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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: HLA-DOA (CAeditome ID:3111)

Gene summary for HLA-DOA

check button Gene summary
Gene informationGene symbol

HLA-DOA

Gene ID

3111

Gene namemajor histocompatibility complex, class II, DO alpha
SynonymsHLA-DNA|HLA-DZA|HLADZ
Cytomap

6p21.32

Type of geneprotein-coding
DescriptionHLA class II histocompatibility antigen, DO alpha chainHLA-D0-alphaMHC DN-alphaMHC DZ alphaMHC class II antigen DOAlymphocyte antigenmajor histocompatibility complex, class II, DN alpha
Modification date20210518
UniProtAcc

P06340

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HLA-DOA

GO:0023026

HLA class II histocompatibility antigen, DO alpha chain

22733780

HLA-DOA

GO:0002587

HLA class II histocompatibility antigen, DO alpha chain

22733780

HLA-DOA

GO:0042613

HLA class II histocompatibility antigen, DO alpha chain

22733780


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RNA A-to-I events for HLA-DOA

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000204252.11
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_469436(33005238, -), CAediting_469437(33005242, -), CAediting_469438(33005250, -), CAediting_469439(33005251, -), CAediting_469440(33005300, -), CAediting_469441(33005309, -), CAediting_469442(33005326, -), CAediting_469443(33005343, -), CAediting_469444(33005344, -), CAediting_469445(33005354, -), CAediting_469446(33005370, -), CAediting_469447(33005380, -), CAediting_469448(33005392, -), CAediting_469449(33005409, -), CAediting_469450(33005410, -), CAediting_469451(33005429, -), CAediting_469452(33005435, -), CAediting_469453(33005448, -), CAediting_469454(33005453, -), CAediting_469455(33005459, -), CAediting_469456(33005613, -), CAediting_469457(33005630, -), CAediting_469458(33005645, -), CAediting_469459(33005650, -), CAediting_469460(33005661, -), CAediting_469461(33005670, -), CAediting_469462(33005675, -), CAediting_469463(33005693, -), CAediting_469464(33005699, -), CAediting_469465(33005706, -), CAediting_469466(33005710, -), CAediting_469467(33005716, -), CAediting_469468(33005738, -), CAediting_469469(33005741, -), CAediting_469470(33005742, -), CAediting_469471(33005769, -), CAediting_469472(33005778, -), CAediting_469473(33005780, -), CAediting_469474(33005784, -), CAediting_469475(33005797, -), CAediting_469476(33005798, -), CAediting_469477(33005805, -), CAediting_469478(33005807, -), CAediting_469479(33005808, -), CAediting_469480(33005813, -), CAediting_469481(33005832, -), CAediting_469482(33005845, -), CAediting_469483(33005853, -), CAediting_469484(33005854, -), CAediting_469485(33005862, -), CAediting_469486(33005870, -), CAediting_469487(33005887, -),

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RNA editing positional annotations for HLA-DOA using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_469436chr6_33005238_-UTR3
CAediting_469437chr6_33005242_-UTR3
CAediting_469438chr6_33005250_-UTR3
CAediting_469439chr6_33005251_-UTR3
CAediting_469440chr6_33005300_-UTR3
CAediting_469441chr6_33005309_-UTR3
CAediting_469442chr6_33005326_-UTR3
CAediting_469443chr6_33005343_-UTR3
CAediting_469444chr6_33005344_-UTR3
CAediting_469445chr6_33005354_-UTR3
CAediting_469446chr6_33005370_-UTR3
CAediting_469447chr6_33005380_-UTR3
CAediting_469448chr6_33005392_-UTR3
CAediting_469449chr6_33005409_-UTR3
CAediting_469450chr6_33005410_-UTR3
CAediting_469451chr6_33005429_-UTR3
CAediting_469452chr6_33005435_-UTR3
CAediting_469453chr6_33005448_-UTR3
CAediting_469454chr6_33005453_-UTR3
CAediting_469455chr6_33005459_-UTR3
CAediting_469456chr6_33005613_-UTR3
CAediting_469457chr6_33005630_-UTR3
CAediting_469458chr6_33005645_-UTR3
CAediting_469459chr6_33005650_-UTR3
CAediting_469460chr6_33005661_-UTR3
CAediting_469461chr6_33005670_-UTR3
CAediting_469462chr6_33005675_-UTR3
CAediting_469463chr6_33005693_-UTR3
CAediting_469464chr6_33005699_-UTR3
CAediting_469465chr6_33005706_-UTR3
CAediting_469466chr6_33005710_-UTR3
CAediting_469467chr6_33005716_-UTR3
CAediting_469468chr6_33005738_-UTR3
CAediting_469469chr6_33005741_-UTR3
CAediting_469470chr6_33005742_-UTR3
CAediting_469471chr6_33005769_-UTR3
CAediting_469472chr6_33005778_-UTR3
CAediting_469473chr6_33005780_-UTR3
CAediting_469474chr6_33005784_-UTR3
CAediting_469475chr6_33005797_-UTR3
CAediting_469476chr6_33005798_-UTR3
CAediting_469477chr6_33005805_-UTR3
CAediting_469478chr6_33005807_-UTR3
CAediting_469479chr6_33005808_-UTR3
CAediting_469480chr6_33005813_-UTR3
CAediting_469481chr6_33005832_-UTR3
CAediting_469482chr6_33005845_-UTR3
CAediting_469483chr6_33005853_-UTR3
CAediting_469484chr6_33005854_-UTR3
CAediting_469485chr6_33005862_-UTR3
CAediting_469486chr6_33005870_-UTR3
CAediting_469487chr6_33005887_-UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_469436chr6_33005238_-SINEAluAluSc
CAediting_469437chr6_33005242_-SINEAluAluSc
CAediting_469438chr6_33005250_-SINEAluAluSc
CAediting_469439chr6_33005251_-SINEAluAluSc
CAediting_469440chr6_33005300_-SINEAluAluSc
CAediting_469441chr6_33005309_-SINEAluAluSc
CAediting_469442chr6_33005326_-SINEAluAluSc
CAediting_469443chr6_33005343_-SINEAluAluSc
CAediting_469444chr6_33005344_-SINEAluAluSc
CAediting_469445chr6_33005354_-SINEAluAluSc
CAediting_469446chr6_33005370_-SINEAluAluSc
CAediting_469447chr6_33005380_-SINEAluAluSc
CAediting_469448chr6_33005392_-SINEAluAluSc
CAediting_469449chr6_33005409_-SINEAluAluSc
CAediting_469450chr6_33005410_-SINEAluAluSc
CAediting_469451chr6_33005429_-SINEAluAluSc
CAediting_469452chr6_33005435_-SINEAluAluSc
CAediting_469453chr6_33005448_-SINEAluAluSc
CAediting_469454chr6_33005453_-SINEAluAluSc
CAediting_469455chr6_33005459_-SINEAluAluSc
CAediting_469456chr6_33005613_-SINEAluAluJr
CAediting_469457chr6_33005630_-SINEAluAluJr
CAediting_469458chr6_33005645_-SINEAluAluJr
CAediting_469459chr6_33005650_-SINEAluAluJr
CAediting_469460chr6_33005661_-SINEAluAluJr
CAediting_469461chr6_33005670_-SINEAluAluJr
CAediting_469462chr6_33005675_-SINEAluAluJr
CAediting_469463chr6_33005693_-SINEAluAluJr
CAediting_469464chr6_33005699_-SINEAluAluJr
CAediting_469465chr6_33005706_-SINEAluAluJr
CAediting_469466chr6_33005710_-SINEAluAluJr
CAediting_469467chr6_33005716_-SINEAluAluJr
CAediting_469468chr6_33005738_-SINEAluAluJr
CAediting_469469chr6_33005741_-SINEAluAluJr
CAediting_469470chr6_33005742_-SINEAluAluJr
CAediting_469471chr6_33005769_-SINEAluAluJr
CAediting_469472chr6_33005778_-SINEAluAluJr
CAediting_469473chr6_33005780_-SINEAluAluJr
CAediting_469474chr6_33005784_-SINEAluAluJr
CAediting_469475chr6_33005797_-SINEAluAluJr
CAediting_469476chr6_33005798_-SINEAluAluJr
CAediting_469477chr6_33005805_-SINEAluAluJr
CAediting_469478chr6_33005807_-SINEAluAluJr
CAediting_469479chr6_33005808_-SINEAluAluJr
CAediting_469480chr6_33005813_-SINEAluAluJr
CAediting_469481chr6_33005832_-SINEAluAluJr
CAediting_469482chr6_33005845_-SINEAluAluJr
CAediting_469483chr6_33005853_-SINEAluAluJr
CAediting_469484chr6_33005854_-SINEAluAluJr
CAediting_469485chr6_33005862_-SINEAluAluJr
CAediting_469486chr6_33005870_-SINEAluAluJr
CAediting_469487chr6_33005887_-DNAhAT-CharlieMER5B

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RNA A-to-I editing events in the alternative splicing sites for HLA-DOA

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_469436chr6_33005238_-33005232:330052543SS0+4iCCAAAGTACTGGAATTACAGGCA-2.1CCAAAGTACTGGAATTGCAGGCA-1.11
IRCAediting_469437chr6_33005242_-33005232:330052543SS0+8iCCAAAGTACTGGAATTACAGGCA-2.1CCAAAGTACTGGGATTACAGGCA-2.54
IRCAediting_469438chr6_33005250_-33005232:330052543SS0+16iCCAAAGTACTGGAATTACAGGCA-2.1CCAAGGTACTGGAATTACAGGCA-1.44
IRCAediting_469439chr6_33005251_-33005232:330052543SS0+17iCCAAAGTACTGGAATTACAGGCA-2.1CCAGAGTACTGGAATTACAGGCA-2.72
IRCAediting_469487chr6_33005887_-33005879:330058875SS3+0iAGGCATTGG-16.4GGGCATTGG-19.03

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000204252.11.HLA-DOA.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000204252.11.HLA-DOA.
boxplot

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HLA-DOA

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
COAD.CAediting_469470.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469436.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469438.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469447.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469458.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469473.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469475.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469476.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469483.ENSG00000204252.HLA-DOA.png
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KIRC.CAediting_469484.ENSG00000204252.HLA-DOA.png
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KIRP.CAediting_469447.ENSG00000204252.HLA-DOA.png
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LGG.CAediting_469447.ENSG00000204252.HLA-DOA.png
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LUAD.CAediting_469439.ENSG00000204252.HLA-DOA.png
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LUAD.CAediting_469464.ENSG00000204252.HLA-DOA.png
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TGCT.CAediting_469447.ENSG00000204252.HLA-DOA.png
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THCA.CAediting_469447.ENSG00000204252.HLA-DOA.png
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THCA.CAediting_469473.ENSG00000204252.HLA-DOA.png
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THYM.CAediting_469438.ENSG00000204252.HLA-DOA.png
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THYM.CAediting_469447.ENSG00000204252.HLA-DOA.png
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THYM.CAediting_469484.ENSG00000204252.HLA-DOA.png
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Protein coding region RNA A-to-I editings for HLA-DOA

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for HLA-DOA

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network
boxplot

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The effects of the RNA editing to the stability of the RNA structures for HLA-DOA

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000229829.6protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_469436ENST00000229829.6chr6_33005238_--1379.00-1379.00-1415.90
CAediting_469437ENST00000229829.6chr6_33005242_--1385.90-1379.00-1415.90
CAediting_469438ENST00000229829.6chr6_33005250_--1378.70-1379.00-1415.90
CAediting_469439ENST00000229829.6chr6_33005251_--1379.10-1379.00-1415.90
CAediting_469440ENST00000229829.6chr6_33005300_--1378.20-1379.00-1415.90
CAediting_469441ENST00000229829.6chr6_33005309_--1378.60-1379.00-1415.90
CAediting_469442ENST00000229829.6chr6_33005326_--1378.70-1379.00-1415.90
CAediting_469443ENST00000229829.6chr6_33005343_--1379.00-1379.00-1415.90
CAediting_469444ENST00000229829.6chr6_33005344_--1379.10-1379.00-1415.90
CAediting_469445ENST00000229829.6chr6_33005354_--1378.20-1379.00-1415.90
CAediting_469446ENST00000229829.6chr6_33005370_--1379.00-1379.00-1415.90
CAediting_469447ENST00000229829.6chr6_33005380_--1385.60-1379.00-1415.90
CAediting_469448ENST00000229829.6chr6_33005392_--1378.30-1379.00-1415.90
CAediting_469449ENST00000229829.6chr6_33005409_--1378.70-1379.00-1415.90
CAediting_469450ENST00000229829.6chr6_33005410_--1378.70-1379.00-1415.90
CAediting_469451ENST00000229829.6chr6_33005429_--1385.70-1379.00-1415.90
CAediting_469452ENST00000229829.6chr6_33005435_--1378.60-1379.00-1415.90
CAediting_469453ENST00000229829.6chr6_33005448_--1384.40-1379.00-1415.90
CAediting_469454ENST00000229829.6chr6_33005453_--1382.50-1379.00-1415.90
CAediting_469455ENST00000229829.6chr6_33005459_--1378.10-1379.00-1415.90
CAediting_469456ENST00000229829.6chr6_33005613_--1378.30-1379.00-1415.90
CAediting_469457ENST00000229829.6chr6_33005630_--1378.60-1379.00-1415.90
CAediting_469458ENST00000229829.6chr6_33005645_--1378.60-1379.00-1415.90
CAediting_469459ENST00000229829.6chr6_33005650_--1378.10-1379.00-1415.90
CAediting_469460ENST00000229829.6chr6_33005661_--1379.00-1379.00-1415.90
CAediting_469461ENST00000229829.6chr6_33005670_--1378.30-1379.00-1415.90
CAediting_469462ENST00000229829.6chr6_33005675_--1378.00-1379.00-1415.90
CAediting_469463ENST00000229829.6chr6_33005693_--1378.10-1379.00-1415.90
CAediting_469464ENST00000229829.6chr6_33005699_--1378.10-1379.00-1415.90
CAediting_469465ENST00000229829.6chr6_33005706_--1379.30-1379.00-1415.90
CAediting_469466ENST00000229829.6chr6_33005710_--1378.30-1379.00-1415.90
CAediting_469467ENST00000229829.6chr6_33005716_--1378.70-1379.00-1415.90
CAediting_469468ENST00000229829.6chr6_33005738_--1381.90-1379.00-1415.90
CAediting_469469ENST00000229829.6chr6_33005741_--1385.70-1379.00-1415.90
CAediting_469470ENST00000229829.6chr6_33005742_--1378.70-1379.00-1415.90
CAediting_469471ENST00000229829.6chr6_33005769_--1384.80-1379.00-1415.90
CAediting_469472ENST00000229829.6chr6_33005778_--1378.10-1379.00-1415.90
CAediting_469473ENST00000229829.6chr6_33005780_--1383.00-1379.00-1415.90
CAediting_469474ENST00000229829.6chr6_33005784_--1379.40-1379.00-1415.90
CAediting_469475ENST00000229829.6chr6_33005797_--1382.90-1379.00-1415.90
CAediting_469476ENST00000229829.6chr6_33005798_--1382.30-1379.00-1415.90
CAediting_469477ENST00000229829.6chr6_33005805_--1378.10-1379.00-1415.90
CAediting_469478ENST00000229829.6chr6_33005807_--1378.70-1379.00-1415.90
CAediting_469479ENST00000229829.6chr6_33005808_--1378.70-1379.00-1415.90
CAediting_469480ENST00000229829.6chr6_33005813_--1378.10-1379.00-1415.90
CAediting_469481ENST00000229829.6chr6_33005832_--1379.40-1379.00-1415.90
CAediting_469482ENST00000229829.6chr6_33005845_--1379.30-1379.00-1415.90
CAediting_469483ENST00000229829.6chr6_33005853_--1379.00-1379.00-1415.90
CAediting_469484ENST00000229829.6chr6_33005854_--1379.10-1379.00-1415.90
CAediting_469485ENST00000229829.6chr6_33005862_--1379.30-1379.00-1415.90
CAediting_469486ENST00000229829.6chr6_33005870_--1378.30-1379.00-1415.90
CAediting_469487ENST00000229829.6chr6_33005887_--1378.30-1379.00-1415.90

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Relation with ADAR for HLA-DOA

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_469436chr6_33005238_-5.7319066504084e-060.33903705332006....
BRCACAediting_469436chr6_33005238_-3.60542618127001e-120.24412515927591....
CESCCAediting_469436chr6_33005238_-0.001836591517462430.271764321775903....
LUADCAediting_469436chr6_33005238_-0.01096926371388390.141370507940886....
GBMCAediting_469436chr6_33005238_-5.74719497741885e-050.37223994881808....
KIRCCAediting_469436chr6_33005238_-2.04675507796568e-070.241660540258652....
UCECCAediting_469436chr6_33005238_-..0.006382808174053580.2255276812757360.005805075764859940.228035957904003
KIRPCAediting_469436chr6_33005238_-0.002082441625590680.29307895476253....
OVCAediting_469436chr6_33005238_-6.04057450175579e-060.277506894941438....
PAADCAediting_469436chr6_33005238_-0.04275223020167840.2128968370597....
PCPGCAediting_469436chr6_33005238_-0.01952136219458260.300809859897398....
SKCMCAediting_469436chr6_33005238_-0.00103205566032860.203157696062129....
MESOCAediting_469436chr6_33005238_-0.0125877427512050.347069600229464..0.01314107458059860.345073954600568
LGGCAediting_469438chr6_33005250_-4.2806732135756e-120.403877370875002....
BRCACAediting_469438chr6_33005250_-3.6489741277725e-170.271246788751275....
CESCCAediting_469438chr6_33005250_-7.65536048580582e-060.3215078520957....
LUADCAediting_469438chr6_33005250_-8.5394044659625e-080.246501609261171....
LUSCCAediting_469438chr6_33005250_-0.005427630603246780.139307186879903....
GBMCAediting_469438chr6_33005250_-7.76114476745255e-080.426846860262129....
HNSCCAediting_469438chr6_33005250_-0.0008568689031069350.191805423756211....
STADCAediting_469438chr6_33005250_-0.01365581880633850.159339558374018....
THCACAediting_469438chr6_33005250_-0.02076514530954740.123385763230423....
KIRCCAediting_469438chr6_33005250_-5.83026610550186e-110.286805740425404....
UCECCAediting_469438chr6_33005250_-0.00146059994548710.215240150334874....
KIRPCAediting_469438chr6_33005250_-0.001945798274148390.216220741268679....
ESCACAediting_469438chr6_33005250_-0.04413651920488730.215121082578889....
OVCAediting_469438chr6_33005250_-8.01172397179693e-070.281271500226982....
PAADCAediting_469438chr6_33005250_-0.01112129419034860.208166988043945....
SKCMCAediting_469438chr6_33005250_-4.12403344624421e-070.274793954888473....
SARCCAediting_469438chr6_33005250_-0.0001104507495848770.287319343353571....
TGCTCAediting_469438chr6_33005250_-0.001607196660527530.278235863448715....
THYMCAediting_469438chr6_33005250_-0.002171054583524590.35095449624766....
LGGCAediting_469440chr6_33005300_-0.001178321426148740.269561891272328....
BRCACAediting_469440chr6_33005300_-0.0001268827208986760.142247643472383....
CESCCAediting_469440chr6_33005300_-1.14552297899668e-050.381344280036295....
LUADCAediting_469440chr6_33005300_-1.67375751783083e-070.297462984240956....
STADCAediting_469440chr6_33005300_-0.02320424745423030.181695586624569....
KIRCCAediting_469440chr6_33005300_-0.03777206759733560.101524652243846....
KIRPCAediting_469440chr6_33005300_-0.001524015561128790.311427114025598....
OVCAediting_469440chr6_33005300_-0.01229833600274670.166289129844825....
BRCACAediting_469441chr6_33005309_-0.0005179822611250430.149720327076236....
KIRCCAediting_469441chr6_33005309_-0.004735645614509850.169550950728065....
OVCAediting_469441chr6_33005309_-0.01632115341932930.178809309730638....
LUADCAediting_469445chr6_33005354_-0.01082732678949080.285260685181855....
BLCACAediting_469447chr6_33005380_-0.004990396016977220.2368819645757....
LGGCAediting_469447chr6_33005380_-0.008341940077374940.183346719592025....
BRCACAediting_469447chr6_33005380_-0.0003998325279111530.136893591157132....
CESCCAediting_469447chr6_33005380_-0.003460696979436580.257577282538092....
LUADCAediting_469447chr6_33005380_-0.009642132764126460.130757486140833....
SKCMCAediting_469447chr6_33005380_-0.001921292081503010.191525085572961....
THYMCAediting_469447chr6_33005380_-0.004356759783209070.341613828437859..0.04522015467866020.243694435469353
BRCACAediting_469448chr6_33005392_-0.04566777336097020.109596460155383....
SKCMCAediting_469448chr6_33005392_-....0.01374758201262590.201464373343531
GBMCAediting_469449chr6_33005409_-0.002534439906430380.276626992536854....
UCECCAediting_469449chr6_33005409_-..0.01036713238419110.346071848348811..
OVCAediting_469449chr6_33005409_-9.34554693375368e-070.33314527071717....
OVCAediting_469451chr6_33005429_-0.0004107053747463330.308864880615184....
OVCAediting_469454chr6_33005453_-0.01064827083948980.211526148878975..0.03185870295078290.17834262418345
LGGCAediting_469458chr6_33005645_-0.0002301861326839290.326310043459894....
BRCACAediting_469458chr6_33005645_-5.94023176470656e-120.281976925563113....
CESCCAediting_469458chr6_33005645_-0.01430559542739580.264843871256511....
LUADCAediting_469458chr6_33005645_-0.002637298096623180.169152079130319....
GBMCAediting_469458chr6_33005645_-1.31582319350387e-060.435076146441668....
HNSCCAediting_469458chr6_33005645_-4.52810265307093e-050.335282356569339....
STADCAediting_469458chr6_33005645_-0.003242875060577780.210336959683043....
THCACAediting_469458chr6_33005645_-0.006773193911851710.182896951910653....
KIRCCAediting_469458chr6_33005645_-2.0722142722842e-070.245848850674889....
ESCACAediting_469458chr6_33005645_-0.02762603718295410.273272885453024....
OVCAediting_469458chr6_33005645_-4.01284378381818e-090.375698427165098....
SKCMCAediting_469458chr6_33005645_-0.0006606701609354960.235355892316038....
SARCCAediting_469458chr6_33005645_-0.0001662542482968560.408865927772156....
OVCAediting_469460chr6_33005661_-0.02898600579841560.227776712682736..0.01053525290312560.265489803879135
LGGCAediting_469462chr6_33005675_-..0.03969497313592070.191283501836703..
PRADCAediting_469462chr6_33005675_-....0.02306171790586860.209990861555993
OVCAediting_469462chr6_33005675_-0.005518891857399920.200598346560889....
BRCACAediting_469465chr6_33005706_-0.003751608793332650.16769255027913....
OVCAediting_469465chr6_33005706_-0.001859098394609140.269421183801057....
BLCACAediting_469470chr6_33005742_-0.002582826073623070.313962670582142....
LGGCAediting_469470chr6_33005742_-6.34665233780306e-060.444665528817839....
BRCACAediting_469470chr6_33005742_-1.83686327044461e-060.20549092323097....
LUADCAediting_469470chr6_33005742_-1.9549606322019e-050.256223776941452....
GBMCAediting_469470chr6_33005742_-2.6202944076478e-060.55668764540639....
STADCAediting_469470chr6_33005742_-0.01909734594845550.18121214423303....
THCACAediting_469470chr6_33005742_-....0.01038648468058810.201462787497899
KIRCCAediting_469470chr6_33005742_-0.00432022917950240.153733867226376....
OVCAediting_469470chr6_33005742_-0.0002639669465598270.251023153583759....
PAADCAediting_469470chr6_33005742_-0.04422977069519410.237853663376335....
TGCTCAediting_469470chr6_33005742_-0.04980444010180570.258802820886707....
BLCACAediting_469473chr6_33005780_-0.0005825464794256650.245386394622876....
LGGCAediting_469473chr6_33005780_-3.28167984597836e-100.36733225471886....
BRCACAediting_469473chr6_33005780_-2.50063563476272e-160.271147352432278....
CESCCAediting_469473chr6_33005780_-2.47122624114832e-090.445787758792277....
LUADCAediting_469473chr6_33005780_-5.34660323448436e-100.283959803230407....
LUSCCAediting_469473chr6_33005780_-0.0001042092179106210.196480268490633..0.01612558970807790.122560102425696
GBMCAediting_469473chr6_33005780_-2.32344885432714e-070.403479582298911....
HNSCCAediting_469473chr6_33005780_-0.001366792940511080.200623170043635....
STADCAediting_469473chr6_33005780_-0.0002005727321497750.226507985828058....
THCACAediting_469473chr6_33005780_-4.01312335014241e-050.213787267982231....
KIRCCAediting_469473chr6_33005780_-3.3248534400185e-130.318210025086553....
UCECCAediting_469473chr6_33005780_-0.002353541532338430.2457535895586790.002431039502370080.244988689287882..
OVCAediting_469473chr6_33005780_-6.38943627404597e-190.492242859756473....
PAADCAediting_469473chr6_33005780_-0.01256677463184060.20970973363894....
SKCMCAediting_469473chr6_33005780_-1.89459672814245e-050.243016382968852....
SARCCAediting_469473chr6_33005780_-2.0425273851058e-060.374208197592771....
TGCTCAediting_469473chr6_33005780_-2.29380683712352e-050.374695810209745....
THYMCAediting_469473chr6_33005780_-9.27326861839777e-060.4932246531624....
LGGCAediting_469475chr6_33005797_-5.78727765874029e-060.40700682738019....
BRCACAediting_469475chr6_33005797_-6.78259290574912e-110.245932265737156....
CESCCAediting_469475chr6_33005797_-0.03603903243210850.206857643129421....
LUADCAediting_469475chr6_33005797_-2.36747212756341e-050.231116014711861....
GBMCAediting_469475chr6_33005797_-0.02214605858668340.250898292623316....
STADCAediting_469475chr6_33005797_-2.53134596668445e-050.289619297322808....
THCACAediting_469475chr6_33005797_-....0.007641734710323870.185368152248422
KIRCCAediting_469475chr6_33005797_-0.0001102095035970160.18434464606768....
OVCAediting_469475chr6_33005797_-6.28903063690397e-050.257984905215184....
SARCCAediting_469475chr6_33005797_-0.006864822790820080.254084902850261....
TGCTCAediting_469475chr6_33005797_-0.03769568741649960.223210044533371....
BLCACAediting_469476chr6_33005798_-0.02937108204216620.168632498084611....
LGGCAediting_469476chr6_33005798_-2.73429837633321e-090.412594267235549....
BRCACAediting_469476chr6_33005798_-1.16727109633226e-080.198257210718528....
CESCCAediting_469476chr6_33005798_-0.0005282685493685320.295470851697445....
LUADCAediting_469476chr6_33005798_-6.1982489771865e-050.195065251482863....
GBMCAediting_469476chr6_33005798_-3.09021908154072e-060.400432036918114....
HNSCCAediting_469476chr6_33005798_-0.008897712272476170.175200674553092....
STADCAediting_469476chr6_33005798_-0.01004377888779990.165541410947701....
KIRCCAediting_469476chr6_33005798_-0.0001288945122669030.17532192320709....
KIRPCAediting_469476chr6_33005798_-0.003394264866832840.222840618621098....
OVCAediting_469476chr6_33005798_-3.54802153800876e-120.408062804364327....
PAADCAediting_469476chr6_33005798_-0.01419881729921920.215458623098639....
SKCMCAediting_469476chr6_33005798_-0.001301284785274340.198022352570663....
SARCCAediting_469476chr6_33005798_-0.03474156843835950.183254400276677....
TGCTCAediting_469476chr6_33005798_-0.0001340095956261360.383832840167029....
THYMCAediting_469476chr6_33005798_-0.01112137813655050.322986339460833....
STADCAediting_469477chr6_33005805_-....0.004859713876166760.361864852653729
SARCCAediting_469477chr6_33005805_-....0.01314634044910880.332439143909512
LGGCAediting_469478chr6_33005807_-....0.007504018864395020.35996984067454
LGGCAediting_469483chr6_33005853_-0.0002906948590731830.317570302634964....
BRCACAediting_469483chr6_33005853_-4.31867473460681e-080.210258976781136....
CESCCAediting_469483chr6_33005853_-4.49741422058798e-050.399964289834912....
LUADCAediting_469483chr6_33005853_-0.0001859560121438340.214868908287458....
GBMCAediting_469483chr6_33005853_-0.001638147602129390.342431288771733....
STADCAediting_469483chr6_33005853_-0.02913786092990290.164030192232425....
THCACAediting_469483chr6_33005853_-....0.02208401109919760.154978375804583
KIRCCAediting_469483chr6_33005853_-0.001156158775773270.157474274989196....
OVCAediting_469483chr6_33005853_-4.49460821644914e-050.273901539500707....
SKCMCAediting_469483chr6_33005853_-0.02549203536734820.159558640604961....
BLCACAediting_469484chr6_33005854_-0.0009317594665726050.2352367204829510.02142955128735570.164662625106652..
LGGCAediting_469484chr6_33005854_-3.41065410810381e-050.252119393725572....
BRCACAediting_469484chr6_33005854_-4.00981912236969e-130.237261744427936....
CESCCAediting_469484chr6_33005854_-1.58958524749756e-060.365649225711995....
LUADCAediting_469484chr6_33005854_-2.68949033540339e-080.255907127297057....
COADCAediting_469484chr6_33005854_-0.005090754885132630.232259396558133....
LUSCCAediting_469484chr6_33005854_-0.0004284284903430070.180023509683932....
GBMCAediting_469484chr6_33005854_-2.03306014420518e-060.380212511052635....
HNSCCAediting_469484chr6_33005854_-0.0002101574346093030.223741159179894....
STADCAediting_469484chr6_33005854_-0.001798756837475860.18878787207333....
THCACAediting_469484chr6_33005854_-0.01156698628250240.135223105157953....
KIRCCAediting_469484chr6_33005854_-6.32485689670503e-110.286569905200205....
OVCAediting_469484chr6_33005854_-2.035315112172e-120.402679148784727....
PAADCAediting_469484chr6_33005854_-0.01225216114044460.208254294848909....
SKCMCAediting_469484chr6_33005854_-3.1369769057341e-050.233741243566405..0.01918678525213740.132742282086156
TGCTCAediting_469484chr6_33005854_-8.12442786200305e-070.429166578729658....
THYMCAediting_469484chr6_33005854_-0.01357092894082370.274963847639135....

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Relation with cancer stages for HLA-DOA

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BLCApathologic_stageCAediting_469447chr6_33005380_-0.02427357671011040.191039305455374
BLCApathologic_stageCAediting_469473chr6_33005780_-0.01831704940293330.1701245940419
BLCApathologic_stageCAediting_469476chr6_33005798_-0.00419671365531670.221124087535937
BLCApathologic_stageCAediting_469478chr6_33005807_-0.02161073834336330.314968969002364
BRCApathologic_stageCAediting_469438chr6_33005250_-0.02107707967537970.076414253486794
BRCApathologic_stageCAediting_469440chr6_33005300_-0.009238646413906340.0979067824531469
BRCApathologic_stageCAediting_469448chr6_33005392_-0.01930234347943180.129930711055562
BRCApathologic_stageCAediting_469449chr6_33005409_-0.003241480372057330.340089003764219
CESCclinical_stageCAediting_469438chr6_33005250_-0.009854603070288890.189826181638558
CESCclinical_stageCAediting_469458chr6_33005645_-0.0194995489874420.252967309011675
CESCclinical_stageCAediting_469473chr6_33005780_-0.01549064730704780.1911043596295
HNSCclinical_stageCAediting_469476chr6_33005798_-0.01318513840722510.167654612132046
HNSCpathologic_stageCAediting_469438chr6_33005250_-0.02576446234950390.140184052745626
HNSCpathologic_stageCAediting_469447chr6_33005380_-0.003096575238898290.240779796232324
HNSCpathologic_stageCAediting_469473chr6_33005780_-0.02831824059532370.150281547502467
HNSCpathologic_stageCAediting_469475chr6_33005797_-0.006412724502361310.212052403555144
HNSCpathologic_stageCAediting_469476chr6_33005798_-0.002816631374581410.215014651103943
KIRCpathologic_stageCAediting_469436chr6_33005238_-0.04373165921573380.095220862047819
KIRCpathologic_stageCAediting_469438chr6_33005250_-0.006521524903980520.121510248403894
KIRCpathologic_stageCAediting_469441chr6_33005309_-0.001596665278372410.189823131245023
KIRCpathologic_stageCAediting_469475chr6_33005797_-0.001077267719732110.156605675606516
KIRCpathologic_stageCAediting_469476chr6_33005798_-8.86879893790263e-050.179801927080447
KIRCpathologic_stageCAediting_469478chr6_33005807_-0.02237300587299030.159862737745447
KIRCpathologic_stageCAediting_469484chr6_33005854_-0.02823919815861310.0982233054118955
KIRPclinical_stageCAediting_469438chr6_33005250_-0.0007787614989070160.286842647255513
KIRPclinical_stageCAediting_469447chr6_33005380_-0.01579476614633930.217241511986898
KIRPclinical_stageCAediting_469470chr6_33005742_-0.01225266236638930.370426288704839
KIRPclinical_stageCAediting_469473chr6_33005780_-0.03373045238886890.183581415667397
KIRPpathologic_stageCAediting_469438chr6_33005250_-0.0005796132590745930.250634403134343
KIRPpathologic_stageCAediting_469470chr6_33005742_-0.03670875312381190.263788869327402
KIRPpathologic_stageCAediting_469473chr6_33005780_-0.005751890256779370.20284925952543
KIRPpathologic_stageCAediting_469476chr6_33005798_-0.02924368925605750.174615594598331
KIRPpathologic_stageCAediting_469484chr6_33005854_-0.01482898928289070.179874370184474
LUADpathologic_stageCAediting_469436chr6_33005238_-0.01289616763033360.139530065333298
LUADpathologic_stageCAediting_469458chr6_33005645_-0.006101971013463060.155931370931161
LUADpathologic_stageCAediting_469475chr6_33005797_-0.03297566194515740.118873497892887
LUSCpathologic_stageCAediting_469462chr6_33005675_-0.04347253465723410.1381721696537
LUSCpathologic_stageCAediting_469476chr6_33005798_-0.008828358813819240.141199121687074
LUSCpathologic_stageCAediting_469484chr6_33005854_-0.0001737709981306060.192698593756442
MESOpathologic_stageCAediting_469447chr6_33005380_-0.03830355112375450.293896167066111
SKCMpathologic_stageCAediting_469476chr6_33005798_-0.01973056545533880.155349303150578
STADpathologic_stageCAediting_469454chr6_33005453_-0.00837622633258081-0.292886735644054
STADpathologic_stageCAediting_469470chr6_33005742_-0.04765973075852390.157317053150316
STADpathologic_stageCAediting_469471chr6_33005769_-0.0101886915518025-0.295004493058632

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Relation with survival for HLA-DOA

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
BLCACAediting_469438chr6_33005250_-0.03489687885634810.0028404515.9623
BLCACAediting_469458chr6_33005645_-0.0005139738380526281.05921e-054055.99
LIHCCAediting_469441chr6_33005309_-0.004934880565959030.04866441572
COADCAediting_469462chr6_33005675_-0.03218963555846670.01061299.76691e-07
GBMCAediting_469473chr6_33005780_-0.007521943533904230.02010920.159766
GBMCAediting_469484chr6_33005854_-0.007663217379681790.04819420.207438
STADCAediting_469476chr6_33005798_-0.0008544401826465760.00016605125.2718
UCECCAediting_469475chr6_33005797_-0.008006066325589980.0163566.42982e-05
UCECCAediting_469483chr6_33005853_-0.02063506224257280.027588844023.3
OVCAediting_469449chr6_33005409_-0.02718359928560240.01948366.4251
OVCAediting_469473chr6_33005780_-0.02065820002179210.02240663.06602
SKCMCAediting_469475chr6_33005797_-0.04482283767813270.005320669.92546
SKCMCAediting_469476chr6_33005798_-0.02271510821156690.0064730112.2153

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RelatedDrugs for HLA-DOA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HLA-DOA

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
HLA-DOAC2931456Prostate cancer, familial1CTD_human
HLA-DOAC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human