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Editing gene: C2orf81 (CAeditome ID:388963)

Gene summary for C2orf81

Gene summary

Gene information	Gene symbol	C2orf81
	Gene ID	388963
	Gene name	chromosome 2 open reading frame 81
	Synonyms	hCG40743
	Cytomap	2p13.1
	Type of gene	protein-coding
	Description	uncharacterized protein C2orf81
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for C2orf81

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000159239.10

RNA A-to-I editing events in Cancer.

CAediting_195034(74416484, -), CAediting_195035(74416521, -), CAediting_195036(74418924, -), CAediting_195037(74418937, -), CAediting_195038(74418938, -), CAediting_195039(74418962, -), CAediting_195040(74418963, -), CAediting_195041(74418964, -), CAediting_195042(74418998, -), CAediting_195043(74419001, -), CAediting_195044(74419018, -), CAediting_195045(74419021, -), CAediting_195046(74419049, -), CAediting_195047(74419063, -), CAediting_195048(74419069, -), CAediting_195049(74419099, -), CAediting_195050(74419124, -), CAediting_195051(74419129, -), CAediting_195052(74419140, -), CAediting_195053(74419173, -), CAediting_195054(74419175, -), CAediting_195055(74419177, -), CAediting_195056(74419179, -), CAediting_195057(74419289, -), CAediting_195058(74419290, -), CAediting_195059(74419293, -), CAediting_195060(74419807, -), CAediting_195061(74419829, -), CAediting_195062(74419861, -), CAediting_195063(74419909, -), CAediting_195064(74419910, -), CAediting_195065(74419920, -), CAediting_195066(74419932, -), CAediting_195067(74419936, -), CAediting_195068(74419940, -), CAediting_195069(74419976, -), CAediting_195070(74419978, -), CAediting_195071(74419991, -), CAediting_195072(74419993, -), CAediting_195073(74419994, -), CAediting_195074(74420014, -), CAediting_195075(74420779, -), CAediting_195076(74420794, -), CAediting_195077(74420816, -), CAediting_195078(74420818, -), CAediting_195079(74420838, -), CAediting_195080(74420848, -), CAediting_195081(74420853, -), CAediting_195082(74420878, -), CAediting_195083(74420886, -), CAediting_195084(74420892, -), CAediting_195085(74420898, -), CAediting_195086(74420902, -), CAediting_195087(74420909, -), CAediting_195088(74420918, -), CAediting_195089(74420919, -), CAediting_195090(74420946, -), CAediting_195091(74420949, -), CAediting_195092(74420950, -), CAediting_195093(74420952, -), CAediting_195094(74420953, -), CAediting_195095(74420956, -), CAediting_195096(74420958, -), CAediting_195097(74420960, -), CAediting_195098(74420961, -), CAediting_195099(74420977, -), CAediting_195100(74420983, -), CAediting_195101(74420985, -), CAediting_195102(74420986, -), CAediting_195103(74420995, -), CAediting_195104(74420998, -), CAediting_195105(74421000, -), CAediting_195106(74421001, -), CAediting_195107(74421009, -), CAediting_195108(74421014, -), CAediting_195109(74421040, -), CAediting_195110(74421046, -), CAediting_195111(74421049, -), CAediting_195112(74421054, -), CAediting_195113(74421055, -), CAediting_195114(74421071, -),

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RNA editing positional annotations for C2orf81 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_195034	chr2_74416484_-	UTR5
CAediting_195035	chr2_74416521_-	UTR5
CAediting_195036	chr2_74418924_-	intronic
CAediting_195037	chr2_74418937_-	intronic
CAediting_195038	chr2_74418938_-	intronic
CAediting_195039	chr2_74418962_-	intronic
CAediting_195040	chr2_74418963_-	intronic
CAediting_195041	chr2_74418964_-	intronic
CAediting_195042	chr2_74418998_-	intronic
CAediting_195043	chr2_74419001_-	intronic
CAediting_195044	chr2_74419018_-	intronic
CAediting_195045	chr2_74419021_-	intronic
CAediting_195046	chr2_74419049_-	intronic
CAediting_195047	chr2_74419063_-	intronic
CAediting_195048	chr2_74419069_-	intronic
CAediting_195049	chr2_74419099_-	intronic
CAediting_195050	chr2_74419124_-	intronic
CAediting_195051	chr2_74419129_-	intronic
CAediting_195052	chr2_74419140_-	intronic
CAediting_195053	chr2_74419173_-	intronic
CAediting_195054	chr2_74419175_-	intronic
CAediting_195055	chr2_74419177_-	intronic
CAediting_195056	chr2_74419179_-	intronic
CAediting_195057	chr2_74419289_-	intronic
CAediting_195058	chr2_74419290_-	intronic
CAediting_195059	chr2_74419293_-	intronic
CAediting_195060	chr2_74419807_-	intronic
CAediting_195061	chr2_74419829_-	intronic
CAediting_195062	chr2_74419861_-	intronic
CAediting_195063	chr2_74419909_-	intronic
CAediting_195064	chr2_74419910_-	intronic
CAediting_195065	chr2_74419920_-	intronic
CAediting_195066	chr2_74419932_-	intronic
CAediting_195067	chr2_74419936_-	intronic
CAediting_195068	chr2_74419940_-	intronic
CAediting_195069	chr2_74419976_-	intronic
CAediting_195070	chr2_74419978_-	intronic
CAediting_195071	chr2_74419991_-	intronic
CAediting_195072	chr2_74419993_-	intronic
CAediting_195073	chr2_74419994_-	intronic
CAediting_195074	chr2_74420014_-	intronic
CAediting_195075	chr2_74420779_-	intronic
CAediting_195076	chr2_74420794_-	intronic
CAediting_195077	chr2_74420816_-	intronic
CAediting_195078	chr2_74420818_-	intronic
CAediting_195079	chr2_74420838_-	intronic
CAediting_195080	chr2_74420848_-	intronic
CAediting_195081	chr2_74420853_-	intronic
CAediting_195082	chr2_74420878_-	intronic
CAediting_195083	chr2_74420886_-	intronic
CAediting_195084	chr2_74420892_-	intronic
CAediting_195085	chr2_74420898_-	intronic
CAediting_195086	chr2_74420902_-	intronic
CAediting_195087	chr2_74420909_-	intronic
CAediting_195088	chr2_74420918_-	intronic
CAediting_195089	chr2_74420919_-	intronic
CAediting_195090	chr2_74420946_-	intronic
CAediting_195091	chr2_74420949_-	intronic
CAediting_195092	chr2_74420950_-	intronic
CAediting_195093	chr2_74420952_-	intronic
CAediting_195094	chr2_74420953_-	intronic
CAediting_195095	chr2_74420956_-	intronic
CAediting_195096	chr2_74420958_-	intronic
CAediting_195097	chr2_74420960_-	intronic
CAediting_195098	chr2_74420961_-	intronic
CAediting_195099	chr2_74420977_-	intronic
CAediting_195100	chr2_74420983_-	intronic
CAediting_195101	chr2_74420985_-	intronic
CAediting_195102	chr2_74420986_-	intronic
CAediting_195103	chr2_74420995_-	intronic
CAediting_195104	chr2_74420998_-	intronic
CAediting_195105	chr2_74421000_-	intronic
CAediting_195106	chr2_74421001_-	intronic
CAediting_195107	chr2_74421009_-	intronic
CAediting_195108	chr2_74421014_-	intronic
CAediting_195109	chr2_74421040_-	intronic
CAediting_195110	chr2_74421046_-	intronic
CAediting_195111	chr2_74421049_-	intronic
CAediting_195112	chr2_74421054_-	intronic
CAediting_195113	chr2_74421055_-	intronic
CAediting_195114	chr2_74421071_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_195034	chr2_74416484_-	SINE	Alu	AluSc
CAediting_195035	chr2_74416521_-	SINE	Alu	AluSc
CAediting_195036	chr2_74418924_-	SINE	Alu	AluSx1
CAediting_195037	chr2_74418937_-	SINE	Alu	AluSx1
CAediting_195038	chr2_74418938_-	SINE	Alu	AluSx1
CAediting_195039	chr2_74418962_-	SINE	Alu	AluSx1
CAediting_195040	chr2_74418963_-	SINE	Alu	AluSx1
CAediting_195041	chr2_74418964_-	SINE	Alu	AluSx1
CAediting_195042	chr2_74418998_-	SINE	Alu	AluSx1
CAediting_195043	chr2_74419001_-	SINE	Alu	AluSx1
CAediting_195044	chr2_74419018_-	SINE	Alu	AluSx1
CAediting_195045	chr2_74419021_-	SINE	Alu	AluSx1
CAediting_195046	chr2_74419049_-	SINE	Alu	AluSx1
CAediting_195047	chr2_74419063_-	SINE	Alu	AluSx1
CAediting_195048	chr2_74419069_-	SINE	Alu	AluSx1
CAediting_195049	chr2_74419099_-	SINE	Alu	AluSx1
CAediting_195050	chr2_74419124_-	SINE	Alu	AluSx1
CAediting_195051	chr2_74419129_-	SINE	Alu	AluSx1
CAediting_195052	chr2_74419140_-	SINE	Alu	AluSx1
CAediting_195053	chr2_74419173_-	SINE	Alu	AluSx1
CAediting_195054	chr2_74419175_-	SINE	Alu	AluSx1
CAediting_195055	chr2_74419177_-	SINE	Alu	AluSx1
CAediting_195056	chr2_74419179_-	SINE	Alu	AluSx1
CAediting_195057	chr2_74419289_-	SINE	Alu	FRAM
CAediting_195058	chr2_74419290_-	SINE	Alu	FRAM
CAediting_195059	chr2_74419293_-	SINE	Alu	FRAM
CAediting_195060	chr2_74419807_-	SINE	Alu	AluSx1
CAediting_195061	chr2_74419829_-	SINE	Alu	AluSx1
CAediting_195062	chr2_74419861_-	SINE	Alu	AluSx1
CAediting_195063	chr2_74419909_-	SINE	Alu	AluSx1
CAediting_195064	chr2_74419910_-	SINE	Alu	AluSx1
CAediting_195065	chr2_74419920_-	SINE	Alu	AluSx1
CAediting_195066	chr2_74419932_-	SINE	Alu	AluSx1
CAediting_195067	chr2_74419936_-	SINE	Alu	AluSx1
CAediting_195068	chr2_74419940_-	SINE	Alu	AluSx1
CAediting_195069	chr2_74419976_-	SINE	Alu	AluSx1
CAediting_195070	chr2_74419978_-	SINE	Alu	AluSx1
CAediting_195071	chr2_74419991_-	SINE	Alu	AluSx1
CAediting_195072	chr2_74419993_-	SINE	Alu	AluSx1
CAediting_195073	chr2_74419994_-	SINE	Alu	AluSx1
CAediting_195074	chr2_74420014_-	SINE	Alu	AluSx1
CAediting_195075	chr2_74420779_-	SINE	Alu	AluSx
CAediting_195076	chr2_74420794_-	SINE	Alu	AluSx
CAediting_195077	chr2_74420816_-	SINE	Alu	AluSx
CAediting_195078	chr2_74420818_-	SINE	Alu	AluSx
CAediting_195079	chr2_74420838_-	SINE	Alu	AluSx
CAediting_195080	chr2_74420848_-	SINE	Alu	AluSx
CAediting_195081	chr2_74420853_-	SINE	Alu	AluSx
CAediting_195082	chr2_74420878_-	SINE	Alu	AluSx
CAediting_195083	chr2_74420886_-	SINE	Alu	AluSx
CAediting_195084	chr2_74420892_-	SINE	Alu	AluSx
CAediting_195085	chr2_74420898_-	SINE	Alu	AluSx
CAediting_195086	chr2_74420902_-	SINE	Alu	AluSx
CAediting_195087	chr2_74420909_-	SINE	Alu	AluSx
CAediting_195088	chr2_74420918_-	SINE	Alu	AluSx
CAediting_195089	chr2_74420919_-	SINE	Alu	AluSx
CAediting_195090	chr2_74420946_-	SINE	Alu	AluSx
CAediting_195091	chr2_74420949_-	SINE	Alu	AluSx
CAediting_195092	chr2_74420950_-	SINE	Alu	AluSx
CAediting_195093	chr2_74420952_-	SINE	Alu	AluSx
CAediting_195094	chr2_74420953_-	SINE	Alu	AluSx
CAediting_195095	chr2_74420956_-	SINE	Alu	AluSx
CAediting_195096	chr2_74420958_-	SINE	Alu	AluSx
CAediting_195097	chr2_74420960_-	SINE	Alu	AluSx
CAediting_195098	chr2_74420961_-	SINE	Alu	AluSx
CAediting_195099	chr2_74420977_-	SINE	Alu	AluSx
CAediting_195100	chr2_74420983_-	SINE	Alu	AluSx
CAediting_195101	chr2_74420985_-	SINE	Alu	AluSx
CAediting_195102	chr2_74420986_-	SINE	Alu	AluSx
CAediting_195103	chr2_74420995_-	SINE	Alu	AluSx
CAediting_195104	chr2_74420998_-	SINE	Alu	AluSx
CAediting_195105	chr2_74421000_-	SINE	Alu	AluSx
CAediting_195106	chr2_74421001_-	SINE	Alu	AluSx
CAediting_195107	chr2_74421009_-	SINE	Alu	AluSx
CAediting_195108	chr2_74421014_-	SINE	Alu	AluSx
CAediting_195109	chr2_74421040_-	SINE	Alu	AluSx
CAediting_195110	chr2_74421046_-	SINE	Alu	AluSx
CAediting_195111	chr2_74421049_-	SINE	Alu	AluSx
CAediting_195112	chr2_74421054_-	SINE	Alu	AluSx
CAediting_195113	chr2_74421055_-	SINE	Alu	AluSx
CAediting_195114	chr2_74421071_-	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for C2orf81

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000159239.10.C2orf81.

Correlation between RNA A-to-I editing and PSI for ENSG00000159239.10.C2orf81.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for C2orf81

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for C2orf81

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for C2orf81

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for C2orf81

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000517883.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_195034	ENST00000517883.1	chr2_74416484_-	-1038.10	-1036.40	-1037.40
CAediting_195035	ENST00000517883.1	chr2_74416521_-	-1035.70	-1036.40	-1037.40

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Relation with ADAR for C2orf81

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for C2orf81

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for C2orf81

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for C2orf81

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for C2orf81

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene