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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: KCNA1 (CAeditome ID:3736) |
Gene summary for KCNA1 |
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Gene information | Gene symbol | KCNA1 | Gene ID | 3736 |
Gene name | potassium voltage-gated channel subfamily A member 1 | |
Synonyms | AEMK|EA1|HBK1|HUK1|KV1.1|MBK1|MK1|RBK1 | |
Cytomap | 12p13.32 | |
Type of gene | protein-coding | |
Description | potassium voltage-gated channel subfamily A member 1potassium channel, voltage gated shaker related subfamily A, member 1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)voltage-gated K(+) channel HuKI | |
Modification date | 20210518 | |
UniProtAcc | Q09470 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
KCNA1 | GO:0005249 | Potassium voltage-gated channel subfamily A member 1 | 19912772 |
KCNA1 | GO:0005251 | Potassium voltage-gated channel subfamily A member 1 | 19912772 |
KCNA1 | GO:0005887 | Potassium voltage-gated channel subfamily A member 1 | 17136396 |
KCNA1 | GO:0033270 | Potassium voltage-gated channel subfamily A member 1 | 11086297 |
KCNA1 | GO:0044224 | Potassium voltage-gated channel subfamily A member 1 | 11086297 |
KCNA1 | GO:0008076 | Potassium voltage-gated channel subfamily A member 1 | 11086297 |
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RNA A-to-I events for KCNA1 |
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CAediting_864167(4912576, +), |
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RNA editing positional annotations for KCNA1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_864167 | chr12_4912576_+ | nonsynonymous SNV | ENST00000382545.3 | c.A1198G | p.I400V | D | P | N |
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CAeditome ID | Position | Variant type |
CAediting_864167 | chr12_4912576_+ | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for KCNA1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KCNA1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for KCNA1 |
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The effects of the RNA editing to the miRNA binding sites for KCNA1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for KCNA1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for KCNA1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for KCNA1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for KCNA1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for KCNA1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
KCNA1 | Q09470 | DB00321 | Amitriptyline | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved |
KCNA1 | Q09470 | DB01189 | Desflurane | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved |
KCNA1 | Q09470 | DB06637 | Dalfampridine | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved |
KCNA1 | Q09470 | DB01069 | Promethazine | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|investigational |
KCNA1 | Q09470 | DB11640 | Amifampridine | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|investigational |
KCNA1 | Q09470 | DB00228 | Enflurane | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|investigational|vet_approved |
KCNA1 | Q09470 | DB01028 | Methoxyflurane | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|investigational|vet_approved |
KCNA1 | Q09470 | DB01110 | Miconazole | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|investigational|vet_approved |
KCNA1 | Q09470 | DB00753 | Isoflurane | Potassium voltage-gated channel subfamily A member 1 | SmallMoleculeDrug | approved|vet_approved |
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RelatedDiseases for KCNA1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
KCNA1 | C1719788 | Episodic ataxia type 1 | 17 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
KCNA1 | C0393706 | Early infantile epileptic encephalopathy with suppression bursts | 1 | ORPHANET |
KCNA1 | C0684219 | Myokymia | 1 | GENOMICS_ENGLAND |
KCNA1 | C1720189 | Episodic Ataxia | 1 | GENOMICS_ENGLAND |
KCNA1 | C1834559 | Continuous Muscle Fiber Activity, Hereditary | 1 | ORPHANET |
KCNA1 | C1868682 | Paroxysmal kinesigenic choreoathetosis | 1 | ORPHANET |