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Center for Computational Systems Medicine
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Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with cancer stages

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Relation with survival state

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Related drugs with this gene

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Related diseases with this gene

Editing gene: MIR27A (CAeditome ID:407018)

Gene summary for MIR27A

check button Gene summary
Gene informationGene symbol

MIR27A

Gene ID

407018

Gene namemicroRNA 27a
SynonymsMIR27|MIRN27A|mir-27a
Cytomap

19p13.12

Type of genencRNA
Descriptionhsa-mir-27a
Modification date20210531
UniProtAcc

.

Context- 30365154(miR27a promotes human breast cancer cell migration by inducing EMT in a FBXW7dependent manner)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for MIR27A

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000207808.1
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1306321(13836454, -), CAediting_1306322(13836455, -), CAediting_1306323(13836462, -), CAediting_1306324(13836464, -), CAediting_1306325(13836501, -), CAediting_1306326(13836508, -), CAediting_1306327(13836514, -),

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RNA editing positional annotations for MIR27A using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1306321chr19_13836454_-ncRNA_exonic
CAediting_1306322chr19_13836455_-ncRNA_exonic
CAediting_1306323chr19_13836462_-ncRNA_exonic
CAediting_1306324chr19_13836464_-ncRNA_exonic
CAediting_1306325chr19_13836501_-ncRNA_exonic
CAediting_1306326chr19_13836508_-ncRNA_exonic
CAediting_1306327chr19_13836514_-ncRNA_exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name

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RNA A-to-I editing events in the alternative splicing sites for MIR27A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000207808.1.MIR27A.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000207808.1.MIR27A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIR27A

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MIR27A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MIR27A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network
boxplot

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The effects of the RNA editing to the stability of the RNA structures for MIR27A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for MIR27A

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1306327chr19_13836514_-0.0001467279063058590.494030948436936....

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Relation with cancer stages for MIR27A

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
KIRCpathologic_stageCAediting_1306327chr19_13836514_-0.004423704300293540.353992448424949

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Relation with survival for MIR27A

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for MIR27A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIR27A

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
MIR27AC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
MIR27AC0027055Myocardial Reperfusion Injury1CTD_human
MIR27AC0030305Pancreatitis1CTD_human