483390(39483223, +), CAediting_1483391(39483233, +), CAediting_1483392(39483261, +), CAediting_1483393(39483270, +), CAediting_1483394(39483330, +), CAediting_1483395(39483334, +), CAediting_1483396(39483335, +), CAediting_1483397(39483356, +), CAediting_1483398(39483372, +), CAediting_1483399(39483382, +), CAediting_1483400(39483386, +), CAediting_1483401(39483394, +), CAediting_1483402(39483395, +), CAediting_1483403(39483417, +), CAediting_1483404(39483435, +), CAediting_1483405(39483450, +), CAediting_1483406(39483464, +), CAediting_1483407(39483473, +), CAediting_1483408(39483474, +), CAediting_1483409(39484801, +), CAediting_1483410(39484802, +), CAediting_1483411(39484852, +), CAediting_1483412(39484864, +), CAediting_1483413(39485670, +), CAediting_1483414(39486204, +), CAediting_1483415(39486247, +), CAediting_1483416(39486248, +), CAediting_1483417(39486643, +), CAediting_1483418(39486710, +), CAediting_1483419(39486711, +),

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RNA editing positional annotations for MGAT3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_1483415chr22_39486247_+nonsynonymous SNVENST00000418314.1c.A82Gp.K28ED.N
CAediting_1483416chr22_39486248_+nonsynonymous SNVENST00000418314.1c.A83Gp.K28RD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1483333chr22_39459658_+intronic
CAediting_1483334chr22_39460542_+intronic
CAediting_1483335chr22_39460543_+intronic
CAediting_1483336chr22_39460736_+intronic
CAediting_1483337chr22_39462002_+intronic
CAediting_1483338chr22_39462031_+intronic
CAediting_1483339chr22_39462085_+intronic
CAediting_1483340chr22_39462160_+intronic
CAediting_1483341chr22_39462161_+intronic
CAediting_1483342chr22_39462173_+intronic
CAediting_1483343chr22_39463726_+intronic
CAediting_1483344chr22_39463730_+intronic
CAediting_1483345chr22_39463761_+intronic
CAediting_1483346chr22_39463769_+intronic
CAediting_1483347chr22_39463777_+intronic
CAediting_1483348chr22_39463795_+intronic
CAediting_1483349chr22_39463805_+intronic
CAediting_1483350chr22_39463825_+intronic
CAediting_1483351chr22_39463835_+intronic
CAediting_1483352chr22_39463840_+intronic
CAediting_1483353chr22_39463849_+intronic
CAediting_1483354chr22_39463872_+intronic
CAediting_1483355chr22_39463902_+intronic
CAediting_1483356chr22_39463903_+intronic
CAediting_1483357chr22_39464937_+intronic
CAediting_1483358chr22_39465029_+intronic
CAediting_1483359chr22_39465712_+intronic
CAediting_1483360chr22_39465717_+intronic
CAediting_1483361chr22_39465730_+intronic
CAediting_1483362chr22_39465736_+intronic
CAediting_1483363chr22_39465745_+intronic
CAediting_1483364chr22_39465746_+intronic
CAediting_1483365chr22_39465754_+intronic
CAediting_1483366chr22_39465755_+intronic
CAediting_1483367chr22_39465772_+intronic
CAediting_1483368chr22_39465781_+intronic
CAediting_1483369chr22_39465782_+intronic
CAediting_1483370chr22_39465785_+intronic
CAediting_1483371chr22_39465811_+intronic
CAediting_1483372chr22_39465812_+intronic
CAediting_1483373chr22_39465821_+intronic
CAediting_1483374chr22_39465864_+intronic
CAediting_1483375chr22_39465877_+intronic
CAediting_1483376chr22_39465884_+intronic
CAediting_1483377chr22_39467780_+intronic
CAediting_1483378chr22_39479218_+intronic
CAediting_1483379chr22_39479232_+intronic
CAediting_1483380chr22_39479254_+intronic
CAediting_1483381chr22_39481975_+intronic
CAediting_1483382chr22_39482053_+intronic
CAediting_1483383chr22_39482057_+intronic
CAediting_1483384chr22_39482071_+intronic
CAediting_1483385chr22_39482079_+intronic
CAediting_1483386chr22_39482087_+intronic
CAediting_1483387chr22_39482222_+intronic
CAediting_1483388chr22_39482234_+intronic
CAediting_1483389chr22_39483217_+intronic
CAediting_1483390chr22_39483223_+intronic
CAediting_1483391chr22_39483233_+intronic
CAediting_1483392chr22_39483261_+intronic
CAediting_1483393chr22_39483270_+intronic
CAediting_1483394chr22_39483330_+intronic
CAediting_1483395chr22_39483334_+intronic
CAediting_1483396chr22_39483335_+intronic
CAediting_1483397chr22_39483356_+intronic
CAediting_1483398chr22_39483372_+intronic
CAediting_1483399chr22_39483382_+intronic
CAediting_1483400chr22_39483386_+intronic
CAediting_1483401chr22_39483394_+intronic
CAediting_1483402chr22_39483395_+intronic
CAediting_1483403chr22_39483417_+intronic
CAediting_1483404chr22_39483435_+intronic
CAediting_1483405chr22_39483450_+intronic
CAediting_1483406chr22_39483464_+intronic
CAediting_1483407chr22_39483473_+intronic
CAediting_1483408chr22_39483474_+intronic
CAediting_1483409chr22_39484801_+intronic
CAediting_1483410chr22_39484802_+intronic
CAediting_1483411chr22_39484852_+intronic
CAediting_1483412chr22_39484864_+intronic
CAediting_1483413chr22_39485670_+intronic
CAediting_1483414chr22_39486204_+exonic
CAediting_1483415chr22_39486247_+exonic
CAediting_1483416chr22_39486248_+exonic
CAediting_1483417chr22_39486643_+intronic
CAediting_1483418chr22_39486710_+intronic
CAediting_1483419chr22_39486711_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1483333chr22_39459658_+SINEAluAluJo
CAediting_1483334chr22_39460542_+SINEAluAluSx1
CAediting_1483335chr22_39460543_+SINEAluAluSx1
CAediting_1483336chr22_39460736_+SINEAluAluSx1
CAediting_1483337chr22_39462002_+SINEAluAluSc5
CAediting_1483338chr22_39462031_+SINEAluAluSc5
CAediting_1483339chr22_39462085_+SINEAluAluSc5
CAediting_1483340chr22_39462160_+SINEAluAluSc5
CAediting_1483341chr22_39462161_+SINEAluAluSc5
CAediting_1483342chr22_39462173_+SINEAluAluSc5
CAediting_1483343chr22_39463726_+SINEAluAluJr
CAediting_1483344chr22_39463730_+SINEAluAluJr
CAediting_1483345chr22_39463761_+SINEAluAluJr
CAediting_1483346chr22_39463769_+SINEAluAluJr
CAediting_1483347chr22_39463777_+SINEAluAluJr
CAediting_1483348chr22_39463795_+SINEAluAluJr
CAediting_1483349chr22_39463805_+SINEAluAluJr
CAediting_1483350chr22_39463825_+SINEAluAluJr
CAediting_1483351chr22_39463835_+SINEAluAluJr
CAediting_1483352chr22_39463840_+SINEAluAluJr
CAediting_1483353chr22_39463849_+SINEAluAluJr
CAediting_1483354chr22_39463872_+SINEAluAluJr
CAediting_1483355chr22_39463902_+SINEAluAluJr
CAediting_1483356chr22_39463903_+SINEAluAluJr
CAediting_1483357chr22_39464937_+SINEAluAluY
CAediting_1483358chr22_39465029_+SINEAluAluY
CAediting_1483359chr22_39465712_+SINEAluAluSx1
CAediting_1483360chr22_39465717_+SINEAluAluSx1
CAediting_1483361chr22_39465730_+SINEAluAluSx1
CAediting_1483362chr22_39465736_+SINEAluAluSx1
CAediting_1483363chr22_39465745_+SINEAluAluSx1
CAediting_1483364chr22_39465746_+SINEAluAluSx1
CAediting_1483365chr22_39465754_+SINEAluAluSx1
CAediting_1483366chr22_39465755_+SINEAluAluSx1
CAediting_1483367chr22_39465772_+SINEAluAluSx1
CAediting_1483368chr22_39465781_+SINEAluAluSx1
CAediting_1483369chr22_39465782_+SINEAluAluSx1
CAediting_1483370chr22_39465785_+SINEAluAluSx1
CAediting_1483371chr22_39465811_+SINEAluAluSx1
CAediting_1483372chr22_39465812_+SINEAluAluSx1
CAediting_1483373chr22_39465821_+SINEAluAluSx1
CAediting_1483374chr22_39465864_+SINEAluAluSx1
CAediting_1483375chr22_39465877_+SINEAluAluSx1
CAediting_1483376chr22_39465884_+SINEAluAluSx1
CAediting_1483377chr22_39467780_+SINEAluAluYj4
CAediting_1483378chr22_39479218_+SINEAluAluJo
CAediting_1483379chr22_39479232_+SINEAluAluJo
CAediting_1483380chr22_39479254_+SINEAluAluJo
CAediting_1483381chr22_39481975_+SINEAluAluJb
CAediting_1483382chr22_39482053_+SINEAluAluJb
CAediting_1483383chr22_39482057_+SINEAluAluJb
CAediting_1483384chr22_39482071_+SINEAluAluJb
CAediting_1483385chr22_39482079_+SINEAluAluJb
CAediting_1483386chr22_39482087_+SINEAluAluJb
CAediting_1483387chr22_39482222_+SINEAluAluJb
CAediting_1483388chr22_39482234_+SINEAluAluJb
CAediting_1483389chr22_39483217_+SINEAluAluSp
