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Editing gene: ACAT2 (CAeditome ID:39)

Gene summary for ACAT2

Gene summary

Gene information	Gene symbol	ACAT2
	Gene ID	39
	Gene name	acetyl-CoA acetyltransferase 2
	Synonyms	-
	Cytomap	6q25.3
	Type of gene	protein-coding
	Description	acetyl-CoA acetyltransferase, cytosolicacetoacetyl Coenzyme A thiolaseacetyl-CoA transferase-like proteincytosolic acetoacetyl-CoA thiolase
	Modification date	20210518
	UniProtAcc	Q9BWD1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ACAT2	GO:0003985	Acetyl-CoA acetyltransferase, cytosolic	7911016
ACAT2	GO:0005737	Acetyl-CoA acetyltransferase, cytosolic	7911016

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RNA A-to-I events for ACAT2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000120437.8

RNA A-to-I editing events in Cancer.

CAediting_517259(159770565, +), CAediting_517260(159770630, +), CAediting_517261(159770796, +), CAediting_517262(159770864, +), CAediting_517263(159770944, +), CAediting_517264(159770945, +), CAediting_517265(159771153, +), CAediting_517266(159771221, +), CAediting_517267(159771259, +), CAediting_517268(159771260, +), CAediting_517269(159771731, +), CAediting_517270(159771771, +), CAediting_517271(159771781, +), CAediting_517272(159771786, +), CAediting_517273(159771798, +), CAediting_517274(159771816, +), CAediting_517275(159772091, +), CAediting_517276(159772094, +), CAediting_517277(159772104, +), CAediting_517278(159772151, +), CAediting_517279(159772213, +), CAediting_517280(159772910, +), CAediting_517281(159772994, +), CAediting_517282(159773037, +), CAediting_517283(159773040, +), CAediting_517284(159773075, +), CAediting_517285(159774533, +), CAediting_517286(159774573, +), CAediting_517287(159774625, +), CAediting_517288(159774676, +), CAediting_517289(159775207, +), CAediting_517290(159778214, +), CAediting_517291(159778472, +),

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RNA editing positional annotations for ACAT2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_517259	chr6_159770565_+	ncRNA_intronic
CAediting_517260	chr6_159770630_+	ncRNA_intronic
CAediting_517261	chr6_159770796_+	ncRNA_intronic
CAediting_517262	chr6_159770864_+	ncRNA_intronic
CAediting_517263	chr6_159770944_+	ncRNA_intronic
CAediting_517264	chr6_159770945_+	ncRNA_intronic
CAediting_517265	chr6_159771153_+	ncRNA_intronic
CAediting_517266	chr6_159771221_+	ncRNA_intronic
CAediting_517267	chr6_159771259_+	ncRNA_intronic
CAediting_517268	chr6_159771260_+	ncRNA_intronic
CAediting_517269	chr6_159771731_+	ncRNA_intronic
CAediting_517270	chr6_159771771_+	ncRNA_intronic
CAediting_517271	chr6_159771781_+	ncRNA_intronic
CAediting_517272	chr6_159771786_+	ncRNA_intronic
CAediting_517273	chr6_159771798_+	ncRNA_intronic
CAediting_517274	chr6_159771816_+	ncRNA_intronic
CAediting_517275	chr6_159772091_+	ncRNA_intronic
CAediting_517276	chr6_159772094_+	ncRNA_intronic
CAediting_517277	chr6_159772104_+	ncRNA_intronic
CAediting_517278	chr6_159772151_+	ncRNA_intronic
CAediting_517279	chr6_159772213_+	ncRNA_intronic
CAediting_517280	chr6_159772910_+	ncRNA_intronic
CAediting_517281	chr6_159772994_+	ncRNA_intronic
CAediting_517282	chr6_159773037_+	ncRNA_intronic
CAediting_517283	chr6_159773040_+	ncRNA_intronic
CAediting_517284	chr6_159773075_+	ncRNA_intronic
CAediting_517285	chr6_159774533_+	ncRNA_intronic
CAediting_517286	chr6_159774573_+	ncRNA_intronic
CAediting_517287	chr6_159774625_+	ncRNA_intronic
CAediting_517288	chr6_159774676_+	ncRNA_intronic
CAediting_517289	chr6_159775207_+	exonic
CAediting_517290	chr6_159778214_+	exonic
CAediting_517291	chr6_159778472_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_517259	chr6_159770565_+	SINE	Alu	FLAM_C
CAediting_517260	chr6_159770630_+	SINE	Alu	FLAM_C
CAediting_517261	chr6_159770796_+	SINE	Alu	AluSx
CAediting_517262	chr6_159770864_+	SINE	Alu	AluSx
CAediting_517263	chr6_159770944_+	SINE	Alu	AluSx
CAediting_517264	chr6_159770945_+	SINE	Alu	AluSx
CAediting_517265	chr6_159771153_+	SINE	Alu	AluSp
CAediting_517266	chr6_159771221_+	SINE	Alu	AluSp
CAediting_517267	chr6_159771259_+	SINE	Alu	AluSp
CAediting_517268	chr6_159771260_+	SINE	Alu	AluSp
CAediting_517269	chr6_159771731_+	SINE	Alu	AluJo
CAediting_517270	chr6_159771771_+	SINE	Alu	AluJo
CAediting_517271	chr6_159771781_+	SINE	Alu	AluJo
CAediting_517272	chr6_159771786_+	SINE	Alu	AluJo
CAediting_517273	chr6_159771798_+	SINE	Alu	AluJo
CAediting_517274	chr6_159771816_+	SINE	Alu	AluJo
CAediting_517275	chr6_159772091_+	SINE	Alu	AluSc8
CAediting_517276	chr6_159772094_+	SINE	Alu	AluSc8
CAediting_517277	chr6_159772104_+	SINE	Alu	AluSc8
CAediting_517278	chr6_159772151_+	SINE	Alu	AluSc8
CAediting_517279	chr6_159772213_+	SINE	Alu	AluSc8
CAediting_517280	chr6_159772910_+	SINE	Alu	AluJb
CAediting_517281	chr6_159772994_+	SINE	Alu	AluJb
CAediting_517282	chr6_159773037_+	SINE	Alu	AluJb
CAediting_517283	chr6_159773040_+	SINE	Alu	AluJb
CAediting_517284	chr6_159773075_+	SINE	Alu	AluJb
CAediting_517285	chr6_159774533_+	SINE	Alu	AluJo
CAediting_517286	chr6_159774573_+	SINE	Alu	AluJo
CAediting_517287	chr6_159774625_+	SINE	Alu	AluJo
CAediting_517288	chr6_159774676_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for ACAT2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000120437.8.ACAT2.

Correlation between RNA A-to-I editing and PSI for ENSG00000120437.8.ACAT2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACAT2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ACAT2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ACAT2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ACAT2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000367048.4	protein_coding
ENST00000467951.1	processed_transcript
ENST00000472052.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_517289	ENST00000367048.4	chr6_159775207_+	-1100.30	-1100.60	-1100.40
CAediting_517290	ENST00000367048.4	chr6_159778214_+	-1100.70	-1100.60	-1100.40
CAediting_517289	ENST00000467951.1	chr6_159775207_+	-325.00	-325.30	-325.00
CAediting_517290	ENST00000472052.1	chr6_159778214_+	-465.80	-465.70	-465.80

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Relation with ADAR for ACAT2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ACAT2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ACAT2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ACAT2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ACAT2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene