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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NCR3LG1 (CAeditome ID:374383)

Gene summary for NCR3LG1

check button Gene summary
Gene informationGene symbol

NCR3LG1

Gene ID

374383

Gene namenatural killer cell cytotoxicity receptor 3 ligand 1
SynonymsB7-H6|B7H6|DKFZp686O24166
Cytomap

11p15.1

Type of geneprotein-coding
Descriptionnatural cytotoxicity triggering receptor 3 ligand 1B7 homolog 6putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
Modification date20210531
UniProtAcc

Q68D85

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for NCR3LG1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000188211.7

check button RNA A-to-I editing events in Cancer.
CAediting_801235(17355128, +), CAediting_801236(17355138, +), CAediting_801237(17355215, +), CAediting_801238(17355219, +), CAediting_801239(17355234, +), CAediting_801240(17355235, +), CAediting_801241(17355237, +), CAediting_801242(17355247, +), CAediting_801243(17355250, +), CAediting_801244(17355276, +), CAediting_801245(17355846, +), CAediting_801246(17355854, +), CAediting_801247(17355915, +), CAediting_801248(17355940, +), CAediting_801249(17355984, +), CAediting_801250(17359645, +), CAediting_801251(17367936, +), CAediting_801252(17377201, +), CAediting_801253(17377218, +), CAediting_801254(17377223, +), CAediting_801255(17377229, +), CAediting_801256(17377250, +), CAediting_801257(17377254, +), CAediting_801258(17377267, +), CAediting_801259(17377270, +), CAediting_801260(17377275, +), CAediting_801261(17377276, +), CAediting_801262(17377299, +), CAediting_801263(17377300, +), CAediting_801264(17377319, +),

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RNA editing positional annotations for NCR3LG1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_801235chr11_17355128_+intronic
CAediting_801236chr11_17355138_+intronic
CAediting_801237chr11_17355215_+intronic
CAediting_801238chr11_17355219_+intronic
CAediting_801239chr11_17355234_+intronic
CAediting_801240chr11_17355235_+intronic
CAediting_801241chr11_17355237_+intronic
CAediting_801242chr11_17355247_+intronic
CAediting_801243chr11_17355250_+intronic
CAediting_801244chr11_17355276_+intronic
CAediting_801245chr11_17355846_+intronic
CAediting_801246chr11_17355854_+intronic
CAediting_801247chr11_17355915_+intronic
CAediting_801248chr11_17355940_+intronic
CAediting_801249chr11_17355984_+intronic
CAediting_801250chr11_17359645_+intronic
CAediting_801251chr11_17367936_+intronic
CAediting_801252chr11_17377201_+UTR3
CAediting_801253chr11_17377218_+UTR3
CAediting_801254chr11_17377223_+UTR3
CAediting_801255chr11_17377229_+UTR3
CAediting_801256chr11_17377250_+UTR3
CAediting_801257chr11_17377254_+UTR3
CAediting_801258chr11_17377267_+UTR3
CAediting_801259chr11_17377270_+UTR3
CAediting_801260chr11_17377275_+UTR3
CAediting_801261chr11_17377276_+UTR3
CAediting_801262chr11_17377299_+UTR3
CAediting_801263chr11_17377300_+UTR3
CAediting_801264chr11_17377319_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_801235chr11_17355128_+SINEAluAluJo
CAediting_801236chr11_17355138_+SINEAluAluJo
CAediting_801237chr11_17355215_+SINEAluAluJo
CAediting_801238chr11_17355219_+SINEAluAluJo
CAediting_801239chr11_17355234_+SINEAluAluJo
CAediting_801240chr11_17355235_+SINEAluAluJo
CAediting_801241chr11_17355237_+SINEAluAluJo
CAediting_801242chr11_17355247_+SINEAluAluJo
CAediting_801243chr11_17355250_+SINEAluAluJo
CAediting_801244chr11_17355276_+SINEAluAluJo
CAediting_801245chr11_17355846_+SINEAluAluJo
CAediting_801246chr11_17355854_+SINEAluAluJo
CAediting_801247chr11_17355915_+SINEAluAluJo
CAediting_801248chr11_17355940_+SINEAluAluJo
CAediting_801249chr11_17355984_+SINEAluAluJo
CAediting_801250chr11_17359645_+SINEAluAluSx1
CAediting_801251chr11_17367936_+SINEAluAluSp
CAediting_801252chr11_17377201_+SINEAluAluSx3
CAediting_801253chr11_17377218_+SINEAluAluSx3
CAediting_801254chr11_17377223_+SINEAluAluSx3
CAediting_801255chr11_17377229_+SINEAluAluSx3
CAediting_801256chr11_17377250_+SINEAluAluSx3
CAediting_801257chr11_17377254_+SINEAluAluSx3
CAediting_801258chr11_17377267_+SINEAluAluSx3
CAediting_801259chr11_17377270_+SINEAluAluSx3
CAediting_801260chr11_17377275_+SINEAluAluSx3
CAediting_801261chr11_17377276_+SINEAluAluSx3
CAediting_801262chr11_17377299_+SINEAluAluSx3
CAediting_801263chr11_17377300_+SINEAluAluSx3
CAediting_801264chr11_17377319_+SINEAluAluSx3

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RNA A-to-I editing events in the alternative splicing sites for NCR3LG1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000188211.7.NCR3LG1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000188211.7.NCR3LG1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NCR3LG1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NCR3LG1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NCR3LG1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-6850-3p17377195173772017mer-m81737718317377202143.00-22.88
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-94117377197173772037mer-m81737718517377204152.00-25.74
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-94117377197173772037mer-m81737718517377204152.00-25.74
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-94117377197173772037mer-m81737718517377204152.00-25.74
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-94117377197173772037mer-m81737718517377204152.00-25.74
CAediting_801252chr11_17377201_+ENSG00000188211.7ENST00000338965hsa-miR-94117377197173772037mer-m81737718517377204152.00-25.74
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-27a-3p17377217173772237mer-m81737720517377224157.00-20.16
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-27b-3p17377217173772237mer-m81737720517377224155.00-16.15
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-63817377222173772287mer-1a1737720417377228147.00-29.95
CAediting_801255chr11_17377229_+ENSG00000188211.7ENST00000338965hsa-miR-371a-3p17377227173772337mer-m81737721217377234144.00-14.81
CAediting_801259chr11_17377270_+ENSG00000188211.7ENST00000338965hsa-miR-331-3p17377265173772706mer1737725117377271141.00-21.46
CAediting_801259chr11_17377270_+ENSG00000188211.7ENST00000338965hsa-miR-4732-3p17377263173772697mer-m81737724917377270158.00-23.29
CAediting_801261chr11_17377276_+ENSG00000188211.7ENST00000338965hsa-miR-1211317377269173772757mer-m81737725617377276147.00-17.05
CAediting_801261chr11_17377276_+ENSG00000188211.7ENST00000338965hsa-miR-453917377269173772757mer-m81737725717377276151.00-17.82
CAediting_801261chr11_17377276_+ENSG00000188211.7ENST00000338965hsa-miR-454017377274173772807mer-m81737726017377281146.00-19.66
CAediting_801261chr11_17377276_+ENSG00000188211.7ENST00000338965hsa-miR-6838-3p17377273173772808mer-1a1737725917377280153.00-19.53
CAediting_801262chr11_17377299_+ENSG00000188211.7ENST00000338965hsa-miR-23a-5p17377297173773037mer-m81737728317377304141.00-16.90
CAediting_801262chr11_17377299_+ENSG00000188211.7ENST00000338965hsa-miR-23b-5p17377297173773037mer-m81737728417377304152.00-19.56
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-1229-3p17377294173773007mer-m81737728017377301148.00-14.69
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511a-3p17377293173773008mer-1a1737727817377300147.00-15.32
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511a-3p17377293173773008mer-1a1737727817377300147.00-15.32
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511a-3p17377293173773008mer-1a1737727817377300147.00-15.32
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511a-3p17377293173773008mer-1a1737727817377300147.00-15.32
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511b-3p17377293173773008mer-1a1737727817377300140.00-13.75
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-6511b-3p17377293173773008mer-1a1737727817377300140.00-13.75

