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Editing gene: ZNF404 (CAeditome ID:342908)

Gene summary for ZNF404

Gene summary

Gene information	Gene symbol	ZNF404
	Gene ID	342908
	Gene name	zinc finger protein 404
	Synonyms	-
	Cytomap	19q13.31
	Type of gene	protein-coding
	Description	zinc finger protein 404
	Modification date	20210518
	UniProtAcc	Q494X3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ZNF404

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000176222.8

RNA A-to-I editing events in Cancer.

CAediting_1359503(43873342, -), CAediting_1359504(43873346, -), CAediting_1359505(43881785, -), CAediting_1359506(43881791, -), CAediting_1359507(43895451, -), CAediting_1359508(43895454, -), CAediting_1359509(43896883, -), CAediting_1359510(43896921, -), CAediting_1359511(43896988, -), CAediting_1359512(43897028, -), CAediting_1359513(43897032, -), CAediting_1359514(43897105, -), CAediting_1359515(43897106, -), CAediting_1359516(43898450, -), CAediting_1359517(43898451, -), CAediting_1359518(43898551, -), CAediting_1359519(43898560, -), CAediting_1359520(43898574, -), CAediting_1359521(43899098, -), CAediting_1359522(43899116, -), CAediting_1359523(43899126, -), CAediting_1359524(43899194, -), CAediting_1359525(43899238, -), CAediting_1359526(43899248, -), CAediting_1359527(43899284, -),

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RNA editing positional annotations for ZNF404 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1359504	chr19_43873346_-	nonsynonymous SNV	ENST00000324394.7	c.A865G	p.K289E	D	B	N
CAediting_1359504	chr19_43873346_-	nonsynonymous SNV	ENST00000587539.1	c.A868G	p.K290E	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1359503	chr19_43873342_-	exonic
CAediting_1359504	chr19_43873346_-	exonic
CAediting_1359505	chr19_43881785_-	ncRNA_intronic
CAediting_1359506	chr19_43881791_-	ncRNA_intronic
CAediting_1359507	chr19_43895451_-	ncRNA_intronic
CAediting_1359508	chr19_43895454_-	ncRNA_intronic
CAediting_1359509	chr19_43896883_-	ncRNA_intronic
CAediting_1359510	chr19_43896921_-	ncRNA_intronic
CAediting_1359511	chr19_43896988_-	ncRNA_intronic
CAediting_1359512	chr19_43897028_-	ncRNA_intronic
CAediting_1359513	chr19_43897032_-	ncRNA_intronic
CAediting_1359514	chr19_43897105_-	ncRNA_intronic
CAediting_1359515	chr19_43897106_-	ncRNA_intronic
CAediting_1359516	chr19_43898450_-	ncRNA_intronic
CAediting_1359517	chr19_43898451_-	ncRNA_intronic
CAediting_1359518	chr19_43898551_-	ncRNA_intronic
CAediting_1359519	chr19_43898560_-	ncRNA_intronic
CAediting_1359520	chr19_43898574_-	ncRNA_intronic
CAediting_1359521	chr19_43899098_-	ncRNA_intronic
CAediting_1359522	chr19_43899116_-	ncRNA_intronic
CAediting_1359523	chr19_43899126_-	ncRNA_intronic
CAediting_1359524	chr19_43899194_-	ncRNA_intronic
CAediting_1359525	chr19_43899238_-	ncRNA_intronic
CAediting_1359526	chr19_43899248_-	ncRNA_intronic
CAediting_1359527	chr19_43899284_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1359505	chr19_43881785_-	SINE	Alu	AluSp
CAediting_1359506	chr19_43881791_-	SINE	Alu	AluSp
CAediting_1359507	chr19_43895451_-	LINE	L1	L1M5
CAediting_1359508	chr19_43895454_-	LINE	L1	L1M5
CAediting_1359509	chr19_43896883_-	SINE	Alu	AluJb
CAediting_1359510	chr19_43896921_-	SINE	Alu	AluJb
CAediting_1359511	chr19_43896988_-	SINE	Alu	AluJb
CAediting_1359512	chr19_43897028_-	SINE	Alu	AluJb
CAediting_1359513	chr19_43897032_-	SINE	Alu	AluJb
CAediting_1359514	chr19_43897105_-	SINE	Alu	AluJb
CAediting_1359515	chr19_43897106_-	SINE	Alu	AluJb
CAediting_1359516	chr19_43898450_-	LINE	L1	L1MB8
CAediting_1359517	chr19_43898451_-	LINE	L1	L1MB8
CAediting_1359518	chr19_43898551_-	LINE	L1	L1MB8
CAediting_1359519	chr19_43898560_-	LINE	L1	L1MB8
CAediting_1359520	chr19_43898574_-	LINE	L1	L1MB8
CAediting_1359521	chr19_43899098_-	SINE	Alu	AluSc
CAediting_1359522	chr19_43899116_-	SINE	Alu	AluSc
CAediting_1359523	chr19_43899126_-	SINE	Alu	AluSc
CAediting_1359524	chr19_43899194_-	SINE	Alu	AluSc
CAediting_1359525	chr19_43899238_-	SINE	Alu	AluSc
CAediting_1359526	chr19_43899248_-	SINE	Alu	AluSc
CAediting_1359527	chr19_43899284_-	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for ZNF404

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1359506	chr19_43881791_-	43881790:43881812	3SS	2+0i	GCTAATTTTGTATGTTTTAGTAG	5.12	GCTAATTTTGTATGTTTTAGTGG	6.45
IR	CAediting_1359506	chr19_43881791_-	43881790:43881812	3SS	2+0i	GCTAATTTTGTATGTTTTAGTAG	5.12	GCTAATTTTGTATGTTTTAGTGG	6.45

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000176222.8.ZNF404.

Correlation between RNA A-to-I editing and PSI for ENSG00000176222.8.ZNF404.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF404

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZNF404

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZNF404

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF404

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZNF404

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ZNF404

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ZNF404

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ZNF404

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF404

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ZNF404	C0006142	Malignant neoplasm of breast	1	CTD_human
ZNF404	C0678222	Breast Carcinoma	1	CTD_human
ZNF404	C1257931	Mammary Neoplasms, Human	1	CTD_human
ZNF404	C1458155	Mammary Neoplasms	1	CTD_human
ZNF404	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene