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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: JAK3 (CAeditome ID:3718)

Gene summary for JAK3

check button Gene summary
Gene informationGene symbol

JAK3

Gene ID

3718

Gene nameJanus kinase 3
SynonymsJAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK
Cytomap

19p13.11

Type of geneprotein-coding
Descriptiontyrosine-protein kinase JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)leukocyte Janus kinase
Modification date20210524
UniProtAcc

P52333

Context- 33083484(JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
JAK3

GO:0035771

Tyrosine-protein kinase JAK3

7538655

JAK3

GO:0070670

Tyrosine-protein kinase JAK3

7538655

JAK3

GO:0070670

Tyrosine-protein kinase JAK3

7594533


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RNA A-to-I events for JAK3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000105639.17

check button RNA A-to-I editing events in Cancer.
CAediting_1317606(17825632, -), CAediting_1317607(17825645, -), CAediting_1317608(17825657, -), CAediting_1317609(17825658, -), CAediting_1317610(17825659, -), CAediting_1317611(17825708, -), CAediting_1317612(17825712, -), CAediting_1317613(17825720, -), CAediting_1317614(17825730, -), CAediting_1317615(17825734, -), CAediting_1317616(17825737, -), CAediting_1317617(17825761, -), CAediting_1317618(17825777, -), CAediting_1317619(17825779, -), CAediting_1317620(17825789, -), CAediting_1317621(17825792, -), CAediting_1317622(17825801, -), CAediting_1317623(17825838, -), CAediting_1317624(17825839, -), CAediting_1317625(17825844, -), CAediting_1317626(17825850, -), CAediting_1317627(17825855, -), CAediting_1317628(17826105, -), CAediting_1317629(17826125, -), CAediting_1317630(17826127, -), CAediting_1317631(17826128, -), CAediting_1317632(17826131, -), CAediting_1317633(17826139, -), CAediting_1317634(17826140, -), CAediting_1317635(17826149, -), CAediting_1317636(17826154, -), CAediting_1317637(17826166, -), CAediting_1317638(17826167, -), CAediting_1317639(17826172, -), CAediting_1317640(17826179, -), CAediting_1317641(17826180, -), CAediting_1317642(17826186, -), CAediting_1317643(17826192, -), CAediting_1317644(17826201, -), CAediting_1317645(17826204, -), CAediting_1317646(17826211, -), CAediting_1317647(17826218, -), CAediting_1317648(17826253, -), CAediting_1317649(17826261, -), CAediting_1317650(17826263, -), CAediting_1317651(17826285, -), CAediting_1317652(17826302, -), CAediting_1317653(17826309, -), CAediting_1317654(17826322, -), CAediting_1317655(17826328, -), CAediting_1317656(17826347, -), CAediting_1317657(17826363, -), CAediting_1317658(17826379, -), CAediting_1317659(17826383, -), CAediting_1317660(17827047, -), CAediting_1317661(17827056, -), CAediting_1317662(17827077, -), CAediting_1317663(17827140, -), CAediting_1317664(17827415, -), CAediting_1317665(17827459, -), CAediting_1317666(17827790, -), CAediting_1317667(17828400, -), CAediting_1317668(17828661, -), CAediting_1317669(17828910, -), CAediting_1317670(17829121, -), CAediting_1317671(17829430, -), CAediting_1317672(17829431, -), CAediting_1317673(17829540, -), CAediting_1317674(17829651, -), CAediting_1317675(17833997, -), CAediting_1317676(17834029, -), CAediting_1317677(17834163, -), CAediting_1317678(17834200, -), CAediting_1317679(17834210, -), CAediting_1317680(17834270, -), CAediting_1317681(17836290, -), CAediting_1317682(17836313, -), CAediting_1317683(17836343, -), CAediting_1317684(17836368, -), CAediting_1317685(17836388, -), CAediting_1317686(17836391, -), CAediting_1317687(17836407, -), CAediting_1317688(17836411, -), CAediting_1317689(17836421, -), CAediting_1317690(17836447, -), CAediting_1317691(17836501, -), CAediting_1317692(17836527, -), CAediting_1317693(17836537, -), CAediting_1317694(17836539, -), CAediting_1317695(17836540, -), CAediting_1317696(17838556, -), CAediting_1317697(17838684, -), CAediting_1317698(17838692, -), CAediting_1317699(17838986, -), CAediting_1317700(17838989, -), CAediting_1317701(17840956, -), CAediting_1317702(17844553, -), CAediting_1317703(17844633, -), CAediting_1317704(17844669, -), CAediting_1317705(17844675, -), CAediting_1317706(17845571, -), CAediting_1317707(17847080, -),

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RNA editing positional annotations for JAK3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1317606chr19_17825632_-ncRNA_intronic
CAediting_1317607chr19_17825645_-ncRNA_intronic
CAediting_1317608chr19_17825657_-ncRNA_intronic
CAediting_1317609chr19_17825658_-ncRNA_intronic
CAediting_1317610chr19_17825659_-ncRNA_intronic
CAediting_1317611chr19_17825708_-ncRNA_intronic
CAediting_1317612chr19_17825712_-ncRNA_intronic
CAediting_1317613chr19_17825720_-ncRNA_intronic
CAediting_1317614chr19_17825730_-ncRNA_intronic
CAediting_1317615chr19_17825734_-ncRNA_intronic
CAediting_1317616chr19_17825737_-ncRNA_intronic
CAediting_1317617chr19_17825761_-ncRNA_intronic
CAediting_1317618chr19_17825777_-ncRNA_intronic
CAediting_1317619chr19_17825779_-ncRNA_intronic
CAediting_1317620chr19_17825789_-ncRNA_intronic
CAediting_1317621chr19_17825792_-ncRNA_intronic
CAediting_1317622chr19_17825801_-ncRNA_intronic
CAediting_1317623chr19_17825838_-ncRNA_intronic
CAediting_1317624chr19_17825839_-ncRNA_intronic
CAediting_1317625chr19_17825844_-ncRNA_intronic
CAediting_1317626chr19_17825850_-ncRNA_intronic
CAediting_1317627chr19_17825855_-ncRNA_intronic
CAediting_1317628chr19_17826105_-ncRNA_intronic
CAediting_1317629chr19_17826125_-ncRNA_intronic
CAediting_1317630chr19_17826127_-ncRNA_intronic
CAediting_1317631chr19_17826128_-ncRNA_intronic
CAediting_1317632chr19_17826131_-ncRNA_intronic
CAediting_1317633chr19_17826139_-ncRNA_intronic
CAediting_1317634chr19_17826140_-ncRNA_intronic
CAediting_1317635chr19_17826149_-ncRNA_intronic
CAediting_1317636chr19_17826154_-ncRNA_intronic
CAediting_1317637chr19_17826166_-ncRNA_intronic
CAediting_1317638chr19_17826167_-ncRNA_intronic
CAediting_1317639chr19_17826172_-ncRNA_intronic
CAediting_1317640chr19_17826179_-ncRNA_intronic
CAediting_1317641chr19_17826180_-ncRNA_intronic
CAediting_1317642chr19_17826186_-ncRNA_intronic
CAediting_1317643chr19_17826192_-ncRNA_intronic
CAediting_1317644chr19_17826201_-ncRNA_intronic
CAediting_1317645chr19_17826204_-ncRNA_intronic
CAediting_1317646chr19_17826211_-ncRNA_intronic
CAediting_1317647chr19_17826218_-ncRNA_intronic
CAediting_1317648chr19_17826253_-ncRNA_intronic
CAediting_1317649chr19_17826261_-ncRNA_intronic
CAediting_1317650chr19_17826263_-ncRNA_intronic
CAediting_1317651chr19_17826285_-ncRNA_intronic
CAediting_1317652chr19_17826302_-ncRNA_intronic
CAediting_1317653chr19_17826309_-ncRNA_intronic
CAediting_1317654chr19_17826322_-ncRNA_intronic
CAediting_1317655chr19_17826328_-ncRNA_intronic
CAediting_1317656chr19_17826347_-ncRNA_intronic
CAediting_1317657chr19_17826363_-ncRNA_intronic
CAediting_1317658chr19_17826379_-ncRNA_intronic
CAediting_1317659chr19_17826383_-ncRNA_intronic
CAediting_1317660chr19_17827047_-ncRNA_intronic
CAediting_1317661chr19_17827056_-ncRNA_intronic
CAediting_1317662chr19_17827077_-ncRNA_intronic
CAediting_1317663chr19_17827140_-ncRNA_intronic
CAediting_1317664chr19_17827415_-ncRNA_intronic
CAediting_1317665chr19_17827459_-ncRNA_intronic
CAediting_1317666chr19_17827790_-ncRNA_intronic
CAediting_1317667chr19_17828400_-ncRNA_intronic
CAediting_1317668chr19_17828661_-ncRNA_intronic
CAediting_1317669chr19_17828910_-ncRNA_intronic
CAediting_1317670chr19_17829121_-ncRNA_intronic
CAediting_1317671chr19_17829430_-ncRNA_intronic
CAediting_1317672chr19_17829431_-ncRNA_intronic
CAediting_1317673chr19_17829540_-ncRNA_intronic
CAediting_1317674chr19_17829651_-ncRNA_intronic
CAediting_1317675chr19_17833997_-ncRNA_intronic
CAediting_1317676chr19_17834029_-ncRNA_intronic
CAediting_1317677chr19_17834163_-ncRNA_intronic
CAediting_1317678chr19_17834200_-ncRNA_intronic
CAediting_1317679chr19_17834210_-ncRNA_intronic
CAediting_1317680chr19_17834270_-ncRNA_intronic
CAediting_1317681chr19_17836290_-ncRNA_intronic
CAediting_1317682chr19_17836313_-ncRNA_intronic
CAediting_1317683chr19_17836343_-ncRNA_intronic
CAediting_1317684chr19_17836368_-ncRNA_intronic
CAediting_1317685chr19_17836388_-ncRNA_intronic
CAediting_1317686chr19_17836391_-ncRNA_intronic
CAediting_1317687chr19_17836407_-ncRNA_intronic
CAediting_1317688chr19_17836411_-ncRNA_intronic
CAediting_1317689chr19_17836421_-ncRNA_intronic
CAediting_1317690chr19_17836447_-ncRNA_intronic
CAediting_1317691chr19_17836501_-ncRNA_intronic
CAediting_1317692chr19_17836527_-ncRNA_intronic
CAediting_1317693chr19_17836537_-ncRNA_intronic
CAediting_1317694chr19_17836539_-ncRNA_intronic
CAediting_1317695chr19_17836540_-ncRNA_intronic
CAediting_1317696chr19_17838556_-ncRNA_intronic
CAediting_1317697chr19_17838684_-ncRNA_intronic
CAediting_1317698chr19_17838692_-ncRNA_intronic
CAediting_1317699chr19_17838986_-ncRNA_intronic
CAediting_1317700chr19_17838989_-ncRNA_intronic
CAediting_1317701chr19_17840956_-ncRNA_intronic
CAediting_1317702chr19_17844553_-ncRNA_intronic
CAediting_1317703chr19_17844633_-ncRNA_intronic
CAediting_1317704chr19_17844669_-ncRNA_intronic
CAediting_1317705chr19_17844675_-ncRNA_intronic
CAediting_1317706chr19_17845571_-ncRNA_intronic
CAediting_1317707chr19_17847080_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1317606chr19_17825632_-SINEAluAluY
CAediting_1317607chr19_17825645_-SINEAluAluY
CAediting_1317608chr19_17825657_-SINEAluAluY
CAediting_1317609chr19_17825658_-SINEAluAluY
CAediting_1317610chr19_17825659_-SINEAluAluY
CAediting_1317611chr19_17825708_-SINEAluAluY
CAediting_1317612chr19_17825712_-SINEAluAluY
CAediting_1317613chr19_17825720_-SINEAluAluY
CAediting_1317614chr19_17825730_-SINEAluAluY
CAediting_1317615chr19_17825734_-SINEAluAluY
CAediting_1317616chr19_17825737_-SINEAluAluY
CAediting_1317617chr19_17825761_-SINEAluAluY
CAediting_1317618chr19_17825777_-SINEAluAluY
CAediting_1317619chr19_17825779_-SINEAluAluY
CAediting_1317620chr19_17825789_-SINEAluAluY
CAediting_1317621chr19_17825792_-SINEAluAluY
CAediting_1317622chr19_17825801_-SINEAluAluY
CAediting_1317623chr19_17825838_-SINEAluAluY
CAediting_1317624chr19_17825839_-SINEAluAluY
CAediting_1317625chr19_17825844_-SINEAluAluY
CAediting_1317626chr19_17825850_-SINEAluAluY
CAediting_1317627chr19_17825855_-SINEAluAluY
CAediting_1317628chr19_17826105_-SINEAluAluSz
CAediting_1317629chr19_17826125_-SINEAluAluSz
CAediting_1317630chr19_17826127_-SINEAluAluSz
CAediting_1317631chr19_17826128_-SINEAluAluSz
CAediting_1317632chr19_17826131_-SINEAluAluSz
CAediting_1317633chr19_17826139_-SINEAluAluSz
CAediting_1317634chr19_17826140_-SINEAluAluSz
CAediting_1317635chr19_17826149_-SINEAluAluSz
CAediting_1317636chr19_17826154_-SINEAluAluSz
CAediting_1317637chr19_17826166_-SINEAluAluSz
CAediting_1317638chr19_17826167_-SINEAluAluSz
CAediting_1317639chr19_17826172_-SINEAluAluSz
CAediting_1317640chr19_17826179_-SINEAluAluSz
CAediting_1317641chr19_17826180_-SINEAluAluSz
CAediting_1317642chr19_17826186_-SINEAluAluSz
CAediting_1317643chr19_17826192_-SINEAluAluSz
CAediting_1317644chr19_17826201_-SINEAluAluSz
CAediting_1317645chr19_17826204_-SINEAluAluSz
CAediting_1317646chr19_17826211_-SINEAluAluSz
CAediting_1317647chr19_17826218_-SINEAluAluSz
CAediting_1317648chr19_17826253_-SINEAluAluSz
CAediting_1317649chr19_17826261_-SINEAluAluSz
CAediting_1317650chr19_17826263_-SINEAluAluSz
CAediting_1317651chr19_17826285_-SINEAluAluSz
CAediting_1317652chr19_17826302_-SINEAluAluSz
CAediting_1317653chr19_17826309_-SINEAluAluSz
CAediting_1317654chr19_17826322_-SINEAluAluSz
CAediting_1317655chr19_17826328_-SINEAluAluSz
CAediting_1317656chr19_17826347_-SINEAluAluSz
CAediting_1317657chr19_17826363_-SINEAluAluSz
CAediting_1317658chr19_17826379_-SINEAluAluSz
CAediting_1317659chr19_17826383_-SINEAluAluSz
CAediting_1317660chr19_17827047_-SINEAluAluSx
CAediting_1317661chr19_17827056_-SINEAluAluSx
CAediting_1317662chr19_17827077_-SINEAluAluSx
CAediting_1317663chr19_17827140_-SINEAluAluSx
CAediting_1317664chr19_17827415_-SINEAluAluSq
CAediting_1317665chr19_17827459_-SINEAluAluSq
CAediting_1317666chr19_17827790_-SINEAluAluSp
CAediting_1317667chr19_17828400_-SINEAluAluJb
CAediting_1317668chr19_17828661_-SINEAluAluJo
CAediting_1317669chr19_17828910_-SINEAluAluJo
CAediting_1317670chr19_17829121_-SINEAluAluJo
CAediting_1317671chr19_17829430_-SINEAluAluSx1
CAediting_1317672chr19_17829431_-SINEAluAluSx1
CAediting_1317673chr19_17829540_-SINEAluAluJo
CAediting_1317674chr19_17829651_-SINEAluAluJo
CAediting_1317675chr19_17833997_-SINEAluAluJo
CAediting_1317676chr19_17834029_-SINEAluAluJo
CAediting_1317677chr19_17834163_-SINEAluAluSx
CAediting_1317678chr19_17834200_-SINEAluAluSx
CAediting_1317679chr19_17834210_-SINEAluAluSx
CAediting_1317680chr19_17834270_-SINEAluAluSx
CAediting_1317681chr19_17836290_-SINEAluAluSx
CAediting_1317682chr19_17836313_-SINEAluAluSx
CAediting_1317683chr19_17836343_-SINEAluAluSx
CAediting_1317684chr19_17836368_-SINEAluAluSx
CAediting_1317685chr19_17836388_-SINEAluAluSx
CAediting_1317686chr19_17836391_-SINEAluAluSx
CAediting_1317687chr19_17836407_-SINEAluAluSx
CAediting_1317688chr19_17836411_-SINEAluAluSx
CAediting_1317689chr19_17836421_-SINEAluAluSx
CAediting_1317690chr19_17836447_-SINEAluAluSx
CAediting_1317691chr19_17836501_-SINEAluAluSx
CAediting_1317692chr19_17836527_-SINEAluAluSx
CAediting_1317693chr19_17836537_-SINEAluAluSx
CAediting_1317694chr19_17836539_-SINEAluAluSx
CAediting_1317695chr19_17836540_-SINEAluAluSx
CAediting_1317696chr19_17838556_-SINEAluAluSc8
CAediting_1317697chr19_17838684_-SINEAluAluSc8
CAediting_1317698chr19_17838692_-SINEAluAluSc8
CAediting_1317699chr19_17838986_-SINEAluAluSx
CAediting_1317700chr19_17838989_-SINEAluAluSx
CAediting_1317701chr19_17840956_-SINEAluAluJo
CAediting_1317702chr19_17844553_-SINEAluAluSz
CAediting_1317703chr19_17844633_-SINEAluAluSz
CAediting_1317704chr19_17844669_-SINEAluAluSz
CAediting_1317705chr19_17844675_-SINEAluAluSz
CAediting_1317706chr19_17845571_-SINEAluAluJb
CAediting_1317707chr19_17847080_-SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for JAK3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000105639.17.JAK3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000105639.17.JAK3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for JAK3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for JAK3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for JAK3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1317653chr19_17826309_-ENSG00000105639.17ENST00000527670hsa-miR-1247-3p17826307178263137mer-m81782630617826328160.00-23.05
CAediting_1317658chr19_17826379_-ENSG00000105639.17ENST00000527670hsa-miR-340-3p17826377178263848mer-1a1782637717826398146.00-18.79
CAediting_1317658chr19_17826379_-ENSG00000105639.17ENST00000527670hsa-miR-6827-3p17826377178263848mer-1a1782637717826397140.00-14.67
CAediting_1317637chr19_17826166_-ENSG00000105639.17ENST00000527670hsa-miR-3622a-3p17826162178261698mer-1a1782616217826183140.00-12.75
CAediting_1317637chr19_17826166_-ENSG00000105639.17ENST00000527670hsa-miR-3622b-3p17826162178261698mer-1a1782616217826182147.00-16.66
CAediting_1317637chr19_17826166_-ENSG00000105639.17ENST00000527670hsa-miR-544b17826165178261717mer-m81782616417826184161.00-19.42
CAediting_1317637chr19_17826166_-ENSG00000105639.17ENST00000527670hsa-miR-7162-3p17826166178261727mer-m81782616517826185142.00-16.34
CAediting_1317639chr19_17826172_-ENSG00000105639.17ENST00000527670hsa-miR-397517826167178261748mer-1a1782616717826188140.00-12.59
CAediting_1317639chr19_17826172_-ENSG00000105639.17ENST00000527670hsa-miR-606917826170178261767mer-m81782616917826189141.00-15.75
CAediting_1317642chr19_17826186_-ENSG00000105639.17ENST00000527670hsa-miR-4786-5p17826182178261887mer-m81782618117826201153.00-26.55
CAediting_1317642chr19_17826186_-ENSG00000105639.17ENST00000527670hsa-miR-6849-3p17826186178261927mer-m81782618517826204149.00-21.68
CAediting_1317643chr19_17826192_-ENSG00000105639.17ENST00000527670hsa-miR-3940-3p17826188178261947mer-m81782618717826208142.00-21.65
CAediting_1317644chr19_17826201_-ENSG00000105639.17ENST00000527670hsa-miR-433-5p17826200178262067mer-m81782619917826222162.00-23.80
CAediting_1317647chr19_17826218_-ENSG00000105639.17ENST00000527670hsa-miR-136-5p17826214178262218mer-1a1782621417826236143.00-9.15
CAediting_1317648chr19_17826253_-ENSG00000105639.17ENST00000527670hsa-miR-6722-5p17826250178262578mer-1a1782625017826269142.00-18.02
CAediting_1317649chr19_17826261_-ENSG00000105639.17ENST00000527670hsa-miR-100-5p17826258178262647mer-m81782625717826277160.00-20.88
CAediting_1317649chr19_17826261_-ENSG00000105639.17ENST00000527670hsa-miR-99a-5p17826258178262647mer-m81782625717826277160.00-19.76
CAediting_1317649chr19_17826261_-ENSG00000105639.17ENST00000527670hsa-miR-99b-5p17826258178262647mer-m81782625717826277152.00-24.40
CAediting_1317652chr19_17826302_-ENSG00000105639.17ENST00000527670hsa-miR-607817826298178263058mer-1a1782629817826316149.00-21.50
CAediting_1317655chr19_17826328_-ENSG00000105639.17ENST00000527670hsa-miR-615-3p17826327178263337mer-m81782632617826347159.00-26.47
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-196a-3p17826361178263677mer-m81782636017826382144.00-16.72
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-3187-5p17826358178263647mer-m81782635717826382157.00-30.54
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-5189-5p17826358178263647mer-m81782635717826381153.00-28.47
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-61217826358178263647mer-m81782635717826381150.00-24.96
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-686017826358178263647mer-m81782635717826378147.00-21.68
CAediting_1317659chr19_17826383_-ENSG00000105639.17ENST00000527670hsa-miR-186-3p17826381178263877mer-1a1782638117826402141.00-14.08
CAediting_1317659chr19_17826383_-ENSG00000105639.17ENST00000527670hsa-miR-4433b-5p17826379178263857mer-m81782637817826398140.00-10.81
CAediting_1317640chr19_17826179_-ENSG00000105639.17ENST00000527670hsa-miR-28-5p17826173178261808mer-1a1782617317826198150.00-20.93
CAediting_1317640chr19_17826179_-ENSG00000105639.17ENST00000527670hsa-miR-313917826173178261808mer-1a1782617317826195165.00-26.93
CAediting_1317640chr19_17826179_-ENSG00000105639.17ENST00000527670hsa-miR-708-5p17826173178261808mer-1a1782617317826194154.00-20.84
CAediting_1317641chr19_17826180_-ENSG00000105639.17ENST00000527670hsa-miR-128917826175178261817mer-m81782617417826195158.00-21.80
CAediting_1317641chr19_17826180_-ENSG00000105639.17ENST00000527670hsa-miR-128917826175178261817mer-m81782617417826195158.00-21.80
CAediting_1317646chr19_17826211_-ENSG00000105639.17ENST00000527670hsa-miR-6771-3p17826206178262127mer-m81782620517826226153.00-14.92
CAediting_1317654chr19_17826322_-ENSG00000105639.17ENST00000527670hsa-miR-485-5p17826318178263247mer-m81782631717826340150.00-23.29
CAediting_1317654chr19_17826322_-ENSG00000105639.17ENST00000527670hsa-miR-6884-5p17826318178263247mer-m81782631717826340143.00-22.20

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-1233-5p17826153178261597mer-m81782615217826173145-19.65
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-1233-5p17826153178261597mer-m81782615217826173145-19.65
CAediting_1317639chr19_17826172_-ENSG00000105639.17ENST00000527670hsa-miR-125817826171178261777mer-m81782617017826193150-14.55
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-1273h-5p17826154178261607mer-m81782615317826174146-18.83
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-194-5p17826362178263687mer-m81782636117826384142-12.47
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-194-5p17826362178263687mer-m81782636117826384142-12.47
CAediting_1317644chr19_17826201_-ENSG00000105639.17ENST00000527670hsa-miR-2681-3p17826197178262037mer-m81782619617826217142-12.75
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-30b-3p17826154178261607mer-m81782615317826174140-15.74
CAediting_1317643chr19_17826192_-ENSG00000105639.17ENST00000527670hsa-miR-3187-3p17826192178261987mer-m81782619117826210147-16.73
CAediting_1317643chr19_17826192_-ENSG00000105639.17ENST00000527670hsa-miR-3190-5p17826191178261977mer-m81782619017826209143-15.58
CAediting_1317653chr19_17826309_-ENSG00000105639.17ENST00000527670hsa-miR-3192-5p17826308178263136mer1782630717826332140-24.28
CAediting_1317656chr19_17826347_-ENSG00000105639.17ENST00000527670hsa-miR-324-3p17826343178263497mer-m81782634217826364147-21.68
CAediting_1317647chr19_17826218_-ENSG00000105639.17ENST00000527670hsa-miR-3675-3p17826213178262197mer-m81782621217826233145-12.58
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-3689a-3p17826154178261607mer-m81782615317826173142-16.91
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-3689b-3p17826154178261607mer-m81782615317826172148-20.02
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-3689c17826154178261607mer-m81782615317826172148-20.02
CAediting_1317659chr19_17826383_-ENSG00000105639.17ENST00000527670hsa-miR-371b-5p17826381178263888mer-1a1782638117826401144-7.98
CAediting_1317659chr19_17826383_-ENSG00000105639.17ENST00000527670hsa-miR-373-5p17826381178263888mer-1a1782638117826403141-8.87
CAediting_1317651chr19_17826285_-ENSG00000105639.17ENST00000527670hsa-miR-447817826281178262877mer-m81782628017826295149-25.05
CAediting_1317651chr19_17826285_-ENSG00000105639.17ENST00000527670hsa-miR-4649-3p17826284178262907mer-m81782628317826303140-14.11
CAediting_1317656chr19_17826347_-ENSG00000105639.17ENST00000527670hsa-miR-4793-3p17826346178263527mer-m81782634517826367153-20.65
CAediting_1317653chr19_17826309_-ENSG00000105639.17ENST00000527670hsa-miR-490-3p17826305178263117mer-m81782630417826326142-14.39
CAediting_1317646chr19_17826211_-ENSG00000105639.17ENST00000527670hsa-miR-607217826209178262157mer-m81782620817826230143-12.97
CAediting_1317654chr19_17826322_-ENSG00000105639.17ENST00000527670hsa-miR-608617826318178263247mer-m81782631717826336150-21.69
CAediting_1317659chr19_17826383_-ENSG00000105639.17ENST00000527670hsa-miR-616-5p17826381178263888mer-1a1782638117826402140-6.3
CAediting_1317639chr19_17826172_-ENSG00000105639.17ENST00000527670hsa-miR-655-5p17826167178261748mer-1a1782616717826188144-9.35
CAediting_1317655chr19_17826328_-ENSG00000105639.17ENST00000527670hsa-miR-6751-3p17826327178263337mer-m81782632617826346147-19.26
CAediting_1317657chr19_17826363_-ENSG00000105639.17ENST00000527670hsa-miR-6776-5p17826358178263636mer1782635717826376140-25.2
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-6778-5p17826153178261597mer-m81782615217826176155-28.74
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-6779-5p17826154178261607mer-m81782615317826176150-23.1
CAediting_1317636chr19_17826154_-ENSG00000105639.17ENST00000527670hsa-miR-6780a-5p17826154178261607mer-m81782615317826175141-19.09
CAediting_1317656chr19_17826347_-ENSG00000105639.17ENST00000527670hsa-miR-6807-3p17826345178263506mer1782634417826366154-28.7
CAediting_1317653chr19_17826309_-ENSG00000105639.17ENST00000527670hsa-miR-6852-5p17826307178263126mer1782630617826326140-22.85
CAediting_1317658chr19_17826379_-ENSG00000105639.17ENST00000527670hsa-miR-6888-3p17826377178263837mer-m81782637617826396151-15.45
CAediting_1317646chr19_17826211_-ENSG00000105639.17ENST00000527670hsa-miR-6891-3p17826209178262157mer-m81782620817826228146-12.88
CAediting_1317651chr19_17826285_-ENSG00000105639.17ENST00000527670hsa-miR-7160-5p17826283178262897mer-m81782628217826302146-20.4
CAediting_1317658chr19_17826379_-ENSG00000105639.17ENST00000527670hsa-miR-76017826374178263807mer-m81782637317826392144-13.89
CAediting_1317656chr19_17826347_-ENSG00000105639.17ENST00000527670hsa-miR-770317826347178263537mer-m81782634617826368154-20.29
CAediting_1317644chr19_17826201_-ENSG00000105639.17ENST00000527670hsa-miR-7855-5p17826201178262066mer1782620017826219140-18.7
CAediting_1317645chr19_17826204_-ENSG00000105639.17ENST00000527670hsa-miR-7855-5p17826201178262066mer1782620017826219140-18.7

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1399425chr20_1392958_-ENSG00000105639.17ENST00000527670hsa-miR-6869-5p17826359178263646mer1782635817826379155-25.6
CAediting_396018chr5_1062918_-ENSG00000105639.17ENST00000527670hsa-miR-463517826165178261717mer-m81782616417826184154-16.26

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for JAK3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for JAK3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
KIRCCAediting_1317658chr19_17826379_-....0.02981744770332520.20095234838108

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Relation with cancer stages for JAK3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for JAK3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
BRCACAediting_1317658chr19_17826379_-0.008066519667866760.02508922179.96

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RelatedDrugs for JAK3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
JAK3P52333DB08895TofacitinibTyrosine-protein kinase JAK3 SmallMoleculeDrugapproved|investigational
JAK3P52333DB11817BaricitinibTyrosine-protein kinase JAK3 SmallMoleculeDrugapproved|investigational
JAK3P52333DB12010FostamatinibTyrosine-protein kinase JAK3 SmallMoleculeDrugapproved|investigational
JAK3P52333DB15035ZanubrutinibTyrosine-protein kinase JAK3 SmallMoleculeDrugapproved|investigational

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RelatedDiseases for JAK3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
JAK3C1833275Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
JAK3C0085110Severe Combined Immunodeficiency2CTD_human;GENOMICS_ENGLAND
JAK3C0242583Bare Lymphocyte Syndrome2CTD_human
JAK3C0392788Nasal Type Extranodal NK/T-Cell Lymphoma2CTD_human
JAK3C1955906Lymphoma, Extranodal NK-T-Cell2CTD_human
JAK3C2700553Omenn Syndrome2CTD_human;GENOMICS_ENGLAND
JAK3C0025063Mediastinal Neoplasms1CTD_human
JAK3C0079731B-Cell Lymphomas1CTD_human
JAK3C0153504Malignant tumor of mediastinum1CTD_human
JAK3C0349639Juvenile Myelomonocytic Leukemia1CTD_human
JAK3C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
JAK3C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
JAK3C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human