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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: APAF1 (CAeditome ID:317)

Gene summary for APAF1

check button Gene summary
Gene informationGene symbol

APAF1

Gene ID

317

Gene nameapoptotic peptidase activating factor 1
SynonymsAPAF-1|CED4
Cytomap

12q23.1

Type of geneprotein-coding
Descriptionapoptotic protease-activating factor 1
Modification date20210518
UniProtAcc

O14727

Context- 28989589(Aberrant Methylation of APAF-1 Gene in Acute Myeloid Leukemia Patients)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
APAF1

GO:0006919

Apoptotic protease-activating factor 1

21827945

APAF1

GO:0008635

Apoptotic protease-activating factor 1

9267021

APAF1

GO:0032991

Apoptotic protease-activating factor 1

11821383

APAF1

GO:0043293

Apoptotic protease-activating factor 1

21827945


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RNA A-to-I events for APAF1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000120868.12

check button RNA A-to-I editing events in Cancer.
CAediting_916980(98650281, +), CAediting_916981(98650406, +), CAediting_916982(98650407, +), CAediting_916983(98650411, +), CAediting_916984(98651678, +), CAediting_916985(98651684, +), CAediting_916986(98651692, +), CAediting_916987(98651704, +), CAediting_916988(98651715, +), CAediting_916989(98651729, +), CAediting_916990(98651734, +), CAediting_916991(98651739, +), CAediting_916992(98651753, +), CAediting_916993(98651760, +), CAediting_916994(98651786, +), CAediting_916995(98651801, +), CAediting_916996(98651835, +), CAediting_916997(98651836, +), CAediting_916998(98651838, +), CAediting_916999(98651854, +), CAediting_917000(98651876, +), CAediting_917001(98651878, +), CAediting_917002(98651894, +), CAediting_917003(98651895, +), CAediting_917004(98651914, +), CAediting_917005(98651927, +), CAediting_917006(98651956, +), CAediting_917007(98651972, +), CAediting_917008(98651980, +), CAediting_917009(98651981, +), CAediting_917010(98652020, +), CAediting_917011(98652076, +), CAediting_917012(98652077, +), CAediting_917013(98652136, +), CAediting_917014(98652142, +), CAediting_917015(98652162, +), CAediting_917016(98652173, +), CAediting_917017(98652174, +), CAediting_917018(98652175, +), CAediting_917019(98652187, +), CAediting_917020(98652188, +), CAediting_917021(98652214, +), CAediting_917022(98652215, +), CAediting_917023(98652227, +), CAediting_917024(98652645, +), CAediting_917025(98652683, +), CAediting_917026(98652701, +), CAediting_917027(98652704, +), CAediting_917028(98652727, +), CAediting_917029(98652744, +), CAediting_917030(98652753, +), CAediting_917031(98652756, +), CAediting_917032(98652766, +), CAediting_917033(98652809, +), CAediting_917034(98652847, +), CAediting_917035(98652860, +), CAediting_917036(98652886, +), CAediting_917037(98652887, +), CAediting_917038(98653375, +), CAediting_917039(98653401, +), CAediting_917040(98653402, +), CAediting_917041(98653407, +), CAediting_917042(98653418, +), CAediting_917043(98653424, +), CAediting_917044(98653432, +), CAediting_917045(98653437, +), CAediting_917046(98653442, +), CAediting_917047(98653447, +), CAediting_917048(98653450, +), CAediting_917049(98653456, +), CAediting_917050(98653461, +), CAediting_917051(98653470, +), CAediting_917052(98653471, +), CAediting_917053(98653479, +), CAediting_917054(98653480, +), CAediting_917055(98653481, +), CAediting_917056(98653492, +), CAediting_917057(98653495, +), CAediting_917058(98653496, +), CAediting_917059(98653497, +), CAediting_917060(98653498, +), CAediting_917061(98653499, +), CAediting_917062(98653501, +), CAediting_917063(98653503, +), CAediting_917064(98653504, +), CAediting_917065(98653505, +), CAediting_917066(98653506, +), CAediting_917067(98653507, +), CAediting_917068(98653528, +), CAediting_917069(98653536, +), CAediting_917070(98653537, +), CAediting_917071(98653542, +), CAediting_917072(98653546, +), CAediting_917073(98653550, +), CAediting_917074(98653559, +), CAediting_917075(98653565, +), CAediting_917076(98653566, +), CAediting_917077(98653569, +), CAediting_917078(98653577, +), CAediting_917079(98653578, +), CAediting_917080(98653589, +), CAediting_917081(98653591, +), CAediting_917082(98653598, +), CAediting_917083(98653602, +), CAediting_917084(98653606, +), CAediting_917085(98653607, +), CAediting_917086(98653614, +), CAediting_917087(98653639, +), CAediting_917088(98653645, +), CAediting_917089(98659631, +), CAediting_917090(98659632, +), CAediting_917091(98660090, +), CAediting_917092(98661020, +), CAediting_917093(98663752, +), CAediting_917094(98672239, +), CAediting_917095(98672337, +), CAediting_917096(98672400, +), CAediting_917097(98673305, +), CAediting_917098(98673368, +), CAediting_917099(98673377, +), CAediting_917100(98673381, +), CAediting_917101(98673418, +), CAediting_917102(98673419, +), CAediting_917103(98674070, +), CAediting_917104(98687833, +), CAediting_917105(98720975, +),

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RNA editing positional annotations for APAF1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_916980chr12_98650281_+intronic
CAediting_916981chr12_98650406_+intronic
CAediting_916982chr12_98650407_+intronic
CAediting_916983chr12_98650411_+intronic
CAediting_916984chr12_98651678_+intronic
CAediting_916985chr12_98651684_+intronic
CAediting_916986chr12_98651692_+intronic
CAediting_916987chr12_98651704_+intronic
CAediting_916988chr12_98651715_+intronic
CAediting_916989chr12_98651729_+intronic
CAediting_916990chr12_98651734_+intronic
CAediting_916991chr12_98651739_+intronic
CAediting_916992chr12_98651753_+intronic
CAediting_916993chr12_98651760_+intronic
CAediting_916994chr12_98651786_+intronic
CAediting_916995chr12_98651801_+intronic
CAediting_916996chr12_98651835_+intronic
CAediting_916997chr12_98651836_+intronic
CAediting_916998chr12_98651838_+intronic
CAediting_916999chr12_98651854_+intronic
CAediting_917000chr12_98651876_+intronic
CAediting_917001chr12_98651878_+intronic
CAediting_917002chr12_98651894_+intronic
CAediting_917003chr12_98651895_+intronic
CAediting_917004chr12_98651914_+intronic
CAediting_917005chr12_98651927_+intronic
CAediting_917006chr12_98651956_+intronic
CAediting_917007chr12_98651972_+intronic
CAediting_917008chr12_98651980_+intronic
CAediting_917009chr12_98651981_+intronic
CAediting_917010chr12_98652020_+intronic
CAediting_917011chr12_98652076_+intronic
CAediting_917012chr12_98652077_+intronic
CAediting_917013chr12_98652136_+intronic
CAediting_917014chr12_98652142_+intronic
CAediting_917015chr12_98652162_+intronic
CAediting_917016chr12_98652173_+intronic
CAediting_917017chr12_98652174_+intronic
CAediting_917018chr12_98652175_+intronic
CAediting_917019chr12_98652187_+intronic
CAediting_917020chr12_98652188_+intronic
CAediting_917021chr12_98652214_+intronic
CAediting_917022chr12_98652215_+intronic
CAediting_917023chr12_98652227_+intronic
CAediting_917024chr12_98652645_+intronic
CAediting_917025chr12_98652683_+intronic
CAediting_917026chr12_98652701_+intronic
CAediting_917027chr12_98652704_+intronic
CAediting_917028chr12_98652727_+intronic
CAediting_917029chr12_98652744_+intronic
CAediting_917030chr12_98652753_+intronic
CAediting_917031chr12_98652756_+intronic
CAediting_917032chr12_98652766_+intronic
CAediting_917033chr12_98652809_+intronic
CAediting_917034chr12_98652847_+intronic
CAediting_917035chr12_98652860_+intronic
CAediting_917036chr12_98652886_+intronic
CAediting_917037chr12_98652887_+intronic
CAediting_917038chr12_98653375_+intronic
CAediting_917039chr12_98653401_+intronic
CAediting_917040chr12_98653402_+intronic
CAediting_917041chr12_98653407_+intronic
CAediting_917042chr12_98653418_+intronic
CAediting_917043chr12_98653424_+intronic
CAediting_917044chr12_98653432_+intronic
CAediting_917045chr12_98653437_+intronic
CAediting_917046chr12_98653442_+intronic
CAediting_917047chr12_98653447_+intronic
CAediting_917048chr12_98653450_+intronic
CAediting_917049chr12_98653456_+intronic
CAediting_917050chr12_98653461_+intronic
CAediting_917051chr12_98653470_+intronic
CAediting_917052chr12_98653471_+intronic
CAediting_917053chr12_98653479_+intronic
CAediting_917054chr12_98653480_+intronic
CAediting_917055chr12_98653481_+intronic
CAediting_917056chr12_98653492_+intronic
CAediting_917057chr12_98653495_+intronic
CAediting_917058chr12_98653496_+intronic
CAediting_917059chr12_98653497_+intronic
CAediting_917060chr12_98653498_+intronic
CAediting_917061chr12_98653499_+intronic
CAediting_917062chr12_98653501_+intronic
CAediting_917063chr12_98653503_+intronic
CAediting_917064chr12_98653504_+intronic
CAediting_917065chr12_98653505_+intronic
CAediting_917066chr12_98653506_+intronic
CAediting_917067chr12_98653507_+intronic
CAediting_917068chr12_98653528_+intronic
CAediting_917069chr12_98653536_+intronic
CAediting_917070chr12_98653537_+intronic
CAediting_917071chr12_98653542_+intronic
CAediting_917072chr12_98653546_+intronic
CAediting_917073chr12_98653550_+intronic
CAediting_917074chr12_98653559_+intronic
CAediting_917075chr12_98653565_+intronic
CAediting_917076chr12_98653566_+intronic
CAediting_917077chr12_98653569_+intronic
CAediting_917078chr12_98653577_+intronic
CAediting_917079chr12_98653578_+intronic
CAediting_917080chr12_98653589_+intronic
CAediting_917081chr12_98653591_+intronic
CAediting_917082chr12_98653598_+intronic
CAediting_917083chr12_98653602_+intronic
CAediting_917084chr12_98653606_+intronic
CAediting_917085chr12_98653607_+intronic
CAediting_917086chr12_98653614_+intronic
CAediting_917087chr12_98653639_+intronic
CAediting_917088chr12_98653645_+intronic
CAediting_917089chr12_98659631_+intronic
CAediting_917090chr12_98659632_+intronic
CAediting_917091chr12_98660090_+intronic
CAediting_917092chr12_98661020_+intronic
CAediting_917093chr12_98663752_+intronic
CAediting_917094chr12_98672239_+intronic
CAediting_917095chr12_98672337_+intronic
CAediting_917096chr12_98672400_+intronic
CAediting_917097chr12_98673305_+intronic
CAediting_917098chr12_98673368_+intronic
CAediting_917099chr12_98673377_+intronic
CAediting_917100chr12_98673381_+intronic
CAediting_917101chr12_98673418_+intronic
CAediting_917102chr12_98673419_+intronic
CAediting_917103chr12_98674070_+intronic
CAediting_917104chr12_98687833_+intronic
CAediting_917105chr12_98720975_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_916980chr12_98650281_+SINEAluAluSq
CAediting_916981chr12_98650406_+SINEAluAluSq
CAediting_916982chr12_98650407_+SINEAluAluSq
CAediting_916983chr12_98650411_+SINEAluAluSq
CAediting_916984chr12_98651678_+SINEAluAluJo
CAediting_916985chr12_98651684_+SINEAluAluJo
CAediting_916986chr12_98651692_+SINEAluAluJo
CAediting_916987chr12_98651704_+SINEAluAluJo
CAediting_916988chr12_98651715_+SINEAluAluJo
CAediting_916989chr12_98651729_+SINEAluAluJo
CAediting_916990chr12_98651734_+SINEAluAluJo
CAediting_916991chr12_98651739_+SINEAluAluJo
CAediting_916992chr12_98651753_+SINEAluAluJo
CAediting_916993chr12_98651760_+SINEAluAluJo
CAediting_916994chr12_98651786_+SINEAluAluJo
CAediting_916995chr12_98651801_+SINEAluAluJo
CAediting_916996chr12_98651835_+SINEAluAluJb
CAediting_916997chr12_98651836_+SINEAluAluJb
CAediting_916998chr12_98651838_+SINEAluAluJb
CAediting_916999chr12_98651854_+SINEAluAluJb
CAediting_917000chr12_98651876_+SINEAluAluJb
CAediting_917001chr12_98651878_+SINEAluAluJb
CAediting_917002chr12_98651894_+SINEAluAluJb
CAediting_917003chr12_98651895_+SINEAluAluJb
CAediting_917004chr12_98651914_+SINEAluAluJb
CAediting_917005chr12_98651927_+SINEAluAluJb
CAediting_917006chr12_98651956_+SINEAluAluJb
CAediting_917007chr12_98651972_+SINEAluAluJb
CAediting_917008chr12_98651980_+SINEAluAluJb
CAediting_917009chr12_98651981_+SINEAluAluJb
CAediting_917010chr12_98652020_+SINEAluAluJb
CAediting_917011chr12_98652076_+SINEAluAluJb
CAediting_917012chr12_98652077_+SINEAluAluJb
CAediting_917013chr12_98652136_+SINEAluAluJo
CAediting_917014chr12_98652142_+SINEAluAluJo
CAediting_917015chr12_98652162_+SINEAluAluJo
CAediting_917016chr12_98652173_+SINEAluAluJo
CAediting_917017chr12_98652174_+SINEAluAluJo
CAediting_917018chr12_98652175_+SINEAluAluJo
CAediting_917019chr12_98652187_+SINEAluAluJo
CAediting_917020chr12_98652188_+SINEAluAluJo
CAediting_917021chr12_98652214_+SINEAluAluJo
CAediting_917022chr12_98652215_+SINEAluAluJo
CAediting_917023chr12_98652227_+SINEAluAluJo
CAediting_917024chr12_98652645_+SINEAluAluSp
CAediting_917025chr12_98652683_+SINEAluAluSp
CAediting_917026chr12_98652701_+SINEAluAluSp
CAediting_917027chr12_98652704_+SINEAluAluSp
CAediting_917028chr12_98652727_+SINEAluAluSp
CAediting_917029chr12_98652744_+SINEAluAluSp
CAediting_917030chr12_98652753_+SINEAluAluSp
CAediting_917031chr12_98652756_+SINEAluAluSp
CAediting_917032chr12_98652766_+SINEAluAluSp
CAediting_917033chr12_98652809_+SINEAluAluSp
CAediting_917034chr12_98652847_+SINEAluAluSp
CAediting_917035chr12_98652860_+SINEAluAluSp
CAediting_917036chr12_98652886_+SINEAluAluSp
CAediting_917037chr12_98652887_+SINEAluAluSp
CAediting_917039chr12_98653401_+SINEAluAluSz
CAediting_917040chr12_98653402_+SINEAluAluSz
CAediting_917041chr12_98653407_+SINEAluAluSz
CAediting_917042chr12_98653418_+SINEAluAluSz
CAediting_917043chr12_98653424_+SINEAluAluSz
CAediting_917044chr12_98653432_+SINEAluAluSz
CAediting_917045chr12_98653437_+SINEAluAluSz
CAediting_917046chr12_98653442_+SINEAluAluSz
CAediting_917047chr12_98653447_+SINEAluAluSz
CAediting_917048chr12_98653450_+SINEAluAluSz
CAediting_917049chr12_98653456_+SINEAluAluSz
CAediting_917050chr12_98653461_+SINEAluAluSz
CAediting_917051chr12_98653470_+SINEAluAluSz
CAediting_917052chr12_98653471_+SINEAluAluSz
CAediting_917053chr12_98653479_+SINEAluAluSz
CAediting_917054chr12_98653480_+SINEAluAluSz
CAediting_917055chr12_98653481_+SINEAluAluSz
CAediting_917056chr12_98653492_+SINEAluAluSz
CAediting_917057chr12_98653495_+SINEAluAluSz
CAediting_917058chr12_98653496_+SINEAluAluSz
CAediting_917059chr12_98653497_+SINEAluAluSz
CAediting_917060chr12_98653498_+SINEAluAluSz
CAediting_917061chr12_98653499_+SINEAluAluSz
CAediting_917062chr12_98653501_+SINEAluAluSz
CAediting_917063chr12_98653503_+SINEAluAluSz
CAediting_917064chr12_98653504_+SINEAluAluSz
CAediting_917065chr12_98653505_+SINEAluAluSz
CAediting_917066chr12_98653506_+SINEAluAluSz
CAediting_917067chr12_98653507_+SINEAluAluSz
CAediting_917068chr12_98653528_+SINEAluAluSz
CAediting_917069chr12_98653536_+SINEAluAluSz
CAediting_917070chr12_98653537_+SINEAluAluSz
CAediting_917071chr12_98653542_+SINEAluAluSz
CAediting_917072chr12_98653546_+SINEAluAluSz
CAediting_917073chr12_98653550_+SINEAluAluSz
CAediting_917074chr12_98653559_+SINEAluAluSz
CAediting_917075chr12_98653565_+SINEAluAluSz
CAediting_917076chr12_98653566_+SINEAluAluSz
CAediting_917077chr12_98653569_+SINEAluAluSz
CAediting_917078chr12_98653577_+SINEAluAluSz
CAediting_917079chr12_98653578_+SINEAluAluSz
CAediting_917080chr12_98653589_+SINEAluAluSz
CAediting_917081chr12_98653591_+SINEAluAluSz
CAediting_917082chr12_98653598_+SINEAluAluSz
CAediting_917083chr12_98653602_+SINEAluAluSz
CAediting_917084chr12_98653606_+SINEAluAluSz
CAediting_917085chr12_98653607_+SINEAluAluSz
CAediting_917086chr12_98653614_+SINEAluAluSz
CAediting_917087chr12_98653639_+SINEAluAluSz
CAediting_917088chr12_98653645_+SINEAluAluSz
CAediting_917089chr12_98659631_+SINEAluAluSq2
CAediting_917090chr12_98659632_+SINEAluAluSq2
CAediting_917091chr12_98660090_+SINEAluAluJb
CAediting_917092chr12_98661020_+SINEAluAluY
CAediting_917093chr12_98663752_+SINEAluAluSx
CAediting_917094chr12_98672239_+SINEAluAluSx1
CAediting_917095chr12_98672337_+SINEAluAluSx1
CAediting_917096chr12_98672400_+SINEAluAluSx1
CAediting_917097chr12_98673305_+SINEAluAluSq
CAediting_917098chr12_98673368_+SINEAluAluSq
CAediting_917099chr12_98673377_+SINEAluAluSq
CAediting_917100chr12_98673381_+SINEAluAluSq
CAediting_917101chr12_98673418_+SINEAluAluSq
CAediting_917102chr12_98673419_+SINEAluAluSq
CAediting_917103chr12_98674070_+SINEAluAluJb
CAediting_917104chr12_98687833_+SINEAluAluSx1
CAediting_917105chr12_98720975_+SINEAluAluY

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RNA A-to-I editing events in the alternative splicing sites for APAF1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000120868.12.APAF1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000120868.12.APAF1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for APAF1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for APAF1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for APAF1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000120868.12ENST00000333991hsa-miR-624-3p98735071987350777mer-m89873505898735078164-16.39
CAediting_393chr1_1167164_+ENSG00000120868.12ENST00000333991hsa-miR-200b-3p98733078987330847mer-m89873306598733085152-15.02
CAediting_980496chr14_31014685_-ENSG00000120868.12ENST00000357310hsa-miR-624-3p98735071987350777mer-m89873505898735078164-16.39
CAediting_393chr1_1167164_+ENSG00000120868.12ENST00000357310hsa-miR-200b-3p98733078987330847mer-m89873306598733085152-15.02
CAediting_980496chr14_31014685_-ENSG00000120868.12ENST00000359972hsa-miR-624-3p98735071987350777mer-m89873505898735078164-16.39
CAediting_393chr1_1167164_+ENSG00000120868.12ENST00000359972hsa-miR-200b-3p98733078987330847mer-m89873306598733085152-15.02
CAediting_980496chr14_31014685_-ENSG00000120868.12ENST00000550527hsa-miR-624-3p98735071987350777mer-m89873505898735078164-16.39
CAediting_393chr1_1167164_+ENSG00000120868.12ENST00000550527hsa-miR-200b-3p98733078987330847mer-m89873306598733085152-15.02
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000333991hsa-miR-451298733123987331297mer-m89873311098733130151-18.94
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000333991hsa-miR-451298733430987334367mer-m89873341698733437141-17.03
CAediting_1229414chr17_67471546_+ENSG00000120868.12ENST00000333991hsa-miR-548aa98733646987336527mer-m89873362998733653140-10.92
CAediting_1351755chr19_40282625_-ENSG00000120868.12ENST00000333991hsa-miR-64198734782987347887mer-m89873476698734789149-14.77
CAediting_1368054chr19_46709310_-ENSG00000120868.12ENST00000333991hsa-miR-320e98734995987350017mer-m89873498598735002151-22.53
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000333991hsa-miR-561-3p98733654987336596mer9873363798733660151-18.48
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000333991hsa-miR-561-3p98735317987353237mer-m89873530398735324156-8.83
CAediting_396018chr5_1062918_-ENSG00000120868.12ENST00000333991hsa-miR-463598733663987336697mer-m89873365098733670154-18.85
CAediting_442554chr5_154685830_+ENSG00000120868.12ENST00000333991hsa-miR-130398734260987342667mer-m89873424698734267141-12.28
CAediting_604450chr7_133034877_-ENSG00000120868.12ENST00000333991hsa-miR-365498735047987350537mer-m89873503398735054151-22.46
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000357310hsa-miR-451298733123987331297mer-m89873311098733130151-18.94
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000357310hsa-miR-451298733430987334367mer-m89873341698733437141-17.03
CAediting_1229414chr17_67471546_+ENSG00000120868.12ENST00000357310hsa-miR-548aa98733646987336527mer-m89873362998733653140-10.92
CAediting_1351755chr19_40282625_-ENSG00000120868.12ENST00000357310hsa-miR-64198734782987347887mer-m89873476698734789149-14.77
CAediting_1368054chr19_46709310_-ENSG00000120868.12ENST00000357310hsa-miR-320e98734995987350017mer-m89873498598735002151-22.53
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000357310hsa-miR-561-3p98733654987336596mer9873363798733660151-18.48
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000357310hsa-miR-561-3p98735317987353237mer-m89873530398735324156-8.83
CAediting_396018chr5_1062918_-ENSG00000120868.12ENST00000357310hsa-miR-463598733663987336697mer-m89873365098733670154-18.85
CAediting_442554chr5_154685830_+ENSG00000120868.12ENST00000357310hsa-miR-130398734260987342667mer-m89873424698734267141-12.28
CAediting_604450chr7_133034877_-ENSG00000120868.12ENST00000357310hsa-miR-365498735047987350537mer-m89873503398735054151-22.46
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000359972hsa-miR-451298733123987331297mer-m89873311098733130151-18.94
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000359972hsa-miR-451298733430987334367mer-m89873341698733437141-17.03
CAediting_1229414chr17_67471546_+ENSG00000120868.12ENST00000359972hsa-miR-548aa98733646987336527mer-m89873362998733653140-10.92
CAediting_1351755chr19_40282625_-ENSG00000120868.12ENST00000359972hsa-miR-64198734782987347887mer-m89873476698734789149-14.77
CAediting_1368054chr19_46709310_-ENSG00000120868.12ENST00000359972hsa-miR-320e98734995987350017mer-m89873498598735002151-22.53
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000359972hsa-miR-561-3p98733654987336596mer9873363798733660151-18.48
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000359972hsa-miR-561-3p98735317987353237mer-m89873530398735324156-8.83
CAediting_396018chr5_1062918_-ENSG00000120868.12ENST00000359972hsa-miR-463598733663987336697mer-m89873365098733670154-18.85
CAediting_442554chr5_154685830_+ENSG00000120868.12ENST00000359972hsa-miR-130398734260987342667mer-m89873424698734267141-12.28
CAediting_604450chr7_133034877_-ENSG00000120868.12ENST00000359972hsa-miR-365498735047987350537mer-m89873503398735054151-22.46
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000550527hsa-miR-451298733123987331297mer-m89873311098733130151-18.94
CAediting_1054808chr15_66496985_-ENSG00000120868.12ENST00000550527hsa-miR-451298733430987334367mer-m89873341698733437141-17.03
CAediting_1229414chr17_67471546_+ENSG00000120868.12ENST00000550527hsa-miR-548aa98733646987336527mer-m89873362998733653140-10.92
CAediting_1351755chr19_40282625_-ENSG00000120868.12ENST00000550527hsa-miR-64198734782987347887mer-m89873476698734789149-14.77
CAediting_1368054chr19_46709310_-ENSG00000120868.12ENST00000550527hsa-miR-320e98734995987350017mer-m89873498598735002151-22.53
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000550527hsa-miR-561-3p98733654987336596mer9873363798733660151-18.48
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000550527hsa-miR-561-3p98735317987353237mer-m89873530398735324156-8.83
CAediting_396018chr5_1062918_-ENSG00000120868.12ENST00000550527hsa-miR-463598733663987336697mer-m89873365098733670154-18.85
CAediting_442554chr5_154685830_+ENSG00000120868.12ENST00000550527hsa-miR-130398734260987342667mer-m89873424698734267141-12.28
CAediting_604450chr7_133034877_-ENSG00000120868.12ENST00000550527hsa-miR-365498735047987350537mer-m89873503398735054151-22.46
CAediting_1524209chrX_134546392_-ENSG00000120868.12ENST00000333991hsa-miR-503-5p98733216987332227mer-m89873320198733223141-18.53
CAediting_1524209chrX_134546392_-ENSG00000120868.12ENST00000357310hsa-miR-503-5p98733216987332227mer-m89873320198733223141-18.53
CAediting_1524209chrX_134546392_-ENSG00000120868.12ENST00000359972hsa-miR-503-5p98733216987332227mer-m89873320198733223141-18.53
CAediting_1524209chrX_134546392_-ENSG00000120868.12ENST00000550527hsa-miR-503-5p98733216987332227mer-m89873320198733223141-18.53

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000120868.12ENST00000333991hsa-miR-195-3p98733052987330587mer-m89873303898733059140-5.36
CAediting_1306323chr19_13836462_-ENSG00000120868.12ENST00000333991hsa-miR-27a-3p98734716987347227mer-m89873469998734723147-13.66
CAediting_414656chr5_72878640_+ENSG00000120868.12ENST00000333991hsa-miR-4804-3p98732570987325778mer-1a9873255798732577140-9.79
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000333991hsa-miR-561-3p98732590987325956mer9873257598732596143-6.61
CAediting_1160181chr17_7017644_-ENSG00000120868.12ENST00000357310hsa-miR-195-3p98733052987330587mer-m89873303898733059140-5.36
CAediting_1306323chr19_13836462_-ENSG00000120868.12ENST00000357310hsa-miR-27a-3p98734716987347227mer-m89873469998734723147-13.66
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000357310hsa-miR-561-3p98732590987325956mer9873257598732596143-6.61
CAediting_1160181chr17_7017644_-ENSG00000120868.12ENST00000359972hsa-miR-195-3p98733052987330587mer-m89873303898733059140-5.36
CAediting_1306323chr19_13836462_-ENSG00000120868.12ENST00000359972hsa-miR-27a-3p98734716987347227mer-m89873469998734723147-13.66
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000359972hsa-miR-561-3p98732590987325956mer9873257598732596143-6.61
CAediting_1160181chr17_7017644_-ENSG00000120868.12ENST00000550527hsa-miR-195-3p98733052987330587mer-m89873303898733059140-5.36
CAediting_1306323chr19_13836462_-ENSG00000120868.12ENST00000550527hsa-miR-27a-3p98734716987347227mer-m89873469998734723147-13.66
CAediting_228905chr2_188297554_+ENSG00000120868.12ENST00000550527hsa-miR-561-3p98732590987325956mer9873257598732596143-6.61

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for APAF1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for APAF1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for APAF1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for APAF1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for APAF1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APAF1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
APAF1C0041696Unipolar Depression2PSYGENET
APAF1C0376634Craniofacial Abnormalities2CTD_human
APAF1C1269683Major Depressive Disorder2PSYGENET
APAF1C0007134Renal Cell Carcinoma1CTD_human
APAF1C0007138Carcinoma, Transitional Cell1CTD_human
APAF1C0015393Eye Abnormalities1CTD_human
APAF1C0023893Liver Cirrhosis, Experimental1CTD_human
APAF1C0035305Retinal Detachment1CTD_human
APAF1C0037268Skin Abnormalities1CTD_human
APAF1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
APAF1C0339546Retinal Pigment Epithelial Detachment1CTD_human
APAF1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
APAF1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
APAF1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
APAF1C1306837Papillary Renal Cell Carcinoma1CTD_human