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Editing gene: KCNC3 (CAeditome ID:3748)

Gene summary for KCNC3

Gene summary

Gene information	Gene symbol	KCNC3
	Gene ID	3748
	Gene name	potassium voltage-gated channel subfamily C member 3
	Synonyms	KSHIIID\|KV3.3\|SCA13
	Cytomap	19q13.33
	Type of gene	protein-coding
	Description	potassium voltage-gated channel subfamily C member 3Shaw-related voltage-gated potassium channel protein 3potassium channel, voltage gated Shaw related subfamily C, member 3potassium voltage-gated channel, Shaw-related subfamily, member 3voltage-gated
	Modification date	20210518
	UniProtAcc	Q14003
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
KCNC3	GO:0051262	Potassium voltage-gated channel subfamily C member 3	23734863
KCNC3	GO:0005886	Potassium voltage-gated channel subfamily C member 3	23734863
KCNC3	GO:0005886	Potassium voltage-gated channel subfamily C member 3	25152487
KCNC3	GO:0005886	Potassium voltage-gated channel subfamily C member 3	25756792
KCNC3	GO:0008076	Potassium voltage-gated channel subfamily C member 3	23734863

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RNA A-to-I events for KCNC3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000131398.12

RNA A-to-I editing events in Cancer.

CAediting_1378856(50316484, -), CAediting_1378857(50316496, -), CAediting_1378858(50316497, -), CAediting_1378859(50316519, -), CAediting_1378860(50316523, -), CAediting_1378861(50316524, -), CAediting_1378862(50316528, -), CAediting_1378863(50316536, -), CAediting_1378864(50316549, -), CAediting_1378865(50316587, -), CAediting_1378866(50316588, -), CAediting_1378867(50316596, -), CAediting_1378868(50316614, -), CAediting_1378869(50316624, -), CAediting_1378870(50316636, -), CAediting_1378871(50316654, -), CAediting_1378872(50316674, -), CAediting_1378873(50316690, -), CAediting_1378874(50316710, -), CAediting_1378875(50316732, -), CAediting_1378876(50317870, -), CAediting_1378877(50317874, -), CAediting_1378878(50317892, -), CAediting_1378879(50317897, -), CAediting_1378880(50317915, -), CAediting_1378881(50317921, -), CAediting_1378882(50317932, -), CAediting_1378883(50317938, -), CAediting_1378884(50318006, -), CAediting_1378885(50318016, -), CAediting_1378886(50318017, -), CAediting_1378887(50318018, -), CAediting_1378888(50318036, -), CAediting_1378889(50318043, -), CAediting_1378890(50318044, -), CAediting_1378891(50318065, -), CAediting_1378892(50318066, -), CAediting_1378893(50318068, -), CAediting_1378894(50318084, -), CAediting_1378895(50318169, -), CAediting_1378896(50318172, -), CAediting_1378897(50318182, -), CAediting_1378898(50318185, -), CAediting_1378899(50318186, -), CAediting_1378900(50318187, -), CAediting_1378901(50318235, -), CAediting_1378902(50318237, -), CAediting_1378903(50318240, -), CAediting_1378904(50318242, -), CAediting_1378905(50318243, -), CAediting_1378906(50318247, -), CAediting_1378907(50318264, -), CAediting_1378908(50318271, -), CAediting_1378909(50318272, -), CAediting_1378910(50318277, -), CAediting_1378911(50318280, -), CAediting_1378912(50318303, -), CAediting_1378913(50318307, -), CAediting_1378914(50318313, -), CAediting_1378915(50318342, -), CAediting_1378916(50318388, -), CAediting_1378917(50318391, -), CAediting_1378918(50318399, -), CAediting_1378919(50318402, -), CAediting_1378920(50318407, -), CAediting_1378921(50318412, -), CAediting_1378922(50318442, -), CAediting_1378923(50318447, -), CAediting_1378924(50318448, -), CAediting_1378925(50318454, -), CAediting_1378926(50318456, -), CAediting_1378927(50318814, -), CAediting_1378928(50318818, -), CAediting_1378929(50318820, -), CAediting_1378930(50318825, -), CAediting_1378931(50318832, -), CAediting_1378932(50318856, -), CAediting_1378933(50318859, -), CAediting_1378934(50318885, -), CAediting_1378935(50318931, -), CAediting_1378936(50318932, -), CAediting_1378937(50318937, -), CAediting_1378938(50318948, -), CAediting_1378939(50318956, -), CAediting_1378940(50318961, -), CAediting_1378941(50318972, -),

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RNA editing positional annotations for KCNC3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1378856	chr19_50316484_-	intronic
CAediting_1378857	chr19_50316496_-	intronic
CAediting_1378858	chr19_50316497_-	intronic
CAediting_1378859	chr19_50316519_-	intronic
CAediting_1378860	chr19_50316523_-	intronic
CAediting_1378861	chr19_50316524_-	intronic
CAediting_1378862	chr19_50316528_-	intronic
CAediting_1378863	chr19_50316536_-	intronic
CAediting_1378864	chr19_50316549_-	intronic
CAediting_1378865	chr19_50316587_-	intronic
CAediting_1378866	chr19_50316588_-	intronic
CAediting_1378867	chr19_50316596_-	intronic
CAediting_1378868	chr19_50316614_-	intronic
CAediting_1378869	chr19_50316624_-	intronic
CAediting_1378870	chr19_50316636_-	intronic
CAediting_1378871	chr19_50316654_-	intronic
CAediting_1378872	chr19_50316674_-	intronic
CAediting_1378873	chr19_50316690_-	intronic
CAediting_1378874	chr19_50316710_-	intronic
CAediting_1378875	chr19_50316732_-	intronic
CAediting_1378876	chr19_50317870_-	intronic
CAediting_1378877	chr19_50317874_-	intronic
CAediting_1378878	chr19_50317892_-	intronic
CAediting_1378879	chr19_50317897_-	intronic
CAediting_1378880	chr19_50317915_-	intronic
CAediting_1378881	chr19_50317921_-	intronic
CAediting_1378882	chr19_50317932_-	intronic
CAediting_1378883	chr19_50317938_-	intronic
CAediting_1378884	chr19_50318006_-	intronic
CAediting_1378885	chr19_50318016_-	intronic
CAediting_1378886	chr19_50318017_-	intronic
CAediting_1378887	chr19_50318018_-	intronic
CAediting_1378888	chr19_50318036_-	intronic
CAediting_1378889	chr19_50318043_-	intronic
CAediting_1378890	chr19_50318044_-	intronic
CAediting_1378891	chr19_50318065_-	intronic
CAediting_1378892	chr19_50318066_-	intronic
CAediting_1378893	chr19_50318068_-	intronic
CAediting_1378894	chr19_50318084_-	intronic
CAediting_1378895	chr19_50318169_-	intronic
CAediting_1378896	chr19_50318172_-	intronic
CAediting_1378897	chr19_50318182_-	intronic
CAediting_1378898	chr19_50318185_-	intronic
CAediting_1378899	chr19_50318186_-	intronic
CAediting_1378900	chr19_50318187_-	intronic
CAediting_1378901	chr19_50318235_-	intronic
CAediting_1378902	chr19_50318237_-	intronic
CAediting_1378903	chr19_50318240_-	intronic
CAediting_1378904	chr19_50318242_-	intronic
CAediting_1378905	chr19_50318243_-	intronic
CAediting_1378906	chr19_50318247_-	intronic
CAediting_1378907	chr19_50318264_-	intronic
CAediting_1378908	chr19_50318271_-	intronic
CAediting_1378909	chr19_50318272_-	intronic
CAediting_1378910	chr19_50318277_-	intronic
CAediting_1378911	chr19_50318280_-	intronic
CAediting_1378912	chr19_50318303_-	intronic
CAediting_1378913	chr19_50318307_-	intronic
CAediting_1378914	chr19_50318313_-	intronic
CAediting_1378915	chr19_50318342_-	intronic
CAediting_1378916	chr19_50318388_-	intronic
CAediting_1378917	chr19_50318391_-	intronic
CAediting_1378918	chr19_50318399_-	intronic
CAediting_1378919	chr19_50318402_-	intronic
CAediting_1378920	chr19_50318407_-	intronic
CAediting_1378921	chr19_50318412_-	intronic
CAediting_1378922	chr19_50318442_-	intronic
CAediting_1378923	chr19_50318447_-	intronic
CAediting_1378924	chr19_50318448_-	intronic
CAediting_1378925	chr19_50318454_-	intronic
CAediting_1378926	chr19_50318456_-	intronic
CAediting_1378927	chr19_50318814_-	intronic
CAediting_1378928	chr19_50318818_-	intronic
CAediting_1378929	chr19_50318820_-	intronic
CAediting_1378930	chr19_50318825_-	intronic
CAediting_1378931	chr19_50318832_-	intronic
CAediting_1378932	chr19_50318856_-	intronic
CAediting_1378933	chr19_50318859_-	intronic
CAediting_1378934	chr19_50318885_-	intronic
CAediting_1378935	chr19_50318931_-	intronic
CAediting_1378936	chr19_50318932_-	intronic
CAediting_1378937	chr19_50318937_-	intronic
CAediting_1378938	chr19_50318948_-	intronic
CAediting_1378939	chr19_50318956_-	intronic
CAediting_1378940	chr19_50318961_-	intronic
CAediting_1378941	chr19_50318972_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1378856	chr19_50316484_-	SINE	Alu	AluSx1
CAediting_1378857	chr19_50316496_-	SINE	Alu	AluSx1
CAediting_1378858	chr19_50316497_-	SINE	Alu	AluSx1
CAediting_1378859	chr19_50316519_-	SINE	Alu	AluSx1
CAediting_1378860	chr19_50316523_-	SINE	Alu	AluSx1
CAediting_1378861	chr19_50316524_-	SINE	Alu	AluSx1
CAediting_1378862	chr19_50316528_-	SINE	Alu	AluSx1
CAediting_1378863	chr19_50316536_-	SINE	Alu	AluSx1
CAediting_1378864	chr19_50316549_-	SINE	Alu	AluSx1
CAediting_1378865	chr19_50316587_-	SINE	Alu	AluSx1
CAediting_1378866	chr19_50316588_-	SINE	Alu	AluSx1
CAediting_1378867	chr19_50316596_-	SINE	Alu	AluSx1
CAediting_1378868	chr19_50316614_-	SINE	Alu	AluSx1
CAediting_1378869	chr19_50316624_-	SINE	Alu	AluSx1
CAediting_1378870	chr19_50316636_-	SINE	Alu	AluSx1
CAediting_1378871	chr19_50316654_-	SINE	Alu	AluSx1
CAediting_1378872	chr19_50316674_-	SINE	Alu	AluSx1
CAediting_1378873	chr19_50316690_-	SINE	Alu	AluSx1
CAediting_1378874	chr19_50316710_-	SINE	Alu	AluSx1
CAediting_1378875	chr19_50316732_-	SINE	Alu	AluSx1
CAediting_1378876	chr19_50317870_-	SINE	Alu	AluJo
CAediting_1378877	chr19_50317874_-	SINE	Alu	AluJo
CAediting_1378878	chr19_50317892_-	SINE	Alu	AluJo
CAediting_1378879	chr19_50317897_-	SINE	Alu	AluJo
CAediting_1378880	chr19_50317915_-	SINE	Alu	AluJo
CAediting_1378881	chr19_50317921_-	SINE	Alu	AluJo
CAediting_1378882	chr19_50317932_-	SINE	Alu	AluJo
CAediting_1378883	chr19_50317938_-	SINE	Alu	AluJo
CAediting_1378884	chr19_50318006_-	SINE	Alu	AluJo
CAediting_1378885	chr19_50318016_-	SINE	Alu	AluJo
CAediting_1378886	chr19_50318017_-	SINE	Alu	AluJo
CAediting_1378887	chr19_50318018_-	SINE	Alu	AluJo
CAediting_1378888	chr19_50318036_-	SINE	Alu	AluJo
CAediting_1378889	chr19_50318043_-	SINE	Alu	AluJo
CAediting_1378890	chr19_50318044_-	SINE	Alu	AluJo
CAediting_1378891	chr19_50318065_-	SINE	Alu	AluJo
CAediting_1378892	chr19_50318066_-	SINE	Alu	AluJo
CAediting_1378893	chr19_50318068_-	SINE	Alu	AluJo
CAediting_1378894	chr19_50318084_-	SINE	Alu	AluJo
CAediting_1378895	chr19_50318169_-	Simple_repeat	Simple_repeat	(CTT)n
CAediting_1378896	chr19_50318172_-	Simple_repeat	Simple_repeat	(CTT)n
CAediting_1378897	chr19_50318182_-	Simple_repeat	Simple_repeat	(CTT)n
CAediting_1378898	chr19_50318185_-	SINE	Alu	AluSx1
CAediting_1378899	chr19_50318186_-	SINE	Alu	AluSx1
CAediting_1378900	chr19_50318187_-	SINE	Alu	AluSx1
CAediting_1378901	chr19_50318235_-	SINE	Alu	AluSx1
CAediting_1378902	chr19_50318237_-	SINE	Alu	AluSx1
CAediting_1378903	chr19_50318240_-	SINE	Alu	AluSx1
CAediting_1378904	chr19_50318242_-	SINE	Alu	AluSx1
CAediting_1378905	chr19_50318243_-	SINE	Alu	AluSx1
CAediting_1378906	chr19_50318247_-	SINE	Alu	AluSx1
CAediting_1378907	chr19_50318264_-	SINE	Alu	AluSx1
CAediting_1378908	chr19_50318271_-	SINE	Alu	AluSx1
CAediting_1378909	chr19_50318272_-	SINE	Alu	AluSx1
CAediting_1378910	chr19_50318277_-	SINE	Alu	AluSx1
CAediting_1378911	chr19_50318280_-	SINE	Alu	AluSx1
CAediting_1378912	chr19_50318303_-	SINE	Alu	AluSx1
CAediting_1378913	chr19_50318307_-	SINE	Alu	AluSx1
CAediting_1378914	chr19_50318313_-	SINE	Alu	AluSx1
CAediting_1378915	chr19_50318342_-	SINE	Alu	AluSx1
CAediting_1378916	chr19_50318388_-	SINE	Alu	AluSx1
CAediting_1378917	chr19_50318391_-	SINE	Alu	AluSx1
CAediting_1378918	chr19_50318399_-	SINE	Alu	AluSx1
CAediting_1378919	chr19_50318402_-	SINE	Alu	AluSx1
CAediting_1378920	chr19_50318407_-	SINE	Alu	AluSx1
CAediting_1378921	chr19_50318412_-	SINE	Alu	AluSx1
CAediting_1378922	chr19_50318442_-	SINE	Alu	AluSx1
CAediting_1378923	chr19_50318447_-	SINE	Alu	AluSx1
CAediting_1378924	chr19_50318448_-	SINE	Alu	AluSx1
CAediting_1378925	chr19_50318454_-	SINE	Alu	AluSx1
CAediting_1378926	chr19_50318456_-	SINE	Alu	AluSx1
CAediting_1378927	chr19_50318814_-	SINE	Alu	AluSz6
CAediting_1378928	chr19_50318818_-	SINE	Alu	AluSz6
CAediting_1378929	chr19_50318820_-	SINE	Alu	AluSz6
CAediting_1378930	chr19_50318825_-	SINE	Alu	AluSz6
CAediting_1378931	chr19_50318832_-	SINE	Alu	AluSz6
CAediting_1378932	chr19_50318856_-	SINE	Alu	AluSz6
CAediting_1378933	chr19_50318859_-	SINE	Alu	AluSz6
CAediting_1378934	chr19_50318885_-	SINE	Alu	AluSz6
CAediting_1378935	chr19_50318931_-	SINE	Alu	AluSz6
CAediting_1378936	chr19_50318932_-	SINE	Alu	AluSz6
CAediting_1378937	chr19_50318937_-	SINE	Alu	AluSz6
CAediting_1378938	chr19_50318948_-	SINE	Alu	AluSz6
CAediting_1378939	chr19_50318956_-	SINE	Alu	AluSz6
CAediting_1378940	chr19_50318961_-	SINE	Alu	AluSz6
CAediting_1378941	chr19_50318972_-	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for KCNC3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000131398.12.KCNC3.

Correlation between RNA A-to-I editing and PSI for ENSG00000131398.12.KCNC3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KCNC3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

UCEC.CAediting_1378925.ENSG00000131398.KCNC3.png
Soverview

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Protein coding region RNA A-to-I editings for KCNC3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for KCNC3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000131398.12	ENST00000376959	hsa-miR-605-3p	50314864	50314870	7mer-m8	50314863	50314884	140	-13.75
CAediting_980496	chr14_31014685_-	ENSG00000131398.12	ENST00000376959	hsa-miR-624-3p	50314329	50314335	7mer-m8	50314328	50314346	148	-23.06
CAediting_688081	chr9_63819627_+	ENSG00000131398.12	ENST00000376959	hsa-miR-4477b	50314498	50314504	7mer-m8	50314497	50314522	146	-13.37
CAediting_748296	chr10_51299626_+	ENSG00000131398.12	ENST00000474951	hsa-miR-605-3p	50314864	50314870	7mer-m8	50314863	50314884	140	-13.75
CAediting_980496	chr14_31014685_-	ENSG00000131398.12	ENST00000474951	hsa-miR-624-3p	50314329	50314335	7mer-m8	50314328	50314346	148	-23.06
CAediting_688081	chr9_63819627_+	ENSG00000131398.12	ENST00000474951	hsa-miR-4477b	50314498	50314504	7mer-m8	50314497	50314522	146	-13.37
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000376959	hsa-miR-320e	50313243	50313249	7mer-m8	50313242	50313259	150	-18.42
CAediting_86358	chr1_109598906_+	ENSG00000131398.12	ENST00000376959	hsa-miR-197-5p	50314913	50314918	6mer	50314912	50314934	140	-32.39
CAediting_580943	chr7_100356700_+	ENSG00000131398.12	ENST00000376959	hsa-miR-6840-3p	50314395	50314401	7mer-m8	50314394	50314415	140	-20.83
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000474951	hsa-miR-320e	50313243	50313249	7mer-m8	50313242	50313259	150	-18.42
CAediting_86358	chr1_109598906_+	ENSG00000131398.12	ENST00000474951	hsa-miR-197-5p	50314913	50314918	6mer	50314912	50314934	140	-32.39
CAediting_580943	chr7_100356700_+	ENSG00000131398.12	ENST00000474951	hsa-miR-6840-3p	50314395	50314401	7mer-m8	50314394	50314415	140	-20.83

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000376959	hsa-miR-320e	50312657	50312663	7mer-m8	50312656	50312673	150	-17.94
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000376959	hsa-miR-320e	50312644	50312649	6mer	50312643	50312660	144	-20.4
CAediting_1524209	chrX_134546392_-	ENSG00000131398.12	ENST00000376959	hsa-miR-503-5p	50313373	50313379	7mer-m8	50313372	50313394	147	-21.94
CAediting_748296	chr10_51299626_+	ENSG00000131398.12	ENST00000376959	hsa-miR-605-3p	50314503	50314509	7mer-m8	50314502	50314523	140	-11.4
CAediting_580943	chr7_100356700_+	ENSG00000131398.12	ENST00000376959	hsa-miR-6840-3p	50314048	50314055	8mer-1a	50314048	50314070	155	-23.18
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000474951	hsa-miR-320e	50312657	50312663	7mer-m8	50312656	50312673	150	-17.94
CAediting_1368054	chr19_46709310_-	ENSG00000131398.12	ENST00000474951	hsa-miR-320e	50312644	50312649	6mer	50312643	50312660	144	-20.4
CAediting_1524209	chrX_134546392_-	ENSG00000131398.12	ENST00000474951	hsa-miR-503-5p	50313373	50313379	7mer-m8	50313372	50313394	147	-21.94
CAediting_748296	chr10_51299626_+	ENSG00000131398.12	ENST00000474951	hsa-miR-605-3p	50314503	50314509	7mer-m8	50314502	50314523	140	-11.4
CAediting_580943	chr7_100356700_+	ENSG00000131398.12	ENST00000474951	hsa-miR-6840-3p	50314048	50314055	8mer-1a	50314048	50314070	155	-23.18

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for KCNC3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for KCNC3

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
THCA	CAediting_1378892	chr19_50318066_-	2.55014583834284e-06	0.310342650897408	.	.	.	.
THCA	CAediting_1378893	chr19_50318068_-	0.000178188251146734	0.223359136715211	.	.	.	.
OV	CAediting_1378893	chr19_50318068_-	0.0378306530085286	0.143419226262283	.	.	.	.
THCA	CAediting_1378914	chr19_50318313_-	0.0310015637254945	0.141363082078622	.	.	.	.
OV	CAediting_1378914	chr19_50318313_-	0.0218578102903752	0.229104704474207	.	.	.	.
BRCA	CAediting_1378925	chr19_50318454_-	0.0363655153783027	0.1348947425593	.	.	.	.
THCA	CAediting_1378925	chr19_50318454_-	0.000162755289511767	0.208630281651735	.	.	.	.
THCA	CAediting_1378933	chr19_50318859_-	0.016625907335056	0.260673669051733	.	.	.	.
BRCA	CAediting_1378934	chr19_50318885_-	0.0112143092257838	0.172257236962012	.	.	.	.
LUAD	CAediting_1378934	chr19_50318885_-	0.0158956462179412	0.310104800946455	.	.	.	.
UCEC	CAediting_1378934	chr19_50318885_-	0.0462272364206892	0.260580271662758	0.0348344247395548	0.275292054221952	0.0463756730280669	0.260409346809922
OV	CAediting_1378934	chr19_50318885_-	0.0207903389523075	0.23569707961721	.	.	.	.
BRCA	CAediting_1378936	chr19_50318932_-	0.0134060381542891	0.305275920067562	.	.	.	.
THCA	CAediting_1378937	chr19_50318937_-	0.00676189460373012	0.203459389415044	.	.	.	.
BRCA	CAediting_1378938	chr19_50318948_-	0.000668618038159256	0.258392607075771	.	.	.	.
THCA	CAediting_1378938	chr19_50318948_-	0.00296423498014834	0.206553505097936	.	.	.	.

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Relation with cancer stages for KCNC3

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_1378929	chr19_50318820_-	0.0491956935577199	0.236005596591238
KIRC	pathologic_stage	CAediting_1378925	chr19_50318454_-	0.0063143323403741	0.306686366890062
OV	clinical_stage	CAediting_1378905	chr19_50318243_-	0.0337729390046154	0.187067294413605
THCA	pathologic_stage	CAediting_1378886	chr19_50318017_-	0.0441926424142737	0.194043098435775
THCA	pathologic_stage	CAediting_1378893	chr19_50318068_-	0.0457903228476094	0.120552503999526
THCA	pathologic_stage	CAediting_1378925	chr19_50318454_-	0.0346778254375183	0.118489777119504
THCA	pathologic_stage	CAediting_1378938	chr19_50318948_-	0.0247101507613244	0.157618254996848
UCEC	clinical_stage	CAediting_1378925	chr19_50318454_-	0.00825916534139684	-0.36955619056973

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Relation with survival for KCNC3

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
BRCA	CAediting_1378914	chr19_50318313_-	0.0121643573120896	0.0220398	0.0430506
BRCA	CAediting_1378938	chr19_50318948_-	0.00720130445536582	0.0246672	0.0239683

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RelatedDrugs for KCNC3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
KCNC3	Q14003	DB06637	Dalfampridine	Potassium voltage-gated channel subfamily C member 3	SmallMoleculeDrug	approved
KCNC3	Q14003	DB01069	Promethazine	Potassium voltage-gated channel subfamily C member 3	SmallMoleculeDrug	approved\|investigational
KCNC3	Q14003	DB00228	Enflurane	Potassium voltage-gated channel subfamily C member 3	SmallMoleculeDrug	approved\|investigational\|vet_approved
KCNC3	Q14003	DB01110	Miconazole	Potassium voltage-gated channel subfamily C member 3	SmallMoleculeDrug	approved\|investigational\|vet_approved

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RelatedDiseases for KCNC3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
KCNC3	C1854488	Spinocerebellar ataxia 13	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene