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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ITGA6 (CAeditome ID:3655)

Gene summary for ITGA6

check button Gene summary
Gene informationGene symbol

ITGA6

Gene ID

3655

Gene nameintegrin subunit alpha 6
SynonymsCD49f|ITGA6B|VLA-6
Cytomap

2q31.1

Type of geneprotein-coding
Descriptionintegrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6
Modification date20210531
UniProtAcc

P23229

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ITGA6

GO:0031994

Integrin alpha-6

22351760

ITGA6

GO:0038132

Integrin alpha-6

20682778

ITGA6

GO:0005886

Integrin alpha-6

21310825

ITGA6

GO:0009986

Integrin alpha-6

19933311

ITGA6

GO:0009986

Integrin alpha-6

20563599

ITGA6

GO:0009986

Integrin alpha-6

23154389


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RNA A-to-I events for ITGA6

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000091409.13

check button RNA A-to-I editing events in Cancer.
CAediting_225408(172441485, +), CAediting_225409(172441495, +), CAediting_225410(172441501, +), CAediting_225411(172442157, +), CAediting_225412(172443805, +), CAediting_225413(172443861, +), CAediting_225414(172443874, +), CAediting_225415(172443914, +), CAediting_225416(172443995, +), CAediting_225417(172444036, +), CAediting_225418(172444419, +), CAediting_225419(172444420, +), CAediting_225420(172444991, +), CAediting_225421(172444993, +), CAediting_225422(172445005, +), CAediting_225423(172445059, +), CAediting_225424(172445065, +), CAediting_225425(172445066, +), CAediting_225426(172445070, +), CAediting_225427(172445083, +), CAediting_225428(172445092, +), CAediting_225429(172445107, +), CAediting_225430(172445148, +), CAediting_225431(172445157, +), CAediting_225432(172445218, +), CAediting_225433(172445227, +), CAediting_225434(172445235, +), CAediting_225435(172445240, +), CAediting_225436(172445246, +), CAediting_225437(172445546, +), CAediting_225438(172447298, +), CAediting_225439(172447322, +), CAediting_225440(172447330, +), CAediting_225441(172447331, +), CAediting_225442(172447334, +), CAediting_225443(172447366, +), CAediting_225444(172447370, +), CAediting_225445(172447385, +), CAediting_225446(172447388, +), CAediting_225447(172447439, +), CAediting_225448(172447440, +), CAediting_225449(172447457, +), CAediting_225450(172447473, +), CAediting_225451(172449688, +), CAediting_225452(172449732, +), CAediting_225453(172449757, +), CAediting_225454(172449782, +), CAediting_225455(172449800, +), CAediting_225456(172449801, +), CAediting_225457(172449823, +), CAediting_225458(172449841, +), CAediting_225459(172449842, +), CAediting_225460(172450395, +), CAediting_225461(172450741, +), CAediting_225462(172451232, +), CAediting_225463(172451263, +), CAediting_225464(172451264, +), CAediting_225465(172451371, +), CAediting_225466(172453301, +), CAediting_225467(172453311, +), CAediting_225468(172453312, +), CAediting_225469(172453348, +), CAediting_225470(172453413, +), CAediting_225471(172453427, +), CAediting_225472(172453445, +), CAediting_225473(172453450, +), CAediting_225474(172453510, +), CAediting_225475(172454184, +), CAediting_225476(172454213, +), CAediting_225477(172457030, +), CAediting_225478(172457036, +), CAediting_225479(172457084, +), CAediting_225480(172457092, +), CAediting_225481(172457116, +), CAediting_225482(172457117, +), CAediting_225483(172457118, +), CAediting_225484(172457141, +), CAediting_225485(172457142, +), CAediting_225486(172457143, +), CAediting_225487(172457147, +), CAediting_225488(172457151, +), CAediting_225489(172457173, +), CAediting_225490(172457179, +), CAediting_225491(172457183, +), CAediting_225492(172457187, +), CAediting_225493(172457197, +), CAediting_225494(172457200, +), CAediting_225495(172457215, +), CAediting_225496(172458299, +), CAediting_225497(172459361, +), CAediting_225498(172459384, +), CAediting_225499(172459425, +), CAediting_225500(172459486, +),

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RNA editing positional annotations for ITGA6 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_225408chr2_172441485_+intronic
CAediting_225409chr2_172441495_+intronic
CAediting_225410chr2_172441501_+intronic
CAediting_225411chr2_172442157_+intronic
CAediting_225412chr2_172443805_+intronic
CAediting_225413chr2_172443861_+intronic
CAediting_225414chr2_172443874_+intronic
CAediting_225415chr2_172443914_+intronic
CAediting_225416chr2_172443995_+intronic
CAediting_225417chr2_172444036_+intronic
CAediting_225418chr2_172444419_+intronic
CAediting_225419chr2_172444420_+intronic
CAediting_225420chr2_172444991_+intronic
CAediting_225421chr2_172444993_+intronic
CAediting_225422chr2_172445005_+intronic
CAediting_225423chr2_172445059_+intronic
CAediting_225424chr2_172445065_+intronic
CAediting_225425chr2_172445066_+intronic
CAediting_225426chr2_172445070_+intronic
CAediting_225427chr2_172445083_+intronic
CAediting_225428chr2_172445092_+intronic
CAediting_225429chr2_172445107_+intronic
CAediting_225430chr2_172445148_+intronic
CAediting_225431chr2_172445157_+intronic
CAediting_225432chr2_172445218_+intronic
CAediting_225433chr2_172445227_+intronic
CAediting_225434chr2_172445235_+intronic
CAediting_225435chr2_172445240_+intronic
CAediting_225436chr2_172445246_+intronic
CAediting_225437chr2_172445546_+intronic
CAediting_225438chr2_172447298_+intronic
CAediting_225439chr2_172447322_+intronic
CAediting_225440chr2_172447330_+intronic
CAediting_225441chr2_172447331_+intronic
CAediting_225442chr2_172447334_+intronic
CAediting_225443chr2_172447366_+intronic
CAediting_225444chr2_172447370_+intronic
CAediting_225445chr2_172447385_+intronic
CAediting_225446chr2_172447388_+intronic
CAediting_225447chr2_172447439_+intronic
CAediting_225448chr2_172447440_+intronic
CAediting_225449chr2_172447457_+intronic
CAediting_225450chr2_172447473_+intronic
CAediting_225451chr2_172449688_+intronic
CAediting_225452chr2_172449732_+intronic
CAediting_225453chr2_172449757_+intronic
CAediting_225454chr2_172449782_+intronic
CAediting_225455chr2_172449800_+intronic
CAediting_225456chr2_172449801_+intronic
CAediting_225457chr2_172449823_+intronic
CAediting_225458chr2_172449841_+intronic
CAediting_225459chr2_172449842_+intronic
CAediting_225460chr2_172450395_+intronic
CAediting_225461chr2_172450741_+intronic
CAediting_225462chr2_172451232_+intronic
CAediting_225463chr2_172451263_+intronic
CAediting_225464chr2_172451264_+intronic
CAediting_225465chr2_172451371_+intronic
CAediting_225466chr2_172453301_+intronic
CAediting_225467chr2_172453311_+intronic
CAediting_225468chr2_172453312_+intronic
CAediting_225469chr2_172453348_+intronic
CAediting_225470chr2_172453413_+intronic
CAediting_225471chr2_172453427_+intronic
CAediting_225472chr2_172453445_+intronic
CAediting_225473chr2_172453450_+intronic
CAediting_225474chr2_172453510_+intronic
CAediting_225475chr2_172454184_+intronic
CAediting_225476chr2_172454213_+intronic
CAediting_225477chr2_172457030_+intronic
CAediting_225478chr2_172457036_+intronic
CAediting_225479chr2_172457084_+intronic
CAediting_225480chr2_172457092_+intronic
CAediting_225481chr2_172457116_+intronic
CAediting_225482chr2_172457117_+intronic
CAediting_225483chr2_172457118_+intronic
CAediting_225484chr2_172457141_+intronic
CAediting_225485chr2_172457142_+intronic
CAediting_225486chr2_172457143_+intronic
CAediting_225487chr2_172457147_+intronic
CAediting_225488chr2_172457151_+intronic
CAediting_225489chr2_172457173_+intronic
CAediting_225490chr2_172457179_+intronic
CAediting_225491chr2_172457183_+intronic
CAediting_225492chr2_172457187_+intronic
CAediting_225493chr2_172457197_+intronic
CAediting_225494chr2_172457200_+intronic
CAediting_225495chr2_172457215_+intronic
CAediting_225496chr2_172458299_+intronic
CAediting_225497chr2_172459361_+intronic
CAediting_225498chr2_172459384_+intronic
CAediting_225499chr2_172459425_+intronic
CAediting_225500chr2_172459486_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_225408chr2_172441485_+SINEAluAluJr
CAediting_225409chr2_172441495_+SINEAluAluJr
CAediting_225410chr2_172441501_+SINEAluAluJr
CAediting_225412chr2_172443805_+SINEAluAluJb
CAediting_225413chr2_172443861_+SINEAluAluJb
CAediting_225414chr2_172443874_+SINEAluAluJb
CAediting_225415chr2_172443914_+SINEAluAluJb
CAediting_225416chr2_172443995_+SINEAluAluJb
CAediting_225417chr2_172444036_+SINEAluAluJb
CAediting_225418chr2_172444419_+DNATcMar-TiggerTigger4a
CAediting_225419chr2_172444420_+DNATcMar-TiggerTigger4a
CAediting_225420chr2_172444991_+SINEAluAluSx1
CAediting_225421chr2_172444993_+SINEAluAluSx1
CAediting_225422chr2_172445005_+SINEAluAluSx1
CAediting_225423chr2_172445059_+SINEAluAluSx1
CAediting_225424chr2_172445065_+SINEAluAluSx1
CAediting_225425chr2_172445066_+SINEAluAluSx1
CAediting_225426chr2_172445070_+SINEAluAluSx1
CAediting_225427chr2_172445083_+SINEAluAluSx1
CAediting_225428chr2_172445092_+SINEAluAluSx1
CAediting_225429chr2_172445107_+SINEAluAluSx1
CAediting_225430chr2_172445148_+SINEAluAluSx1
CAediting_225431chr2_172445157_+SINEAluAluSx1
CAediting_225432chr2_172445218_+SINEAluAluSx1
CAediting_225433chr2_172445227_+SINEAluAluSx1
CAediting_225434chr2_172445235_+SINEAluAluSx1
CAediting_225435chr2_172445240_+SINEAluAluSx1
CAediting_225436chr2_172445246_+SINEAluAluSx1
CAediting_225437chr2_172445546_+SINEAluAluY
CAediting_225438chr2_172447298_+SINEAluAluSx1
CAediting_225439chr2_172447322_+SINEAluAluSx1
CAediting_225440chr2_172447330_+SINEAluAluSx1
CAediting_225441chr2_172447331_+SINEAluAluSx1
CAediting_225442chr2_172447334_+SINEAluAluSx1
CAediting_225443chr2_172447366_+SINEAluAluSx1
CAediting_225444chr2_172447370_+SINEAluAluSx1
CAediting_225445chr2_172447385_+SINEAluAluSx1
CAediting_225446chr2_172447388_+SINEAluAluSx1
CAediting_225447chr2_172447439_+SINEAluAluSx1
CAediting_225448chr2_172447440_+SINEAluAluSx1
CAediting_225449chr2_172447457_+SINEAluAluSx1
CAediting_225450chr2_172447473_+SINEAluAluSx1
CAediting_225451chr2_172449688_+SINEAluAluSp
CAediting_225452chr2_172449732_+SINEAluAluSp
CAediting_225453chr2_172449757_+SINEAluAluSp
CAediting_225454chr2_172449782_+SINEAluAluSp
CAediting_225455chr2_172449800_+SINEAluAluSp
CAediting_225456chr2_172449801_+SINEAluAluSp
CAediting_225457chr2_172449823_+SINEAluAluSp
CAediting_225458chr2_172449841_+SINEAluAluSp
CAediting_225459chr2_172449842_+SINEAluAluSp
CAediting_225460chr2_172450395_+LINEL2L2a
CAediting_225461chr2_172450741_+SINEAluAluSx
CAediting_225462chr2_172451232_+SINEAluAluSx1
CAediting_225463chr2_172451263_+SINEAluAluSx1
CAediting_225464chr2_172451264_+SINEAluAluSx1
CAediting_225465chr2_172451371_+SINEAluAluSx1
CAediting_225466chr2_172453301_+SINEAluAluJb
CAediting_225467chr2_172453311_+SINEAluAluJb
CAediting_225468chr2_172453312_+SINEAluAluJb
CAediting_225469chr2_172453348_+SINEAluAluJb
CAediting_225470chr2_172453413_+SINEAluAluJb
CAediting_225471chr2_172453427_+SINEAluAluJb
CAediting_225472chr2_172453445_+SINEAluAluJb
CAediting_225473chr2_172453450_+SINEAluAluJb
CAediting_225474chr2_172453510_+SINEAluAluJb
CAediting_225475chr2_172454184_+SINEAluAluSc8
CAediting_225476chr2_172454213_+SINEAluAluSc8
CAediting_225477chr2_172457030_+SINEAluAluSx1
CAediting_225478chr2_172457036_+SINEAluAluSx1
CAediting_225479chr2_172457084_+SINEAluAluSx1
CAediting_225480chr2_172457092_+SINEAluAluSx1
CAediting_225481chr2_172457116_+SINEAluAluSx1
CAediting_225482chr2_172457117_+SINEAluAluSx1
CAediting_225483chr2_172457118_+SINEAluAluSx1
CAediting_225484chr2_172457141_+SINEAluAluSx1
CAediting_225485chr2_172457142_+SINEAluAluSx1
CAediting_225486chr2_172457143_+SINEAluAluSx1
CAediting_225487chr2_172457147_+SINEAluAluSx1
CAediting_225488chr2_172457151_+SINEAluAluSx1
CAediting_225489chr2_172457173_+SINEAluAluSx1
CAediting_225490chr2_172457179_+SINEAluAluSx1
CAediting_225491chr2_172457183_+SINEAluAluSx1
CAediting_225492chr2_172457187_+SINEAluAluSx1
CAediting_225493chr2_172457197_+SINEAluAluSx1
CAediting_225494chr2_172457200_+SINEAluAluSx1
CAediting_225495chr2_172457215_+SINEAluAluSx1
CAediting_225496chr2_172458299_+SINEAluAluSz6
CAediting_225497chr2_172459361_+SINEAluAluSz6
CAediting_225498chr2_172459384_+SINEAluAluSz6
CAediting_225499chr2_172459425_+SINEAluAluSz6
CAediting_225500chr2_172459486_+SINEAluAluSz6

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RNA A-to-I editing events in the alternative splicing sites for ITGA6

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000091409.13.ITGA6.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000091409.13.ITGA6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ITGA6

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
ESCA.CAediting_225418.ENSG00000091409.ITGA6.png
Soverview
ESCA.CAediting_225419.ENSG00000091409.ITGA6.png
Soverview

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Protein coding region RNA A-to-I editings for ITGA6

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ITGA6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000091409.13ENST00000264107hsa-miR-200b-3p1725062101725062167mer-m8172506194172506217147-14.46
CAediting_688081chr9_63819627_+ENSG00000091409.13ENST00000264107hsa-miR-4477b1725058891725058957mer-m8172505875172505896155-19.82
CAediting_86358chr1_109598906_+ENSG00000091409.13ENST00000264107hsa-miR-197-5p1725051201725051267mer-m8172505103172505127151-26.08

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1399425chr20_1392958_-ENSG00000091409.13ENST00000409532hsa-miR-6869-5p1725042421725042487mer-m8172504228172504249141-16.64
CAediting_846604chr11_93733708_-ENSG00000091409.13ENST00000264107hsa-miR-1304-3p1725054071725054137mer-m8172505391172505414143-13.03
CAediting_1399425chr20_1392958_-ENSG00000091409.13ENST00000264107hsa-miR-6869-5p1725042421725042487mer-m8172504228172504249141-16.64

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ITGA6

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ITGA6

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for ITGA6

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for ITGA6

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for ITGA6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGA6

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
ITGA6C1856934Epidermolysis bullosa with pyloric atresia2CTD_human;GENOMICS_ENGLAND;ORPHANET
ITGA6C0003873Rheumatoid Arthritis1CTD_human