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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: HSD17B1 (CAeditome ID:3292)

Gene summary for HSD17B1

check button Gene summary
Gene informationGene symbol

HSD17B1

Gene ID

3292

Gene namehydroxysteroid 17-beta dehydrogenase 1
Synonyms17-beta-HSD|20-alpha-HSD|E2DH|EDH17B2|EDHB17|HSD17|SDR28C1
Cytomap

17q21.2

Type of geneprotein-coding
Description17-beta-hydroxysteroid dehydrogenase type 117-beta-HSD 120 alpha-hydroxysteroid dehydrogenaseestradiol 17-beta-dehydrogenase 1placental 17-beta-hydroxysteroid dehydrogenaseshort chain dehydrogenase/reductase family 28C member 1short chain dehydrogen
Modification date20210518
UniProtAcc

P14061

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HSD17B1

GO:0004303

17-beta-hydroxysteroid dehydrogenase type 1

10625652

HSD17B1

GO:0004303

17-beta-hydroxysteroid dehydrogenase type 1

4396689

HSD17B1

GO:0004303

17-beta-hydroxysteroid dehydrogenase type 1

8994190

HSD17B1

GO:0004303

17-beta-hydroxysteroid dehydrogenase type 1

9525918

HSD17B1

GO:0005496

17-beta-hydroxysteroid dehydrogenase type 1

4396689

HSD17B1

GO:0042803

17-beta-hydroxysteroid dehydrogenase type 1

8994190

HSD17B1

GO:0050661

17-beta-hydroxysteroid dehydrogenase type 1

8805577

HSD17B1

GO:1903924

17-beta-hydroxysteroid dehydrogenase type 1

10625652

HSD17B1

GO:0006703

17-beta-hydroxysteroid dehydrogenase type 1

8994190

HSD17B1

GO:0005829

17-beta-hydroxysteroid dehydrogenase type 1

0000052


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RNA A-to-I events for HSD17B1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000108786.9

check button RNA A-to-I editing events in Cancer.
CAediting_1197558(42549358, +), CAediting_1197559(42549370, +), CAediting_1197560(42549383, +), CAediting_1197561(42549398, +), CAediting_1197562(42549409, +), CAediting_1197563(42549417, +), CAediting_1197564(42549419, +), CAediting_1197565(42549420, +), CAediting_1197566(42549445, +), CAediting_1197567(42549449, +), CAediting_1197568(42549477, +), CAediting_1197569(42549495, +), CAediting_1197570(42549524, +), CAediting_1197571(42549589, +), CAediting_1197572(42549595, +), CAediting_1197573(42551015, +), CAediting_1197574(42551042, +), CAediting_1197575(42551185, +), CAediting_1197576(42551193, +), CAediting_1197577(42551242, +), CAediting_1197578(42551256, +), CAediting_1197579(42551270, +), CAediting_1197580(42551271, +), CAediting_1197581(42551273, +), CAediting_1197582(42551277, +), CAediting_1197583(42551280, +), CAediting_1197584(42551281, +), CAediting_1197585(42551292, +), CAediting_1197586(42551296, +), CAediting_1197587(42551298, +), CAediting_1197588(42551303, +), CAediting_1197589(42551304, +), CAediting_1197590(42551306, +), CAediting_1197591(42551307, +), CAediting_1197592(42551310, +), CAediting_1197593(42551337, +), CAediting_1197594(42551342, +), CAediting_1197595(42551378, +), CAediting_1197596(42551398, +), CAediting_1197597(42551406, +), CAediting_1197598(42551408, +), CAediting_1197599(42551419, +), CAediting_1197600(42551437, +), CAediting_1197601(42551446, +), CAediting_1197602(42551448, +), CAediting_1197603(42551491, +), CAediting_1197604(42551519, +), CAediting_1197605(42551530, +), CAediting_1197606(42551559, +), CAediting_1197607(42551583, +), CAediting_1197608(42551623, +), CAediting_1197609(42551666, +), CAediting_1197610(42551681, +), CAediting_1197611(42551711, +), CAediting_1197612(42551719, +), CAediting_1197613(42551745, +), CAediting_1197614(42551785, +), CAediting_1197615(42551788, +), CAediting_1197616(42551886, +), CAediting_1197617(42551887, +), CAediting_1197618(42551912, +), CAediting_1197619(42551920, +), CAediting_1197620(42551951, +), CAediting_1197621(42551953, +), CAediting_1197622(42551976, +), CAediting_1197623(42551977, +), CAediting_1197624(42551995, +), CAediting_1197625(42552011, +), CAediting_1197626(42555097, +), CAediting_1197627(42555123, +), CAediting_1197628(42555126, +), CAediting_1197629(42555137, +), CAediting_1197630(42555153, +), CAediting_1197631(42555170, +),

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RNA editing positional annotations for HSD17B1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1197558chr17_42549358_+ncRNA_intronic
CAediting_1197559chr17_42549370_+ncRNA_intronic
CAediting_1197560chr17_42549383_+ncRNA_intronic
CAediting_1197561chr17_42549398_+ncRNA_intronic
CAediting_1197562chr17_42549409_+ncRNA_intronic
CAediting_1197563chr17_42549417_+ncRNA_intronic
CAediting_1197564chr17_42549419_+ncRNA_intronic
CAediting_1197565chr17_42549420_+ncRNA_intronic
CAediting_1197566chr17_42549445_+ncRNA_intronic
CAediting_1197567chr17_42549449_+ncRNA_intronic
CAediting_1197568chr17_42549477_+ncRNA_intronic
CAediting_1197569chr17_42549495_+ncRNA_intronic
CAediting_1197570chr17_42549524_+ncRNA_intronic
CAediting_1197571chr17_42549589_+ncRNA_intronic
CAediting_1197572chr17_42549595_+ncRNA_intronic
CAediting_1197573chr17_42551015_+ncRNA_intronic
CAediting_1197574chr17_42551042_+ncRNA_intronic
CAediting_1197575chr17_42551185_+ncRNA_intronic
CAediting_1197576chr17_42551193_+ncRNA_intronic
CAediting_1197577chr17_42551242_+ncRNA_intronic
CAediting_1197578chr17_42551256_+ncRNA_intronic
CAediting_1197579chr17_42551270_+ncRNA_intronic
CAediting_1197580chr17_42551271_+ncRNA_intronic
CAediting_1197581chr17_42551273_+ncRNA_intronic
CAediting_1197582chr17_42551277_+ncRNA_intronic
CAediting_1197583chr17_42551280_+ncRNA_intronic
CAediting_1197584chr17_42551281_+ncRNA_intronic
CAediting_1197585chr17_42551292_+ncRNA_intronic
CAediting_1197586chr17_42551296_+ncRNA_intronic
CAediting_1197587chr17_42551298_+ncRNA_intronic
CAediting_1197588chr17_42551303_+ncRNA_intronic
CAediting_1197589chr17_42551304_+ncRNA_intronic
CAediting_1197590chr17_42551306_+ncRNA_intronic
CAediting_1197591chr17_42551307_+ncRNA_intronic
CAediting_1197592chr17_42551310_+ncRNA_intronic
CAediting_1197593chr17_42551337_+ncRNA_intronic
CAediting_1197594chr17_42551342_+ncRNA_intronic
CAediting_1197595chr17_42551378_+ncRNA_intronic
CAediting_1197596chr17_42551398_+ncRNA_intronic
CAediting_1197597chr17_42551406_+ncRNA_intronic
CAediting_1197598chr17_42551408_+ncRNA_intronic
CAediting_1197599chr17_42551419_+ncRNA_intronic
CAediting_1197600chr17_42551437_+ncRNA_intronic
CAediting_1197601chr17_42551446_+ncRNA_intronic
CAediting_1197602chr17_42551448_+ncRNA_intronic
CAediting_1197603chr17_42551491_+ncRNA_intronic
CAediting_1197604chr17_42551519_+ncRNA_intronic
CAediting_1197605chr17_42551530_+ncRNA_intronic
CAediting_1197606chr17_42551559_+ncRNA_intronic
CAediting_1197607chr17_42551583_+ncRNA_intronic
CAediting_1197608chr17_42551623_+ncRNA_intronic
CAediting_1197609chr17_42551666_+ncRNA_intronic
CAediting_1197610chr17_42551681_+ncRNA_intronic
CAediting_1197611chr17_42551711_+ncRNA_intronic
CAediting_1197612chr17_42551719_+ncRNA_intronic
CAediting_1197613chr17_42551745_+ncRNA_intronic
CAediting_1197614chr17_42551785_+ncRNA_intronic
CAediting_1197615chr17_42551788_+ncRNA_intronic
CAediting_1197616chr17_42551886_+ncRNA_intronic
CAediting_1197617chr17_42551887_+ncRNA_intronic
CAediting_1197618chr17_42551912_+ncRNA_intronic
CAediting_1197619chr17_42551920_+ncRNA_intronic
CAediting_1197620chr17_42551951_+ncRNA_intronic
CAediting_1197621chr17_42551953_+ncRNA_intronic
CAediting_1197622chr17_42551976_+ncRNA_intronic
CAediting_1197623chr17_42551977_+ncRNA_intronic
CAediting_1197624chr17_42551995_+ncRNA_intronic
CAediting_1197625chr17_42552011_+ncRNA_intronic
CAediting_1197626chr17_42555097_+ncRNA_intronic
CAediting_1197627chr17_42555123_+ncRNA_intronic
CAediting_1197628chr17_42555126_+ncRNA_intronic
CAediting_1197629chr17_42555137_+ncRNA_intronic
CAediting_1197630chr17_42555153_+ncRNA_intronic
CAediting_1197631chr17_42555170_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1197558chr17_42549358_+SINEAluAluSp
CAediting_1197559chr17_42549370_+SINEAluAluSp
CAediting_1197560chr17_42549383_+SINEAluAluSp
CAediting_1197561chr17_42549398_+SINEAluAluSp
CAediting_1197562chr17_42549409_+SINEAluAluSp
CAediting_1197563chr17_42549417_+SINEAluAluSp
CAediting_1197564chr17_42549419_+SINEAluAluSp
CAediting_1197565chr17_42549420_+SINEAluAluSp
CAediting_1197566chr17_42549445_+SINEAluAluSp
CAediting_1197567chr17_42549449_+SINEAluAluSp
CAediting_1197568chr17_42549477_+SINEAluAluSp
CAediting_1197569chr17_42549495_+SINEAluAluSp
CAediting_1197570chr17_42549524_+SINEAluAluSp
CAediting_1197571chr17_42549589_+SINEAluAluSp
CAediting_1197572chr17_42549595_+SINEAluAluSp
CAediting_1197573chr17_42551015_+LINEL2L2
CAediting_1197574chr17_42551042_+LINEL2L2
CAediting_1197575chr17_42551185_+SINEAluAluSp
CAediting_1197576chr17_42551193_+SINEAluAluSp
CAediting_1197577chr17_42551242_+SINEAluAluSp
CAediting_1197578chr17_42551256_+SINEAluAluSp
CAediting_1197579chr17_42551270_+SINEAluAluSp
CAediting_1197580chr17_42551271_+SINEAluAluSp
CAediting_1197581chr17_42551273_+SINEAluAluSp
CAediting_1197582chr17_42551277_+SINEAluAluSp
CAediting_1197583chr17_42551280_+SINEAluAluSp
CAediting_1197584chr17_42551281_+SINEAluAluSp
CAediting_1197585chr17_42551292_+SINEAluAluSp
CAediting_1197586chr17_42551296_+SINEAluAluSp
CAediting_1197587chr17_42551298_+SINEAluAluSp
CAediting_1197588chr17_42551303_+SINEAluAluSp
CAediting_1197589chr17_42551304_+SINEAluAluSp
CAediting_1197590chr17_42551306_+SINEAluAluSp
CAediting_1197591chr17_42551307_+SINEAluAluSp
CAediting_1197592chr17_42551310_+SINEAluAluSp
CAediting_1197593chr17_42551337_+SINEAluAluSp
CAediting_1197594chr17_42551342_+SINEAluAluSp
CAediting_1197595chr17_42551378_+SINEAluAluSp
CAediting_1197596chr17_42551398_+SINEAluAluSp
CAediting_1197597chr17_42551406_+SINEAluAluSp
CAediting_1197598chr17_42551408_+SINEAluAluSp
CAediting_1197599chr17_42551419_+SINEAluAluSp
CAediting_1197600chr17_42551437_+SINEAluAluSp
CAediting_1197601chr17_42551446_+SINEAluAluSp
CAediting_1197602chr17_42551448_+SINEAluAluSp
CAediting_1197603chr17_42551491_+SINEAluAluSq
CAediting_1197604chr17_42551519_+SINEAluAluSq
CAediting_1197605chr17_42551530_+SINEAluAluSq
CAediting_1197606chr17_42551559_+SINEAluAluSq
CAediting_1197607chr17_42551583_+SINEAluAluSq
CAediting_1197608chr17_42551623_+SINEAluAluSq
CAediting_1197609chr17_42551666_+SINEAluAluSq
CAediting_1197610chr17_42551681_+SINEAluAluSq
CAediting_1197611chr17_42551711_+SINEAluAluSq
CAediting_1197612chr17_42551719_+SINEAluAluSq
CAediting_1197613chr17_42551745_+SINEAluAluSq
CAediting_1197614chr17_42551785_+SINEAluAluJr
CAediting_1197615chr17_42551788_+SINEAluAluJr
CAediting_1197616chr17_42551886_+SINEAluAluJo
CAediting_1197617chr17_42551887_+SINEAluAluJo
CAediting_1197618chr17_42551912_+SINEAluAluJo
CAediting_1197619chr17_42551920_+SINEAluAluJo
CAediting_1197620chr17_42551951_+SINEAluAluJo
CAediting_1197621chr17_42551953_+SINEAluAluJo
CAediting_1197622chr17_42551976_+SINEAluAluJo
CAediting_1197623chr17_42551977_+SINEAluAluJo
CAediting_1197624chr17_42551995_+SINEAluAluJo
CAediting_1197625chr17_42552011_+SINEAluAluJo
CAediting_1197626chr17_42555097_+SINEAluAluJo
CAediting_1197627chr17_42555123_+SINEAluAluJo
CAediting_1197628chr17_42555126_+SINEAluAluJo
CAediting_1197629chr17_42555137_+SINEAluAluJo
CAediting_1197630chr17_42555153_+SINEAluAluJo
CAediting_1197631chr17_42555170_+SINEAluAluJo

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RNA A-to-I editing events in the alternative splicing sites for HSD17B1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000108786.9.HSD17B1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000108786.9.HSD17B1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HSD17B1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
LGG.CAediting_1197559.ENSG00000108786.HSD17B1.png
Soverview

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Protein coding region RNA A-to-I editings for HSD17B1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for HSD17B1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1197628chr17_42555126_+ENSG00000108786.9ENST00000225929hsa-miR-6801-3p42555120425551267mer-m84255510842555127152.00-22.90
CAediting_1197628chr17_42555126_+ENSG00000108786.9ENST00000225929hsa-miR-6810-3p42555120425551267mer-m84255510542555127159.00-29.73
CAediting_1197629chr17_42555137_+ENSG00000108786.9ENST00000225929hsa-miR-286142555134425551407mer-m84255512242555141152.00-27.51
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-317642555150425551567mer-m84255513942555157152.00-27.32
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-3922-3p42555150425551567mer-m84255513542555157149.00-18.07
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-6878-3p42555149425551557mer-m84255513642555156147.00-23.54

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1197626chr17_42555097_+ENSG00000108786.9ENST00000225929hsa-miR-10399-5p42555091425550977mer-m84255507842555098140-11.16
CAediting_1197631chr17_42555170_+ENSG00000108786.9ENST00000225929hsa-miR-1304-3p42555168425551758mer-1a4255515442555175145-17.44
CAediting_1197627chr17_42555123_+ENSG00000108786.9ENST00000225929hsa-miR-197642555120425551267mer-m84255510742555127153-27.68
CAediting_1197628chr17_42555126_+ENSG00000108786.9ENST00000225929hsa-miR-197642555120425551267mer-m84255510742555127153-27.68
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-3663-5p42555150425551567mer-m84255513342555157145-24.93
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-515-5p42555146425551527mer-m84255513042555153140-14.57
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-515-5p42555146425551527mer-m84255513042555153140-14.57
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-519e-5p42555146425551527mer-m84255513242555153140-17.97
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-613142555151425551577mer-m84255514042555158140-18.2
CAediting_1197627chr17_42555123_+ENSG00000108786.9ENST00000225929hsa-miR-660-3p42555121425551288mer-1a4255510842555128145-17.53
CAediting_1197628chr17_42555126_+ENSG00000108786.9ENST00000225929hsa-miR-660-3p42555121425551288mer-1a4255510842555128145-17.53
CAediting_1197627chr17_42555123_+ENSG00000108786.9ENST00000225929hsa-miR-6727-3p42555119425551257mer-1a4255510642555125140-30.57
CAediting_1197627chr17_42555123_+ENSG00000108786.9ENST00000225929hsa-miR-6836-3p42555116425551227mer-m84255510342555123151-25.75
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-6843-3p42555149425551557mer-m84255513642555156155-22.61
CAediting_1197630chr17_42555153_+ENSG00000108786.9ENST00000225929hsa-miR-6848-3p42555149425551557mer-m84255513942555156146-14.56
CAediting_1197631chr17_42555170_+ENSG00000108786.9ENST00000225929hsa-miR-892a42555165425551717mer-m84255515042555172147-20.18

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HSD17B1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for HSD17B1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for HSD17B1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for HSD17B1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for HSD17B1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HSD17B1P14061DB00157NADHEstradiol 17-beta-dehydrogenase 1 SmallMoleculeDrugapproved|nutraceutical

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RelatedDiseases for HSD17B1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
HSD17B1C0000786Spontaneous abortion1CTD_human
HSD17B1C0000822Abortion, Tubal1CTD_human
HSD17B1C0014175Endometriosis1CTD_human
HSD17B1C0033578Prostatic Neoplasms1CTD_human
HSD17B1C0269102Endometrioma1CTD_human
HSD17B1C0376358Malignant neoplasm of prostate1CTD_human
HSD17B1C3830362Early Pregnancy Loss1CTD_human
HSD17B1C4552766Miscarriage1CTD_human