CAediting_1483390chr22_39483223_+SINEAluAluSp
CAediting_1483391chr22_39483233_+SINEAluAluSp
CAediting_1483392chr22_39483261_+SINEAluAluSp
CAediting_1483393chr22_39483270_+SINEAluAluSp
CAediting_1483394chr22_39483330_+SINEAluAluSp
CAediting_1483395chr22_39483334_+SINEAluAluSp
CAediting_1483396chr22_39483335_+SINEAluAluSp
CAediting_1483397chr22_39483356_+SINEAluAluSp
CAediting_1483398chr22_39483372_+SINEAluAluSp
CAediting_1483399chr22_39483382_+SINEAluAluSp
CAediting_1483400chr22_39483386_+SINEAluAluSp
CAediting_1483401chr22_39483394_+SINEAluAluSp
CAediting_1483402chr22_39483395_+SINEAluAluSp
CAediting_1483403chr22_39483417_+SINEAluAluSp
CAediting_1483404chr22_39483435_+SINEAluAluSp
CAediting_1483405chr22_39483450_+SINEAluAluSp
CAediting_1483406chr22_39483464_+SINEAluAluSp
CAediting_1483407chr22_39483473_+SINEAluAluSp
CAediting_1483408chr22_39483474_+SINEAluAluSp
CAediting_1483409chr22_39484801_+SINEAluAluSz
CAediting_1483410chr22_39484802_+SINEAluAluSz
CAediting_1483411chr22_39484852_+SINEAluAluSz
CAediting_1483412chr22_39484864_+SINEAluAluSz
CAediting_1483413chr22_39485670_+SINEAluAluSx
CAediting_1483414chr22_39486204_+SINEAluAluSg
CAediting_1483415chr22_39486247_+SINEAluAluSg
CAediting_1483416chr22_39486248_+SINEAluAluSg
CAediting_1483417chr22_39486643_+SINEAluAluJb
CAediting_1483418chr22_39486710_+SINEAluAluJb
CAediting_1483419chr22_39486711_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for MGAT3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1483415chr22_39486247_+39486246:394862545SS2+0iCAAGTAATT3.86CGAGTAATT2.27
ESCAediting_1483416chr22_39486248_+39486246:394862545SS1+0iCAAGTAATT3.86CAGGTAATT8.55

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000128268.11.MGAT3.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000128268.11.MGAT3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MGAT3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MGAT3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MGAT3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000128268.11ENST00000341184hsa-miR-320e39490519394905257mer-m83949050739490526149-20.93
CAediting_1368054chr19_46709310_-ENSG00000128268.11ENST00000341184hsa-miR-320e39491520394915278mer-1a3949151039491527140-14.56
CAediting_86358chr1_109598906_+ENSG00000128268.11ENST00000341184hsa-miR-197-5p39491910394919178mer-1a3949189439491917160-26.45
CAediting_86358chr1_109598906_+ENSG00000128268.11ENST00000341184hsa-miR-197-5p39489544394895507mer-m83948952939489551145-16.73
CAediting_77128chr1_85133844_+ENSG00000128268.11ENST00000341184hsa-miR-4423-3p39491162394911687mer-m83949114939491169144-13.52
CAediting_1399425chr20_1392958_-ENSG00000128268.11ENST00000341184hsa-miR-6869-5p39490653394906608mer-1a3949063839490660158-25.77

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1306323chr19_13836462_-ENSG00000128268.11ENST00000341184hsa-miR-27a-3p39490057394900626mer3949004339490063147-17.43
CAediting_604450chr7_133034877_-ENSG00000128268.11ENST00000341184hsa-miR-365439489758394897647mer-m83948974739489765140-15.61
CAediting_1054808chr15_66496985_-ENSG00000128268.11ENST00000341184hsa-miR-451239491430394914367mer-m83949141539491437145-20.6
CAediting_748296chr10_51299626_+ENSG00000128268.11ENST00000341184hsa-miR-605-3p39491573394915797mer-m83949155939491580140-14.49
CAediting_1351755chr19_40282625_-ENSG00000128268.11ENST00000341184hsa-miR-64139490028394900347mer-m83949001139490035143-14.11

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MGAT3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for MGAT3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for MGAT3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for MGAT3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for MGAT3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MGAT3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource