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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: MAD2L1 (CAeditome ID:4085)

Gene summary for MAD2L1

check button Gene summary
Gene informationGene symbol

MAD2L1

Gene ID

4085

Gene namemitotic arrest deficient 2 like 1
SynonymsHSMAD2|MAD2
Cytomap

4q27

Type of geneprotein-coding
Descriptionmitotic spindle assembly checkpoint protein MAD2AMAD2 (mitotic arrest deficient, yeast, homolog)-like 1MAD2 mitotic arrest deficient-like 1MAD2-like protein 1mitotic arrest deficient 2-like protein 1mitotic arrest deficient, yeast, homolog-like 1
Modification date20210518
UniProtAcc

Q13257

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MAD2L1

GO:0000776

Mitotic spindle assembly checkpoint protein MAD2A

17363900

MAD2L1

GO:0000776

Mitotic spindle assembly checkpoint protein MAD2A

19468067

MAD2L1

GO:0007094

Mitotic spindle assembly checkpoint protein MAD2A

18981471

MAD2L1

GO:0042177

Mitotic spindle assembly checkpoint protein MAD2A

11459825

MAD2L1

GO:0090267

Mitotic spindle assembly checkpoint protein MAD2A

8824189

MAD2L1

GO:1904667

Mitotic spindle assembly checkpoint protein MAD2A

11459825

MAD2L1

GO:0000776

Mitotic spindle assembly checkpoint protein MAD2A

19229290

MAD2L1

GO:0000776

Mitotic spindle assembly checkpoint protein MAD2A

20133940

MAD2L1

GO:0000776

Mitotic spindle assembly checkpoint protein MAD2A

8824189

MAD2L1

GO:0005634

Mitotic spindle assembly checkpoint protein MAD2A

18981471

MAD2L1

GO:0005634

Mitotic spindle assembly checkpoint protein MAD2A

19010891

MAD2L1

GO:0005634

Mitotic spindle assembly checkpoint protein MAD2A

20870947

MAD2L1

GO:0005654

Mitotic spindle assembly checkpoint protein MAD2A

0000052

MAD2L1

GO:0005829

Mitotic spindle assembly checkpoint protein MAD2A

18981471

MAD2L1

GO:0048471

Mitotic spindle assembly checkpoint protein MAD2A

20870947

MAD2L1

GO:0048471

Mitotic spindle assembly checkpoint protein MAD2A

8824189

MAD2L1

GO:0072686

Mitotic spindle assembly checkpoint protein MAD2A

20133940

MAD2L1

GO:0044615

Mitotic spindle assembly checkpoint protein MAD2A

18981471


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RNA A-to-I events for MAD2L1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000164109.12

check button RNA A-to-I editing events in Cancer.
CAediting_381941(120057892, -), CAediting_381942(120057898, -), CAediting_381943(120057915, -), CAediting_381944(120057930, -), CAediting_381945(120057931, -), CAediting_381946(120057935, -), CAediting_381947(120057952, -), CAediting_381948(120057968, -), CAediting_381949(120057979, -), CAediting_381950(120058023, -), CAediting_381951(120058026, -), CAediting_381952(120058027, -), CAediting_381953(120058028, -), CAediting_381954(120058029, -), CAediting_381955(120058032, -), CAediting_381956(120058034, -), CAediting_381957(120058036, -), CAediting_381958(120058037, -), CAediting_381959(120058038, -), CAediting_381960(120058052, -), CAediting_381961(120058063, -), CAediting_381962(120058072, -), CAediting_381963(120058075, -), CAediting_381964(120058086, -), CAediting_381965(120058089, -), CAediting_381966(120058091, -), CAediting_381967(120058094, -), CAediting_381968(120058103, -), CAediting_381969(120058124, -), CAediting_381970(120058129, -), CAediting_381971(120058130, -), CAediting_381972(120058373, -), CAediting_381973(120058375, -), CAediting_381974(120058387, -), CAediting_381975(120058396, -), CAediting_381976(120058413, -), CAediting_381977(120058418, -), CAediting_381978(120058433, -), CAediting_381979(120058458, -), CAediting_381980(120058464, -), CAediting_381981(120058467, -), CAediting_381982(120058475, -), CAediting_381983(120058481, -), CAediting_381984(120058482, -), CAediting_381985(120058490, -), CAediting_381986(120058492, -), CAediting_381987(120058502, -), CAediting_381988(120058518, -), CAediting_381989(120058530, -), CAediting_381990(120058543, -), CAediting_381991(120058547, -), CAediting_381992(120058578, -), CAediting_381993(120058591, -), CAediting_381994(120058593, -), CAediting_381995(120058615, -),

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RNA editing positional annotations for MAD2L1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_381941chr4_120057892_-UTR3
CAediting_381942chr4_120057898_-UTR3
CAediting_381943chr4_120057915_-UTR3
CAediting_381944chr4_120057930_-UTR3
CAediting_381945chr4_120057931_-UTR3
CAediting_381946chr4_120057935_-UTR3
CAediting_381947chr4_120057952_-UTR3
CAediting_381948chr4_120057968_-UTR3
CAediting_381949chr4_120057979_-UTR3
CAediting_381950chr4_120058023_-UTR3
CAediting_381951chr4_120058026_-UTR3
CAediting_381952chr4_120058027_-UTR3
CAediting_381953chr4_120058028_-UTR3
CAediting_381954chr4_120058029_-UTR3
CAediting_381955chr4_120058032_-UTR3
CAediting_381956chr4_120058034_-UTR3
CAediting_381957chr4_120058036_-UTR3
CAediting_381958chr4_120058037_-UTR3
CAediting_381959chr4_120058038_-UTR3
CAediting_381960chr4_120058052_-UTR3
CAediting_381961chr4_120058063_-UTR3
CAediting_381962chr4_120058072_-UTR3
CAediting_381963chr4_120058075_-UTR3
CAediting_381964chr4_120058086_-UTR3
CAediting_381965chr4_120058089_-UTR3
CAediting_381966chr4_120058091_-UTR3
CAediting_381967chr4_120058094_-UTR3
CAediting_381968chr4_120058103_-UTR3
CAediting_381969chr4_120058124_-UTR3
CAediting_381970chr4_120058129_-UTR3
CAediting_381971chr4_120058130_-UTR3
CAediting_381972chr4_120058373_-UTR3
CAediting_381973chr4_120058375_-UTR3
CAediting_381974chr4_120058387_-UTR3
CAediting_381975chr4_120058396_-UTR3
CAediting_381976chr4_120058413_-UTR3
CAediting_381977chr4_120058418_-UTR3
CAediting_381978chr4_120058433_-UTR3
CAediting_381979chr4_120058458_-UTR3
CAediting_381980chr4_120058464_-UTR3
CAediting_381981chr4_120058467_-UTR3
CAediting_381982chr4_120058475_-UTR3
CAediting_381983chr4_120058481_-UTR3
CAediting_381984chr4_120058482_-UTR3
CAediting_381985chr4_120058490_-UTR3
CAediting_381986chr4_120058492_-UTR3
CAediting_381987chr4_120058502_-UTR3
CAediting_381988chr4_120058518_-UTR3
CAediting_381989chr4_120058530_-UTR3
CAediting_381990chr4_120058543_-UTR3
CAediting_381991chr4_120058547_-UTR3
CAediting_381992chr4_120058578_-UTR3
CAediting_381993chr4_120058591_-UTR3
CAediting_381994chr4_120058593_-UTR3
CAediting_381995chr4_120058615_-UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_381941chr4_120057892_-SINEAluAluSg4
CAediting_381942chr4_120057898_-SINEAluAluSg4
CAediting_381943chr4_120057915_-SINEAluAluSg4
CAediting_381944chr4_120057930_-SINEAluAluSg4
CAediting_381945chr4_120057931_-SINEAluAluSg4
CAediting_381946chr4_120057935_-SINEAluAluSg4
CAediting_381947chr4_120057952_-SINEAluAluSg4
CAediting_381948chr4_120057968_-SINEAluAluSg4
CAediting_381949chr4_120057979_-SINEAluAluSg4
CAediting_381950chr4_120058023_-SINEAluAluSg4
CAediting_381951chr4_120058026_-SINEAluAluSg4
CAediting_381952chr4_120058027_-SINEAluAluSg4
CAediting_381953chr4_120058028_-SINEAluAluSg4
CAediting_381954chr4_120058029_-SINEAluAluSg4
CAediting_381955chr4_120058032_-SINEAluAluSg4
CAediting_381956chr4_120058034_-SINEAluAluSg4
CAediting_381957chr4_120058036_-SINEAluAluSg4
CAediting_381958chr4_120058037_-SINEAluAluSg4
CAediting_381959chr4_120058038_-SINEAluAluSg4
CAediting_381960chr4_120058052_-SINEAluAluSg4
CAediting_381961chr4_120058063_-SINEAluAluSg4
CAediting_381962chr4_120058072_-SINEAluAluSg4
CAediting_381963chr4_120058075_-SINEAluAluSg4
CAediting_381964chr4_120058086_-SINEAluAluSg4
CAediting_381965chr4_120058089_-SINEAluAluSg4
CAediting_381966chr4_120058091_-SINEAluAluSg4
CAediting_381967chr4_120058094_-SINEAluAluSg4
CAediting_381968chr4_120058103_-SINEAluAluSg4
CAediting_381969chr4_120058124_-SINEAluAluSg4
CAediting_381970chr4_120058129_-SINEAluAluSg4
CAediting_381971chr4_120058130_-SINEAluAluSg4
CAediting_381972chr4_120058373_-SINEAluAluSg
CAediting_381973chr4_120058375_-SINEAluAluSg
CAediting_381974chr4_120058387_-SINEAluAluSg
CAediting_381975chr4_120058396_-SINEAluAluSg
CAediting_381976chr4_120058413_-SINEAluAluSg
CAediting_381977chr4_120058418_-SINEAluAluSg
CAediting_381978chr4_120058433_-SINEAluAluSg
CAediting_381979chr4_120058458_-SINEAluAluSg
CAediting_381980chr4_120058464_-SINEAluAluSg
CAediting_381981chr4_120058467_-SINEAluAluSg
CAediting_381982chr4_120058475_-SINEAluAluSg
CAediting_381983chr4_120058481_-SINEAluAluSg
CAediting_381984chr4_120058482_-SINEAluAluSg
CAediting_381985chr4_120058490_-SINEAluAluSg
CAediting_381986chr4_120058492_-SINEAluAluSg
CAediting_381987chr4_120058502_-SINEAluAluSg
CAediting_381988chr4_120058518_-SINEAluAluSg
CAediting_381989chr4_120058530_-SINEAluAluSg
CAediting_381990chr4_120058543_-SINEAluAluSg
CAediting_381991chr4_120058547_-SINEAluAluSg
CAediting_381992chr4_120058578_-SINEAluAluSg
CAediting_381993chr4_120058591_-SINEAluAluSg
CAediting_381994chr4_120058593_-SINEAluAluSg
CAediting_381995chr4_120058615_-SINEAluAluSg

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RNA A-to-I editing events in the alternative splicing sites for MAD2L1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164109.12.MAD2L1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000164109.12.MAD2L1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MAD2L1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
STAD.CAediting_381995.ENSG00000164109.MAD2L1.png
Soverview

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Protein coding region RNA A-to-I editings for MAD2L1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MAD2L1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000164109.12ENST00000333047hsa-miR-195-3p1200598681200598747mer-m8120059867120059888151-14.25
CAediting_228905chr2_188297554_+ENSG00000164109.12ENST00000333047hsa-miR-561-3p1200595111200595166mer120059510120059531140-10.29
CAediting_1160181chr17_7017644_-ENSG00000164109.12ENST00000504707hsa-miR-195-3p1200598681200598747mer-m8120059867120059888151-14.25

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000164109.12ENST00000333047hsa-miR-195-3p1200596541200596607mer-m8120059653120059675141-6.05

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MAD2L1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000296509.9protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_381941ENST00000296509.9chr4_120057892_--1704.10-1704.40-1743.10
CAediting_381942ENST00000296509.9chr4_120057898_--1703.70-1704.40-1743.10
CAediting_381943ENST00000296509.9chr4_120057915_--1704.40-1704.40-1743.10
CAediting_381944ENST00000296509.9chr4_120057930_--1704.00-1704.40-1743.10
CAediting_381945ENST00000296509.9chr4_120057931_--1707.80-1704.40-1743.10
CAediting_381946ENST00000296509.9chr4_120057935_--1703.50-1704.40-1743.10
CAediting_381947ENST00000296509.9chr4_120057952_--1703.50-1704.40-1743.10
CAediting_381948ENST00000296509.9chr4_120057968_--1705.50-1704.40-1743.10
CAediting_381949ENST00000296509.9chr4_120057979_--1703.50-1704.40-1743.10
CAediting_381950ENST00000296509.9chr4_120058023_--1704.10-1704.40-1743.10
CAediting_381951ENST00000296509.9chr4_120058026_--1704.40-1704.40-1743.10
CAediting_381952ENST00000296509.9chr4_120058027_--1704.50-1704.40-1743.10
CAediting_381953ENST00000296509.9chr4_120058028_--1704.50-1704.40-1743.10
CAediting_381954ENST00000296509.9chr4_120058029_--1704.50-1704.40-1743.10
CAediting_381955ENST00000296509.9chr4_120058032_--1704.40-1704.40-1743.10
CAediting_381956ENST00000296509.9chr4_120058034_--1704.40-1704.40-1743.10
CAediting_381957ENST00000296509.9chr4_120058036_--1704.50-1704.40-1743.10
CAediting_381958ENST00000296509.9chr4_120058037_--1704.50-1704.40-1743.10
CAediting_381959ENST00000296509.9chr4_120058038_--1704.50-1704.40-1743.10
CAediting_381960ENST00000296509.9chr4_120058052_--1704.40-1704.40-1743.10
CAediting_381961ENST00000296509.9chr4_120058063_--1704.10-1704.40-1743.10
CAediting_381962ENST00000296509.9chr4_120058072_--1704.40-1704.40-1743.10
CAediting_381963ENST00000296509.9chr4_120058075_--1703.80-1704.40-1743.10
CAediting_381964ENST00000296509.9chr4_120058086_--1703.70-1704.40-1743.10
CAediting_381965ENST00000296509.9chr4_120058089_--1711.10-1704.40-1743.10
CAediting_381966ENST00000296509.9chr4_120058091_--1703.50-1704.40-1743.10
CAediting_381967ENST00000296509.9chr4_120058094_--1704.40-1704.40-1743.10
CAediting_381968ENST00000296509.9chr4_120058103_--1710.60-1704.40-1743.10
CAediting_381969ENST00000296509.9chr4_120058124_--1703.60-1704.40-1743.10
CAediting_381970ENST00000296509.9chr4_120058129_--1704.40-1704.40-1743.10
CAediting_381971ENST00000296509.9chr4_120058130_--1704.50-1704.40-1743.10
CAediting_381972ENST00000296509.9chr4_120058373_--1703.70-1704.40-1743.10
CAediting_381973ENST00000296509.9chr4_120058375_--1704.40-1704.40-1743.10
CAediting_381974ENST00000296509.9chr4_120058387_--1704.10-1704.40-1743.10
CAediting_381975ENST00000296509.9chr4_120058396_--1711.60-1704.40-1743.10
CAediting_381976ENST00000296509.9chr4_120058413_--1710.20-1704.40-1743.10
CAediting_381977ENST00000296509.9chr4_120058418_--1703.50-1704.40-1743.10
CAediting_381978ENST00000296509.9chr4_120058433_--1711.00-1704.40-1743.10
CAediting_381979ENST00000296509.9chr4_120058458_--1709.30-1704.40-1743.10
CAediting_381980ENST00000296509.9chr4_120058464_--1704.10-1704.40-1743.10
CAediting_381981ENST00000296509.9chr4_120058467_--1704.10-1704.40-1743.10
CAediting_381982ENST00000296509.9chr4_120058475_--1704.40-1704.40-1743.10
CAediting_381983ENST00000296509.9chr4_120058481_--1704.40-1704.40-1743.10
CAediting_381984ENST00000296509.9chr4_120058482_--1704.50-1704.40-1743.10
CAediting_381985ENST00000296509.9chr4_120058490_--1709.80-1704.40-1743.10
CAediting_381986ENST00000296509.9chr4_120058492_--1704.00-1704.40-1743.10
CAediting_381987ENST00000296509.9chr4_120058502_--1709.80-1704.40-1743.10
CAediting_381988ENST00000296509.9chr4_120058518_--1704.10-1704.40-1743.10
CAediting_381989ENST00000296509.9chr4_120058530_--1703.70-1704.40-1743.10
CAediting_381990ENST00000296509.9chr4_120058543_--1704.40-1704.40-1743.10
CAediting_381991ENST00000296509.9chr4_120058547_--1704.40-1704.40-1743.10
CAediting_381992ENST00000296509.9chr4_120058578_--1708.00-1704.40-1743.10
CAediting_381993ENST00000296509.9chr4_120058591_--1703.70-1704.40-1743.10
CAediting_381994ENST00000296509.9chr4_120058593_--1704.40-1704.40-1743.10
CAediting_381995ENST00000296509.9chr4_120058615_--1710.90-1704.40-1743.10

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Relation with ADAR for MAD2L1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_381995chr4_120058615_-4.21777845809224e-050.354993112415149....
SKCMCAediting_381995chr4_120058615_-0.004628799956115220.337029750469647....

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Relation with cancer stages for MAD2L1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for MAD2L1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for MAD2L1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAD2L1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
MAD2L1C0032460Polycystic Ovary Syndrome1CTD_human
MAD2L1C0279626Squamous cell carcinoma of esophagus1CTD_human
MAD2L1C1136382Sclerocystic Ovaries1CTD_human
MAD2L1C2239176Liver carcinoma1CTD_human