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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with cancer stages

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Relation with survival state

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Related drugs with this gene

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Related diseases with this gene

Editing gene: JUND (CAeditome ID:3727)

Gene summary for JUND

check button Gene summary
Gene informationGene symbol

JUND

Gene ID

3727

Gene nameJunD proto-oncogene, AP-1 transcription factor subunit
SynonymsAP-1
Cytomap

19p13.11

Type of geneprotein-coding
Descriptiontranscription factor jun-Dactivator protein 1jun D proto-oncogene
Modification date20210518
UniProtAcc

P17535

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
JUND

GO:0000976

Transcription factor jun-D

1903194

JUND

GO:1990837

Transcription factor jun-D

28473536

JUND

GO:0045944

Transcription factor jun-D

10508860

JUND

GO:0005654

Transcription factor jun-D

0000052

JUND

GO:0035976

Transcription factor jun-D

10508860


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RNA A-to-I events for JUND

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000130522.5

check button RNA A-to-I editing events in Cancer.
CAediting_1318777(18280506, -), CAediting_1318778(18280565, -), CAediting_1318779(18280583, -), CAediting_1318780(18280653, -),

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RNA editing positional annotations for JUND using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_1318777chr19_18280506_-nonsynonymous SNVENST00000252818.4c.A979Gp.K327EDPD
CAediting_1318777chr19_18280506_-nonsynonymous SNVENST00000600972.1c.A424Gp.K142EDPD
CAediting_1318778chr19_18280565_-nonsynonymous SNVENST00000252818.4c.A920Gp.N307SDDD
CAediting_1318778chr19_18280565_-nonsynonymous SNVENST00000600972.1c.A365Gp.N122SDDD
CAediting_1318779chr19_18280583_-nonsynonymous SNVENST00000252818.4c.A902Gp.K301RTDD
CAediting_1318779chr19_18280583_-nonsynonymous SNVENST00000600972.1c.A347Gp.K116RTDD
CAediting_1318780chr19_18280653_-nonsynonymous SNVENST00000252818.4c.A832Gp.N278DDDD
CAediting_1318780chr19_18280653_-nonsynonymous SNVENST00000600972.1c.A277Gp.N93DDDD

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1318777chr19_18280506_-exonic
CAediting_1318778chr19_18280565_-exonic
CAediting_1318779chr19_18280583_-exonic
CAediting_1318780chr19_18280653_-exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1318780chr19_18280653_-Simple_repeatSimple_repeat(TGCGCT)n

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RNA A-to-I editing events in the alternative splicing sites for JUND

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000130522.5.JUND.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000130522.5.JUND.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for JUND

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for JUND

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for JUND

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for JUND

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for JUND

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for JUND

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for JUND

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for JUND

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for JUND

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
JUNDC0009171Cocaine Abuse1CTD_human
JUNDC0017658Glomerulonephritis1CTD_human
JUNDC0019193Hepatitis, Toxic1CTD_human
JUNDC0023890Liver Cirrhosis1CTD_human
JUNDC0024121Lung Neoplasms1CTD_human
JUNDC0038220Status Epilepticus1CTD_human
JUNDC0236736Cocaine-Related Disorders1CTD_human
JUNDC0239946Fibrosis, Liver1CTD_human
JUNDC0242379Malignant neoplasm of lung1CTD_human
JUNDC0270823Petit mal status1CTD_human
JUNDC0311335Grand Mal Status Epilepticus1CTD_human
JUNDC0393734Complex Partial Status Epilepticus1CTD_human
JUNDC0600427Cocaine Dependence1CTD_human
JUNDC0751522Status Epilepticus, Subclinical1CTD_human
JUNDC0751523Non-Convulsive Status Epilepticus1CTD_human
JUNDC0751524Simple Partial Status Epilepticus1CTD_human
JUNDC0860207Drug-Induced Liver Disease1CTD_human
JUNDC1262760Hepatitis, Drug-Induced1CTD_human
JUNDC1704377Bright Disease1CTD_human
JUNDC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
JUNDC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
JUNDC3658290Drug-Induced Acute Liver Injury1CTD_human
JUNDC4277682Chemical and Drug Induced Liver Injury1CTD_human
JUNDC4279912Chemically-Induced Liver Toxicity1CTD_human
JUNDC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human