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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: IRF3 (CAeditome ID:3661)

Gene summary for IRF3

check button Gene summary
Gene informationGene symbol

IRF3

Gene ID

3661

Gene nameinterferon regulatory factor 3
SynonymsIIAE7
Cytomap

19q13.33

Type of geneprotein-coding
Descriptioninterferon regulatory factor 3
Modification date20210524
UniProtAcc

Q14653

Context- 33188184(IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of beta-catenin)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
IRF3

GO:0000978

Interferon regulatory factor 3

8524823

IRF3

GO:0000981

Interferon regulatory factor 3

8524823

IRF3

GO:0042803

Interferon regulatory factor 3

22394562

IRF3

GO:0043565

Interferon regulatory factor 3

23332764

IRF3

GO:1990837

Interferon regulatory factor 3

28473536

IRF3

GO:0032481

Interferon regulatory factor 3

25636800

IRF3

GO:0035666

Interferon regulatory factor 3

25636800

IRF3

GO:0042981

Interferon regulatory factor 3

25609812

IRF3

GO:0045944

Interferon regulatory factor 3

8524823

IRF3

GO:0045944

Interferon regulatory factor 3

9660935

IRF3

GO:0098586

Interferon regulatory factor 3

25609812

IRF3

GO:0005634

Interferon regulatory factor 3

17079289

IRF3

GO:0005634

Interferon regulatory factor 3

18818105

IRF3

GO:0005737

Interferon regulatory factor 3

17079289

IRF3

GO:0005737

Interferon regulatory factor 3

18818105

IRF3

GO:0005739

Interferon regulatory factor 3

25609812

IRF3

GO:0005829

Interferon regulatory factor 3

0000052


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RNA A-to-I events for IRF3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000126456.14

check button RNA A-to-I editing events in Cancer.
CAediting_1376756(49661645, -), CAediting_1376757(49661647, -), CAediting_1376758(49661717, -), CAediting_1376759(49661718, -), CAediting_1376760(49661728, -), CAediting_1376761(49661754, -), CAediting_1376762(49661780, -), CAediting_1376763(49661784, -), CAediting_1376764(49661797, -), CAediting_1376765(49661808, -), CAediting_1376766(49661813, -), CAediting_1376767(49661821, -), CAediting_1376768(49661846, -), CAediting_1376769(49661852, -), CAediting_1376770(49661870, -), CAediting_1376771(49663763, -), CAediting_1376772(49663778, -), CAediting_1376773(49663982, -), CAediting_1376774(49664705, -),

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RNA editing positional annotations for IRF3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000309877.10c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000377139.6c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000442265.2c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000593337.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000596756.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000597198.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000597636.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000598108.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000599223.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000600453.1c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000600911.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000601291.4c.A134Gp.D45GDBD
CAediting_1376774chr19_49664705_-nonsynonymous SNVENST00000601809.4c.A134Gp.D45GDBD

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1376756chr19_49661645_-ncRNA_intronic
CAediting_1376757chr19_49661647_-ncRNA_intronic
CAediting_1376758chr19_49661717_-ncRNA_intronic
CAediting_1376759chr19_49661718_-ncRNA_intronic
CAediting_1376760chr19_49661728_-ncRNA_intronic
CAediting_1376761chr19_49661754_-ncRNA_intronic
CAediting_1376762chr19_49661780_-ncRNA_intronic
CAediting_1376763chr19_49661784_-ncRNA_intronic
CAediting_1376764chr19_49661797_-ncRNA_intronic
CAediting_1376765chr19_49661808_-ncRNA_intronic
CAediting_1376766chr19_49661813_-ncRNA_intronic
CAediting_1376767chr19_49661821_-ncRNA_intronic
CAediting_1376768chr19_49661846_-ncRNA_intronic
CAediting_1376769chr19_49661852_-ncRNA_intronic
CAediting_1376770chr19_49661870_-ncRNA_intronic
CAediting_1376771chr19_49663763_-ncRNA_exonic
CAediting_1376772chr19_49663778_-ncRNA_exonic
CAediting_1376773chr19_49663982_-ncRNA_intronic
CAediting_1376774chr19_49664705_-exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1376756chr19_49661645_-SINEAluAluSx3
CAediting_1376757chr19_49661647_-SINEAluAluSx3
CAediting_1376758chr19_49661717_-SINEAluAluSx3
CAediting_1376759chr19_49661718_-SINEAluAluSx3
CAediting_1376760chr19_49661728_-SINEAluAluSx3
CAediting_1376761chr19_49661754_-SINEAluAluSx3
CAediting_1376762chr19_49661780_-SINEAluAluSx3
CAediting_1376763chr19_49661784_-SINEAluAluSx3
CAediting_1376764chr19_49661797_-SINEAluAluSx3
CAediting_1376765chr19_49661808_-SINEAluAluSx3
CAediting_1376766chr19_49661813_-SINEAluAluSx3
CAediting_1376767chr19_49661821_-SINEAluAluSx3
CAediting_1376768chr19_49661846_-SINEAluAluSx3
CAediting_1376769chr19_49661852_-SINEAluAluSx3
CAediting_1376770chr19_49661870_-SINEAluAluSx3
CAediting_1376771chr19_49663763_-SINEAluAluSq2
CAediting_1376772chr19_49663778_-SINEAluAluSq2
CAediting_1376773chr19_49663982_-SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for IRF3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1376756chr19_49661645_-49661623:496616453SS0+20iATCGCACCACTGCACTCTAGCCT0.96GTCGCACCACTGCACTCTAGCCT0.68

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000126456.14.IRF3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000126456.14.IRF3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IRF3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for IRF3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for IRF3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1376757chr19_49661647_-ENSG00000126456.14ENST00000597636hsa-miR-426749661647496616537mer-m84966164649661661148.00-20.54
CAediting_1376757chr19_49661647_-ENSG00000126456.14ENST00000597636hsa-miR-797749661645496616517mer-m84966164449661662150.00-18.31
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-317649661793496617997mer-m84966179249661810160.00-25.38
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-3922-3p49661793496617997mer-m84966179249661817156.00-24.26
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-6878-3p49661794496618007mer-m84966179349661813148.00-24.06
CAediting_1376766chr19_49661813_-ENSG00000126456.14ENST00000597636hsa-miR-215-3p49661813496618197mer-m84966181249661834152.00-19.24
CAediting_1376766chr19_49661813_-ENSG00000126456.14ENST00000597636hsa-miR-64949661810496618167mer-m84966180949661832150.00-17.40
CAediting_1376768chr19_49661846_-ENSG00000126456.14ENST00000597636hsa-miR-371a-3p49661841496618477mer-m84966184049661862141.00-18.86
CAediting_1376769chr19_49661852_-ENSG00000126456.14ENST00000597636hsa-miR-140-3p49661850496618567mer-m84966184949661869164.00-25.37
CAediting_1376770chr19_49661870_-ENSG00000126456.14ENST00000597636hsa-miR-1292-3p49661868496618747mer-m84966186749661888148.00-26.23
CAediting_1376758chr19_49661717_-ENSG00000126456.14ENST00000597636hsa-miR-139-5p49661717496617226mer4966171649661737147.00-33.19
CAediting_1376758chr19_49661717_-ENSG00000126456.14ENST00000597636hsa-miR-805249661712496617187mer-1a4966171249661732141.00-25.19
CAediting_1376759chr19_49661718_-ENSG00000126456.14ENST00000597636hsa-miR-513a-5p49661717496617237mer-m84966171649661733160.00-23.52
CAediting_1376759chr19_49661718_-ENSG00000126456.14ENST00000597636hsa-miR-513a-5p49661717496617237mer-m84966171649661733160.00-23.52
CAediting_1376759chr19_49661718_-ENSG00000126456.14ENST00000597636hsa-miR-63849661712496617187mer-1a4966171249661736163.00-37.19
CAediting_1376761chr19_49661754_-ENSG00000126456.14ENST00000597636hsa-miR-3680-3p49661749496617568mer-1a4966174949661769144.00-15.16
CAediting_1376761chr19_49661754_-ENSG00000126456.14ENST00000597636hsa-miR-3680-3p49661749496617568mer-1a4966174949661769144.00-15.16
CAediting_1376762chr19_49661780_-ENSG00000126456.14ENST00000597636hsa-miR-4716-5p49661779496617857mer-m84966177849661799140.00-14.47
CAediting_1376763chr19_49661784_-ENSG00000126456.14ENST00000597636hsa-miR-4728-3p49661780496617878mer-1a4966178049661804151.00-16.71
CAediting_1376763chr19_49661784_-ENSG00000126456.14ENST00000597636hsa-miR-628-5p49661782496617887mer-m84966178149661802140.00-13.66
CAediting_1376763chr19_49661784_-ENSG00000126456.14ENST00000597636hsa-miR-971849661782496617887mer-m84966178149661800169.00-26.61
CAediting_1376765chr19_49661808_-ENSG00000126456.14ENST00000597636hsa-miR-6716-3p49661807496618137mer-m84966180649661828150.00-19.59

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1376758chr19_49661717_-ENSG00000126456.14ENST00000597636hsa-miR-10399-5p49661716496617227mer-m84966171549661736148-12.12
CAediting_1376759chr19_49661718_-ENSG00000126456.14ENST00000597636hsa-miR-10399-5p49661716496617227mer-m84966171549661736148-12.12
CAediting_1376765chr19_49661808_-ENSG00000126456.14ENST00000597636hsa-miR-1211349661807496618137mer-m84966180649661829142-14.3
CAediting_1376760chr19_49661728_-ENSG00000126456.14ENST00000597636hsa-miR-1227-3p49661727496617337mer-m84966172649661745147-23.88
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-3663-5p49661793496617997mer-m84966179249661811148-21.98
CAediting_1376767chr19_49661821_-ENSG00000126456.14ENST00000597636hsa-miR-452-3p49661816496618227mer-m84966181549661836145-13.29
CAediting_1376765chr19_49661808_-ENSG00000126456.14ENST00000597636hsa-miR-453949661807496618137mer-m84966180649661825148-14.75
CAediting_1376760chr19_49661728_-ENSG00000126456.14ENST00000597636hsa-miR-4715-3p49661728496617347mer-m84966172749661749143-20.57
CAediting_1376768chr19_49661846_-ENSG00000126456.14ENST00000597636hsa-miR-4731-5p49661843496618497mer-1a4966184349661863146-24.82
CAediting_1376758chr19_49661717_-ENSG00000126456.14ENST00000597636hsa-miR-5089-5p49661712496617187mer-m84966171149661730146-12.33
CAediting_1376768chr19_49661846_-ENSG00000126456.14ENST00000597636hsa-miR-512-3p49661841496618477mer-m84966184049661861145-17.14
CAediting_1376768chr19_49661846_-ENSG00000126456.14ENST00000597636hsa-miR-512-3p49661841496618477mer-m84966184049661861145-17.14
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-613149661792496617987mer-m84966179149661809140-18.33
CAediting_1376760chr19_49661728_-ENSG00000126456.14ENST00000597636hsa-miR-6767-3p49661724496617307mer-m84966172349661744155-20.84
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-6843-3p49661794496618007mer-m84966179349661812152-19.47
CAediting_1376764chr19_49661797_-ENSG00000126456.14ENST00000597636hsa-miR-6848-3p49661794496618007mer-m84966179349661810142-14.3
CAediting_1376759chr19_49661718_-ENSG00000126456.14ENST00000597636hsa-miR-7151-3p49661717496617248mer-1a4966171749661737140-14.13
CAediting_1376769chr19_49661852_-ENSG00000126456.14ENST00000597636hsa-miR-7151-3p49661852496618587mer-m84966185149661871144-21.1
CAediting_1376769chr19_49661852_-ENSG00000126456.14ENST00000597636hsa-miR-805249661846496618527mer-1a4966184649661864140-24.15

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000126456.14ENST00000597636hsa-miR-605-3p49660779496607857mer-m84966077849660799142-17.49
CAediting_748296chr10_51299626_+ENSG00000126456.14ENST00000596788hsa-miR-605-3p49663427496634348mer-1a4966342749663449150-16.91
CAediting_468389chr6_31355314_-ENSG00000126456.14ENST00000597636hsa-miR-6891-5p49659775496597817mer-m84965977449659792140-16.55

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IRF3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for IRF3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for IRF3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for IRF3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
KIRCCAediting_1376774chr19_49664705_-0.01288319660979630.02513130.00160645

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RelatedDrugs for IRF3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IRF3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
IRF3C4225294ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 72GENOMICS_ENGLAND;UNIPROT