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-10399-5p17377218173772247mer-m81737720617377225147-11.25
CAediting_801264chr11_17377319_+ENSG00000188211.7ENST00000338965hsa-miR-126-5p17377313173773208mer-1a1737730017377320144-9.2
CAediting_801263chr11_17377300_+ENSG00000188211.7ENST00000338965hsa-miR-193b-5p17377298173773047mer-m81737728417377305142-16.21
CAediting_801258chr11_17377267_+ENSG00000188211.7ENST00000338965hsa-miR-378a-5p17377263173772697mer-m81737725117377270149-21.26
CAediting_801259chr11_17377270_+ENSG00000188211.7ENST00000338965hsa-miR-378a-5p17377263173772697mer-m81737725117377270149-21.26
CAediting_801264chr11_17377319_+ENSG00000188211.7ENST00000338965hsa-miR-4795-3p17377314173773207mer-m81737730017377321150-11.32
CAediting_801255chr11_17377229_+ENSG00000188211.7ENST00000338965hsa-miR-5089-5p17377222173772287mer-m81737720817377229148-14.13
CAediting_801255chr11_17377229_+ENSG00000188211.7ENST00000338965hsa-miR-512-3p17377227173772337mer-m81737721317377234149-15.51
CAediting_801255chr11_17377229_+ENSG00000188211.7ENST00000338965hsa-miR-512-3p17377227173772337mer-m81737721317377234149-15.51
CAediting_801253chr11_17377218_+ENSG00000188211.7ENST00000338965hsa-miR-582-5p17377217173772237mer-1a1737719917377223140-20.4
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-582-5p17377217173772237mer-1a1737719917377223140-20.4
CAediting_801254chr11_17377223_+ENSG00000188211.7ENST00000338965hsa-miR-6504-3p17377218173772247mer-m81737720417377225148-14.59
CAediting_801255chr11_17377229_+ENSG00000188211.7ENST00000338965hsa-miR-6506-5p17377223173772297mer-m81737720817377230146-13.6
CAediting_801256chr11_17377250_+ENSG00000188211.7ENST00000338965hsa-miR-6747-3p17377245173772517mer-m81737723117377252150-22.65

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000188211.7ENST00000338965hsa-miR-624-3p17373398173734047mer-m81737338517373405146-14.99
CAediting_393chr1_1167164_+ENSG00000188211.7ENST00000338965hsa-miR-200b-3p17374025173740317mer-m81737401117374032143-13.83
CAediting_393chr1_1167164_+ENSG00000188211.7ENST00000338965hsa-miR-200b-3p17372796173728027mer-m81737278217372803148-9.38
CAediting_688080chr9_63819626_+ENSG00000188211.7ENST00000338965hsa-miR-4477b17375161173751677mer-m81737514517375168150-14.71
CAediting_688081chr9_63819627_+ENSG00000188211.7ENST00000338965hsa-miR-4477b17376320173763267mer-m81737630617376327140-13.26
CAediting_980496chr14_31014685_-ENSG00000188211.7ENST00000530403hsa-miR-624-3p17373398173734047mer-m81737338517373405146-14.99
CAediting_393chr1_1167164_+ENSG00000188211.7ENST00000530403hsa-miR-200b-3p17372796173728027mer-m81737278217372803148-9.38
CAediting_1054808chr15_66496985_-ENSG00000188211.7ENST00000338965hsa-miR-451217375771173757788mer-1a1737575917375778147-19.41
CAediting_1054808chr15_66496985_-ENSG00000188211.7ENST00000338965hsa-miR-451217375796173758027mer-m81737578117375803157-20.48
CAediting_1229414chr17_67471546_+ENSG00000188211.7ENST00000338965hsa-miR-548aa17374591173745977mer-m81737457017374598153-14.5
CAediting_1229414chr17_67471546_+ENSG00000188211.7ENST00000338965hsa-miR-548aa17377172173771787mer-m81737715417377179146-18.44
CAediting_1160181chr17_7017644_-ENSG00000188211.7ENST00000338965hsa-miR-195-3p17375423173754308mer-1a1737540817375430151-13.25
CAediting_1368054chr19_46709310_-ENSG00000188211.7ENST00000338965hsa-miR-320e17374950173749578mer-1a1737494017374957156-20.13
CAediting_1399425chr20_1392958_-ENSG00000188211.7ENST00000338965hsa-miR-6869-5p17376368173763747mer-m81737635417376375152-18.3
CAediting_228905chr2_188297554_+ENSG00000188211.7ENST00000338965hsa-miR-561-3p17372684173726907mer-m81737267017372691162-13.1
CAediting_228905chr2_188297554_+ENSG00000188211.7ENST00000338965hsa-miR-561-3p17372951173729577mer-m81737293717372958151-7.09
CAediting_396018chr5_1062918_-ENSG00000188211.7ENST00000338965hsa-miR-463517373950173739567mer-m81737393817373957152-17.31
CAediting_396018chr5_1062918_-ENSG00000188211.7ENST00000338965hsa-miR-463517374668173746747mer-m81737465517374675140-10.62
CAediting_396018chr5_1062918_-ENSG00000188211.7ENST00000338965hsa-miR-463517375162173751687mer-m81737514917375169140-15.87
CAediting_442554chr5_154685830_+ENSG00000188211.7ENST00000338965hsa-miR-130317373636173736427mer-m81737362217373643147-15.38
CAediting_604450chr7_133034877_-ENSG00000188211.7ENST00000338965hsa-miR-365417373486173734938mer-1a1737347517373493149-18.57
CAediting_228905chr2_188297554_+ENSG00000188211.7ENST00000530403hsa-miR-561-3p17372684173726907mer-m81737267017372691162-13.1
CAediting_228905chr2_188297554_+ENSG00000188211.7ENST00000530403hsa-miR-561-3p17372951173729577mer-m81737293717372958151-7.09
CAediting_442554chr5_154685830_+ENSG00000188211.7ENST00000530403hsa-miR-130317373637173736426mer1737362317373643147-14.49
CAediting_468389chr6_31355314_-ENSG00000188211.7ENST00000338965hsa-miR-6891-5p17375159173751668mer-1a1737514817375166150-20.4
CAediting_468389chr6_31355314_-ENSG00000188211.7ENST00000338965hsa-miR-6891-5p17376748173767547mer-m81737673717376755142-16.55

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_86358chr1_109598906_+ENSG00000188211.7ENST00000338965hsa-miR-197-5p17373550173735556mer1737353417373556141-32.13
CAediting_86358chr1_109598906_+ENSG00000188211.7ENST00000338965hsa-miR-197-5p17376367173763748mer-1a1737635217376374145-15.51
CAediting_393chr1_1167164_+ENSG00000188211.7ENST00000338965hsa-miR-200b-3p17373875173738828mer-1a1737386117373882147-9.6
CAediting_393chr1_1167164_+ENSG00000188211.7ENST00000338965hsa-miR-200b-3p17375840173758467mer-m81737582617375847140-9.23
CAediting_1368054chr19_46709310_-ENSG00000188211.7ENST00000338965hsa-miR-320e17375010173750167mer-m81737500017375017140-10.89
CAediting_604450chr7_133034877_-ENSG00000188211.7ENST00000338965hsa-miR-365417375199173752057mer-m81737518917375206145-14.82
CAediting_688080chr9_63819626_+ENSG00000188211.7ENST00000338965hsa-miR-4477b17374507173745137mer-m81737449417374514146-12.89
CAediting_688081chr9_63819627_+ENSG00000188211.7ENST00000338965hsa-miR-4477b17374507173745137mer-m81737449417374514146-12.89
CAediting_1351755chr19_40282625_-ENSG00000188211.7ENST00000338965hsa-miR-64117372751173727577mer-m81737273517372758140-12.65
CAediting_1351755chr19_40282625_-ENSG00000188211.7ENST00000338965hsa-miR-64117376201173762077mer-m81737618517376208153-14.15
CAediting_580943chr7_100356700_+ENSG00000188211.7ENST00000338965hsa-miR-6840-3p17373505173735117mer-m81737349117373512147-23.75
CAediting_468389chr6_31355314_-ENSG00000188211.7ENST00000338965hsa-miR-6891-5p17374052173740598mer-1a1737404117374059140-13.94
CAediting_1351755chr19_40282625_-ENSG00000188211.7ENST00000530403hsa-miR-64117372751173727577mer-m81737273517372758140-12.65

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NCR3LG1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for NCR3LG1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for NCR3LG1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for NCR3LG1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for NCR3LG1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCR3LG1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource