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Editing gene: LEPR (CAeditome ID:3953)

Gene summary for LEPR

Gene summary

Gene information	Gene symbol	LEPR
	Gene ID	3953
	Gene name	leptin receptor
	Synonyms	CD295\|LEP-R\|LEPRD\|OB-R\|OBR
	Cytomap	1p31.3
	Type of gene	protein-coding
	Description	leptin receptorOB receptorhuB219
	Modification date	20210518
	UniProtAcc	P48357
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
LEPR	GO:0038021	Leptin receptor	20977476
LEPR	GO:0038021	Leptin receptor	27037668
LEPR	GO:0001934	Leptin receptor	27037668
LEPR	GO:0010507	Leptin receptor	25060689
LEPR	GO:0033210	Leptin receptor	27037668
LEPR	GO:0051049	Leptin receptor	20977476
LEPR	GO:0043235	Leptin receptor	23382219

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RNA A-to-I events for LEPR

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000116678.17

RNA A-to-I editing events in Cancer.

CAediting_72683(65426788, +), CAediting_72684(65426891, +), CAediting_72685(65427360, +), CAediting_72686(65427364, +), CAediting_72687(65427392, +), CAediting_72688(65427469, +), CAediting_72689(65427789, +), CAediting_72690(65427792, +), CAediting_72691(65427794, +), CAediting_72692(65427798, +), CAediting_72693(65427814, +), CAediting_72694(65427824, +), CAediting_72695(65427826, +), CAediting_72696(65427832, +), CAediting_72697(65427850, +), CAediting_72698(65427880, +), CAediting_72699(65427902, +), CAediting_72700(65435411, +), CAediting_72701(65435442, +), CAediting_72702(65435494, +), CAediting_72703(65435578, +), CAediting_72704(65437859, +), CAediting_72705(65437937, +), CAediting_72706(65438429, +), CAediting_72707(65438439, +), CAediting_72708(65438456, +), CAediting_72709(65438471, +), CAediting_72710(65439724, +), CAediting_72711(65439729, +), CAediting_72712(65439895, +), CAediting_72713(65439908, +), CAediting_72714(65488917, +), CAediting_72715(65489502, +), CAediting_72716(65489528, +), CAediting_72717(65494921, +), CAediting_72718(65494935, +), CAediting_72719(65494971, +), CAediting_72720(65494984, +), CAediting_72721(65495033, +), CAediting_72722(65495042, +), CAediting_72723(65495118, +), CAediting_72724(65495119, +), CAediting_72725(65495137, +), CAediting_72726(65495145, +), CAediting_72727(65495169, +), CAediting_72728(65495170, +), CAediting_72729(65495185, +), CAediting_72730(65495194, +), CAediting_72731(65495207, +), CAediting_72732(65495214, +), CAediting_72733(65495409, +), CAediting_72734(65495584, +), CAediting_72735(65495589, +), CAediting_72736(65495625, +), CAediting_72737(65495650, +), CAediting_72738(65495873, +), CAediting_72739(65497195, +), CAediting_72740(65497196, +), CAediting_72741(65497197, +), CAediting_72742(65497225, +), CAediting_72743(65497234, +), CAediting_72744(65497728, +), CAediting_72745(65497743, +), CAediting_72746(65497747, +), CAediting_72747(65497749, +), CAediting_72748(65497757, +), CAediting_72749(65497759, +), CAediting_72750(65497763, +), CAediting_72751(65497782, +), CAediting_72752(65497789, +), CAediting_72753(65497829, +), CAediting_72754(65497836, +), CAediting_72755(65497911, +), CAediting_72756(65497941, +), CAediting_72757(65497947, +), CAediting_72758(65506754, +), CAediting_72759(65519276, +), CAediting_72760(65519279, +), CAediting_72761(65519568, +), CAediting_72762(65519577, +), CAediting_72763(65519662, +), CAediting_72764(65519663, +), CAediting_72765(65519666, +), CAediting_72766(65566303, +), CAediting_72767(65569600, +), CAediting_72768(65569652, +), CAediting_72769(65569657, +), CAediting_72770(65574309, +), CAediting_72771(65626870, +), CAediting_72772(65630210, +), CAediting_72773(65630226, +), CAediting_72774(65630256, +), CAediting_72775(65638094, +), CAediting_72776(65640860, +), CAediting_72777(65640861, +), CAediting_72778(65640956, +), CAediting_72779(65640959, +), CAediting_72780(65640961, +),

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RNA editing positional annotations for LEPR using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_72774	chr1_65630256_+	nonsynonymous SNV	ENST00000371059.6	c.A2728G	p.T910A	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_72683	chr1_65426788_+	ncRNA_intronic
CAediting_72684	chr1_65426891_+	ncRNA_intronic
CAediting_72685	chr1_65427360_+	ncRNA_intronic
CAediting_72686	chr1_65427364_+	ncRNA_intronic
CAediting_72687	chr1_65427392_+	ncRNA_intronic
CAediting_72688	chr1_65427469_+	ncRNA_intronic
CAediting_72689	chr1_65427789_+	ncRNA_exonic
CAediting_72690	chr1_65427792_+	ncRNA_exonic
CAediting_72691	chr1_65427794_+	ncRNA_exonic
CAediting_72692	chr1_65427798_+	ncRNA_exonic
CAediting_72693	chr1_65427814_+	ncRNA_exonic
CAediting_72694	chr1_65427824_+	ncRNA_exonic
CAediting_72695	chr1_65427826_+	ncRNA_exonic
CAediting_72696	chr1_65427832_+	ncRNA_exonic
CAediting_72697	chr1_65427850_+	ncRNA_exonic
CAediting_72698	chr1_65427880_+	ncRNA_exonic
CAediting_72699	chr1_65427902_+	ncRNA_exonic
CAediting_72700	chr1_65435411_+	UTR3
CAediting_72701	chr1_65435442_+	UTR3
CAediting_72702	chr1_65435494_+	UTR3
CAediting_72703	chr1_65435578_+	UTR3
CAediting_72704	chr1_65437859_+	intronic
CAediting_72705	chr1_65437937_+	intronic
CAediting_72706	chr1_65438429_+	intronic
CAediting_72707	chr1_65438439_+	intronic
CAediting_72708	chr1_65438456_+	intronic
CAediting_72709	chr1_65438471_+	intronic
CAediting_72710	chr1_65439724_+	intronic
CAediting_72711	chr1_65439729_+	intronic
CAediting_72712	chr1_65439895_+	intronic
CAediting_72713	chr1_65439908_+	intronic
CAediting_72714	chr1_65488917_+	ncRNA_intronic
CAediting_72715	chr1_65489502_+	ncRNA_intronic
CAediting_72716	chr1_65489528_+	ncRNA_intronic
CAediting_72717	chr1_65494921_+	intronic
CAediting_72718	chr1_65494935_+	intronic
CAediting_72719	chr1_65494971_+	intronic
CAediting_72720	chr1_65494984_+	intronic
CAediting_72721	chr1_65495033_+	intronic
CAediting_72722	chr1_65495042_+	intronic
CAediting_72723	chr1_65495118_+	intronic
CAediting_72724	chr1_65495119_+	intronic
CAediting_72725	chr1_65495137_+	intronic
CAediting_72726	chr1_65495145_+	intronic
CAediting_72727	chr1_65495169_+	intronic
CAediting_72728	chr1_65495170_+	intronic
CAediting_72729	chr1_65495185_+	intronic
CAediting_72730	chr1_65495194_+	intronic
CAediting_72731	chr1_65495207_+	intronic
CAediting_72732	chr1_65495214_+	intronic
CAediting_72733	chr1_65495409_+	intronic
CAediting_72734	chr1_65495584_+	intronic
CAediting_72735	chr1_65495589_+	intronic
CAediting_72736	chr1_65495625_+	intronic
CAediting_72737	chr1_65495650_+	intronic
CAediting_72738	chr1_65495873_+	intronic
CAediting_72739	chr1_65497195_+	intronic
CAediting_72740	chr1_65497196_+	intronic
CAediting_72741	chr1_65497197_+	intronic
CAediting_72742	chr1_65497225_+	intronic
CAediting_72743	chr1_65497234_+	intronic
CAediting_72744	chr1_65497728_+	intronic
CAediting_72745	chr1_65497743_+	intronic
CAediting_72746	chr1_65497747_+	intronic
CAediting_72747	chr1_65497749_+	intronic
CAediting_72748	chr1_65497757_+	intronic
CAediting_72749	chr1_65497759_+	intronic
CAediting_72750	chr1_65497763_+	intronic
CAediting_72751	chr1_65497782_+	intronic
CAediting_72752	chr1_65497789_+	intronic
CAediting_72753	chr1_65497829_+	intronic
CAediting_72754	chr1_65497836_+	intronic
CAediting_72755	chr1_65497911_+	intronic
CAediting_72756	chr1_65497941_+	intronic
CAediting_72757	chr1_65497947_+	intronic
CAediting_72758	chr1_65506754_+	intronic
CAediting_72759	chr1_65519276_+	intronic
CAediting_72760	chr1_65519279_+	intronic
CAediting_72761	chr1_65519568_+	intronic
CAediting_72762	chr1_65519577_+	intronic
CAediting_72763	chr1_65519662_+	intronic
CAediting_72764	chr1_65519663_+	intronic
CAediting_72765	chr1_65519666_+	intronic
CAediting_72766	chr1_65566303_+	ncRNA_intronic
CAediting_72767	chr1_65569600_+	ncRNA_intronic
CAediting_72768	chr1_65569652_+	ncRNA_intronic
CAediting_72769	chr1_65569657_+	ncRNA_intronic
CAediting_72770	chr1_65574309_+	ncRNA_intronic
CAediting_72771	chr1_65626870_+	intronic
CAediting_72772	chr1_65630210_+	exonic
CAediting_72773	chr1_65630226_+	exonic
CAediting_72774	chr1_65630256_+	exonic
CAediting_72775	chr1_65638094_+	UTR3
CAediting_72776	chr1_65640860_+	UTR3
CAediting_72777	chr1_65640861_+	UTR3
CAediting_72778	chr1_65640956_+	UTR3
CAediting_72779	chr1_65640959_+	UTR3
CAediting_72780	chr1_65640961_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_72683	chr1_65426788_+	SINE	Alu	AluSc
CAediting_72684	chr1_65426891_+	SINE	Alu	AluSc
CAediting_72685	chr1_65427360_+	SINE	Alu	AluJr
CAediting_72686	chr1_65427364_+	SINE	Alu	AluJr
CAediting_72687	chr1_65427392_+	SINE	Alu	AluJr
CAediting_72688	chr1_65427469_+	SINE	Alu	AluJr
CAediting_72689	chr1_65427789_+	SINE	Alu	AluJr4
CAediting_72690	chr1_65427792_+	SINE	Alu	AluJr4
CAediting_72691	chr1_65427794_+	SINE	Alu	AluJr4
CAediting_72692	chr1_65427798_+	SINE	Alu	AluJr4
CAediting_72693	chr1_65427814_+	SINE	Alu	AluJr4
CAediting_72694	chr1_65427824_+	SINE	Alu	AluJr4
CAediting_72695	chr1_65427826_+	SINE	Alu	AluJr4
CAediting_72696	chr1_65427832_+	SINE	Alu	AluJr4
CAediting_72697	chr1_65427850_+	SINE	Alu	AluJr4
CAediting_72698	chr1_65427880_+	SINE	Alu	AluJr4
CAediting_72699	chr1_65427902_+	SINE	Alu	AluJr4
CAediting_72700	chr1_65435411_+	SINE	Alu	AluYh3
CAediting_72701	chr1_65435442_+	SINE	Alu	AluYh3
CAediting_72702	chr1_65435494_+	SINE	Alu	AluYh3
CAediting_72703	chr1_65435578_+	SINE	Alu	AluYh3
CAediting_72704	chr1_65437859_+	SINE	Alu	AluJr
CAediting_72705	chr1_65437937_+	SINE	Alu	AluJr
CAediting_72706	chr1_65438429_+	SINE	Alu	AluSc
CAediting_72707	chr1_65438439_+	SINE	Alu	AluSc
CAediting_72708	chr1_65438456_+	SINE	Alu	AluSc
CAediting_72709	chr1_65438471_+	SINE	Alu	AluSc
CAediting_72710	chr1_65439724_+	SINE	Alu	AluSq2
CAediting_72711	chr1_65439729_+	SINE	Alu	AluSq2
CAediting_72712	chr1_65439895_+	SINE	Alu	AluSg4
CAediting_72713	chr1_65439908_+	SINE	Alu	AluSg4
CAediting_72714	chr1_65488917_+	LINE	L1	L1MA3
CAediting_72715	chr1_65489502_+	LINE	L1	L1MA3
CAediting_72716	chr1_65489528_+	LINE	L1	L1MA3
CAediting_72717	chr1_65494921_+	LINE	L1	L1MA5
CAediting_72718	chr1_65494935_+	LINE	L1	L1MA5
CAediting_72719	chr1_65494971_+	LINE	L1	L1MA5
CAediting_72720	chr1_65494984_+	LINE	L1	L1MA5
CAediting_72721	chr1_65495033_+	LINE	L1	L1MA5
CAediting_72722	chr1_65495042_+	LINE	L1	L1MA5
CAediting_72723	chr1_65495118_+	LINE	L1	L1MA5
CAediting_72724	chr1_65495119_+	LINE	L1	L1MA5
CAediting_72725	chr1_65495137_+	LINE	L1	L1MA5
CAediting_72726	chr1_65495145_+	LINE	L1	L1MA5
CAediting_72727	chr1_65495169_+	LINE	L1	L1MA5
CAediting_72728	chr1_65495170_+	LINE	L1	L1MA5
CAediting_72729	chr1_65495185_+	LINE	L1	L1MA5
CAediting_72730	chr1_65495194_+	LINE	L1	L1MA5
CAediting_72731	chr1_65495207_+	LINE	L1	L1MA5
CAediting_72732	chr1_65495214_+	LINE	L1	L1MA5
CAediting_72733	chr1_65495409_+	LINE	L1	L1MA5
CAediting_72734	chr1_65495584_+	LINE	L1	L1MA5
CAediting_72735	chr1_65495589_+	LINE	L1	L1MA5
CAediting_72736	chr1_65495625_+	LINE	L1	L1MA5
CAediting_72737	chr1_65495650_+	LINE	L1	L1MA5
CAediting_72738	chr1_65495873_+	LINE	L1	L1MA5
CAediting_72750	chr1_65497763_+	LINE	CR1	L3
CAediting_72751	chr1_65497782_+	LINE	CR1	L3
CAediting_72752	chr1_65497789_+	LINE	CR1	L3
CAediting_72753	chr1_65497829_+	LINE	L2	L2c
CAediting_72754	chr1_65497836_+	LINE	L2	L2c
CAediting_72755	chr1_65497911_+	LINE	L2	L2c
CAediting_72758	chr1_65506754_+	LINE	L1	L1MA7
CAediting_72759	chr1_65519276_+	SINE	Alu	AluSz6
CAediting_72760	chr1_65519279_+	SINE	Alu	AluSz6
CAediting_72761	chr1_65519568_+	LTR	ERVL-MaLR	MLT1-int
CAediting_72762	chr1_65519577_+	LTR	ERVL-MaLR	MLT1-int
CAediting_72766	chr1_65566303_+	SINE	Alu	AluSc
CAediting_72767	chr1_65569600_+	SINE	Alu	AluSq
CAediting_72768	chr1_65569652_+	SINE	Alu	AluSq
CAediting_72769	chr1_65569657_+	SINE	Alu	AluSq
CAediting_72770	chr1_65574309_+	LINE	L1	L1PA4
CAediting_72771	chr1_65626870_+	SINE	Alu	AluJb
CAediting_72772	chr1_65630210_+	Retroposon	SVA	SVA_D
CAediting_72773	chr1_65630226_+	Retroposon	SVA	SVA_D
CAediting_72774	chr1_65630256_+	Retroposon	SVA	SVA_D
CAediting_72775	chr1_65638094_+	SINE	Alu	AluJo
CAediting_72776	chr1_65640860_+	SINE	Alu	AluSz
CAediting_72777	chr1_65640861_+	SINE	Alu	AluSz
CAediting_72778	chr1_65640956_+	SINE	Alu	AluSz
CAediting_72779	chr1_65640959_+	SINE	Alu	AluSz
CAediting_72780	chr1_65640961_+	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for LEPR

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000116678.17.LEPR.

Correlation between RNA A-to-I editing and PSI for ENSG00000116678.17.LEPR.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LEPR

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LEPR

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LEPR

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_72775	chr1_65638094_+	ENSG00000116678.17	ENST00000349533	hsa-miR-8052	65638092	65638098	7mer-1a	65638080	65638098	143.00	-23.66
CAediting_72777	chr1_65640861_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4539	65640855	65640860	6mer	65640841	65640861	142.00	-25.96
CAediting_72777	chr1_65640861_+	ENSG00000116678.17	ENST00000349533	hsa-miR-6078	65640857	65640864	8mer-1a	65640846	65640864	149.00	-21.50

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_72775	chr1_65638094_+	ENSG00000116678.17	ENST00000349533	hsa-miR-10399-5p	65638088	65638094	7mer-m8	65638074	65638095	148	-11.23
CAediting_72779	chr1_65640959_+	ENSG00000116678.17	ENST00000349533	hsa-miR-3675-3p	65640957	65640963	7mer-m8	65640942	65640964	152	-16.15
CAediting_72780	chr1_65640961_+	ENSG00000116678.17	ENST00000349533	hsa-miR-3675-3p	65640957	65640963	7mer-m8	65640942	65640964	152	-16.15
CAediting_72779	chr1_65640959_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4684-5p	65640956	65640962	7mer-m8	65640941	65640963	155	-14.09
CAediting_72780	chr1_65640961_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4684-5p	65640956	65640962	7mer-m8	65640941	65640963	155	-14.09
CAediting_72775	chr1_65638094_+	ENSG00000116678.17	ENST00000349533	hsa-miR-5089-5p	65638092	65638098	7mer-m8	65638079	65638099	152	-18.63
CAediting_72775	chr1_65638094_+	ENSG00000116678.17	ENST00000349533	hsa-miR-6504-3p	65638088	65638094	7mer-m8	65638074	65638095	150	-14.15

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000349533	hsa-miR-200b-3p	65640494	65640500	7mer-m8	65640478	65640501	151	-12.04
CAediting_688081	chr9_63819627_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4477b	65640089	65640095	7mer-m8	65640075	65640096	153	-12.88
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000371060	hsa-miR-548aa	65633437	65633443	7mer-m8	65633420	65633444	149	-12.12
CAediting_77128	chr1_85133844_+	ENSG00000116678.17	ENST00000371060	hsa-miR-4423-3p	65634420	65634426	7mer-m8	65634405	65634427	141	-12.1
CAediting_77128	chr1_85133844_+	ENSG00000116678.17	ENST00000371060	hsa-miR-4423-3p	65633847	65633852	6mer	65633832	65633853	142	-17.52
CAediting_1229414	chr17_67471546_+	ENSG00000116678.17	ENST00000349533	hsa-miR-548aa	65639630	65639636	7mer-m8	65639613	65639637	162	-14.02
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000349533	hsa-miR-548aa	65638882	65638889	8mer-1a	65638861	65638889	149	-10.7
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000349533	hsa-miR-548aa	65640760	65640766	7mer-m8	65640739	65640767	150	-14.8
CAediting_1351755	chr19_40282625_-	ENSG00000116678.17	ENST00000349533	hsa-miR-641	65638733	65638740	8mer-1a	65638719	65638740	145	-12.44
CAediting_396018	chr5_1062918_-	ENSG00000116678.17	ENST00000349533	hsa-miR-4635	65637336	65637342	7mer-m8	65637321	65637343	162	-20.98
CAediting_396018	chr5_1062918_-	ENSG00000116678.17	ENST00000349533	hsa-miR-4635	65641005	65641011	7mer-m8	65640992	65641012	162	-21.35
CAediting_524911	chr7_5495852_-	ENSG00000116678.17	ENST00000349533	hsa-miR-589-3p	65640791	65640797	7mer-m8	65640779	65640798	148	-15.44
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000616738	hsa-miR-548aa	65633437	65633443	7mer-m8	65633420	65633444	149	-12.12
CAediting_77128	chr1_85133844_+	ENSG00000116678.17	ENST00000616738	hsa-miR-4423-3p	65634420	65634426	7mer-m8	65634405	65634427	141	-12.1
CAediting_77128	chr1_85133844_+	ENSG00000116678.17	ENST00000616738	hsa-miR-4423-3p	65633847	65633852	6mer	65633832	65633853	142	-17.52
CAediting_1524209	chrX_134546392_-	ENSG00000116678.17	ENST00000371060	hsa-miR-503-5p	65633845	65633850	6mer	65633829	65633851	145	-19.66
CAediting_468389	chr6_31355314_-	ENSG00000116678.17	ENST00000349533	hsa-miR-6891-5p	65640162	65640168	7mer-m8	65640150	65640169	147	-16.73
CAediting_1524209	chrX_134546392_-	ENSG00000116678.17	ENST00000344610	hsa-miR-503-5p	65626197	65626203	7mer-m8	65626182	65626204	146	-22.14
CAediting_1524209	chrX_134546392_-	ENSG00000116678.17	ENST00000616738	hsa-miR-503-5p	65633845	65633850	6mer	65633829	65633851	145	-19.66
CAediting_1524209	chrX_134546392_-	ENSG00000116678.17	ENST00000371058	hsa-miR-503-5p	65626197	65626203	7mer-m8	65626182	65626204	146	-22.14

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000371060	hsa-miR-200b-3p	65634192	65634198	7mer-m8	65634176	65634199	143	-6.77
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000371060	hsa-miR-200b-3p	65634599	65634605	7mer-m8	65634578	65634606	142	-15.76
CAediting_604450	chr7_133034877_-	ENSG00000116678.17	ENST00000371060	hsa-miR-3654	65633372	65633378	7mer-m8	65633358	65633379	141	-13.09
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000371060	hsa-miR-548aa	65634695	65634701	7mer-m8	65634678	65634702	154	-10.41
CAediting_1229413	chr17_67471544_+	ENSG00000116678.17	ENST00000371060	hsa-miR-548aa	65634695	65634701	7mer-m8	65634678	65634702	154	-10.41
CAediting_228905	chr2_188297554_+	ENSG00000116678.17	ENST00000371060	hsa-miR-561-3p	65633650	65633656	7mer-m8	65633638	65633657	144	-5.07
CAediting_573001	chr7_92204086_-	ENSG00000116678.17	ENST00000349533	hsa-miR-1285-5p	65637297	65637303	7mer-m8	65637284	65637304	140	-9.94
CAediting_573001	chr7_92204086_-	ENSG00000116678.17	ENST00000349533	hsa-miR-1285-5p	65640023	65640029	7mer-m8	65640010	65640030	151	-13.56
CAediting_573001	chr7_92204086_-	ENSG00000116678.17	ENST00000349533	hsa-miR-1285-5p	65641278	65641285	8mer-1a	65641265	65641285	145	-11.15
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000349533	hsa-miR-200b-3p	65639068	65639074	7mer-m8	65639054	65639075	142	-8.9
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000349533	hsa-miR-200b-3p	65637607	65637613	7mer-m8	65637593	65637614	144	-9.73
CAediting_604450	chr7_133034877_-	ENSG00000116678.17	ENST00000349533	hsa-miR-3654	65638593	65638599	7mer-m8	65638582	65638600	149	-18.42
CAediting_688080	chr9_63819626_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4477b	65637892	65637899	8mer-1a	65637878	65637899	146	-10.08
CAediting_688081	chr9_63819627_+	ENSG00000116678.17	ENST00000349533	hsa-miR-4477b	65637892	65637899	8mer-1a	65637878	65637899	146	-10.08
CAediting_396018	chr5_1062918_-	ENSG00000116678.17	ENST00000349533	hsa-miR-4635	65638440	65638447	8mer-1a	65638426	65638447	141	-16.93
CAediting_228905	chr2_188297554_+	ENSG00000116678.17	ENST00000349533	hsa-miR-561-3p	65640186	65640193	8mer-1a	65640172	65640193	155	-9.82
CAediting_980496	chr14_31014685_-	ENSG00000116678.17	ENST00000349533	hsa-miR-624-3p	65639472	65639478	7mer-m8	65639459	65639479	151	-14.82
CAediting_1351755	chr19_40282625_-	ENSG00000116678.17	ENST00000349533	hsa-miR-641	65641152	65641158	7mer-m8	65641136	65641159	140	-12.56
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000616738	hsa-miR-200b-3p	65634192	65634198	7mer-m8	65634176	65634199	143	-6.77
CAediting_393	chr1_1167164_+	ENSG00000116678.17	ENST00000616738	hsa-miR-200b-3p	65634599	65634605	7mer-m8	65634578	65634606	142	-15.76
CAediting_604450	chr7_133034877_-	ENSG00000116678.17	ENST00000616738	hsa-miR-3654	65633372	65633378	7mer-m8	65633358	65633379	141	-13.09
CAediting_1229415	chr17_67471547_+	ENSG00000116678.17	ENST00000616738	hsa-miR-548aa	65634695	65634701	7mer-m8	65634678	65634702	154	-10.41
CAediting_1229413	chr17_67471544_+	ENSG00000116678.17	ENST00000616738	hsa-miR-548aa	65634695	65634701	7mer-m8	65634678	65634702	154	-10.41
CAediting_228905	chr2_188297554_+	ENSG00000116678.17	ENST00000616738	hsa-miR-561-3p	65633650	65633656	7mer-m8	65633638	65633657	144	-5.07

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LEPR

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000349533.9	protein_coding
ENST00000371059.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_72775	ENST00000349533.9	chr1_65638094_+	-2053.24	-2053.24	-2056.34
CAediting_72776	ENST00000349533.9	chr1_65640860_+	-2055.34	-2053.24	-2056.34
CAediting_72777	ENST00000349533.9	chr1_65640861_+	-2057.54	-2053.24	-2056.34
CAediting_72778	ENST00000349533.9	chr1_65640956_+	-2053.24	-2053.24	-2056.34
CAediting_72779	ENST00000349533.9	chr1_65640959_+	-2052.94	-2053.24	-2056.34
CAediting_72780	ENST00000349533.9	chr1_65640961_+	-2052.34	-2053.24	-2056.34
CAediting_72772	ENST00000371059.6	chr1_65630210_+	-800.40	-799.30	-808.50
CAediting_72773	ENST00000371059.6	chr1_65630226_+	-802.00	-799.30	-808.50
CAediting_72774	ENST00000371059.6	chr1_65630256_+	-806.00	-799.30	-808.50

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Relation with ADAR for LEPR

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_72694	chr1_65427824_+	0.0321629115133186	0.199075393238366	.	.	.	.
LUAD	CAediting_72694	chr1_65427824_+	0.0459739764204018	0.242872023726645	.	.	.	.
STAD	CAediting_72694	chr1_65427824_+	0.0162634424645117	0.322705066025613	.	.	.	.
BRCA	CAediting_72697	chr1_65427850_+	.	.	.	.	0.0483257490940663	0.258204429520464

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Relation with cancer stages for LEPR

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for LEPR

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for LEPR

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
LEPR	P48357	DB09046	Metreleptin	Leptin receptor	BiotechDrug	approved

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RelatedDiseases for LEPR

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
LEPR	C0028754	Obesity	10	CTD_human
LEPR	C0002152	Alloxan Diabetes	9	CTD_human
LEPR	C0011853	Diabetes Mellitus, Experimental	9	CTD_human
LEPR	C0038433	Streptozotocin Diabetes	9	CTD_human
LEPR	C0020456	Hyperglycemia	8	CTD_human
LEPR	C1855520	Hyperglycemia, Postprandial	8	CTD_human
LEPR	C0020459	Hyperinsulinism	7	CTD_human
LEPR	C1257963	Endogenous Hyperinsulinism	7	CTD_human
LEPR	C1257964	Exogenous Hyperinsulinism	7	CTD_human
LEPR	C1257965	Compensatory Hyperinsulinemia	7	CTD_human
LEPR	C0021655	Insulin Resistance	6	CTD_human
LEPR	C0920563	Insulin Sensitivity	6	CTD_human
LEPR	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	CTD_human
LEPR	C0271650	Impaired glucose tolerance	4	CTD_human
LEPR	C3554225	LEPTIN RECEPTOR DEFICIENCY	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
LEPR	C0001925	Albuminuria	3	CTD_human
LEPR	C0020505	Hyperphagia	3	CTD_human
LEPR	C0015695	Fatty Liver	2	CTD_human
LEPR	C0016059	Fibrosis	2	CTD_human
LEPR	C0019209	Hepatomegaly	2	CTD_human
LEPR	C0242339	Dyslipidemias	2	CTD_human
LEPR	C0598784	Dyslipoproteinemias	2	CTD_human
LEPR	C1623038	Cirrhosis	2	CTD_human
LEPR	C2711227	Steatohepatitis	2	CTD_human
LEPR	C0003257	Antibody Deficiency Syndrome	1	CTD_human
LEPR	C0006142	Malignant neoplasm of breast	1	CTD_human
LEPR	C0011849	Diabetes Mellitus	1	CTD_human
LEPR	C0011881	Diabetic Nephropathy	1	CTD_human
LEPR	C0011882	Diabetic Neuropathies	1	CTD_human
LEPR	C0017639	Gliosis	1	CTD_human
LEPR	C0017667	Nodular glomerulosclerosis	1	CTD_human
LEPR	C0018206	granulosa cell tumor	1	CTD_human
LEPR	C0020473	Hyperlipidemia	1	CTD_human
LEPR	C0020538	Hypertensive disease	1	CTD_human
LEPR	C0020542	Pulmonary Hypertension	1	CTD_human
LEPR	C0020619	Hypogonadism	1	CTD_human
LEPR	C0021051	Immunologic Deficiency Syndromes	1	CTD_human
LEPR	C0021359	Infertility	1	CTD_human
LEPR	C0021361	Female infertility	1	CTD_human
LEPR	C0022658	Kidney Diseases	1	CTD_human
LEPR	C0025521	Inborn Errors of Metabolism	1	CTD_human
LEPR	C0027697	Nephritis	1	CTD_human
LEPR	C0028756	Obesity, Morbid	1	CTD_human
LEPR	C0030286	Pancreatic Diseases	1	CTD_human
LEPR	C0032002	Pituitary Diseases	1	CTD_human
LEPR	C0034012	Delayed Puberty	1	CTD_human
LEPR	C0035078	Kidney Failure	1	CTD_human
LEPR	C0035243	Respiratory Tract Infections	1	CTD_human
LEPR	C0038279	Sterility, Postpartum	1	CTD_human
LEPR	C0041912	Upper Respiratory Infections	1	CTD_human
LEPR	C0043094	Weight Gain	1	CTD_human
LEPR	C0085207	Gestational Diabetes	1	CTD_human
LEPR	C0162770	Right Ventricular Hypertrophy	1	CTD_human
LEPR	C0271623	Hypogonadotropic hypogonadism	1	CTD_human
LEPR	C0271673	Symmetric Diabetic Proximal Motor Neuropathy	1	CTD_human
LEPR	C0271674	Asymmetric Diabetic Proximal Motor Neuropathy	1	CTD_human
LEPR	C0271678	Diabetic Mononeuropathy	1	CTD_human
LEPR	C0271680	Diabetic Polyneuropathies	1	CTD_human
LEPR	C0271685	Diabetic Amyotrophy	1	CTD_human
LEPR	C0271686	Diabetic Autonomic Neuropathy	1	CTD_human
LEPR	C0341869	Subfertility, Female	1	CTD_human
LEPR	C0393835	Diabetic Asymmetric Polyneuropathy	1	CTD_human
LEPR	C0497406	Overweight	1	CTD_human
LEPR	C0678222	Breast Carcinoma	1	CTD_human
LEPR	C0729353	Subfertility	1	CTD_human
LEPR	C0751074	Diabetic Neuralgia	1	CTD_human
LEPR	C0751437	Adenohypophyseal Diseases	1	CTD_human
LEPR	C0751438	Posterior pituitary disease	1	CTD_human
LEPR	C0917730	Female sterility	1	CTD_human
LEPR	C0948896	Primary hypogonadism	1	CTD_human
LEPR	C1257931	Mammary Neoplasms, Human	1	CTD_human
LEPR	C1458155	Mammary Neoplasms	1	CTD_human
LEPR	C1565489	Renal Insufficiency	1	CTD_human
LEPR	C1567257	Granulosa Cell Cancer	1	CTD_human
LEPR	C1706412	Lipidemias	1	CTD_human
LEPR	C3489396	Hypogonadism, Isolated Hypogonadotropic	1	CTD_human
LEPR	C3887640	Astrocytosis	1	CTD_human
LEPR	C4074771	Sterility, Reproductive	1	CTD_human
LEPR	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene