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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: HINT1 (CAeditome ID:3094)

Gene summary for HINT1

check button Gene summary
Gene informationGene symbol

HINT1

Gene ID

3094

Gene namehistidine triad nucleotide binding protein 1
SynonymsHINT|NMAN|PKCI-1|PRKCNH1
Cytomap

5q23.3

Type of geneprotein-coding
Descriptionhistidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseepididymis secretory sperm binding proteinprotein kinase C inhibitor 1protein kinase C-interacting protein 1
Modification date20210522
UniProtAcc

P49773

Context- 32884300(Hint1 Overexpression Inhibits the Cell Cycle and Induces Cell Apoptosis in Human Osteosarcoma Cells)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HINT1

GO:0016787

Histidine triad nucleotide-binding protein 1

16835243

HINT1

GO:0043530

Histidine triad nucleotide-binding protein 1

17217311

HINT1

GO:0009154

Histidine triad nucleotide-binding protein 1

16835243

HINT1

GO:0005654

Histidine triad nucleotide-binding protein 1

0000052

HINT1

GO:0005829

Histidine triad nucleotide-binding protein 1

0000052

HINT1

GO:0005886

Histidine triad nucleotide-binding protein 1

0000052

HINT1

GO:0000118

Histidine triad nucleotide-binding protein 1

16835243


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RNA A-to-I events for HINT1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000169567.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_425613(131159845, -), CAediting_425614(131159874, -), CAediting_425615(131159879, -), CAediting_425616(131159881, -), CAediting_425617(131159882, -), CAediting_425618(131159885, -), CAediting_425619(131159887, -), CAediting_425620(131159893, -), CAediting_425621(131159904, -), CAediting_425622(131159909, -), CAediting_425623(131159917, -), CAediting_425624(131159919, -), CAediting_425625(131159924, -), CAediting_425626(131159928, -), CAediting_425627(131159935, -), CAediting_425628(131159941, -), CAediting_425629(131159954, -), CAediting_425630(131159960, -), CAediting_425631(131159963, -), CAediting_425632(131159984, -), CAediting_425633(131159990, -), CAediting_425634(131160000, -), CAediting_425635(131160016, -), CAediting_425636(131160019, -), CAediting_425637(131160020, -), CAediting_425638(131160021, -), CAediting_425639(131160022, -), CAediting_425640(131160025, -), CAediting_425641(131160027, -), CAediting_425642(131160029, -), CAediting_425643(131160030, -), CAediting_425644(131160031, -), CAediting_425645(131160032, -), CAediting_425646(131160036, -), CAediting_425647(131160041, -), CAediting_425648(131160048, -), CAediting_425649(131160057, -), CAediting_425650(131160067, -), CAediting_425651(131160070, -), CAediting_425652(131160072, -), CAediting_425653(131160078, -), CAediting_425654(131160081, -), CAediting_425655(131160086, -), CAediting_425656(131160087, -), CAediting_425657(131160105, -), CAediting_425658(131160109, -), CAediting_425659(131160120, -), CAediting_425660(131160125, -), CAediting_425661(131160126, -), CAediting_425662(131160142, -), CAediting_425663(131160144, -), CAediting_425664(131160174, -), CAediting_425665(131160410, -), CAediting_425666(131161032, -), CAediting_425667(131161325, -), CAediting_425668(131161338, -), CAediting_425669(131161345, -), CAediting_425670(131161347, -), CAediting_425671(131161359, -), CAediting_425672(131161361, -), CAediting_425673(131161369, -), CAediting_425674(131161378, -), CAediting_425675(131161399, -), CAediting_425676(131161407, -), CAediting_425677(131161438, -), CAediting_425678(131161441, -), CAediting_425679(131161447, -), CAediting_425680(131161464, -), CAediting_425681(131161476, -), CAediting_425682(131161478, -), CAediting_425683(131161488, -), CAediting_425684(131161491, -), CAediting_425685(131161508, -), CAediting_425686(131161532, -), CAediting_425687(131161533, -), CAediting_425688(131161538, -), CAediting_425689(131161548, -), CAediting_425690(131161556, -), CAediting_425691(131161557, -), CAediting_425692(131161569, -), CAediting_425693(131161594, -), CAediting_425694(131162056, -), CAediting_425695(131162069, -), CAediting_425696(131162081, -), CAediting_425697(131162082, -), CAediting_425698(131162083, -), CAediting_425699(131162127, -), CAediting_425700(131162132, -), CAediting_425701(131162144, -), CAediting_425702(131162153, -), CAediting_425703(131162155, -), CAediting_425704(131162157, -), CAediting_425705(131162160, -), CAediting_425706(131162166, -), CAediting_425707(131162175, -), CAediting_425708(131162185, -), CAediting_425709(131162186, -), CAediting_425710(131162189, -), CAediting_425711(131162200, -), CAediting_425712(131162202, -), CAediting_425713(131162203, -), CAediting_425714(131162211, -), CAediting_425715(131162223, -), CAediting_425716(131162254, -), CAediting_425717(131162260, -), CAediting_425718(131162266, -), CAediting_425719(131162281, -), CAediting_425720(131162313, -), CAediting_425721(131163083, -),

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RNA editing positional annotations for HINT1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_425613chr5_131159845_-ncRNA_intronic
CAediting_425614chr5_131159874_-ncRNA_intronic
CAediting_425615chr5_131159879_-ncRNA_intronic
CAediting_425616chr5_131159881_-ncRNA_intronic
CAediting_425617chr5_131159882_-ncRNA_intronic
CAediting_425618chr5_131159885_-ncRNA_intronic
CAediting_425619chr5_131159887_-ncRNA_intronic
CAediting_425620chr5_131159893_-ncRNA_intronic
CAediting_425621chr5_131159904_-ncRNA_intronic
CAediting_425622chr5_131159909_-ncRNA_intronic
CAediting_425623chr5_131159917_-ncRNA_intronic
CAediting_425624chr5_131159919_-ncRNA_intronic
CAediting_425625chr5_131159924_-ncRNA_intronic
CAediting_425626chr5_131159928_-ncRNA_intronic
CAediting_425627chr5_131159935_-ncRNA_intronic
CAediting_425628chr5_131159941_-ncRNA_intronic
CAediting_425629chr5_131159954_-ncRNA_intronic
CAediting_425630chr5_131159960_-ncRNA_intronic
CAediting_425631chr5_131159963_-ncRNA_intronic
CAediting_425632chr5_131159984_-ncRNA_intronic
CAediting_425633chr5_131159990_-ncRNA_intronic
CAediting_425634chr5_131160000_-ncRNA_intronic
CAediting_425635chr5_131160016_-ncRNA_intronic
CAediting_425636chr5_131160019_-ncRNA_intronic
CAediting_425637chr5_131160020_-ncRNA_intronic
CAediting_425638chr5_131160021_-ncRNA_intronic
CAediting_425639chr5_131160022_-ncRNA_intronic
CAediting_425640chr5_131160025_-ncRNA_intronic
CAediting_425641chr5_131160027_-ncRNA_intronic
CAediting_425642chr5_131160029_-ncRNA_intronic
CAediting_425643chr5_131160030_-ncRNA_intronic
CAediting_425644chr5_131160031_-ncRNA_intronic
CAediting_425645chr5_131160032_-ncRNA_intronic
CAediting_425646chr5_131160036_-ncRNA_intronic
CAediting_425647chr5_131160041_-ncRNA_intronic
CAediting_425648chr5_131160048_-ncRNA_intronic
CAediting_425649chr5_131160057_-ncRNA_intronic
CAediting_425650chr5_131160067_-ncRNA_intronic
CAediting_425651chr5_131160070_-ncRNA_intronic
CAediting_425652chr5_131160072_-ncRNA_intronic
CAediting_425653chr5_131160078_-ncRNA_intronic
CAediting_425654chr5_131160081_-ncRNA_intronic
CAediting_425655chr5_131160086_-ncRNA_intronic
CAediting_425656chr5_131160087_-ncRNA_intronic
CAediting_425657chr5_131160105_-ncRNA_intronic
CAediting_425658chr5_131160109_-ncRNA_intronic
CAediting_425659chr5_131160120_-ncRNA_intronic
CAediting_425660chr5_131160125_-ncRNA_intronic
CAediting_425661chr5_131160126_-ncRNA_intronic
CAediting_425662chr5_131160142_-ncRNA_intronic
CAediting_425663chr5_131160144_-ncRNA_intronic
CAediting_425664chr5_131160174_-ncRNA_intronic
CAediting_425665chr5_131160410_-ncRNA_intronic
CAediting_425666chr5_131161032_-ncRNA_intronic
CAediting_425667chr5_131161325_-ncRNA_intronic
CAediting_425668chr5_131161338_-ncRNA_intronic
CAediting_425669chr5_131161345_-ncRNA_intronic
CAediting_425670chr5_131161347_-ncRNA_intronic
CAediting_425671chr5_131161359_-ncRNA_intronic
CAediting_425672chr5_131161361_-ncRNA_intronic
CAediting_425673chr5_131161369_-ncRNA_intronic
CAediting_425674chr5_131161378_-ncRNA_intronic
CAediting_425675chr5_131161399_-ncRNA_intronic
CAediting_425676chr5_131161407_-ncRNA_intronic
CAediting_425677chr5_131161438_-ncRNA_intronic
CAediting_425678chr5_131161441_-ncRNA_intronic
CAediting_425679chr5_131161447_-ncRNA_intronic
CAediting_425680chr5_131161464_-ncRNA_intronic
CAediting_425681chr5_131161476_-ncRNA_intronic
CAediting_425682chr5_131161478_-ncRNA_intronic
CAediting_425683chr5_131161488_-ncRNA_intronic
CAediting_425684chr5_131161491_-ncRNA_intronic
CAediting_425685chr5_131161508_-ncRNA_intronic
CAediting_425686chr5_131161532_-ncRNA_intronic
CAediting_425687chr5_131161533_-ncRNA_intronic
CAediting_425688chr5_131161538_-ncRNA_intronic
CAediting_425689chr5_131161548_-ncRNA_intronic
CAediting_425690chr5_131161556_-ncRNA_intronic
CAediting_425691chr5_131161557_-ncRNA_intronic
CAediting_425692chr5_131161569_-ncRNA_intronic
CAediting_425693chr5_131161594_-ncRNA_intronic
CAediting_425694chr5_131162056_-ncRNA_intronic
CAediting_425695chr5_131162069_-ncRNA_intronic
CAediting_425696chr5_131162081_-ncRNA_intronic
CAediting_425697chr5_131162082_-ncRNA_intronic
CAediting_425698chr5_131162083_-ncRNA_intronic
CAediting_425699chr5_131162127_-ncRNA_intronic
CAediting_425700chr5_131162132_-ncRNA_intronic
CAediting_425701chr5_131162144_-ncRNA_intronic
CAediting_425702chr5_131162153_-ncRNA_intronic
CAediting_425703chr5_131162155_-ncRNA_intronic
CAediting_425704chr5_131162157_-ncRNA_intronic
CAediting_425705chr5_131162160_-ncRNA_intronic
CAediting_425706chr5_131162166_-ncRNA_intronic
CAediting_425707chr5_131162175_-ncRNA_intronic
CAediting_425708chr5_131162185_-ncRNA_intronic
CAediting_425709chr5_131162186_-ncRNA_intronic
CAediting_425710chr5_131162189_-ncRNA_intronic
CAediting_425711chr5_131162200_-ncRNA_intronic
CAediting_425712chr5_131162202_-ncRNA_intronic
CAediting_425713chr5_131162203_-ncRNA_intronic
CAediting_425714chr5_131162211_-ncRNA_intronic
CAediting_425715chr5_131162223_-ncRNA_intronic
CAediting_425716chr5_131162254_-ncRNA_intronic
CAediting_425717chr5_131162260_-ncRNA_intronic
CAediting_425718chr5_131162266_-ncRNA_intronic
CAediting_425719chr5_131162281_-ncRNA_intronic
CAediting_425720chr5_131162313_-ncRNA_intronic
CAediting_425721chr5_131163083_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_425614chr5_131159874_-SINEAluAluJb
CAediting_425615chr5_131159879_-SINEAluAluJb
CAediting_425616chr5_131159881_-SINEAluAluJb
CAediting_425617chr5_131159882_-SINEAluAluJb
CAediting_425618chr5_131159885_-SINEAluAluJb
CAediting_425619chr5_131159887_-SINEAluAluJb
CAediting_425620chr5_131159893_-SINEAluAluJb
CAediting_425621chr5_131159904_-SINEAluAluJb
CAediting_425622chr5_131159909_-SINEAluAluJb
CAediting_425623chr5_131159917_-SINEAluAluJb
CAediting_425624chr5_131159919_-SINEAluAluJb
CAediting_425625chr5_131159924_-SINEAluAluJb
CAediting_425626chr5_131159928_-SINEAluAluJb
CAediting_425627chr5_131159935_-SINEAluAluJb
CAediting_425628chr5_131159941_-SINEAluAluJb
CAediting_425629chr5_131159954_-SINEAluAluJb
CAediting_425630chr5_131159960_-SINEAluAluJb
CAediting_425631chr5_131159963_-SINEAluAluJb
CAediting_425632chr5_131159984_-SINEAluAluJb
CAediting_425633chr5_131159990_-SINEAluAluJb
CAediting_425634chr5_131160000_-SINEAluAluJb
CAediting_425635chr5_131160016_-SINEAluAluJb
CAediting_425636chr5_131160019_-SINEAluAluJb
CAediting_425637chr5_131160020_-SINEAluAluJb
CAediting_425638chr5_131160021_-SINEAluAluJb
CAediting_425639chr5_131160022_-SINEAluAluJb
CAediting_425640chr5_131160025_-SINEAluAluJb
CAediting_425641chr5_131160027_-SINEAluAluJb
CAediting_425642chr5_131160029_-SINEAluAluJb
CAediting_425643chr5_131160030_-SINEAluAluJb
CAediting_425644chr5_131160031_-SINEAluAluJb
CAediting_425645chr5_131160032_-SINEAluAluJb
CAediting_425646chr5_131160036_-SINEAluAluJb
CAediting_425647chr5_131160041_-SINEAluAluJb
CAediting_425648chr5_131160048_-SINEAluAluJb
CAediting_425649chr5_131160057_-SINEAluAluJb
CAediting_425650chr5_131160067_-SINEAluAluJb
CAediting_425651chr5_131160070_-SINEAluAluJb
CAediting_425652chr5_131160072_-SINEAluAluJb
CAediting_425653chr5_131160078_-SINEAluAluJb
CAediting_425654chr5_131160081_-SINEAluAluJb
CAediting_425655chr5_131160086_-SINEAluAluJb
CAediting_425656chr5_131160087_-SINEAluAluJb
CAediting_425657chr5_131160105_-SINEAluAluJb
CAediting_425658chr5_131160109_-SINEAluAluJb
CAediting_425659chr5_131160120_-SINEAluAluJb
CAediting_425660chr5_131160125_-SINEAluAluJb
CAediting_425661chr5_131160126_-SINEAluAluJb
CAediting_425662chr5_131160142_-SINEAluAluJb
CAediting_425663chr5_131160144_-SINEAluAluJb
CAediting_425666chr5_131161032_-DNATcMar-TiggerMER47A
CAediting_425667chr5_131161325_-SINEAluAluSp
CAediting_425668chr5_131161338_-SINEAluAluSp
CAediting_425669chr5_131161345_-SINEAluAluSp
CAediting_425670chr5_131161347_-SINEAluAluSp
CAediting_425671chr5_131161359_-SINEAluAluSp
CAediting_425672chr5_131161361_-SINEAluAluSp
CAediting_425673chr5_131161369_-SINEAluAluSp
CAediting_425674chr5_131161378_-SINEAluAluSp
CAediting_425675chr5_131161399_-SINEAluAluSp
CAediting_425676chr5_131161407_-SINEAluAluSp
CAediting_425677chr5_131161438_-SINEAluAluSp
CAediting_425678chr5_131161441_-SINEAluAluSp
CAediting_425679chr5_131161447_-SINEAluAluSp
CAediting_425680chr5_131161464_-SINEAluAluSp
CAediting_425681chr5_131161476_-SINEAluAluSp
CAediting_425682chr5_131161478_-SINEAluAluSp
CAediting_425683chr5_131161488_-SINEAluAluSp
CAediting_425684chr5_131161491_-SINEAluAluSp
CAediting_425685chr5_131161508_-SINEAluAluSp
CAediting_425686chr5_131161532_-SINEAluAluSp
CAediting_425687chr5_131161533_-SINEAluAluSp
CAediting_425688chr5_131161538_-SINEAluAluSp
CAediting_425689chr5_131161548_-SINEAluAluSp
CAediting_425690chr5_131161556_-SINEAluAluSp
CAediting_425691chr5_131161557_-SINEAluAluSp
CAediting_425692chr5_131161569_-SINEAluAluSp
CAediting_425693chr5_131161594_-SINEAluAluSp
CAediting_425694chr5_131162056_-SINEAluAluY
CAediting_425695chr5_131162069_-SINEAluAluY
CAediting_425696chr5_131162081_-SINEAluAluY
CAediting_425697chr5_131162082_-SINEAluAluY
CAediting_425698chr5_131162083_-SINEAluAluY
CAediting_425699chr5_131162127_-SINEAluAluY
CAediting_425700chr5_131162132_-SINEAluAluY
CAediting_425701chr5_131162144_-SINEAluAluY
CAediting_425702chr5_131162153_-SINEAluAluY
CAediting_425703chr5_131162155_-SINEAluAluY
CAediting_425704chr5_131162157_-SINEAluAluY
CAediting_425705chr5_131162160_-SINEAluAluY
CAediting_425706chr5_131162166_-SINEAluAluY
CAediting_425707chr5_131162175_-SINEAluAluY
CAediting_425708chr5_131162185_-SINEAluAluY
CAediting_425709chr5_131162186_-SINEAluAluY
CAediting_425710chr5_131162189_-SINEAluAluY
CAediting_425711chr5_131162200_-SINEAluAluY
CAediting_425712chr5_131162202_-SINEAluAluY
CAediting_425713chr5_131162203_-SINEAluAluY
CAediting_425714chr5_131162211_-SINEAluAluY
CAediting_425715chr5_131162223_-SINEAluAluY
CAediting_425716chr5_131162254_-SINEAluAluY
CAediting_425717chr5_131162260_-SINEAluAluY
CAediting_425718chr5_131162266_-SINEAluAluY
CAediting_425719chr5_131162281_-SINEAluAluY
CAediting_425720chr5_131162313_-SINEAluAluY
CAediting_425721chr5_131163083_-SINEAluAluSx

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RNA A-to-I editing events in the alternative splicing sites for HINT1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_425693chr5_131161594_-131161590:1311616123SS0+2iCTTTTTTTTTTTTTTTTGAGACG3.87CTTTTTTTTTTTTTTTTGGGACG-4.09
MEX_1CAediting_425693chr5_131161594_-131161590:1311616123SS0+2iCTTTTTTTTTTTTTTTTGAGACG3.87CTTTTTTTTTTTTTTTTGGGACG-4.09
ESCAediting_425696chr5_131162081_-131162077:1311620993SS0+2iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAAGGTGC-5.06
IRCAediting_425696chr5_131162081_-131162077:1311620993SS0+2iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAAGGTGC-5.06
MEX_2CAediting_425696chr5_131162081_-131162077:1311620993SS0+2iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAAGGTGC-5.06
ESCAediting_425697chr5_131162082_-131162077:1311620993SS0+3iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAGAGTGC-15.21
IRCAediting_425697chr5_131162082_-131162077:1311620993SS0+3iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAGAGTGC-15.21
MEX_2CAediting_425697chr5_131162082_-131162077:1311620993SS0+3iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCAGAGTGC-15.21
ESCAediting_425698chr5_131162083_-131162077:1311620993SS0+4iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCGAAGTGC2.53
IRCAediting_425698chr5_131162083_-131162077:1311620993SS0+4iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCGAAGTGC2.53
MEX_2CAediting_425698chr5_131162083_-131162077:1311620993SS0+4iCCCGCCTCGGCCTCCCAAAGTGC2.89CCCGCCTCGGCCTCCCGAAGTGC2.53

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000169567.10.HINT1.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000169567.10.HINT1.
boxplot

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HINT1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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TGCT.CAediting_425635.ENSG00000169567.HINT1.png
Soverview

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Protein coding region RNA A-to-I editings for HINT1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
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The effects of the RNA editing to the miRNA binding sites for HINT1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000169567.10ENST00000511475hsa-miR-548aa1311607661311607727mer-m8131160765131160791159-15.27
CAediting_1229413chr17_67471544_+ENSG00000169567.10ENST00000508495hsa-miR-548aa1311607661311607727mer-m8131160765131160791159-15.27
CAediting_1229413chr17_67471544_+ENSG00000169567.10ENST00000504202hsa-miR-548aa1311607661311607727mer-m8131160765131160791159-15.27

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HINT1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000508488.1protein_codingSoverviewSoverview
ENST00000506908.1protein_codingSoverviewSoverview
ENST00000513012.1protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_425699ENST00000508488.1chr5_131162127_--223.30-223.30-247.80
CAediting_425700ENST00000508488.1chr5_131162132_--222.60-223.30-247.80
CAediting_425701ENST00000508488.1chr5_131162144_--224.70-223.30-247.80
CAediting_425702ENST00000508488.1chr5_131162153_--226.00-223.30-247.80
CAediting_425703ENST00000508488.1chr5_131162155_--225.50-223.30-247.80
CAediting_425704ENST00000508488.1chr5_131162157_--225.90-223.30-247.80
CAediting_425705ENST00000508488.1chr5_131162160_--225.10-223.30-247.80
CAediting_425706ENST00000508488.1chr5_131162166_--223.80-223.30-247.80
CAediting_425707ENST00000508488.1chr5_131162175_--225.40-223.30-247.80
CAediting_425708ENST00000508488.1chr5_131162185_--223.20-223.30-247.80
CAediting_425709ENST00000508488.1chr5_131162186_--223.30-223.30-247.80
CAediting_425710ENST00000508488.1chr5_131162189_--224.10-223.30-247.80
CAediting_425711ENST00000508488.1chr5_131162200_--225.90-223.30-247.80
CAediting_425712ENST00000508488.1chr5_131162202_--224.80-223.30-247.80
CAediting_425713ENST00000508488.1chr5_131162203_--224.00-223.30-247.80
CAediting_425714ENST00000508488.1chr5_131162211_--228.90-223.30-247.80
CAediting_425715ENST00000508488.1chr5_131162223_--226.90-223.30-247.80
CAediting_425716ENST00000508488.1chr5_131162254_--225.40-223.30-247.80
CAediting_425717ENST00000508488.1chr5_131162260_--225.90-223.30-247.80
CAediting_425718ENST00000508488.1chr5_131162266_--223.50-223.30-247.80
CAediting_425719ENST00000508488.1chr5_131162281_--222.90-223.30-247.80
CAediting_425720ENST00000508488.1chr5_131162313_--224.60-223.30-247.80
CAediting_425716ENST00000506908.1chr5_131162254_--218.60-219.00-220.50
CAediting_425717ENST00000506908.1chr5_131162260_--219.00-219.00-220.50
CAediting_425718ENST00000506908.1chr5_131162266_--220.10-219.00-220.50
CAediting_425719ENST00000506908.1chr5_131162281_--219.90-219.00-220.50
CAediting_425720ENST00000506908.1chr5_131162313_--218.30-219.00-220.50
CAediting_425720ENST00000513012.1chr5_131162313_--160.50-161.20-160.50

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Relation with ADAR for HINT1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CESCCAediting_425626chr5_131159928_-0.01037264242864280.184592583917402....
LAMLCAediting_425626chr5_131159928_-....0.008422641854372180.312594481063813
BLCACAediting_425629chr5_131159954_-0.01587045314137230.171654369825405....
LIHCCAediting_425629chr5_131159954_-....0.04482691472670030.137947655057182
CESCCAediting_425629chr5_131159954_-0.001273313588349670.258996884983319....
THCACAediting_425629chr5_131159954_-....0.02071917064775090.157315586653477
THYMCAediting_425629chr5_131159954_-..0.03578984731190750.25507971116878..
LGGCAediting_425633chr5_131159990_-0.01563847057469190.176090328859369....
LAMLCAediting_425633chr5_131159990_-0.0262486520512860.196452991698345....
SKCMCAediting_425633chr5_131159990_-0.007472823601237820.189103316043973....
SARCCAediting_425633chr5_131159990_-....0.01615578006529030.234268585681384
STADCAediting_425634chr5_131160000_-....0.02510690614672380.310426852847098
BLCACAediting_425635chr5_131160016_-0.01956292792605280.212900248734669....
BLCACAediting_425650chr5_131160067_-0.03902823418357960.237284276407219....
BRCACAediting_425650chr5_131160067_-..0.04031946305132510.18593207516829..
PRADCAediting_425650chr5_131160067_-..0.04898632824426380.186482480250112..
STADCAediting_425650chr5_131160067_-0.04169326334523240.28914348668768....
BLCACAediting_425659chr5_131160120_-0.04096149270416660.186892317471509....
CESCCAediting_425659chr5_131160120_-....0.01658583722281570.253373356117037
TGCTCAediting_425662chr5_131160142_-....0.01645291083031570.334442881409484
LAMLCAediting_425663chr5_131160144_-0.02713278602338170.285302588299615....
LUADCAediting_425686chr5_131161532_-..0.01830362871249510.251061865385631..
LUSCCAediting_425717chr5_131162260_-..0.03510025555006940.189433732338728..
STADCAediting_425717chr5_131162260_-..0.001528641912968620.282787483069642..
ESCACAediting_425717chr5_131162260_-..0.002174485871066890.329975523161455..
SKCMCAediting_425717chr5_131162260_-..0.003135067024363130.280489136466105..

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Relation with cancer stages for HINT1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BLCApathologic_stageCAediting_425633chr5_131159990_-0.0001894680387334010.219368660066295
BRCApathologic_stageCAediting_425629chr5_131159954_-0.01335682810072770.137968609852891
ESCAclinical_stageCAediting_425633chr5_131159990_-0.00536344884328242-0.408297256858113
ESCApathologic_stageCAediting_425659chr5_131160120_-0.01612865050098120.269951804673096
HNSCpathologic_stageCAediting_425633chr5_131159990_-0.04018045079347050.16292199022342
KIRCpathologic_stageCAediting_425626chr5_131159928_-0.01829235953084380.137083605392174
KIRCpathologic_stageCAediting_425633chr5_131159990_-1.29646118741231e-060.247864962999086
KIRCpathologic_stageCAediting_425634chr5_131160000_-0.0214196213178960.287137853559809
KIRCpathologic_stageCAediting_425662chr5_131160142_-0.004865646920442940.181197915861639
KIRPclinical_stageCAediting_425626chr5_131159928_-0.0001357904665724110.354357428555564
KIRPclinical_stageCAediting_425659chr5_131160120_-0.002890313868506630.416801896619855
KIRPpathologic_stageCAediting_425626chr5_131159928_-0.01634004914005360.198452306534228
KIRPpathologic_stageCAediting_425659chr5_131160120_-0.004427302416772350.343510368686166
KIRPpathologic_stageCAediting_425663chr5_131160144_-0.0406541984514020.22521188901745
LUADpathologic_stageCAediting_425633chr5_131159990_-0.004956875116921820.155989339225901
LUSCpathologic_stageCAediting_425633chr5_131159990_-0.005012422378902780.154841058340524
LUSCpathologic_stageCAediting_425686chr5_131161532_-0.00495283481343331-0.309342260167182
LUSCpathologic_stageCAediting_425717chr5_131162260_-0.02370143607463160.203063133371895
THCApathologic_stageCAediting_425633chr5_131159990_-0.003285259585978970.162854665033294
THCApathologic_stageCAediting_425717chr5_131162260_-0.03190934808227150.173561649871385

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Relation with survival for HINT1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LIHCCAediting_425629chr5_131159954_-0.00156940909266690.0156130.0504196
LIHCCAediting_425663chr5_131160144_-0.007947629839397010.04837265.54263
LUSCCAediting_425650chr5_131160067_-0.02268822643303990.02982562.72
PRADCAediting_425629chr5_131159954_-0.01766887914154210.03919432.36708e+11
KIRCCAediting_425662chr5_131160142_-0.02974942527592940.04631193.00653
KIRCCAediting_425663chr5_131160144_-0.0005740418464577070.0108445.72367
UCECCAediting_425635chr5_131160016_-0.0442228220180220.02721981377.22

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RelatedDrugs for HINT1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HINT1P49773DB00131Adenosine phosphateHistidine triad nucleotide-binding protein 1 SmallMoleculeDrugapproved|investigational|nutraceutical

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RelatedDiseases for HINT1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
HINT1C0036341Schizophrenia2CTD_human
HINT1C0242287Isaacs syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HINT1C0005586Bipolar Disorder1PSYGENET
HINT1C0026848Myopathy1CTD_human
HINT1C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)1CTD_human
HINT1C2932678Inherited Peripheral Neuropathy1CTD_human