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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: LRRC37A3 (CAeditome ID:374819)

Gene summary for LRRC37A3

check button Gene summary
Gene informationGene symbol

LRRC37A3

Gene ID

374819

Gene nameleucine rich repeat containing 37 member A3
SynonymsLRRC37|LRRC37A
Cytomap

17q24.1

Type of geneprotein-coding
Descriptionleucine-rich repeat-containing protein 37A3
Modification date20210518
UniProtAcc

O60309

Context- NA(NA)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for LRRC37A3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000176809.9

check button RNA A-to-I editing events in Cancer.
CAediting_1227143(64854930, -), CAediting_1227144(64854949, -), CAediting_1227145(64854966, -), CAediting_1227146(64854976, -), CAediting_1227147(64860092, -), CAediting_1227148(64860093, -), CAediting_1227149(64860095, -), CAediting_1227150(64863929, -), CAediting_1227151(64875177, -), CAediting_1227152(64879896, -), CAediting_1227153(64912813, -), CAediting_1227154(64913096, -), CAediting_1227155(64913097, -), CAediting_1227156(64913105, -), CAediting_1227157(64913114, -), CAediting_1227158(64913160, -), CAediting_1227159(64913193, -), CAediting_1227160(64913211, -), CAediting_1227161(64913232, -), CAediting_1227162(64913247, -), CAediting_1227163(64913275, -), CAediting_1227164(64913300, -), CAediting_1227165(64913302, -), CAediting_1227166(64913370, -), CAediting_1227167(64913403, -), CAediting_1227168(64913413, -), CAediting_1227169(64913417, -), CAediting_1227170(64913438, -), CAediting_1227171(64913443, -), CAediting_1227172(64913451, -), CAediting_1227173(64913452, -), CAediting_1227174(64913456, -), CAediting_1227175(64913462, -), CAediting_1227176(64913465, -), CAediting_1227177(64913469, -), CAediting_1227178(64913473, -), CAediting_1227179(64913479, -), CAediting_1227180(64913487, -), CAediting_1227181(64913489, -), CAediting_1227182(64913522, -), CAediting_1227183(64913543, -), CAediting_1227184(64913577, -), CAediting_1227185(64913612, -), CAediting_1227186(64913613, -), CAediting_1227187(64913635, -), CAediting_1227188(64915982, -), CAediting_1227189(64916020, -), CAediting_1227190(64916073, -), CAediting_1227191(64917795, -), CAediting_1227192(64917801, -), CAediting_1227193(64918790, -), CAediting_1227194(64918800, -), CAediting_1227195(64918813, -), CAediting_1227196(64918818, -), CAediting_1227197(64918865, -), CAediting_1227198(64918872, -), CAediting_1227199(64918888, -), CAediting_1227200(64918889, -), CAediting_1227201(64918897, -),

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RNA editing positional annotations for LRRC37A3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_1227147chr17_64860092_-nonsynonymous SNVENST00000319651.8c.A4054Gp.N1352DTPD
CAediting_1227147chr17_64860092_-nonsynonymous SNVENST00000334962.8c.A985Gp.N329DTPD
CAediting_1227147chr17_64860092_-nonsynonymous SNVENST00000339474.8c.A1408Gp.N470DTPD
CAediting_1227147chr17_64860092_-nonsynonymous SNVENST00000400877.6c.A1168Gp.N390DTPD
CAediting_1227147chr17_64860092_-nonsynonymous SNVENST00000584306.4c.A4054Gp.N1352DTPD
CAediting_1227148chr17_64860093_-nonsynonymous SNVENST00000319651.8c.A4053Gp.I1351MDDD
CAediting_1227148chr17_64860093_-nonsynonymous SNVENST00000334962.8c.A984Gp.I328MDDD
CAediting_1227148chr17_64860093_-nonsynonymous SNVENST00000339474.8c.A1407Gp.I469MDDD
CAediting_1227148chr17_64860093_-nonsynonymous SNVENST00000400877.6c.A1167Gp.I389MDDD
CAediting_1227148chr17_64860093_-nonsynonymous SNVENST00000584306.4c.A4053Gp.I1351MDDD

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1227143chr17_64854930_-intronic
CAediting_1227144chr17_64854949_-intronic
CAediting_1227145chr17_64854966_-intronic
CAediting_1227146chr17_64854976_-intronic
CAediting_1227147chr17_64860092_-exonic
CAediting_1227148chr17_64860093_-exonic
CAediting_1227149chr17_64860095_-exonic
CAediting_1227150chr17_64863929_-ncRNA_intronic
CAediting_1227151chr17_64875177_-ncRNA_intronic
CAediting_1227152chr17_64879896_-intronic
CAediting_1227153chr17_64912813_-intronic
CAediting_1227154chr17_64913096_-intronic
CAediting_1227155chr17_64913097_-intronic
CAediting_1227156chr17_64913105_-intronic
CAediting_1227157chr17_64913114_-intronic
CAediting_1227158chr17_64913160_-intronic
CAediting_1227159chr17_64913193_-intronic
CAediting_1227160chr17_64913211_-intronic
CAediting_1227161chr17_64913232_-intronic
CAediting_1227162chr17_64913247_-intronic
CAediting_1227163chr17_64913275_-intronic
CAediting_1227164chr17_64913300_-intronic
CAediting_1227165chr17_64913302_-intronic
CAediting_1227166chr17_64913370_-intronic
CAediting_1227167chr17_64913403_-intronic
CAediting_1227168chr17_64913413_-intronic
CAediting_1227169chr17_64913417_-intronic
CAediting_1227170chr17_64913438_-intronic
CAediting_1227171chr17_64913443_-intronic
CAediting_1227172chr17_64913451_-intronic
CAediting_1227173chr17_64913452_-intronic
CAediting_1227174chr17_64913456_-intronic
CAediting_1227175chr17_64913462_-intronic
CAediting_1227176chr17_64913465_-intronic
CAediting_1227177chr17_64913469_-intronic
CAediting_1227178chr17_64913473_-intronic
CAediting_1227179chr17_64913479_-intronic
CAediting_1227180chr17_64913487_-intronic
CAediting_1227181chr17_64913489_-intronic
CAediting_1227182chr17_64913522_-intronic
CAediting_1227183chr17_64913543_-intronic
CAediting_1227184chr17_64913577_-intronic
CAediting_1227185chr17_64913612_-intronic
CAediting_1227186chr17_64913613_-intronic
CAediting_1227187chr17_64913635_-intronic
CAediting_1227188chr17_64915982_-intronic
CAediting_1227189chr17_64916020_-intronic
CAediting_1227190chr17_64916073_-intronic
CAediting_1227191chr17_64917795_-intronic
CAediting_1227192chr17_64917801_-intronic
CAediting_1227193chr17_64918790_-exonic
CAediting_1227194chr17_64918800_-exonic
CAediting_1227195chr17_64918813_-exonic
CAediting_1227196chr17_64918818_-exonic
CAediting_1227197chr17_64918865_-exonic
CAediting_1227198chr17_64918872_-splicing
CAediting_1227199chr17_64918888_-intronic
CAediting_1227200chr17_64918889_-intronic
CAediting_1227201chr17_64918897_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1227143chr17_64854930_-SINEAluAluSz
CAediting_1227144chr17_64854949_-SINEAluAluSz
CAediting_1227145chr17_64854966_-SINEAluAluSz
CAediting_1227146chr17_64854976_-SINEAluAluSz
CAediting_1227150chr17_64863929_-SINEAluAluJb
CAediting_1227151chr17_64875177_-SINEAluAluJb
CAediting_1227152chr17_64879896_-SINEAluAluJo
CAediting_1227153chr17_64912813_-SINEAluAluSz6
CAediting_1227154chr17_64913096_-SINEAluAluSx1
CAediting_1227155chr17_64913097_-SINEAluAluSx1
CAediting_1227156chr17_64913105_-SINEAluAluSx1
CAediting_1227157chr17_64913114_-SINEAluAluSx1
CAediting_1227158chr17_64913160_-SINEAluAluSx1
CAediting_1227159chr17_64913193_-SINEAluAluSx1
CAediting_1227160chr17_64913211_-SINEAluAluSx1
CAediting_1227161chr17_64913232_-SINEAluAluSx1
CAediting_1227162chr17_64913247_-SINEAluAluSx1
CAediting_1227163chr17_64913275_-SINEAluAluSx1
CAediting_1227164chr17_64913300_-SINEAluAluSx1
CAediting_1227165chr17_64913302_-SINEAluAluSx1
CAediting_1227166chr17_64913370_-SINEAluAluSx
CAediting_1227167chr17_64913403_-SINEAluAluSx
CAediting_1227168chr17_64913413_-SINEAluAluSx
CAediting_1227169chr17_64913417_-SINEAluAluSx
CAediting_1227170chr17_64913438_-SINEAluAluSx
CAediting_1227171chr17_64913443_-SINEAluAluSx
CAediting_1227172chr17_64913451_-SINEAluAluSx
CAediting_1227173chr17_64913452_-SINEAluAluSx
CAediting_1227174chr17_64913456_-SINEAluAluSx
CAediting_1227175chr17_64913462_-SINEAluAluSx
CAediting_1227176chr17_64913465_-SINEAluAluSx
CAediting_1227177chr17_64913469_-SINEAluAluSx
CAediting_1227178chr17_64913473_-SINEAluAluSx
CAediting_1227179chr17_64913479_-SINEAluAluSx
CAediting_1227180chr17_64913487_-SINEAluAluSx
CAediting_1227181chr17_64913489_-SINEAluAluSx
CAediting_1227182chr17_64913522_-SINEAluAluSx
CAediting_1227183chr17_64913543_-SINEAluAluSx
CAediting_1227184chr17_64913577_-SINEAluAluSx
CAediting_1227185chr17_64913612_-SINEAluAluSx
CAediting_1227186chr17_64913613_-SINEAluAluSx
CAediting_1227187chr17_64913635_-SINEAluAluSx
CAediting_1227188chr17_64915982_-SINEAluAluJb
CAediting_1227189chr17_64916020_-SINEAluAluJb
CAediting_1227190chr17_64916073_-SINEAluAluJb
CAediting_1227191chr17_64917795_-SINEAluAluSq
CAediting_1227192chr17_64917801_-SINEAluAluSq
CAediting_1227193chr17_64918790_-SINEAluAluSx1
CAediting_1227194chr17_64918800_-SINEAluAluSx1
CAediting_1227195chr17_64918813_-SINEAluAluSx1
CAediting_1227196chr17_64918818_-SINEAluAluSx1
CAediting_1227197chr17_64918865_-SINEAluAluSx1
CAediting_1227198chr17_64918872_-SINEAluAluSx1
CAediting_1227199chr17_64918888_-SINEAluAluSx1
CAediting_1227200chr17_64918889_-SINEAluAluSx1
CAediting_1227201chr17_64918897_-SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for LRRC37A3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1227197chr17_64918865_-64918865:649188873SS3+0iTTTTTTGTATTTTTTAGTAGAGA5.01TTTTTTGTATTTTTTAGTAGAGG4.72
IRCAediting_1227197chr17_64918865_-64918865:649188873SS3+0iTTTTTTGTATTTTTTAGTAGAGA5.01TTTTTTGTATTTTTTAGTAGAGG4.72
ESCAediting_1227198chr17_64918872_-64918865:649188873SS0+5iTTTTTTGTATTTTTTAGTAGAGA5.01TTTTTTGTATTTTTTGGTAGAGA6.42
ESCAediting_1227198chr17_64918872_-64918868:649188903SS0+2iTAATTTTTTGTATTTTTTAGTAG6.67TAATTTTTTGTATTTTTTGGTAG-1.29
IRCAediting_1227198chr17_64918872_-64918865:649188873SS0+5iTTTTTTGTATTTTTTAGTAGAGA5.01TTTTTTGTATTTTTTGGTAGAGA6.42
IRCAediting_1227198chr17_64918872_-64918868:649188903SS0+2iTAATTTTTTGTATTTTTTAGTAG6.67TAATTTTTTGTATTTTTTGGTAG-1.29
ESCAediting_1227199chr17_64918888_-64918868:649188903SS0+18iTAATTTTTTGTATTTTTTAGTAG6.67TAGTTTTTTGTATTTTTTAGTAG5.5
IRCAediting_1227199chr17_64918888_-64918868:649188903SS0+18iTAATTTTTTGTATTTTTTAGTAG6.67TAGTTTTTTGTATTTTTTAGTAG5.5
ESCAediting_1227200chr17_64918889_-64918868:649188903SS0+19iTAATTTTTTGTATTTTTTAGTAG6.67TGATTTTTTGTATTTTTTAGTAG7.62
IRCAediting_1227200chr17_64918889_-64918868:649188903SS0+19iTAATTTTTTGTATTTTTTAGTAG6.67TGATTTTTTGTATTTTTTAGTAG7.62

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000176809.9.LRRC37A3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000176809.9.LRRC37A3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRRC37A3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LRRC37A3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for LRRC37A3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000176809.9ENST00000339474hsa-miR-605-3p64854364648543707mer-m86485436364854387158-21.76
CAediting_748296chr10_51299626_+ENSG00000176809.9ENST00000400877hsa-miR-605-3p64854364648543707mer-m86485436364854387158-21.76
CAediting_748296chr10_51299626_+ENSG00000176809.9ENST00000334962hsa-miR-605-3p64854364648543707mer-m86485436464854387158-18.99
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000339474hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000400877hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000334962hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000319651hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000584306hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23
CAediting_1160181chr17_7017644_-ENSG00000176809.9ENST00000583510hsa-miR-195-3p64854378648543847mer-m86485437764854398141-9.23

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LRRC37A3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for LRRC37A3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for LRRC37A3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for LRRC37A3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for LRRC37A3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRC37A3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource