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Editing gene: SAMD12 (CAeditome ID:401474)

Gene summary for SAMD12

Gene summary

Gene information	Gene symbol	SAMD12
	Gene ID	401474
	Gene name	sterile alpha motif domain containing 12
	Synonyms	-
	Cytomap	8q24.11-q24.12
	Type of gene	protein-coding
	Description	sterile alpha motif domain-containing protein 12SAM domain-containing protein 12
	Modification date	20210531
	UniProtAcc	Q8N8I0
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for SAMD12

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000177570.12

RNA A-to-I editing events in Cancer.

CAediting_658689(118194017, -), CAediting_658690(118234544, -), CAediting_658691(118234547, -), CAediting_658692(118234576, -), CAediting_658693(118234599, -), CAediting_658694(118242038, -), CAediting_658695(118250723, -), CAediting_658696(118250724, -), CAediting_658697(118250732, -), CAediting_658698(118250742, -), CAediting_658699(118266375, -), CAediting_658700(118266397, -), CAediting_658701(118266401, -), CAediting_658702(118266402, -), CAediting_658703(118266457, -), CAediting_658704(118266469, -), CAediting_658705(118275854, -), CAediting_658706(118275943, -), CAediting_658707(118276706, -), CAediting_658708(118276707, -), CAediting_658709(118276708, -), CAediting_658710(118276952, -), CAediting_658711(118417219, -), CAediting_658712(118429794, -), CAediting_658713(118429880, -), CAediting_658714(118430619, -), CAediting_658715(118448844, -), CAediting_658716(118449093, -), CAediting_658717(118449200, -), CAediting_658718(118472098, -), CAediting_658719(118472123, -), CAediting_658720(118474083, -), CAediting_658721(118474125, -), CAediting_658722(118474131, -), CAediting_658723(118474582, -), CAediting_658724(118474666, -), CAediting_658725(118474668, -), CAediting_658726(118477198, -), CAediting_658727(118477203, -), CAediting_658728(118477262, -), CAediting_658729(118477269, -), CAediting_658730(118477270, -), CAediting_658731(118477339, -), CAediting_658732(118477355, -), CAediting_658733(118477849, -), CAediting_658734(118477887, -), CAediting_658735(118477893, -), CAediting_658736(118477903, -), CAediting_658737(118500147, -), CAediting_658738(118500164, -), CAediting_658739(118500181, -), CAediting_658740(118500190, -), CAediting_658741(118500216, -), CAediting_658742(118500217, -), CAediting_658743(118500260, -), CAediting_658744(118500271, -), CAediting_658745(118500272, -), CAediting_658746(118500281, -), CAediting_658747(118500282, -), CAediting_658748(118500315, -), CAediting_658749(118500328, -), CAediting_658750(118500329, -), CAediting_658751(118500618, -), CAediting_658752(118500684, -), CAediting_658753(118500694, -), CAediting_658754(118500711, -), CAediting_658755(118500723, -), CAediting_658756(118500724, -), CAediting_658757(118500754, -), CAediting_658758(118500760, -), CAediting_658759(118501974, -), CAediting_658760(118508066, -), CAediting_658761(118556760, -), CAediting_658762(118557157, -), CAediting_658763(118557221, -), CAediting_658764(118557231, -), CAediting_658765(118557240, -), CAediting_658766(118557302, -), CAediting_658767(118557311, -), CAediting_658768(118557339, -), CAediting_658769(118557354, -), CAediting_658770(118557358, -), CAediting_658771(118557363, -), CAediting_658772(118557366, -), CAediting_658773(118557389, -), CAediting_658774(118557401, -), CAediting_658775(118557402, -), CAediting_658776(118557411, -), CAediting_658777(118561521, -), CAediting_658778(118561610, -), CAediting_658779(118561628, -), CAediting_658780(118561629, -), CAediting_658781(118561689, -), CAediting_658782(118561707, -), CAediting_658783(118561710, -), CAediting_658784(118561735, -), CAediting_658785(118561747, -),

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RNA editing positional annotations for SAMD12 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_658689	chr8_118194017_-	UTR3
CAediting_658690	chr8_118234544_-	intronic
CAediting_658691	chr8_118234547_-	intronic
CAediting_658692	chr8_118234576_-	intronic
CAediting_658693	chr8_118234599_-	intronic
CAediting_658694	chr8_118242038_-	intronic
CAediting_658695	chr8_118250723_-	intronic
CAediting_658696	chr8_118250724_-	intronic
CAediting_658697	chr8_118250732_-	intronic
CAediting_658698	chr8_118250742_-	intronic
CAediting_658699	chr8_118266375_-	intronic
CAediting_658700	chr8_118266397_-	intronic
CAediting_658701	chr8_118266401_-	intronic
CAediting_658702	chr8_118266402_-	intronic
CAediting_658703	chr8_118266457_-	intronic
CAediting_658704	chr8_118266469_-	intronic
CAediting_658705	chr8_118275854_-	intronic
CAediting_658706	chr8_118275943_-	intronic
CAediting_658707	chr8_118276706_-	intronic
CAediting_658708	chr8_118276707_-	intronic
CAediting_658709	chr8_118276708_-	intronic
CAediting_658710	chr8_118276952_-	intronic
CAediting_658711	chr8_118417219_-	intronic
CAediting_658712	chr8_118429794_-	intronic
CAediting_658713	chr8_118429880_-	intronic
CAediting_658714	chr8_118430619_-	intronic
CAediting_658715	chr8_118448844_-	intronic
CAediting_658716	chr8_118449093_-	intronic
CAediting_658717	chr8_118449200_-	intronic
CAediting_658718	chr8_118472098_-	intronic
CAediting_658719	chr8_118472123_-	intronic
CAediting_658720	chr8_118474083_-	intronic
CAediting_658721	chr8_118474125_-	intronic
CAediting_658722	chr8_118474131_-	intronic
CAediting_658723	chr8_118474582_-	intronic
CAediting_658724	chr8_118474666_-	intronic
CAediting_658725	chr8_118474668_-	intronic
CAediting_658726	chr8_118477198_-	intronic
CAediting_658727	chr8_118477203_-	intronic
CAediting_658728	chr8_118477262_-	intronic
CAediting_658729	chr8_118477269_-	intronic
CAediting_658730	chr8_118477270_-	intronic
CAediting_658731	chr8_118477339_-	intronic
CAediting_658732	chr8_118477355_-	intronic
CAediting_658733	chr8_118477849_-	intronic
CAediting_658734	chr8_118477887_-	intronic
CAediting_658735	chr8_118477893_-	intronic
CAediting_658736	chr8_118477903_-	intronic
CAediting_658737	chr8_118500147_-	intronic
CAediting_658738	chr8_118500164_-	intronic
CAediting_658739	chr8_118500181_-	intronic
CAediting_658740	chr8_118500190_-	intronic
CAediting_658741	chr8_118500216_-	intronic
CAediting_658742	chr8_118500217_-	intronic
CAediting_658743	chr8_118500260_-	intronic
CAediting_658744	chr8_118500271_-	intronic
CAediting_658745	chr8_118500272_-	intronic
CAediting_658746	chr8_118500281_-	intronic
CAediting_658747	chr8_118500282_-	intronic
CAediting_658748	chr8_118500315_-	intronic
CAediting_658749	chr8_118500328_-	intronic
CAediting_658750	chr8_118500329_-	intronic
CAediting_658751	chr8_118500618_-	intronic
CAediting_658752	chr8_118500684_-	intronic
CAediting_658753	chr8_118500694_-	intronic
CAediting_658754	chr8_118500711_-	intronic
CAediting_658755	chr8_118500723_-	intronic
CAediting_658756	chr8_118500724_-	intronic
CAediting_658757	chr8_118500754_-	intronic
CAediting_658758	chr8_118500760_-	intronic
CAediting_658759	chr8_118501974_-	intronic
CAediting_658760	chr8_118508066_-	intronic
CAediting_658761	chr8_118556760_-	intronic
CAediting_658762	chr8_118557157_-	intronic
CAediting_658763	chr8_118557221_-	intronic
CAediting_658764	chr8_118557231_-	intronic
CAediting_658765	chr8_118557240_-	intronic
CAediting_658766	chr8_118557302_-	intronic
CAediting_658767	chr8_118557311_-	intronic
CAediting_658768	chr8_118557339_-	intronic
CAediting_658769	chr8_118557354_-	intronic
CAediting_658770	chr8_118557358_-	intronic
CAediting_658771	chr8_118557363_-	intronic
CAediting_658772	chr8_118557366_-	intronic
CAediting_658773	chr8_118557389_-	intronic
CAediting_658774	chr8_118557401_-	intronic
CAediting_658775	chr8_118557402_-	intronic
CAediting_658776	chr8_118557411_-	intronic
CAediting_658777	chr8_118561521_-	intronic
CAediting_658778	chr8_118561610_-	intronic
CAediting_658779	chr8_118561628_-	intronic
CAediting_658780	chr8_118561629_-	intronic
CAediting_658781	chr8_118561689_-	intronic
CAediting_658782	chr8_118561707_-	intronic
CAediting_658783	chr8_118561710_-	intronic
CAediting_658784	chr8_118561735_-	intronic
CAediting_658785	chr8_118561747_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_658690	chr8_118234544_-	SINE	Alu	AluSx1
CAediting_658691	chr8_118234547_-	SINE	Alu	AluSx1
CAediting_658692	chr8_118234576_-	SINE	Alu	AluSx1
CAediting_658693	chr8_118234599_-	SINE	Alu	AluSx1
CAediting_658694	chr8_118242038_-	SINE	Alu	AluJb
CAediting_658695	chr8_118250723_-	SINE	Alu	AluSz6
CAediting_658696	chr8_118250724_-	SINE	Alu	AluSz6
CAediting_658697	chr8_118250732_-	SINE	Alu	AluSz6
CAediting_658698	chr8_118250742_-	SINE	Alu	AluSz6
CAediting_658699	chr8_118266375_-	LINE	L1	L1MA8
CAediting_658700	chr8_118266397_-	LINE	L1	L1MA8
CAediting_658701	chr8_118266401_-	LINE	L1	L1MA8
CAediting_658702	chr8_118266402_-	LINE	L1	L1MA8
CAediting_658703	chr8_118266457_-	LINE	L1	L1MA8
CAediting_658704	chr8_118266469_-	LINE	L1	L1MA8
CAediting_658705	chr8_118275854_-	LINE	L1	L1PA16
CAediting_658706	chr8_118275943_-	LINE	L1	L1PA16
CAediting_658707	chr8_118276706_-	SINE	Alu	AluSx
CAediting_658708	chr8_118276707_-	SINE	Alu	AluSx
CAediting_658709	chr8_118276708_-	SINE	Alu	AluSx
CAediting_658710	chr8_118276952_-	SINE	Alu	AluSx
CAediting_658711	chr8_118417219_-	SINE	Alu	AluJr4
CAediting_658712	chr8_118429794_-	SINE	Alu	AluSx1
CAediting_658713	chr8_118429880_-	SINE	Alu	AluSx1
CAediting_658714	chr8_118430619_-	SINE	Alu	AluSc
CAediting_658715	chr8_118448844_-	SINE	MIR	MIRb
CAediting_658716	chr8_118449093_-	SINE	Alu	AluSg
CAediting_658717	chr8_118449200_-	SINE	Alu	AluSg
CAediting_658718	chr8_118472098_-	SINE	Alu	AluY
CAediting_658719	chr8_118472123_-	SINE	Alu	AluY
CAediting_658720	chr8_118474083_-	SINE	Alu	AluSz
CAediting_658721	chr8_118474125_-	SINE	Alu	AluSz
CAediting_658722	chr8_118474131_-	SINE	Alu	AluSz
CAediting_658723	chr8_118474582_-	SINE	Alu	AluSq2
CAediting_658724	chr8_118474666_-	SINE	Alu	AluSq2
CAediting_658725	chr8_118474668_-	SINE	Alu	AluSq2
CAediting_658726	chr8_118477198_-	SINE	Alu	AluSx1
CAediting_658727	chr8_118477203_-	SINE	Alu	AluSx1
CAediting_658728	chr8_118477262_-	SINE	Alu	AluSx1
CAediting_658729	chr8_118477269_-	SINE	Alu	AluSx1
CAediting_658730	chr8_118477270_-	SINE	Alu	AluSx1
CAediting_658731	chr8_118477339_-	SINE	Alu	AluSx1
CAediting_658732	chr8_118477355_-	SINE	Alu	AluSx1
CAediting_658733	chr8_118477849_-	SINE	Alu	AluY
CAediting_658734	chr8_118477887_-	SINE	Alu	AluY
CAediting_658735	chr8_118477893_-	SINE	Alu	AluY
CAediting_658736	chr8_118477903_-	SINE	Alu	AluY
CAediting_658737	chr8_118500147_-	SINE	Alu	AluSp
CAediting_658738	chr8_118500164_-	SINE	Alu	AluSp
CAediting_658739	chr8_118500181_-	SINE	Alu	AluSp
CAediting_658740	chr8_118500190_-	SINE	Alu	AluSp
CAediting_658741	chr8_118500216_-	SINE	Alu	AluSp
CAediting_658742	chr8_118500217_-	SINE	Alu	AluSp
CAediting_658743	chr8_118500260_-	SINE	Alu	AluSp
CAediting_658744	chr8_118500271_-	SINE	Alu	AluSp
CAediting_658745	chr8_118500272_-	SINE	Alu	AluSp
CAediting_658746	chr8_118500281_-	SINE	Alu	AluSp
CAediting_658747	chr8_118500282_-	SINE	Alu	AluSp
CAediting_658748	chr8_118500315_-	SINE	Alu	AluSp
CAediting_658749	chr8_118500328_-	SINE	Alu	AluSp
CAediting_658750	chr8_118500329_-	SINE	Alu	AluSp
CAediting_658751	chr8_118500618_-	SINE	Alu	AluSx1
CAediting_658752	chr8_118500684_-	SINE	Alu	AluSx1
CAediting_658753	chr8_118500694_-	SINE	Alu	AluSx1
CAediting_658754	chr8_118500711_-	SINE	Alu	AluSx1
CAediting_658755	chr8_118500723_-	SINE	Alu	AluSx1
CAediting_658756	chr8_118500724_-	SINE	Alu	AluSx1
CAediting_658757	chr8_118500754_-	SINE	Alu	AluSx1
CAediting_658758	chr8_118500760_-	SINE	Alu	AluSx1
CAediting_658759	chr8_118501974_-	SINE	Alu	AluY
CAediting_658760	chr8_118508066_-	SINE	Alu	AluJo
CAediting_658761	chr8_118556760_-	SINE	Alu	AluSx3
CAediting_658762	chr8_118557157_-	LTR	ERVL-MaLR	THE1C
CAediting_658763	chr8_118557221_-	LTR	ERVL-MaLR	THE1C
CAediting_658764	chr8_118557231_-	LTR	ERVL-MaLR	THE1C
CAediting_658765	chr8_118557240_-	LTR	ERVL-MaLR	THE1C
CAediting_658766	chr8_118557302_-	LTR	ERVL-MaLR	THE1C
CAediting_658767	chr8_118557311_-	LTR	ERVL-MaLR	THE1C
CAediting_658768	chr8_118557339_-	LTR	ERVL-MaLR	THE1C
CAediting_658769	chr8_118557354_-	LTR	ERVL-MaLR	THE1C
CAediting_658770	chr8_118557358_-	LTR	ERVL-MaLR	THE1C
CAediting_658771	chr8_118557363_-	LTR	ERVL-MaLR	THE1C
CAediting_658772	chr8_118557366_-	LTR	ERVL-MaLR	THE1C
CAediting_658773	chr8_118557389_-	LTR	ERVL-MaLR	THE1C
CAediting_658774	chr8_118557401_-	LTR	ERVL-MaLR	THE1C
CAediting_658775	chr8_118557402_-	LTR	ERVL-MaLR	THE1C
CAediting_658776	chr8_118557411_-	LTR	ERVL-MaLR	THE1C
CAediting_658777	chr8_118561521_-	LTR	ERVL-MaLR	THE1C
CAediting_658778	chr8_118561610_-	LTR	ERVL-MaLR	THE1C
CAediting_658779	chr8_118561628_-	LTR	ERVL-MaLR	THE1C
CAediting_658780	chr8_118561629_-	LTR	ERVL-MaLR	THE1C
CAediting_658781	chr8_118561689_-	LTR	ERVL-MaLR	THE1C
CAediting_658782	chr8_118561707_-	LTR	ERVL-MaLR	THE1C
CAediting_658783	chr8_118561710_-	LTR	ERVL-MaLR	THE1C
CAediting_658784	chr8_118561735_-	LTR	ERVL-MaLR	THE1C
CAediting_658785	chr8_118561747_-	LTR	ERVL-MaLR	THE1C

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RNA A-to-I editing events in the alternative splicing sites for SAMD12

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000177570.12.SAMD12.

Correlation between RNA A-to-I editing and PSI for ENSG00000177570.12.SAMD12.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SAMD12

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SAMD12

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SAMD12

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SAMD12

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000409003.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_658689	ENST00000409003.4	chr8_118194017_-	-2445.80	-2439.20	-2445.80

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Relation with ADAR for SAMD12

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SAMD12

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SAMD12

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SAMD12

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SAMD12

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SAMD12	C0014550	Myoclonic Epilepsy	1	CTD_human
SAMD12	C0338478	Idiopathic Myoclonic Epilepsy	1	CTD_human
SAMD12	C0338479	Symptomatic Myoclonic Epilepsy	1	CTD_human
SAMD12	C0393695	Early Childhood Epilepsy, Myoclonic	1	CTD_human
SAMD12	C0393702	Myoclonic Astatic Epilepsy	1	CTD_human
SAMD12	C0393703	Myoclonic Absence Epilepsy	1	CTD_human
SAMD12	C0438414	Myoclonic Encephalopathy	1	CTD_human
SAMD12	C0751120	Benign Infantile Myoclonic Epilepsy	1	CTD_human
SAMD12	C0751122	Infantile Severe Myoclonic Epilepsy	1	CTD_human
SAMD12	C0917800	Epilepsy, Myoclonic, Infantile	1	CTD_human
SAMD12	C1832841	EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1	1	CTD_human;ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene