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Editing gene: MAN1A1 (CAeditome ID:4121)

Gene summary for MAN1A1

Gene summary

Gene information	Gene symbol	MAN1A1
	Gene ID	4121
	Gene name	mannosidase alpha class 1A member 1
	Synonyms	HUMM3\|HUMM9\|MAN9
	Cytomap	6q22.31
	Type of gene	protein-coding
	Description	mannosyl-oligosaccharide 1,2-alpha-mannosidase IAMan9-mannosidasealpha-1,2-mannosidase IAman(9)-alpha-mannosidaseprocessing alpha-1,2-mannosidase IA
	Modification date	20210518
	UniProtAcc	P33908
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MAN1A1	GO:0030433	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	27108681
MAN1A1	GO:1904382	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	27108681
MAN1A1	GO:0005793	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	15308636
MAN1A1	GO:0005794	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	0000052
MAN1A1	GO:0005829	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	0000052
MAN1A1	GO:0031410	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	27108681

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RNA A-to-I events for MAN1A1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000111885.6

RNA A-to-I editing events in Cancer.

CAediting_502054(119178352, -), CAediting_502055(119194523, -), CAediting_502056(119194929, -), CAediting_502057(119197288, -), CAediting_502058(119199892, -), CAediting_502059(119208860, -), CAediting_502060(119208915, -), CAediting_502061(119221471, -), CAediting_502062(119221569, -), CAediting_502063(119221725, -), CAediting_502064(119222400, -), CAediting_502065(119222405, -), CAediting_502066(119222424, -), CAediting_502067(119222442, -), CAediting_502068(119222459, -), CAediting_502069(119222465, -), CAediting_502070(119222487, -), CAediting_502071(119222526, -), CAediting_502072(119222551, -), CAediting_502073(119222554, -), CAediting_502074(119224866, -), CAediting_502075(119225387, -), CAediting_502076(119227634, -), CAediting_502077(119227688, -), CAediting_502078(119232316, -), CAediting_502079(119234456, -), CAediting_502080(119234473, -), CAediting_502081(119234474, -), CAediting_502082(119234486, -), CAediting_502083(119234591, -), CAediting_502084(119234597, -), CAediting_502085(119236473, -), CAediting_502086(119236664, -), CAediting_502087(119239051, -), CAediting_502088(119265345, -), CAediting_502089(119265349, -), CAediting_502090(119269856, -), CAediting_502091(119269857, -), CAediting_502092(119269860, -), CAediting_502093(119269865, -), CAediting_502094(119269885, -), CAediting_502095(119275249, -), CAediting_502096(119275635, -), CAediting_502097(119275636, -), CAediting_502098(119275674, -), CAediting_502099(119275709, -), CAediting_502100(119277639, -), CAediting_502101(119277746, -), CAediting_502102(119277747, -), CAediting_502103(119278094, -), CAediting_502104(119278110, -), CAediting_502105(119278713, -), CAediting_502106(119278732, -), CAediting_502107(119278750, -), CAediting_502108(119278765, -), CAediting_502109(119278776, -), CAediting_502110(119278789, -), CAediting_502111(119278962, -), CAediting_502112(119278972, -), CAediting_502113(119278973, -), CAediting_502114(119278979, -), CAediting_502115(119278993, -), CAediting_502116(119278997, -), CAediting_502117(119279002, -), CAediting_502118(119281800, -), CAediting_502119(119284945, -), CAediting_502120(119284948, -), CAediting_502121(119284950, -), CAediting_502122(119284952, -), CAediting_502123(119284965, -), CAediting_502124(119284966, -), CAediting_502125(119284967, -), CAediting_502126(119284969, -), CAediting_502127(119284979, -), CAediting_502128(119285391, -), CAediting_502129(119285429, -), CAediting_502130(119285430, -), CAediting_502131(119321710, -), CAediting_502132(119325557, -), CAediting_502133(119325574, -), CAediting_502134(119327505, -), CAediting_502135(119327572, -), CAediting_502136(119327578, -), CAediting_502137(119327583, -), CAediting_502138(119327584, -), CAediting_502139(119339828, -), CAediting_502140(119339888, -), CAediting_502141(119339894, -),

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RNA editing positional annotations for MAN1A1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_502054	chr6_119178352_-	UTR3
CAediting_502055	chr6_119194523_-	intronic
CAediting_502056	chr6_119194929_-	intronic
CAediting_502057	chr6_119197288_-	intronic
CAediting_502058	chr6_119199892_-	intronic
CAediting_502059	chr6_119208860_-	intronic
CAediting_502060	chr6_119208915_-	intronic
CAediting_502061	chr6_119221471_-	intronic
CAediting_502062	chr6_119221569_-	intronic
CAediting_502063	chr6_119221725_-	intronic
CAediting_502064	chr6_119222400_-	intronic
CAediting_502065	chr6_119222405_-	intronic
CAediting_502066	chr6_119222424_-	intronic
CAediting_502067	chr6_119222442_-	intronic
CAediting_502068	chr6_119222459_-	intronic
CAediting_502069	chr6_119222465_-	intronic
CAediting_502070	chr6_119222487_-	intronic
CAediting_502071	chr6_119222526_-	intronic
CAediting_502072	chr6_119222551_-	intronic
CAediting_502073	chr6_119222554_-	intronic
CAediting_502074	chr6_119224866_-	intronic
CAediting_502075	chr6_119225387_-	intronic
CAediting_502076	chr6_119227634_-	intronic
CAediting_502077	chr6_119227688_-	intronic
CAediting_502078	chr6_119232316_-	intronic
CAediting_502079	chr6_119234456_-	intronic
CAediting_502080	chr6_119234473_-	intronic
CAediting_502081	chr6_119234474_-	intronic
CAediting_502082	chr6_119234486_-	intronic
CAediting_502083	chr6_119234591_-	intronic
CAediting_502084	chr6_119234597_-	intronic
CAediting_502085	chr6_119236473_-	intronic
CAediting_502086	chr6_119236664_-	intronic
CAediting_502087	chr6_119239051_-	intronic
CAediting_502088	chr6_119265345_-	intronic
CAediting_502089	chr6_119265349_-	intronic
CAediting_502090	chr6_119269856_-	intronic
CAediting_502091	chr6_119269857_-	intronic
CAediting_502092	chr6_119269860_-	intronic
CAediting_502093	chr6_119269865_-	intronic
CAediting_502094	chr6_119269885_-	intronic
CAediting_502095	chr6_119275249_-	intronic
CAediting_502096	chr6_119275635_-	intronic
CAediting_502097	chr6_119275636_-	intronic
CAediting_502098	chr6_119275674_-	intronic
CAediting_502099	chr6_119275709_-	intronic
CAediting_502100	chr6_119277639_-	intronic
CAediting_502101	chr6_119277746_-	intronic
CAediting_502102	chr6_119277747_-	intronic
CAediting_502103	chr6_119278094_-	intronic
CAediting_502104	chr6_119278110_-	intronic
CAediting_502105	chr6_119278713_-	intronic
CAediting_502106	chr6_119278732_-	intronic
CAediting_502107	chr6_119278750_-	intronic
CAediting_502108	chr6_119278765_-	intronic
CAediting_502109	chr6_119278776_-	intronic
CAediting_502110	chr6_119278789_-	intronic
CAediting_502111	chr6_119278962_-	intronic
CAediting_502112	chr6_119278972_-	intronic
CAediting_502113	chr6_119278973_-	intronic
CAediting_502114	chr6_119278979_-	intronic
CAediting_502115	chr6_119278993_-	intronic
CAediting_502116	chr6_119278997_-	intronic
CAediting_502117	chr6_119279002_-	intronic
CAediting_502118	chr6_119281800_-	intronic
CAediting_502119	chr6_119284945_-	intronic
CAediting_502120	chr6_119284948_-	intronic
CAediting_502121	chr6_119284950_-	intronic
CAediting_502122	chr6_119284952_-	intronic
CAediting_502123	chr6_119284965_-	intronic
CAediting_502124	chr6_119284966_-	intronic
CAediting_502125	chr6_119284967_-	intronic
CAediting_502126	chr6_119284969_-	intronic
CAediting_502127	chr6_119284979_-	intronic
CAediting_502128	chr6_119285391_-	intronic
CAediting_502129	chr6_119285429_-	intronic
CAediting_502130	chr6_119285430_-	intronic
CAediting_502131	chr6_119321710_-	intronic
CAediting_502132	chr6_119325557_-	intronic
CAediting_502133	chr6_119325574_-	intronic
CAediting_502134	chr6_119327505_-	intronic
CAediting_502135	chr6_119327572_-	intronic
CAediting_502136	chr6_119327578_-	intronic
CAediting_502137	chr6_119327583_-	intronic
CAediting_502138	chr6_119327584_-	intronic
CAediting_502139	chr6_119339828_-	intronic
CAediting_502140	chr6_119339888_-	intronic
CAediting_502141	chr6_119339894_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_502054	chr6_119178352_-	DNA	TcMar-Mariner	MADE2
CAediting_502055	chr6_119194523_-	SINE	Alu	AluJr4
CAediting_502056	chr6_119194929_-	SINE	Alu	AluSx1
CAediting_502057	chr6_119197288_-	SINE	Alu	AluSx1
CAediting_502058	chr6_119199892_-	SINE	Alu	AluJr
CAediting_502059	chr6_119208860_-	SINE	Alu	AluJb
CAediting_502060	chr6_119208915_-	SINE	Alu	AluJb
CAediting_502061	chr6_119221471_-	SINE	Alu	AluSx1
CAediting_502062	chr6_119221569_-	SINE	Alu	AluSx1
CAediting_502063	chr6_119221725_-	SINE	Alu	AluSx1
CAediting_502064	chr6_119222400_-	SINE	Alu	AluJo
CAediting_502065	chr6_119222405_-	SINE	Alu	AluJo
CAediting_502066	chr6_119222424_-	SINE	Alu	AluJo
CAediting_502067	chr6_119222442_-	SINE	Alu	AluJo
CAediting_502068	chr6_119222459_-	SINE	Alu	AluJo
CAediting_502069	chr6_119222465_-	SINE	Alu	AluJo
CAediting_502070	chr6_119222487_-	SINE	Alu	AluJo
CAediting_502071	chr6_119222526_-	SINE	Alu	AluJo
CAediting_502072	chr6_119222551_-	SINE	Alu	AluJo
CAediting_502073	chr6_119222554_-	SINE	Alu	AluJo
CAediting_502074	chr6_119224866_-	SINE	Alu	AluSg
CAediting_502075	chr6_119225387_-	SINE	Alu	AluJr
CAediting_502076	chr6_119227634_-	SINE	Alu	AluJb
CAediting_502077	chr6_119227688_-	SINE	Alu	AluJb
CAediting_502078	chr6_119232316_-	SINE	Alu	AluY
CAediting_502079	chr6_119234456_-	SINE	Alu	AluJo
CAediting_502080	chr6_119234473_-	SINE	Alu	AluJo
CAediting_502081	chr6_119234474_-	SINE	Alu	AluJo
CAediting_502082	chr6_119234486_-	SINE	Alu	AluJo
CAediting_502083	chr6_119234591_-	SINE	Alu	AluJo
CAediting_502084	chr6_119234597_-	SINE	Alu	AluJo
CAediting_502085	chr6_119236473_-	SINE	Alu	AluSx1
CAediting_502086	chr6_119236664_-	SINE	Alu	AluSx1
CAediting_502087	chr6_119239051_-	SINE	Alu	AluYc
CAediting_502088	chr6_119265345_-	SINE	Alu	AluJo
CAediting_502089	chr6_119265349_-	SINE	Alu	AluJo
CAediting_502090	chr6_119269856_-	SINE	Alu	FLAM_A
CAediting_502091	chr6_119269857_-	SINE	Alu	FLAM_A
CAediting_502092	chr6_119269860_-	SINE	Alu	FLAM_A
CAediting_502093	chr6_119269865_-	SINE	Alu	FLAM_A
CAediting_502094	chr6_119269885_-	SINE	Alu	FLAM_A
CAediting_502095	chr6_119275249_-	SINE	Alu	AluSx
CAediting_502096	chr6_119275635_-	SINE	Alu	AluSx
CAediting_502097	chr6_119275636_-	SINE	Alu	AluSx
CAediting_502098	chr6_119275674_-	SINE	Alu	AluSx
CAediting_502099	chr6_119275709_-	SINE	Alu	AluSx
CAediting_502100	chr6_119277639_-	SINE	Alu	AluJb
CAediting_502101	chr6_119277746_-	SINE	Alu	AluY
CAediting_502102	chr6_119277747_-	SINE	Alu	AluY
CAediting_502103	chr6_119278094_-	SINE	Alu	AluJb
CAediting_502104	chr6_119278110_-	SINE	Alu	AluJb
CAediting_502105	chr6_119278713_-	LTR	ERVL-MaLR	MSTB
CAediting_502106	chr6_119278732_-	LTR	ERVL-MaLR	MSTB
CAediting_502107	chr6_119278750_-	LTR	ERVL-MaLR	MSTB
CAediting_502108	chr6_119278765_-	LTR	ERVL-MaLR	MSTB
CAediting_502109	chr6_119278776_-	LTR	ERVL-MaLR	MSTB
CAediting_502110	chr6_119278789_-	LTR	ERVL-MaLR	MSTB
CAediting_502111	chr6_119278962_-	LTR	ERVL-MaLR	MSTB
CAediting_502112	chr6_119278972_-	LTR	ERVL-MaLR	MSTB
CAediting_502113	chr6_119278973_-	LTR	ERVL-MaLR	MSTB
CAediting_502114	chr6_119278979_-	LTR	ERVL-MaLR	MSTB
CAediting_502115	chr6_119278993_-	LTR	ERVL-MaLR	MSTB
CAediting_502116	chr6_119278997_-	LTR	ERVL-MaLR	MSTB
CAediting_502117	chr6_119279002_-	LTR	ERVL-MaLR	MSTB
CAediting_502118	chr6_119281800_-	SINE	Alu	AluSx3
CAediting_502119	chr6_119284945_-	LTR	ERVL-MaLR	MSTB
CAediting_502120	chr6_119284948_-	LTR	ERVL-MaLR	MSTB
CAediting_502121	chr6_119284950_-	LTR	ERVL-MaLR	MSTB
CAediting_502122	chr6_119284952_-	LTR	ERVL-MaLR	MSTB
CAediting_502123	chr6_119284965_-	LTR	ERVL-MaLR	MSTB
CAediting_502124	chr6_119284966_-	LTR	ERVL-MaLR	MSTB
CAediting_502125	chr6_119284967_-	LTR	ERVL-MaLR	MSTB
CAediting_502126	chr6_119284969_-	LTR	ERVL-MaLR	MSTB
CAediting_502127	chr6_119284979_-	LTR	ERVL-MaLR	MSTB
CAediting_502128	chr6_119285391_-	LTR	ERVL-MaLR	MSTB
CAediting_502129	chr6_119285429_-	LTR	ERVL-MaLR	MSTB
CAediting_502130	chr6_119285430_-	LTR	ERVL-MaLR	MSTB
CAediting_502131	chr6_119321710_-	SINE	Alu	AluSz6
CAediting_502132	chr6_119325557_-	SINE	Alu	AluSz
CAediting_502133	chr6_119325574_-	SINE	Alu	AluSz
CAediting_502134	chr6_119327505_-	SINE	Alu	AluSx
CAediting_502135	chr6_119327572_-	SINE	Alu	AluSx
CAediting_502136	chr6_119327578_-	SINE	Alu	AluSx
CAediting_502137	chr6_119327583_-	SINE	Alu	AluSx
CAediting_502138	chr6_119327584_-	SINE	Alu	AluSx
CAediting_502139	chr6_119339828_-	SINE	Alu	AluSx1
CAediting_502140	chr6_119339888_-	SINE	Alu	AluSx1
CAediting_502141	chr6_119339894_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for MAN1A1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000111885.6.MAN1A1.

Correlation between RNA A-to-I editing and PSI for ENSG00000111885.6.MAN1A1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MAN1A1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MAN1A1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MAN1A1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MAN1A1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000368468.3	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_502054	ENST00000368468.3	chr6_119178352_-	-1504.50	-1504.80	-1504.50

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Relation with ADAR for MAN1A1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_502054	chr6_119178352_-	.	.	0.000911621352968989	0.42055475516973	.	.
BRCA	CAediting_502054	chr6_119178352_-	8.62446900647659e-15	0.433926690695479	.	.	.	.
LIHC	CAediting_502054	chr6_119178352_-	3.51448816835882e-09	0.395962273976068	.	.	.	.
LUAD	CAediting_502054	chr6_119178352_-	1.14808433689304e-10	0.579556129339032	.	.	.	.
OV	CAediting_502054	chr6_119178352_-	0.010359194990812	0.235182404531946	.	.	.	.

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Relation with cancer stages for MAN1A1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for MAN1A1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MAN1A1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MAN1A1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene