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Editing gene: ITPK1 (CAeditome ID:3705)

Gene summary for ITPK1

Gene summary

Gene information	Gene symbol	ITPK1
	Gene ID	3705
	Gene name	inositol-tetrakisphosphate 1-kinase
	Synonyms	ITRPK1
	Cytomap	14q32.12
	Type of gene	protein-coding
	Description	inositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase
	Modification date	20210518
	UniProtAcc	Q13572
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ITPK1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000100605.15

RNA A-to-I editing events in Cancer.

CAediting_1014149(92938065, -), CAediting_1014150(92943422, -), CAediting_1014151(92965759, -), CAediting_1014152(93011446, -), CAediting_1014153(93022427, -), CAediting_1014154(93045048, -), CAediting_1014155(93064397, -), CAediting_1014156(93064420, -), CAediting_1014157(93072707, -), CAediting_1014158(93072712, -), CAediting_1014159(93080875, -), CAediting_1014160(93080884, -), CAediting_1014161(93087414, -), CAediting_1014162(93087533, -), CAediting_1014163(93097791, -), CAediting_1014164(93101725, -), CAediting_1014165(93102911, -), CAediting_1014166(93104377, -), CAediting_1014167(93104423, -), CAediting_1014168(93105614, -), CAediting_1014169(93105842, -), CAediting_1014170(93105848, -), CAediting_1014171(93105868, -), CAediting_1014172(93107185, -), CAediting_1014173(93111635, -), CAediting_1014174(93112475, -), CAediting_1014175(93112512, -), CAediting_1014176(93112513, -), CAediting_1014177(93112667, -), CAediting_1014178(93112672, -), CAediting_1014179(93115163, -),

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RNA editing positional annotations for ITPK1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000267615.9	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000354313.6	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000553452.4	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000554999.4	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000555553.4	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000556603.5	c.A1G	p.M1V	D	B	N
CAediting_1014179	chr14_93115163_-	nonsynonymous SNV	ENST00000557309.1	c.A1G	p.M1V	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1014149	chr14_92938065_-	UTR3
CAediting_1014150	chr14_92943422_-	intronic
CAediting_1014151	chr14_92965759_-	ncRNA_intronic
CAediting_1014152	chr14_93011446_-	ncRNA_intronic
CAediting_1014153	chr14_93022427_-	ncRNA_intronic
CAediting_1014154	chr14_93045048_-	ncRNA_intronic
CAediting_1014155	chr14_93064397_-	ncRNA_intronic
CAediting_1014156	chr14_93064420_-	ncRNA_intronic
CAediting_1014157	chr14_93072707_-	intronic
CAediting_1014158	chr14_93072712_-	intronic
CAediting_1014159	chr14_93080875_-	intronic
CAediting_1014160	chr14_93080884_-	intronic
CAediting_1014161	chr14_93087414_-	intronic
CAediting_1014162	chr14_93087533_-	intronic
CAediting_1014163	chr14_93097791_-	intronic
CAediting_1014164	chr14_93101725_-	intronic
CAediting_1014165	chr14_93102911_-	intronic
CAediting_1014166	chr14_93104377_-	intronic
CAediting_1014167	chr14_93104423_-	intronic
CAediting_1014168	chr14_93105614_-	intronic
CAediting_1014169	chr14_93105842_-	intronic
CAediting_1014170	chr14_93105848_-	intronic
CAediting_1014171	chr14_93105868_-	intronic
CAediting_1014172	chr14_93107185_-	intronic
CAediting_1014173	chr14_93111635_-	intronic
CAediting_1014174	chr14_93112475_-	intronic
CAediting_1014175	chr14_93112512_-	intronic
CAediting_1014176	chr14_93112513_-	intronic
CAediting_1014177	chr14_93112667_-	intronic
CAediting_1014178	chr14_93112672_-	intronic
CAediting_1014179	chr14_93115163_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1014149	chr14_92938065_-	SINE	Alu	AluSc
CAediting_1014151	chr14_92965759_-	SINE	Alu	AluSp
CAediting_1014153	chr14_93022427_-	SINE	Alu	FLAM_A
CAediting_1014155	chr14_93064397_-	SINE	Alu	AluJr
CAediting_1014156	chr14_93064420_-	SINE	Alu	AluJr
CAediting_1014157	chr14_93072707_-	SINE	Alu	AluJb
CAediting_1014158	chr14_93072712_-	SINE	Alu	AluJb
CAediting_1014159	chr14_93080875_-	SINE	Alu	AluSx1
CAediting_1014160	chr14_93080884_-	SINE	Alu	AluSx1
CAediting_1014161	chr14_93087414_-	SINE	Alu	FAM
CAediting_1014162	chr14_93087533_-	SINE	Alu	FAM
CAediting_1014163	chr14_93097791_-	SINE	Alu	AluSq2
CAediting_1014164	chr14_93101725_-	SINE	Alu	AluSz
CAediting_1014165	chr14_93102911_-	SINE	Alu	AluY
CAediting_1014166	chr14_93104377_-	SINE	Alu	AluSq2
CAediting_1014167	chr14_93104423_-	SINE	Alu	AluSq2
CAediting_1014168	chr14_93105614_-	SINE	Alu	AluSx1
CAediting_1014169	chr14_93105842_-	SINE	Alu	AluSq2
CAediting_1014170	chr14_93105848_-	SINE	Alu	AluSq2
CAediting_1014171	chr14_93105868_-	SINE	Alu	AluSq2
CAediting_1014172	chr14_93107185_-	SINE	Alu	AluSx1
CAediting_1014173	chr14_93111635_-	SINE	Alu	AluSx
CAediting_1014174	chr14_93112475_-	SINE	Alu	AluSc8
CAediting_1014175	chr14_93112512_-	SINE	Alu	AluSc8
CAediting_1014176	chr14_93112513_-	SINE	Alu	AluSc8
CAediting_1014177	chr14_93112667_-	SINE	Alu	AluSc8
CAediting_1014178	chr14_93112672_-	SINE	Alu	AluSc8

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RNA A-to-I editing events in the alternative splicing sites for ITPK1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000100605.15.ITPK1.

Correlation between RNA A-to-I editing and PSI for ENSG00000100605.15.ITPK1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ITPK1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ITPK1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ITPK1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1014149	chr14_92938065_-	ENSG00000100605.15	ENST00000354313	hsa-miR-891b	92938061	92938066	6mer	92938060	92938081	150.00	-18.80
CAediting_1014149	chr14_92938065_-	ENSG00000100605.15	ENST00000267615	hsa-miR-891b	92938061	92938066	6mer	92938060	92938081	150.00	-18.80

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1014149	chr14_92938065_-	ENSG00000100605.15	ENST00000354313	hsa-miR-5571-5p	92938063	92938069	7mer-m8	92938062	92938084	142	-26.87
CAediting_1014149	chr14_92938065_-	ENSG00000100605.15	ENST00000267615	hsa-miR-5571-5p	92938063	92938069	7mer-m8	92938062	92938084	142	-26.87

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000100605.15	ENST00000354313	hsa-miR-605-3p	92938280	92938286	7mer-m8	92938279	92938300	148	-19.27
CAediting_688080	chr9_63819626_+	ENSG00000100605.15	ENST00000354313	hsa-miR-4477b	92937979	92937986	8mer-1a	92937979	92938000	151	-15.19
CAediting_748296	chr10_51299626_+	ENSG00000100605.15	ENST00000267615	hsa-miR-605-3p	92938280	92938286	7mer-m8	92938279	92938300	148	-19.27
CAediting_688080	chr9_63819626_+	ENSG00000100605.15	ENST00000267615	hsa-miR-4477b	92937979	92937986	8mer-1a	92937979	92938000	151	-15.19
CAediting_1229413	chr17_67471544_+	ENSG00000100605.15	ENST00000354313	hsa-miR-548aa	92937080	92937087	8mer-1a	92937080	92937105	146	-19.45
CAediting_1229415	chr17_67471547_+	ENSG00000100605.15	ENST00000354313	hsa-miR-548aa	92937096	92937102	7mer-m8	92937095	92937119	147	-14.38
CAediting_228905	chr2_188297554_+	ENSG00000100605.15	ENST00000354313	hsa-miR-561-3p	92938258	92938264	7mer-m8	92938257	92938279	143	-16.18
CAediting_228905	chr2_188297554_+	ENSG00000100605.15	ENST00000354313	hsa-miR-561-3p	92937952	92937958	7mer-m8	92937951	92937972	140	-11.4
CAediting_1054808	chr15_66496985_-	ENSG00000100605.15	ENST00000267615	hsa-miR-4512	92940155	92940161	7mer-m8	92940154	92940175	152	-21.71
CAediting_1229413	chr17_67471544_+	ENSG00000100605.15	ENST00000267615	hsa-miR-548aa	92937080	92937087	8mer-1a	92937080	92937105	146	-19.45
CAediting_1229415	chr17_67471547_+	ENSG00000100605.15	ENST00000267615	hsa-miR-548aa	92937096	92937102	7mer-m8	92937095	92937119	147	-14.38
CAediting_1229415	chr17_67471547_+	ENSG00000100605.15	ENST00000267615	hsa-miR-548aa	92940670	92940676	7mer-m8	92940669	92940692	141	-12.83
CAediting_1351755	chr19_40282625_-	ENSG00000100605.15	ENST00000267615	hsa-miR-641	92938582	92938588	7mer-1a	92938582	92938604	146	-23.16
CAediting_1368054	chr19_46709310_-	ENSG00000100605.15	ENST00000267615	hsa-miR-320e	92939363	92939369	7mer-m8	92939362	92939379	151	-18.32
CAediting_86358	chr1_109598906_+	ENSG00000100605.15	ENST00000267615	hsa-miR-197-5p	92940721	92940727	7mer-m8	92940720	92940741	149	-20.01
CAediting_228905	chr2_188297554_+	ENSG00000100605.15	ENST00000267615	hsa-miR-561-3p	92938258	92938264	7mer-m8	92938257	92938279	143	-16.18
CAediting_228905	chr2_188297554_+	ENSG00000100605.15	ENST00000267615	hsa-miR-561-3p	92937952	92937958	7mer-m8	92937951	92937972	140	-11.4
CAediting_442554	chr5_154685830_+	ENSG00000100605.15	ENST00000267615	hsa-miR-1303	92939886	92939893	8mer-1a	92939886	92939907	163	-23.91
CAediting_1054808	chr15_66496985_-	ENSG00000100605.15	ENST00000556603	hsa-miR-4512	92940155	92940161	7mer-m8	92940154	92940175	152	-21.71
CAediting_1229415	chr17_67471547_+	ENSG00000100605.15	ENST00000556603	hsa-miR-548aa	92940670	92940676	7mer-m8	92940669	92940692	141	-12.83
CAediting_86358	chr1_109598906_+	ENSG00000100605.15	ENST00000556603	hsa-miR-197-5p	92940721	92940727	7mer-m8	92940720	92940741	149	-20.01
CAediting_442554	chr5_154685830_+	ENSG00000100605.15	ENST00000556603	hsa-miR-1303	92939886	92939893	8mer-1a	92939886	92939907	163	-23.91
CAediting_1054808	chr15_66496985_-	ENSG00000100605.15	ENST00000555495	hsa-miR-4512	92940155	92940161	7mer-m8	92940154	92940175	152	-21.71
CAediting_1229415	chr17_67471547_+	ENSG00000100605.15	ENST00000555495	hsa-miR-548aa	92940670	92940676	7mer-m8	92940669	92940692	141	-12.83
CAediting_86358	chr1_109598906_+	ENSG00000100605.15	ENST00000555495	hsa-miR-197-5p	92940721	92940727	7mer-m8	92940720	92940741	149	-20.01
CAediting_442554	chr5_154685830_+	ENSG00000100605.15	ENST00000555495	hsa-miR-1303	92939886	92939893	8mer-1a	92939886	92939907	163	-23.91
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000267615	hsa-miR-6891-5p	92940524	92940531	8mer-1a	92940524	92940542	146	-25.17
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000267615	hsa-miR-6891-5p	92939210	92939216	7mer-m8	92939209	92939228	143	-19.93
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000556603	hsa-miR-6891-5p	92940524	92940531	8mer-1a	92940524	92940542	146	-25.17
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000555495	hsa-miR-6891-5p	92940524	92940531	8mer-1a	92940524	92940542	146	-25.17

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000354313	hsa-miR-6891-5p	92937917	92937922	6mer	92937910	92937928	140	-19.63
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000354313	hsa-miR-6891-5p	92937911	92937916	6mer	92937910	92937928	140	-19.63
CAediting_573001	chr7_92204086_-	ENSG00000100605.15	ENST00000267615	hsa-miR-1285-5p	92940198	92940204	7mer-m8	92940197	92940217	147	-15.56
CAediting_846604	chr11_93733708_-	ENSG00000100605.15	ENST00000267615	hsa-miR-1304-3p	92940199	92940206	8mer-1a	92940199	92940219	141	-14.56
CAediting_688080	chr9_63819626_+	ENSG00000100605.15	ENST00000267615	hsa-miR-4477b	92939803	92939810	8mer-1a	92939803	92939821	148	-10.9
CAediting_688081	chr9_63819627_+	ENSG00000100605.15	ENST00000267615	hsa-miR-4477b	92939803	92939810	8mer-1a	92939803	92939821	148	-10.9
CAediting_396018	chr5_1062918_-	ENSG00000100605.15	ENST00000267615	hsa-miR-4635	92937457	92937464	8mer-1a	92937457	92937477	150	-11.61
CAediting_396018	chr5_1062918_-	ENSG00000100605.15	ENST00000267615	hsa-miR-4635	92937271	92937277	7mer-m8	92937270	92937290	148	-13.91
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000267615	hsa-miR-6891-5p	92937917	92937922	6mer	92937910	92937928	140	-19.63
CAediting_468389	chr6_31355314_-	ENSG00000100605.15	ENST00000267615	hsa-miR-6891-5p	92937911	92937916	6mer	92937910	92937928	140	-19.63
CAediting_688081	chr9_63819627_+	ENSG00000100605.15	ENST00000556603	hsa-miR-4477b	92939803	92939810	8mer-1a	92939803	92939821	148	-10.9

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ITPK1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ITPK1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ITPK1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ITPK1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ITPK1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ITPK1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ITPK1	C0027626	Neoplasm Invasiveness	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene