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Editing gene: CFI (CAeditome ID:3426)

Gene summary for CFI

Gene summary

Gene information	Gene symbol	CFI
	Gene ID	3426
	Gene name	complement factor I
	Synonyms	AHUS3\|ARMD13\|C3BINA\|C3b-INA\|FI\|IF\|KAF
	Cytomap	4q25
	Type of gene	protein-coding
	Description	complement factor IC3B/C4B inactivatorC3b-inactivatorKonglutinogen-activating factorcomplement component Icomplement control protein factor Icomplement factor I heavy chainlight chain of factor I
	Modification date	20210518
	UniProtAcc	P05156
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CFI

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000205403.11

RNA A-to-I editing events in Cancer.

CAediting_380220(109745358, -), CAediting_380221(109745362, -), CAediting_380222(109758257, -), CAediting_380223(109761911, -), CAediting_380224(109762005, -), CAediting_380225(109762108, -), CAediting_380226(109762185, -), CAediting_380227(109764137, -), CAediting_380228(109764172, -), CAediting_380229(109792468, -), CAediting_380230(109793692, -), CAediting_380231(109793703, -), CAediting_380232(109800424, -), CAediting_380233(109800442, -), CAediting_380234(109800443, -), CAediting_380235(109800469, -), CAediting_380236(109800492, -),

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RNA editing positional annotations for CFI using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_380220	chr4_109745358_-	ncRNA_intronic
CAediting_380221	chr4_109745362_-	ncRNA_intronic
CAediting_380222	chr4_109758257_-	ncRNA_intronic
CAediting_380223	chr4_109761911_-	ncRNA_exonic
CAediting_380224	chr4_109762005_-	ncRNA_exonic
CAediting_380225	chr4_109762108_-	ncRNA_exonic
CAediting_380226	chr4_109762185_-	ncRNA_exonic
CAediting_380227	chr4_109764137_-	intronic
CAediting_380228	chr4_109764172_-	intronic
CAediting_380229	chr4_109792468_-	intronic
CAediting_380230	chr4_109793692_-	intronic
CAediting_380231	chr4_109793703_-	intronic
CAediting_380232	chr4_109800424_-	intronic
CAediting_380233	chr4_109800442_-	intronic
CAediting_380234	chr4_109800443_-	intronic
CAediting_380235	chr4_109800469_-	intronic
CAediting_380236	chr4_109800492_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_380220	chr4_109745358_-	SINE	Alu	AluJb
CAediting_380221	chr4_109745362_-	SINE	Alu	AluJb
CAediting_380222	chr4_109758257_-	SINE	Alu	Alu
CAediting_380223	chr4_109761911_-	SINE	Alu	AluSx
CAediting_380224	chr4_109762005_-	SINE	Alu	AluSx
CAediting_380225	chr4_109762108_-	SINE	Alu	AluSx
CAediting_380226	chr4_109762185_-	SINE	Alu	AluSx
CAediting_380229	chr4_109792468_-	SINE	Alu	AluSx
CAediting_380230	chr4_109793692_-	SINE	Alu	AluJo
CAediting_380231	chr4_109793703_-	SINE	Alu	AluJo
CAediting_380232	chr4_109800424_-	SINE	Alu	AluJo
CAediting_380233	chr4_109800442_-	SINE	Alu	AluJo
CAediting_380234	chr4_109800443_-	SINE	Alu	AluJo
CAediting_380235	chr4_109800469_-	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for CFI

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000205403.11.CFI.

Correlation between RNA A-to-I editing and PSI for ENSG00000205403.11.CFI.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CFI

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CFI

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CFI

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CFI

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000504853.3	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_380223	ENST00000504853.3	chr4_109761911_-	-652.60	-651.80	-655.30
CAediting_380224	ENST00000504853.3	chr4_109762005_-	-651.80	-651.80	-655.30
CAediting_380225	ENST00000504853.3	chr4_109762108_-	-655.20	-651.80	-655.30
CAediting_380226	ENST00000504853.3	chr4_109762185_-	-651.10	-651.80	-655.30

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Relation with ADAR for CFI

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
KIRP	CAediting_380227	chr4_109764137_-	0.0108402025424099	0.324062552713557	.	.	.	.
OV	CAediting_380227	chr4_109764137_-	0.0386578486657183	0.146713300942225	.	.	.	.

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Relation with cancer stages for CFI

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CFI

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CFI

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CFI	P05156	DB01593	Zinc	Complement factor I	SmallMoleculeDrug	approved\|investigational
CFI	P05156	DB09130	Copper	Complement factor I	SmallMoleculeDrug	approved\|investigational
CFI	P05156	DB14487	Zinc acetate	Complement factor I	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for CFI

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CFI	C2752039	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 3	7	GENOMICS_ENGLAND;UNIPROT
CFI	C3463916	Complement Factor I (C3 inactivator) deficiency	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
CFI	C0242383	Age related macular degeneration	3	CTD_human
CFI	C0162739	HELLP Syndrome	2	ORPHANET
CFI	C3809523	MACULAR DEGENERATION, AGE-RELATED, 13	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
CFI	C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
CFI	C1832174	DOYNE HONEYCOMB RETINAL DYSTROPHY	1	ORPHANET
CFI	C1852020	Malattia Leventinese	1	ORPHANET
CFI	C1852021	Drusen, Radial, Autosomal Dominant	1	ORPHANET
CFI	C4087273	C3 glomerulopathy	1	GENOMICS_ENGLAND
CFI	C4316812	Fibrinogen Deficiency	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene