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Editing gene: MCM4 (CAeditome ID:4173)

Gene summary for MCM4

Gene summary

Gene information	Gene symbol	MCM4
	Gene ID	4173
	Gene name	minichromosome maintenance complex component 4
	Synonyms	CDC21\|CDC54\|IMD54\|NKCD\|NKGCD\|P1-CDC21\|hCdc21
	Cytomap	8q11.21
	Type of gene	protein-coding
	Description	DNA replication licensing factor MCM4homolog of S. pombe cell devision cycle 21minichromosome maintenance deficient 4
	Modification date	20210518
	UniProtAcc	P33991
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MCM4	GO:0003678	DNA replication licensing factor MCM4	9305914
MCM4	GO:0005654	DNA replication licensing factor MCM4	0000052
MCM4	GO:0042555	DNA replication licensing factor MCM4	17296731

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RNA A-to-I events for MCM4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000104738.15

RNA A-to-I editing events in Cancer.

CAediting_637640(47969320, +), CAediting_637641(47972046, +), CAediting_637642(47972056, +), CAediting_637643(47972061, +), CAediting_637644(47972085, +), CAediting_637645(47972111, +), CAediting_637646(47972112, +), CAediting_637647(47972144, +), CAediting_637648(47972155, +), CAediting_637649(47972177, +), CAediting_637650(47972696, +), CAediting_637651(47972740, +), CAediting_637652(47973365, +), CAediting_637653(47977002, +), CAediting_637654(47977010, +), CAediting_637655(47977011, +), CAediting_637656(47977054, +), CAediting_637657(47977062, +), CAediting_637658(47977073, +), CAediting_637659(47977087, +), CAediting_637660(47977099, +), CAediting_637661(47977103, +), CAediting_637662(47977104, +), CAediting_637663(47977109, +), CAediting_637664(47977112, +), CAediting_637665(47977113, +), CAediting_637666(47977114, +), CAediting_637667(47977115, +), CAediting_637668(47977119, +), CAediting_637669(47977145, +), CAediting_637670(47977146, +), CAediting_637671(47977168, +), CAediting_637672(47977172, +), CAediting_637673(47977185, +), CAediting_637674(47977187, +), CAediting_637675(47977191, +), CAediting_637676(47977211, +), CAediting_637677(47977215, +), CAediting_637678(47977236, +), CAediting_637679(47977245, +), CAediting_637680(47977524, +), CAediting_637681(47977532, +), CAediting_637682(47977540, +), CAediting_637683(47977549, +), CAediting_637684(47977554, +), CAediting_637685(47977565, +), CAediting_637686(47977580, +), CAediting_637687(47977643, +), CAediting_637688(47977645, +), CAediting_637689(47977667, +), CAediting_637690(47977693, +), CAediting_637691(47977694, +), CAediting_637692(47977698, +), CAediting_637693(47977706, +), CAediting_637694(47977711, +), CAediting_637695(47977728, +), CAediting_637696(47977735, +), CAediting_637697(47977751, +),

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RNA editing positional annotations for MCM4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_637640	chr8_47969320_+	ncRNA_exonic
CAediting_637641	chr8_47972046_+	ncRNA_intronic
CAediting_637642	chr8_47972056_+	ncRNA_intronic
CAediting_637643	chr8_47972061_+	ncRNA_intronic
CAediting_637644	chr8_47972085_+	ncRNA_intronic
CAediting_637645	chr8_47972111_+	ncRNA_intronic
CAediting_637646	chr8_47972112_+	ncRNA_intronic
CAediting_637647	chr8_47972144_+	ncRNA_intronic
CAediting_637648	chr8_47972155_+	ncRNA_intronic
CAediting_637649	chr8_47972177_+	ncRNA_intronic
CAediting_637650	chr8_47972696_+	ncRNA_intronic
CAediting_637651	chr8_47972740_+	ncRNA_intronic
CAediting_637652	chr8_47973365_+	intronic
CAediting_637653	chr8_47977002_+	ncRNA_exonic
CAediting_637654	chr8_47977010_+	ncRNA_exonic
CAediting_637655	chr8_47977011_+	ncRNA_exonic
CAediting_637656	chr8_47977054_+	ncRNA_exonic
CAediting_637657	chr8_47977062_+	ncRNA_exonic
CAediting_637658	chr8_47977073_+	ncRNA_exonic
CAediting_637659	chr8_47977087_+	ncRNA_exonic
CAediting_637660	chr8_47977099_+	ncRNA_exonic
CAediting_637661	chr8_47977103_+	ncRNA_exonic
CAediting_637662	chr8_47977104_+	ncRNA_exonic
CAediting_637663	chr8_47977109_+	ncRNA_exonic
CAediting_637664	chr8_47977112_+	ncRNA_exonic
CAediting_637665	chr8_47977113_+	ncRNA_exonic
CAediting_637666	chr8_47977114_+	ncRNA_exonic
CAediting_637667	chr8_47977115_+	ncRNA_exonic
CAediting_637668	chr8_47977119_+	ncRNA_exonic
CAediting_637669	chr8_47977145_+	ncRNA_exonic
CAediting_637670	chr8_47977146_+	ncRNA_exonic
CAediting_637671	chr8_47977168_+	ncRNA_exonic
CAediting_637672	chr8_47977172_+	ncRNA_exonic
CAediting_637673	chr8_47977185_+	ncRNA_exonic
CAediting_637674	chr8_47977187_+	ncRNA_exonic
CAediting_637675	chr8_47977191_+	ncRNA_exonic
CAediting_637676	chr8_47977211_+	ncRNA_exonic
CAediting_637677	chr8_47977215_+	ncRNA_exonic
CAediting_637678	chr8_47977236_+	ncRNA_exonic
CAediting_637679	chr8_47977245_+	ncRNA_exonic
CAediting_637680	chr8_47977524_+	UTR3
CAediting_637681	chr8_47977532_+	UTR3
CAediting_637682	chr8_47977540_+	UTR3
CAediting_637683	chr8_47977549_+	UTR3
CAediting_637684	chr8_47977554_+	UTR3
CAediting_637685	chr8_47977565_+	UTR3
CAediting_637686	chr8_47977580_+	UTR3
CAediting_637687	chr8_47977643_+	UTR3
CAediting_637688	chr8_47977645_+	UTR3
CAediting_637689	chr8_47977667_+	UTR3
CAediting_637690	chr8_47977693_+	UTR3
CAediting_637691	chr8_47977694_+	UTR3
CAediting_637692	chr8_47977698_+	UTR3
CAediting_637693	chr8_47977706_+	UTR3
CAediting_637694	chr8_47977711_+	UTR3
CAediting_637695	chr8_47977728_+	UTR3
CAediting_637696	chr8_47977735_+	UTR3
CAediting_637697	chr8_47977751_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_637640	chr8_47969320_+	SINE	Alu	AluSp
CAediting_637641	chr8_47972046_+	SINE	Alu	AluSx
CAediting_637642	chr8_47972056_+	SINE	Alu	AluSx
CAediting_637643	chr8_47972061_+	SINE	Alu	AluSx
CAediting_637644	chr8_47972085_+	SINE	Alu	AluSx
CAediting_637645	chr8_47972111_+	SINE	Alu	AluSx
CAediting_637646	chr8_47972112_+	SINE	Alu	AluSx
CAediting_637647	chr8_47972144_+	SINE	Alu	AluSx
CAediting_637648	chr8_47972155_+	SINE	Alu	AluSx
CAediting_637649	chr8_47972177_+	SINE	Alu	AluSx
CAediting_637650	chr8_47972696_+	SINE	Alu	AluSx
CAediting_637651	chr8_47972740_+	SINE	Alu	AluSx
CAediting_637652	chr8_47973365_+	SINE	Alu	AluSx1
CAediting_637653	chr8_47977002_+	SINE	Alu	AluSx3
CAediting_637654	chr8_47977010_+	SINE	Alu	AluSx3
CAediting_637655	chr8_47977011_+	SINE	Alu	AluSx3
CAediting_637656	chr8_47977054_+	SINE	Alu	AluSx3
CAediting_637657	chr8_47977062_+	SINE	Alu	AluSx3
CAediting_637658	chr8_47977073_+	SINE	Alu	AluSx3
CAediting_637659	chr8_47977087_+	SINE	Alu	AluSx3
CAediting_637660	chr8_47977099_+	SINE	Alu	AluSx3
CAediting_637661	chr8_47977103_+	SINE	Alu	AluSx3
CAediting_637662	chr8_47977104_+	SINE	Alu	AluSx3
CAediting_637663	chr8_47977109_+	SINE	Alu	AluSx3
CAediting_637664	chr8_47977112_+	SINE	Alu	AluSx3
CAediting_637665	chr8_47977113_+	SINE	Alu	AluSx3
CAediting_637666	chr8_47977114_+	SINE	Alu	AluSx3
CAediting_637667	chr8_47977115_+	SINE	Alu	AluSx3
CAediting_637668	chr8_47977119_+	SINE	Alu	AluSx3
CAediting_637669	chr8_47977145_+	SINE	Alu	AluSx3
CAediting_637670	chr8_47977146_+	SINE	Alu	AluSx3
CAediting_637671	chr8_47977168_+	SINE	Alu	AluSx3
CAediting_637672	chr8_47977172_+	SINE	Alu	AluSx3
CAediting_637673	chr8_47977185_+	SINE	Alu	AluSx3
CAediting_637674	chr8_47977187_+	SINE	Alu	AluSx3
CAediting_637675	chr8_47977191_+	SINE	Alu	AluSx3
CAediting_637676	chr8_47977211_+	SINE	Alu	AluSx3
CAediting_637677	chr8_47977215_+	SINE	Alu	AluSx3
CAediting_637678	chr8_47977236_+	SINE	Alu	AluSx3
CAediting_637679	chr8_47977245_+	SINE	Alu	AluSx3
CAediting_637680	chr8_47977524_+	SINE	Alu	AluJb
CAediting_637681	chr8_47977532_+	SINE	Alu	AluJb
CAediting_637682	chr8_47977540_+	SINE	Alu	AluJb
CAediting_637683	chr8_47977549_+	SINE	Alu	AluJb
CAediting_637684	chr8_47977554_+	SINE	Alu	AluJb
CAediting_637685	chr8_47977565_+	SINE	Alu	AluJb
CAediting_637686	chr8_47977580_+	SINE	Alu	AluJb
CAediting_637687	chr8_47977643_+	SINE	Alu	AluJb
CAediting_637688	chr8_47977645_+	SINE	Alu	AluJb
CAediting_637689	chr8_47977667_+	SINE	Alu	AluJb
CAediting_637690	chr8_47977693_+	SINE	Alu	AluJb
CAediting_637691	chr8_47977694_+	SINE	Alu	AluJb
CAediting_637692	chr8_47977698_+	SINE	Alu	AluJb
CAediting_637693	chr8_47977706_+	SINE	Alu	AluJb
CAediting_637694	chr8_47977711_+	SINE	Alu	AluJb
CAediting_637695	chr8_47977728_+	SINE	Alu	AluJb
CAediting_637696	chr8_47977735_+	SINE	Alu	AluJb
CAediting_637697	chr8_47977751_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for MCM4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_637689	chr8_47977667_+	47977648:47977670	3SS	0+1i	CGGCTTCGCCACGTTGCCCAGGC	-13.48	CGGCTTCGCCACGTTGCCCGGGC	-4.73
IR	CAediting_637695	chr8_47977728_+	47977716:47977738	3SS	0+8i	CCGGAAGTGCTGAGATTACAGGT	-25.76	CCGGAAGTGCTGGGATTACAGGT	-19.96
IR	CAediting_637696	chr8_47977735_+	47977716:47977738	3SS	0+1i	CCGGAAGTGCTGAGATTACAGGT	-25.76	CCGGAAGTGCTGAGATTACGGGT	-17.01

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000104738.15.MCM4.

Correlation between RNA A-to-I editing and PSI for ENSG00000104738.15.MCM4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MCM4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LGG.CAediting_637658.ENSG00000104738.MCM4.png
Soverview

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Protein coding region RNA A-to-I editings for MCM4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MCM4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_637658	chr8_47977073_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4435	47977070	47977077	8mer-1a	47977057	47977077	146.00	-17.76
CAediting_637658	chr8_47977073_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4435	47977070	47977077	8mer-1a	47977057	47977077	146.00	-17.76
CAediting_637658	chr8_47977073_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4755-3p	47977068	47977074	7mer-m8	47977054	47977075	145.00	-16.93
CAediting_637664	chr8_47977112_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4652-3p	47977107	47977114	8mer-1a	47977093	47977114	147.00	-8.68
CAediting_637669	chr8_47977145_+	ENSG00000104738.15	ENST00000262105	hsa-miR-513a-5p	47977139	47977145	7mer-m8	47977129	47977146	148.00	-19.36
CAediting_637669	chr8_47977145_+	ENSG00000104738.15	ENST00000262105	hsa-miR-513a-5p	47977139	47977145	7mer-m8	47977129	47977146	148.00	-19.36
CAediting_637669	chr8_47977145_+	ENSG00000104738.15	ENST00000262105	hsa-miR-638	47977144	47977150	7mer-1a	47977126	47977150	163.00	-35.61
CAediting_637677	chr8_47977215_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4638-5p	47977210	47977217	8mer-1a	47977198	47977217	146.00	-20.28
CAediting_637678	chr8_47977236_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4743-5p	47977232	47977238	7mer-m8	47977217	47977239	147.00	-23.99
CAediting_637683	chr8_47977549_+	ENSG00000104738.15	ENST00000262105	hsa-miR-508-5p	47977546	47977553	8mer-1a	47977529	47977553	156.00	-20.80
CAediting_637683	chr8_47977549_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6512-3p	47977544	47977550	7mer-m8	47977530	47977551	142.00	-19.59
CAediting_637683	chr8_47977549_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6720-5p	47977544	47977550	7mer-m8	47977530	47977551	152.00	-25.90
CAediting_637683	chr8_47977549_+	ENSG00000104738.15	ENST00000262105	hsa-miR-766-3p	47977545	47977551	7mer-m8	47977531	47977552	145.00	-20.64
CAediting_637684	chr8_47977554_+	ENSG00000104738.15	ENST00000262105	hsa-miR-148a-3p	47977552	47977558	7mer-m8	47977538	47977559	154.00	-20.65
CAediting_637684	chr8_47977554_+	ENSG00000104738.15	ENST00000262105	hsa-miR-148b-3p	47977552	47977558	7mer-m8	47977538	47977559	142.00	-16.09
CAediting_637684	chr8_47977554_+	ENSG00000104738.15	ENST00000262105	hsa-miR-152-3p	47977552	47977558	7mer-m8	47977539	47977559	142.00	-18.53
CAediting_637684	chr8_47977554_+	ENSG00000104738.15	ENST00000262105	hsa-miR-7703	47977549	47977555	7mer-m8	47977534	47977556	161.00	-23.25
CAediting_637693	chr8_47977706_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6765-5p	47977704	47977711	8mer-1a	47977689	47977711	154.00	-25.51
CAediting_637693	chr8_47977706_+	ENSG00000104738.15	ENST00000262105	hsa-miR-7112-5p	47977699	47977705	7mer-m8	47977685	47977706	148.00	-23.10
CAediting_637695	chr8_47977728_+	ENSG00000104738.15	ENST00000262105	hsa-miR-7977	47977723	47977729	7mer-m8	47977713	47977730	140.00	-15.26
CAediting_637653	chr8_47977002_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4466	47977000	47977005	6mer	47976989	47977006	147.00	-31.78
CAediting_637654	chr8_47977010_+	ENSG00000104738.15	ENST00000262105	hsa-miR-513a-5p	47977004	47977010	7mer-m8	47976994	47977011	144.00	-17.77
CAediting_637654	chr8_47977010_+	ENSG00000104738.15	ENST00000262105	hsa-miR-513a-5p	47977004	47977010	7mer-m8	47976994	47977011	144.00	-17.77
CAediting_637654	chr8_47977010_+	ENSG00000104738.15	ENST00000262105	hsa-miR-638	47977009	47977015	7mer-1a	47976991	47977015	151.00	-32.52
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1229-3p	47977081	47977087	7mer-m8	47977065	47977088	147.00	-14.35
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511a-3p	47977080	47977087	8mer-1a	47977065	47977087	151.00	-19.50
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511a-3p	47977080	47977087	8mer-1a	47977065	47977087	151.00	-19.50
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511a-3p	47977080	47977087	8mer-1a	47977065	47977087	151.00	-19.50
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511a-3p	47977080	47977087	8mer-1a	47977065	47977087	151.00	-19.50
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511b-3p	47977080	47977087	8mer-1a	47977064	47977087	148.00	-15.04
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6511b-3p	47977080	47977087	8mer-1a	47977064	47977087	148.00	-15.04
CAediting_637661	chr8_47977103_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3675-3p	47977100	47977107	8mer-1a	47977084	47977107	145.00	-9.25
CAediting_637661	chr8_47977103_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4684-5p	47977099	47977105	7mer-m8	47977085	47977106	146.00	-12.94
CAediting_637665	chr8_47977113_+	ENSG00000104738.15	ENST00000262105	hsa-miR-578	47977108	47977115	8mer-1a	47977095	47977115	149.00	-12.45
CAediting_637666	chr8_47977114_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6844	47977108	47977115	8mer-1a	47977097	47977115	152.00	-9.71
CAediting_637670	chr8_47977146_+	ENSG00000104738.15	ENST00000262105	hsa-miR-8052	47977144	47977150	7mer-1a	47977130	47977150	153.00	-27.23
CAediting_637671	chr8_47977168_+	ENSG00000104738.15	ENST00000262105	hsa-miR-18a-3p	47977167	47977172	6mer	47977151	47977173	140.00	-25.28
CAediting_637671	chr8_47977168_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1913	47977166	47977172	7mer-m8	47977152	47977173	147.00	-24.48
CAediting_637671	chr8_47977168_+	ENSG00000104738.15	ENST00000262105	hsa-miR-5699-5p	47977164	47977171	8mer-1a	47977150	47977171	145.00	-19.22
CAediting_637671	chr8_47977168_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6793-3p	47977163	47977169	7mer-m8	47977150	47977170	152.00	-27.09
CAediting_637673	chr8_47977185_+	ENSG00000104738.15	ENST00000262105	hsa-miR-498-5p	47977180	47977186	7mer-m8	47977165	47977187	142.00	-9.71
CAediting_637674	chr8_47977187_+	ENSG00000104738.15	ENST00000262105	hsa-miR-27a-5p	47977183	47977190	8mer-1a	47977169	47977190	153.00	-17.57
CAediting_637674	chr8_47977187_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4720-3p	47977181	47977187	7mer-m8	47977168	47977188	146.00	-9.31
CAediting_637676	chr8_47977211_+	ENSG00000104738.15	ENST00000262105	hsa-miR-324-3p	47977204	47977210	7mer-m8	47977189	47977211	157.00	-28.53
CAediting_637679	chr8_47977245_+	ENSG00000104738.15	ENST00000262105	hsa-miR-639	47977240	47977245	6mer	47977225	47977246	142.00	-28.74
CAediting_637681	chr8_47977532_+	ENSG00000104738.15	ENST00000262105	hsa-miR-451b	47977527	47977533	7mer-m8	47977514	47977534	142.00	-11.14
CAediting_637681	chr8_47977532_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4696	47977526	47977532	7mer-m8	47977514	47977533	143.00	-15.65
CAediting_637681	chr8_47977532_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6501-3p	47977530	47977536	7mer-m8	47977515	47977537	145.00	-15.86
CAediting_637682	chr8_47977540_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1273c	47977535	47977540	6mer	47977520	47977541	144.00	-31.47
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-134-5p	47977562	47977568	7mer-m8	47977551	47977569	150.00	-23.20
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3118	47977562	47977568	7mer-m8	47977546	47977569	152.00	-19.00
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3118	47977562	47977568	7mer-m8	47977546	47977569	152.00	-19.00
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3118	47977562	47977568	7mer-m8	47977546	47977569	152.00	-19.00
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3118	47977562	47977568	7mer-m8	47977546	47977569	152.00	-19.00
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-943	47977561	47977567	7mer-m8	47977546	47977568	147.00	-16.65
CAediting_637688	chr8_47977645_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3162-3p	47977639	47977646	8mer-1a	47977626	47977646	140.00	-15.01
CAediting_637689	chr8_47977667_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3940-3p	47977664	47977670	7mer-m8	47977650	47977671	140.00	-20.94
CAediting_637689	chr8_47977667_+	ENSG00000104738.15	ENST00000262105	hsa-miR-7112-5p	47977661	47977666	6mer	47977646	47977667	140.00	-21.35
CAediting_637691	chr8_47977694_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1199-5p	47977687	47977693	7mer-m8	47977675	47977694	153.00	-28.82
CAediting_637691	chr8_47977694_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6078	47977690	47977697	8mer-1a	47977678	47977697	160.00	-22.71
CAediting_637691	chr8_47977694_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6751-3p	47977687	47977693	7mer-m8	47977674	47977694	146.00	-14.94
CAediting_637696	chr8_47977735_+	ENSG00000104738.15	ENST00000262105	hsa-miR-100-5p	47977731	47977737	7mer-m8	47977716	47977738	158.00	-20.74
CAediting_637696	chr8_47977735_+	ENSG00000104738.15	ENST00000262105	hsa-miR-99a-5p	47977731	47977737	7mer-m8	47977716	47977738	150.00	-19.31
CAediting_637696	chr8_47977735_+	ENSG00000104738.15	ENST00000262105	hsa-miR-99b-5p	47977731	47977737	7mer-m8	47977716	47977738	146.00	-23.86
CAediting_637697	chr8_47977751_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4486	47977749	47977755	7mer-m8	47977741	47977756	149.00	-27.10

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_637654	chr8_47977010_+	ENSG00000104738.15	ENST00000262105	hsa-miR-10399-5p	47977005	47977011	7mer-m8	47976991	47977012	148	-11.2
CAediting_637655	chr8_47977011_+	ENSG00000104738.15	ENST00000262105	hsa-miR-10399-5p	47977005	47977011	7mer-m8	47976991	47977012	148	-11.2
CAediting_637669	chr8_47977145_+	ENSG00000104738.15	ENST00000262105	hsa-miR-10399-5p	47977140	47977146	7mer-m8	47977126	47977147	144	-13.07
CAediting_637670	chr8_47977146_+	ENSG00000104738.15	ENST00000262105	hsa-miR-10399-5p	47977140	47977146	7mer-m8	47977126	47977147	144	-13.07
CAediting_637683	chr8_47977549_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1251-5p	47977545	47977551	7mer-m8	47977532	47977552	142	-15.7
CAediting_637679	chr8_47977245_+	ENSG00000104738.15	ENST00000262105	hsa-miR-137-3p	47977241	47977247	7mer-m8	47977226	47977248	144	-10.23
CAediting_637659	chr8_47977087_+	ENSG00000104738.15	ENST00000262105	hsa-miR-193b-5p	47977085	47977091	7mer-m8	47977071	47977092	142	-18.8
CAediting_637672	chr8_47977172_+	ENSG00000104738.15	ENST00000262105	hsa-miR-1976	47977169	47977176	8mer-1a	47977156	47977176	149	-24.45
CAediting_637695	chr8_47977728_+	ENSG00000104738.15	ENST00000262105	hsa-miR-216a-5p	47977725	47977732	8mer-1a	47977711	47977732	150	-18.02
CAediting_637688	chr8_47977645_+	ENSG00000104738.15	ENST00000262105	hsa-miR-340-3p	47977643	47977649	7mer-m8	47977629	47977650	148	-14.11
CAediting_637678	chr8_47977236_+	ENSG00000104738.15	ENST00000262105	hsa-miR-3652	47977232	47977238	7mer-m8	47977220	47977239	148	-20.61
CAediting_637676	chr8_47977211_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4284	47977207	47977214	8mer-1a	47977197	47977214	151	-16.7
CAediting_637675	chr8_47977191_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4485-5p	47977189	47977195	7mer-m8	47977181	47977196	140	-14.86
CAediting_637680	chr8_47977524_+	ENSG00000104738.15	ENST00000262105	hsa-miR-454-5p	47977520	47977526	7mer-m8	47977506	47977527	140	-13.31
CAediting_637687	chr8_47977643_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4684-5p	47977640	47977646	7mer-m8	47977624	47977647	151	-12.52
CAediting_637688	chr8_47977645_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4684-5p	47977640	47977646	7mer-m8	47977624	47977647	151	-12.52
CAediting_637667	chr8_47977115_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4735-5p	47977113	47977119	7mer-m8	47977099	47977120	140	-4.73
CAediting_637668	chr8_47977119_+	ENSG00000104738.15	ENST00000262105	hsa-miR-4735-5p	47977113	47977119	7mer-m8	47977099	47977120	140	-4.73
CAediting_637678	chr8_47977236_+	ENSG00000104738.15	ENST00000262105	hsa-miR-485-5p	47977234	47977241	8mer-1a	47977221	47977241	148	-19.35
CAediting_637685	chr8_47977565_+	ENSG00000104738.15	ENST00000262105	hsa-miR-508-3p	47977560	47977567	8mer-1a	47977545	47977567	145	-14.56
CAediting_637655	chr8_47977011_+	ENSG00000104738.15	ENST00000262105	hsa-miR-5089-5p	47977009	47977015	7mer-m8	47976994	47977016	148	-13.62
CAediting_637670	chr8_47977146_+	ENSG00000104738.15	ENST00000262105	hsa-miR-5089-5p	47977144	47977150	7mer-m8	47977133	47977151	148	-15.16
CAediting_637689	chr8_47977667_+	ENSG00000104738.15	ENST00000262105	hsa-miR-5189-5p	47977661	47977667	7mer-m8	47977643	47977668	150	-25.07
CAediting_637693	chr8_47977706_+	ENSG00000104738.15	ENST00000262105	hsa-miR-541-3p	47977701	47977707	7mer-m8	47977688	47977708	148	-17.05
CAediting_637678	chr8_47977236_+	ENSG00000104738.15	ENST00000262105	hsa-miR-5787	47977233	47977238	6mer	47977219	47977239	145	-27.69
CAediting_637658	chr8_47977073_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6069	47977069	47977076	8mer-1a	47977058	47977076	144	-15.82
CAediting_637693	chr8_47977706_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6134	47977703	47977710	8mer-1a	47977692	47977710	150	-21.68
CAediting_637673	chr8_47977185_+	ENSG00000104738.15	ENST00000262105	hsa-miR-629-5p	47977183	47977190	8mer-1a	47977170	47977190	143	-14.01
CAediting_637674	chr8_47977187_+	ENSG00000104738.15	ENST00000262105	hsa-miR-629-5p	47977183	47977190	8mer-1a	47977170	47977190	143	-14.01
CAediting_637654	chr8_47977010_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6504-3p	47977005	47977011	7mer-m8	47976991	47977012	145	-14.35
CAediting_637655	chr8_47977011_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6504-3p	47977005	47977011	7mer-m8	47976991	47977012	145	-14.35
CAediting_637693	chr8_47977706_+	ENSG00000104738.15	ENST00000262105	hsa-miR-654-5p	47977701	47977707	7mer-m8	47977687	47977708	142	-17.66
CAediting_637675	chr8_47977191_+	ENSG00000104738.15	ENST00000262105	hsa-miR-661	47977187	47977193	7mer-m8	47977171	47977194	147	-20.9
CAediting_637697	chr8_47977751_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6741-5p	47977748	47977754	7mer-m8	47977735	47977755	152	-22.51
CAediting_637675	chr8_47977191_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6742-3p	47977186	47977192	7mer-m8	47977174	47977193	145	-15.21
CAediting_637672	chr8_47977172_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6747-3p	47977167	47977174	8mer-1a	47977152	47977174	149	-23.99
CAediting_637653	chr8_47977002_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6807-5p	47976995	47977001	7mer-m8	47976980	47977002	144	-28.04
CAediting_637688	chr8_47977645_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6827-3p	47977643	47977649	7mer-m8	47977630	47977650	149	-16.73
CAediting_637674	chr8_47977187_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6839-3p	47977184	47977190	7mer-m8	47977170	47977191	140	-15.26
CAediting_637675	chr8_47977191_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6839-3p	47977184	47977190	7mer-m8	47977170	47977191	140	-15.26
CAediting_637678	chr8_47977236_+	ENSG00000104738.15	ENST00000262105	hsa-miR-6884-5p	47977234	47977241	8mer-1a	47977221	47977241	149	-19.08
CAediting_637669	chr8_47977145_+	ENSG00000104738.15	ENST00000262105	hsa-miR-7151-3p	47977138	47977145	8mer-1a	47977127	47977145	144	-13.24
CAediting_637689	chr8_47977667_+	ENSG00000104738.15	ENST00000262105	hsa-miR-939-3p	47977662	47977668	7mer-m8	47977649	47977669	140	-15.63

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_573001	chr7_92204086_-	ENSG00000104738.15	ENST00000524086	hsa-miR-1285-5p	47962150	47962157	8mer-1a	47962137	47962157	151	-23.26
CAediting_1368054	chr19_46709310_-	ENSG00000104738.15	ENST00000518382	hsa-miR-320e	47975794	47975800	7mer-m8	47975783	47975801	146	-17.81

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for MCM4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000262105.5	protein_coding
ENST00000518680.1	processed_transcript
ENST00000523944.4	protein_coding
ENST00000521151.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_637653	ENST00000262105.5	chr8_47977002_+	-1428.90	-1429.30	-1478.90
CAediting_637654	ENST00000262105.5	chr8_47977010_+	-1429.40	-1429.30	-1478.90
CAediting_637655	ENST00000262105.5	chr8_47977011_+	-1429.30	-1429.30	-1478.90
CAediting_637656	ENST00000262105.5	chr8_47977054_+	-1429.30	-1429.30	-1478.90
CAediting_637657	ENST00000262105.5	chr8_47977062_+	-1432.70	-1429.30	-1478.90
CAediting_637658	ENST00000262105.5	chr8_47977073_+	-1435.90	-1429.30	-1478.90
CAediting_637659	ENST00000262105.5	chr8_47977087_+	-1429.00	-1429.30	-1478.90
CAediting_637660	ENST00000262105.5	chr8_47977099_+	-1429.00	-1429.30	-1478.90
CAediting_637661	ENST00000262105.5	chr8_47977103_+	-1429.40	-1429.30	-1478.90
CAediting_637662	ENST00000262105.5	chr8_47977104_+	-1428.90	-1429.30	-1478.90
CAediting_637663	ENST00000262105.5	chr8_47977109_+	-1430.00	-1429.30	-1478.90
CAediting_637664	ENST00000262105.5	chr8_47977112_+	-1429.40	-1429.30	-1478.90
CAediting_637665	ENST00000262105.5	chr8_47977113_+	-1429.40	-1429.30	-1478.90
CAediting_637666	ENST00000262105.5	chr8_47977114_+	-1429.40	-1429.30	-1478.90
CAediting_637667	ENST00000262105.5	chr8_47977115_+	-1429.00	-1429.30	-1478.90
CAediting_637668	ENST00000262105.5	chr8_47977119_+	-1429.00	-1429.30	-1478.90
CAediting_637669	ENST00000262105.5	chr8_47977145_+	-1430.40	-1429.30	-1478.90
CAediting_637670	ENST00000262105.5	chr8_47977146_+	-1430.90	-1429.30	-1478.90
CAediting_637671	ENST00000262105.5	chr8_47977168_+	-1432.30	-1429.30	-1478.90
CAediting_637672	ENST00000262105.5	chr8_47977172_+	-1433.40	-1429.30	-1478.90
CAediting_637673	ENST00000262105.5	chr8_47977185_+	-1431.50	-1429.30	-1478.90
CAediting_637674	ENST00000262105.5	chr8_47977187_+	-1433.90	-1429.30	-1478.90
CAediting_637675	ENST00000262105.5	chr8_47977191_+	-1428.60	-1429.30	-1478.90
CAediting_637676	ENST00000262105.5	chr8_47977211_+	-1428.40	-1429.30	-1478.90
CAediting_637677	ENST00000262105.5	chr8_47977215_+	-1432.40	-1429.30	-1478.90
CAediting_637678	ENST00000262105.5	chr8_47977236_+	-1429.30	-1429.30	-1478.90
CAediting_637679	ENST00000262105.5	chr8_47977245_+	-1433.50	-1429.30	-1478.90
CAediting_637680	ENST00000262105.5	chr8_47977524_+	-1429.30	-1429.30	-1478.90
CAediting_637681	ENST00000262105.5	chr8_47977532_+	-1428.30	-1429.30	-1478.90
CAediting_637682	ENST00000262105.5	chr8_47977540_+	-1432.90	-1429.30	-1478.90
CAediting_637683	ENST00000262105.5	chr8_47977549_+	-1435.90	-1429.30	-1478.90
CAediting_637684	ENST00000262105.5	chr8_47977554_+	-1436.00	-1429.30	-1478.90
CAediting_637685	ENST00000262105.5	chr8_47977565_+	-1429.50	-1429.30	-1478.90
CAediting_637686	ENST00000262105.5	chr8_47977580_+	-1427.90	-1429.30	-1478.90
CAediting_637687	ENST00000262105.5	chr8_47977643_+	-1429.00	-1429.30	-1478.90
CAediting_637688	ENST00000262105.5	chr8_47977645_+	-1428.40	-1429.30	-1478.90
CAediting_637689	ENST00000262105.5	chr8_47977667_+	-1429.30	-1429.30	-1478.90
CAediting_637690	ENST00000262105.5	chr8_47977693_+	-1428.60	-1429.30	-1478.90
CAediting_637691	ENST00000262105.5	chr8_47977694_+	-1429.30	-1429.30	-1478.90
CAediting_637692	ENST00000262105.5	chr8_47977698_+	-1428.70	-1429.30	-1478.90
CAediting_637693	ENST00000262105.5	chr8_47977706_+	-1428.90	-1429.30	-1478.90
CAediting_637694	ENST00000262105.5	chr8_47977711_+	-1429.30	-1429.30	-1478.90
CAediting_637695	ENST00000262105.5	chr8_47977728_+	-1436.20	-1429.30	-1478.90
CAediting_637696	ENST00000262105.5	chr8_47977735_+	-1428.60	-1429.30	-1478.90
CAediting_637697	ENST00000262105.5	chr8_47977751_+	-1434.70	-1429.30	-1478.90
CAediting_637640	ENST00000518680.1	chr8_47969320_+	-266.80	-265.80	-266.80
CAediting_637653	ENST00000523944.4	chr8_47977002_+	-1380.60	-1381.00	-1430.60
CAediting_637654	ENST00000523944.4	chr8_47977010_+	-1381.10	-1381.00	-1430.60
CAediting_637655	ENST00000523944.4	chr8_47977011_+	-1381.00	-1381.00	-1430.60
CAediting_637656	ENST00000523944.4	chr8_47977054_+	-1381.00	-1381.00	-1430.60
CAediting_637657	ENST00000523944.4	chr8_47977062_+	-1384.40	-1381.00	-1430.60
CAediting_637658	ENST00000523944.4	chr8_47977073_+	-1387.60	-1381.00	-1430.60
CAediting_637659	ENST00000523944.4	chr8_47977087_+	-1380.70	-1381.00	-1430.60
CAediting_637660	ENST00000523944.4	chr8_47977099_+	-1380.70	-1381.00	-1430.60
CAediting_637661	ENST00000523944.4	chr8_47977103_+	-1381.10	-1381.00	-1430.60
CAediting_637662	ENST00000523944.4	chr8_47977104_+	-1380.60	-1381.00	-1430.60
CAediting_637663	ENST00000523944.4	chr8_47977109_+	-1381.70	-1381.00	-1430.60
CAediting_637664	ENST00000523944.4	chr8_47977112_+	-1381.10	-1381.00	-1430.60
CAediting_637665	ENST00000523944.4	chr8_47977113_+	-1381.10	-1381.00	-1430.60
CAediting_637666	ENST00000523944.4	chr8_47977114_+	-1381.10	-1381.00	-1430.60
CAediting_637667	ENST00000523944.4	chr8_47977115_+	-1380.70	-1381.00	-1430.60
CAediting_637668	ENST00000523944.4	chr8_47977119_+	-1380.70	-1381.00	-1430.60
CAediting_637669	ENST00000523944.4	chr8_47977145_+	-1382.10	-1381.00	-1430.60
CAediting_637670	ENST00000523944.4	chr8_47977146_+	-1382.60	-1381.00	-1430.60
CAediting_637671	ENST00000523944.4	chr8_47977168_+	-1384.00	-1381.00	-1430.60
CAediting_637672	ENST00000523944.4	chr8_47977172_+	-1385.10	-1381.00	-1430.60
CAediting_637673	ENST00000523944.4	chr8_47977185_+	-1383.20	-1381.00	-1430.60
CAediting_637674	ENST00000523944.4	chr8_47977187_+	-1385.60	-1381.00	-1430.60
CAediting_637675	ENST00000523944.4	chr8_47977191_+	-1380.30	-1381.00	-1430.60
CAediting_637676	ENST00000523944.4	chr8_47977211_+	-1380.10	-1381.00	-1430.60
CAediting_637677	ENST00000523944.4	chr8_47977215_+	-1384.10	-1381.00	-1430.60
CAediting_637678	ENST00000523944.4	chr8_47977236_+	-1381.00	-1381.00	-1430.60
CAediting_637679	ENST00000523944.4	chr8_47977245_+	-1385.20	-1381.00	-1430.60
CAediting_637680	ENST00000523944.4	chr8_47977524_+	-1381.00	-1381.00	-1430.60
CAediting_637681	ENST00000523944.4	chr8_47977532_+	-1380.00	-1381.00	-1430.60
CAediting_637682	ENST00000523944.4	chr8_47977540_+	-1384.60	-1381.00	-1430.60
CAediting_637683	ENST00000523944.4	chr8_47977549_+	-1387.60	-1381.00	-1430.60
CAediting_637684	ENST00000523944.4	chr8_47977554_+	-1387.70	-1381.00	-1430.60
CAediting_637685	ENST00000523944.4	chr8_47977565_+	-1381.20	-1381.00	-1430.60
CAediting_637686	ENST00000523944.4	chr8_47977580_+	-1379.60	-1381.00	-1430.60
CAediting_637687	ENST00000523944.4	chr8_47977643_+	-1380.70	-1381.00	-1430.60
CAediting_637688	ENST00000523944.4	chr8_47977645_+	-1380.10	-1381.00	-1430.60
CAediting_637689	ENST00000523944.4	chr8_47977667_+	-1381.00	-1381.00	-1430.60
CAediting_637690	ENST00000523944.4	chr8_47977693_+	-1380.30	-1381.00	-1430.60
CAediting_637691	ENST00000523944.4	chr8_47977694_+	-1381.00	-1381.00	-1430.60
CAediting_637692	ENST00000523944.4	chr8_47977698_+	-1380.40	-1381.00	-1430.60
CAediting_637693	ENST00000523944.4	chr8_47977706_+	-1380.60	-1381.00	-1430.60
CAediting_637694	ENST00000523944.4	chr8_47977711_+	-1381.00	-1381.00	-1430.60
CAediting_637695	ENST00000523944.4	chr8_47977728_+	-1387.90	-1381.00	-1430.60
CAediting_637696	ENST00000523944.4	chr8_47977735_+	-1380.30	-1381.00	-1430.60
CAediting_637697	ENST00000523944.4	chr8_47977751_+	-1386.40	-1381.00	-1430.60
CAediting_637653	ENST00000521151.1	chr8_47977002_+	-332.30	-329.10	-365.20
CAediting_637654	ENST00000521151.1	chr8_47977010_+	-331.80	-329.10	-365.20
CAediting_637655	ENST00000521151.1	chr8_47977011_+	-329.10	-329.10	-365.20
CAediting_637656	ENST00000521151.1	chr8_47977054_+	-330.80	-329.10	-365.20
CAediting_637657	ENST00000521151.1	chr8_47977062_+	-329.60	-329.10	-365.20
CAediting_637658	ENST00000521151.1	chr8_47977073_+	-333.00	-329.10	-365.20
CAediting_637659	ENST00000521151.1	chr8_47977087_+	-329.10	-329.10	-365.20
CAediting_637660	ENST00000521151.1	chr8_47977099_+	-331.80	-329.10	-365.20
CAediting_637661	ENST00000521151.1	chr8_47977103_+	-330.30	-329.10	-365.20
CAediting_637662	ENST00000521151.1	chr8_47977104_+	-330.30	-329.10	-365.20
CAediting_637663	ENST00000521151.1	chr8_47977109_+	-332.30	-329.10	-365.20
CAediting_637664	ENST00000521151.1	chr8_47977112_+	-329.10	-329.10	-365.20
CAediting_637665	ENST00000521151.1	chr8_47977113_+	-329.10	-329.10	-365.20
CAediting_637666	ENST00000521151.1	chr8_47977114_+	-329.10	-329.10	-365.20
CAediting_637667	ENST00000521151.1	chr8_47977115_+	-330.80	-329.10	-365.20
CAediting_637668	ENST00000521151.1	chr8_47977119_+	-331.10	-329.10	-365.20
CAediting_637669	ENST00000521151.1	chr8_47977145_+	-328.20	-329.10	-365.20
CAediting_637670	ENST00000521151.1	chr8_47977146_+	-329.00	-329.10	-365.20
CAediting_637671	ENST00000521151.1	chr8_47977168_+	-334.80	-329.10	-365.20
CAediting_637672	ENST00000521151.1	chr8_47977172_+	-331.30	-329.10	-365.20
CAediting_637673	ENST00000521151.1	chr8_47977185_+	-332.20	-329.10	-365.20
CAediting_637674	ENST00000521151.1	chr8_47977187_+	-330.50	-329.10	-365.20
CAediting_637675	ENST00000521151.1	chr8_47977191_+	-329.00	-329.10	-365.20
CAediting_637676	ENST00000521151.1	chr8_47977211_+	-331.90	-329.10	-365.20
CAediting_637677	ENST00000521151.1	chr8_47977215_+	-331.30	-329.10	-365.20
CAediting_637678	ENST00000521151.1	chr8_47977236_+	-329.50	-329.10	-365.20
CAediting_637679	ENST00000521151.1	chr8_47977245_+	-330.20	-329.10	-365.20

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Relation with ADAR for MCM4

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_637658	chr8_47977073_+	.	.	0.02910466229405	0.223987712409245	.	.
LGG	CAediting_637658	chr8_47977073_+	0.000152830741060391	0.217982006565743	0.0126519529050531	0.144531855313391	.	.
BRCA	CAediting_637658	chr8_47977073_+	1.90339719936582e-31	0.456103925880569	.	.	.	.
LIHC	CAediting_637658	chr8_47977073_+	2.88601094926504e-05	0.335468570964114	.	.	.	.
CESC	CAediting_637658	chr8_47977073_+	0.000394786098345429	0.41478166068453	.	.	.	.
LUAD	CAediting_637658	chr8_47977073_+	1.08362894369529e-10	0.438098441939525	.	.	.	.
LUSC	CAediting_637658	chr8_47977073_+	9.68715473427782e-12	0.555867591225075	.	.	.	.
GBM	CAediting_637658	chr8_47977073_+	1.07994908437611e-06	0.409568142641099	.	.	.	.
HNSC	CAediting_637658	chr8_47977073_+	5.46830925684469e-05	0.48918978350499	.	.	.	.
STAD	CAediting_637658	chr8_47977073_+	2.18717620690269e-09	0.376266981742905	0.0239219668651159	0.146678736585738	.	.
UCEC	CAediting_637658	chr8_47977073_+	0.000251237978024614	0.24836673131289	0.0305004290170829	0.148294649561601	.	.
ESCA	CAediting_637658	chr8_47977073_+	0.0039036756813081	0.25738202369201	0.0249236323680559	0.201361850893516	.	.
OV	CAediting_637658	chr8_47977073_+	5.2565341121544e-22	0.491366145458009	.	.	.	.
PCPG	CAediting_637658	chr8_47977073_+	0.00164600645758637	0.276572318511971	.	.	.	.
SKCM	CAediting_637658	chr8_47977073_+	7.80842335658238e-05	0.408415051869889	.	.	.	.
SARC	CAediting_637658	chr8_47977073_+	6.43973765774977e-07	0.520209420569503	.	.	.	.
BLCA	CAediting_637660	chr8_47977099_+	0.0305315650069976	0.300309898627527	.	.	.	.
LGG	CAediting_637660	chr8_47977099_+	5.10895744207996e-05	0.464488774146686	.	.	.	.
BRCA	CAediting_637660	chr8_47977099_+	1.3031019937225e-22	0.489524085902073	.	.	.	.
LIHC	CAediting_637660	chr8_47977099_+	0.000507922340503504	0.316500971880462	.	.	.	.
LUAD	CAediting_637660	chr8_47977099_+	1.05230312452242e-08	0.464816859348492	.	.	1.76003135705076e-12	0.555948906595489
STAD	CAediting_637660	chr8_47977099_+	0.0288075170907393	0.294957602013306	.	.	0.0275889103888524	0.297143598050042
OV	CAediting_637660	chr8_47977099_+	0.00448799220218568	0.276534043443904	.	.	.	.
PCPG	CAediting_637660	chr8_47977099_+	0.0419607234263078	0.218575152150448	.	.	.	.
BRCA	CAediting_637664	chr8_47977112_+	1.55056551187112e-06	0.332125171145358	.	.	.	.
LIHC	CAediting_637664	chr8_47977112_+	0.00641169793237653	0.34535725982884	.	.	.	.
LUAD	CAediting_637664	chr8_47977112_+	2.55062144467823e-10	0.68348160482102	.	.	.	.
BLCA	CAediting_637683	chr8_47977549_+	1.75306020872654e-40	0.600047201382	0.0162964205052158	0.120051429795168	.	.
LGG	CAediting_637683	chr8_47977549_+	6.27225721649336e-08	0.23257155256648	1.81931360759129e-10	0.272589735483553	1.81188636530927e-12	0.300065639168089
BRCA	CAediting_637683	chr8_47977549_+	1.74815178086497e-147	0.675312124998365	.	.	.	.
LIHC	CAediting_637683	chr8_47977549_+	7.66710833320213e-25	0.499228883474976	.	.	.	.
CESC	CAediting_637683	chr8_47977549_+	2.75876978326475e-26	0.561149324779433	.	.	.	.
LUAD	CAediting_637683	chr8_47977549_+	1.55803706389522e-51	0.595649122381728	.	.	.	.
COAD	CAediting_637683	chr8_47977549_+	2.95753862560746e-31	0.511643469806035	8.32667722457383e-06	0.208812777721066	.	.
LUSC	CAediting_637683	chr8_47977549_+	3.43742191259991e-52	0.610029986165468	.	.	0.0187544889950254	0.105189010073037
GBM	CAediting_637683	chr8_47977549_+	2.33753804864868e-09	0.440311166459909	.	.	.	.
PRAD	CAediting_637683	chr8_47977549_+	6.40057711809859e-28	0.467072439476877	.	.	.	.
HNSC	CAediting_637683	chr8_47977549_+	1.04620023889575e-25	0.44756468549714	.	.	.	.
STAD	CAediting_637683	chr8_47977549_+	1.21039319870127e-26	0.522806513483017	.	.	.	.
KICH	CAediting_637683	chr8_47977549_+	9.93216141972104e-06	0.521492516349601	.	.	.	.
THCA	CAediting_637683	chr8_47977549_+	4.21838916142284e-24	0.429639747791894	.	.	.	.
KIRC	CAediting_637683	chr8_47977549_+	1.00335225891723e-13	0.315356415215548	.	.	.	.
UCEC	CAediting_637683	chr8_47977549_+	4.87679744515768e-52	0.591750379145865	.	.	.	.
KIRP	CAediting_637683	chr8_47977549_+	8.68314930550918e-08	0.316445113909072	.	.	.	.
ACC	CAediting_637683	chr8_47977549_+	1.05498900879439e-09	0.633590340501335	.	.	.	.
ESCA	CAediting_637683	chr8_47977549_+	4.18658040259884e-09	0.443715969705024	0.015718722559384	0.19069223671342	.	.
LAML	CAediting_637683	chr8_47977549_+	4.4902741863926e-05	0.360648366279312	.	.	.	.
OV	CAediting_637683	chr8_47977549_+	1.15630081408547e-23	0.48751191760764	.	.	.	.
PAAD	CAediting_637683	chr8_47977549_+	6.95143480716978e-11	0.463904693277068	.	.	.	.
PCPG	CAediting_637683	chr8_47977549_+	7.91347939889232e-16	0.549508905070508	7.76966588055142e-05	0.287861050839792	.	.
SKCM	CAediting_637683	chr8_47977549_+	3.23058651532028e-48	0.607357610690903	.	.	.	.
UCS	CAediting_637683	chr8_47977549_+	4.84490469623302e-07	0.627873049545159	.	.	.	.
UVM	CAediting_637683	chr8_47977549_+	0.000118265339881896	0.449954988536779	.	.	.	.
MESO	CAediting_637683	chr8_47977549_+	1.83338010111538e-07	0.527239856344374	.	.	.	.
READ	CAediting_637683	chr8_47977549_+	7.86871706278282e-09	0.437827263541016	0.0314490847314164	0.170705233458719	.	.
SARC	CAediting_637683	chr8_47977549_+	6.86778756930661e-25	0.580285378152301	.	.	.	.
TGCT	CAediting_637683	chr8_47977549_+	1.11352883271442e-20	0.660783706957176	.	.	.	.
THYM	CAediting_637683	chr8_47977549_+	1.33141950453425e-17	0.684229433917152	.	.	4.4647528142012e-05	0.366518226374285
BLCA	CAediting_637684	chr8_47977554_+	6.40436115582803e-07	0.379371160223186	.	.	.	.
LGG	CAediting_637684	chr8_47977554_+	1.48913732949543e-16	0.455988915411114	0.00691870672758588	0.156933495317693	.	.
BRCA	CAediting_637684	chr8_47977554_+	8.4993591666281e-51	0.556042715556547	.	.	.	.
LIHC	CAediting_637684	chr8_47977554_+	1.96790797471937e-13	0.448580345132597	.	.	.	.
CESC	CAediting_637684	chr8_47977554_+	2.52862527735495e-05	0.404119593177818	.	.	.	.
LUAD	CAediting_637684	chr8_47977554_+	3.48614740872133e-29	0.605349767665095	.	.	.	.
LUSC	CAediting_637684	chr8_47977554_+	1.31349576254022e-15	0.533786243784956	.	.	.	.
HNSC	CAediting_637684	chr8_47977554_+	1.54664637933286e-07	0.424563037394823	.	.	.	.
STAD	CAediting_637684	chr8_47977554_+	0.000307829485379651	0.343827857218381	.	.	.	.
THCA	CAediting_637684	chr8_47977554_+	0.000545790605751196	0.290564680709236	.	.	.	.
KIRC	CAediting_637684	chr8_47977554_+	0.0160831655832551	0.18225853814247	.	.	.	.
UCEC	CAediting_637684	chr8_47977554_+	1.19626537534453e-07	0.402576590429759	.	.	.	.
ESCA	CAediting_637684	chr8_47977554_+	0.00676574739884205	0.340522135294092	.	.	.	.
OV	CAediting_637684	chr8_47977554_+	9.26797784369469e-07	0.37320726200511	.	.	.	.
PAAD	CAediting_637684	chr8_47977554_+	0.0017896537092411	0.377317579060604	.	.	.	.
PCPG	CAediting_637684	chr8_47977554_+	1.05654898888348e-09	0.466688889980855	.	.	.	.
SKCM	CAediting_637684	chr8_47977554_+	0.000106712291239907	0.34093548179403	.	.	.	.
SARC	CAediting_637684	chr8_47977554_+	1.0268127245077e-08	0.506691412665713	.	.	.	.
TGCT	CAediting_637684	chr8_47977554_+	1.18090193101973e-08	0.604434052237326	.	.	.	.
BRCA	CAediting_637695	chr8_47977728_+	0.00697674626562008	0.294021546917681	0.00224658951734995	0.330904451598301	.	.
LIHC	CAediting_637695	chr8_47977728_+	0.000457301732998833	0.367791207049965	.	.	.	.

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Relation with cancer stages for MCM4

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BLCA	pathologic_stage	CAediting_637683	chr8_47977549_+	0.0210736146213307	0.115598291243308
BRCA	pathologic_stage	CAediting_637684	chr8_47977554_+	0.0108010386187909	0.1039999274133
HNSC	clinical_stage	CAediting_637683	chr8_47977549_+	0.00162128463205224	0.143499610241998
HNSC	pathologic_stage	CAediting_637683	chr8_47977549_+	0.000541948435622357	0.165564516547064
KIRC	pathologic_stage	CAediting_637658	chr8_47977073_+	0.0193526291507052	0.237132299843722
KIRC	pathologic_stage	CAediting_637683	chr8_47977549_+	0.000825785652268039	0.144965685921646
KIRC	pathologic_stage	CAediting_637684	chr8_47977554_+	0.00301180029189419	0.223648397963366
KIRP	clinical_stage	CAediting_637683	chr8_47977549_+	0.00189011224204004	0.223430645911354
KIRP	pathologic_stage	CAediting_637683	chr8_47977549_+	0.000547317349942522	0.219253497131766
LUAD	pathologic_stage	CAediting_637664	chr8_47977112_+	0.0396057472916481	-0.255941061186552
TGCT	clinical_stage	CAediting_637683	chr8_47977549_+	0.0305132100592951	-0.237650912770541
TGCT	pathologic_stage	CAediting_637683	chr8_47977549_+	0.00233530932530521	-0.333649156011807
THCA	pathologic_stage	CAediting_637683	chr8_47977549_+	0.00713450899916608	0.120307281898771
THCA	pathologic_stage	CAediting_637684	chr8_47977554_+	0.0341233345227705	0.180505883597976
UVM	clinical_stage	CAediting_637683	chr8_47977549_+	0.0435667768359659	0.245538581238906

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Relation with survival for MCM4

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
STAD	CAediting_637683	chr8_47977549_+	0.00387141674617852	0.0376928	3.02466

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RelatedDrugs for MCM4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MCM4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MCM4	C1864947	Natural Killer Cell Deficiency, Familial Isolated	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
MCM4	C0342482	X-linked Adrenal Hypoplasia	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene