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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: HIF1A (CAeditome ID:3091) |
Gene summary for HIF1A |
 Gene summary |
| Gene information | Gene symbol | HIF1A | Gene ID | 3091 |
| Gene name | hypoxia inducible factor 1 subunit alpha | |
| Synonyms | HIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 | |
| Cytomap | 14q23.2 | |
| Type of gene | protein-coding | |
| Description | hypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit | |
| Modification date | 20210531 | |
| UniProtAcc | Q16665 | |
| Context | - 32768595(Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HIF1A | GO:0070101 | Hypoxia-inducible factor 1-alpha | 17178876 |
| HIF1A | GO:0001666 | Hypoxia-inducible factor 1-alpha | 11782478 |
| HIF1A | GO:0006355 | Hypoxia-inducible factor 1-alpha | 11782478 |
| HIF1A | GO:0000981 | Hypoxia-inducible factor 1-alpha | 7539918 |
| HIF1A | GO:0000981 | Hypoxia-inducible factor 1-alpha | 8756616 |
| HIF1A | GO:0043565 | Hypoxia-inducible factor 1-alpha | 7539918 |
| HIF1A | GO:0043565 | Hypoxia-inducible factor 1-alpha | 8756616 |
| HIF1A | GO:0043565 | Hypoxia-inducible factor 1-alpha | 9079689 |
| HIF1A | GO:0000977 | Hypoxia-inducible factor 1-alpha | 19782034 |
| HIF1A | GO:0000981 | Hypoxia-inducible factor 1-alpha | 8387214 |
| HIF1A | GO:0000981 | Hypoxia-inducible factor 1-alpha | 9079689 |
| HIF1A | GO:0001228 | Hypoxia-inducible factor 1-alpha | 19782034 |
| HIF1A | GO:0003700 | Hypoxia-inducible factor 1-alpha | 11782478 |
| HIF1A | GO:0003700 | Hypoxia-inducible factor 1-alpha | 18658046 |
| HIF1A | GO:0003700 | Hypoxia-inducible factor 1-alpha | 25043030 |
| HIF1A | GO:0003700 | Hypoxia-inducible factor 1-alpha | 30125331 |
| HIF1A | GO:0051879 | Hypoxia-inducible factor 1-alpha | 9079689 |
| HIF1A | GO:0000302 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:0001666 | Hypoxia-inducible factor 1-alpha | 15261140 |
| HIF1A | GO:0001666 | Hypoxia-inducible factor 1-alpha | 18419598 |
| HIF1A | GO:0001666 | Hypoxia-inducible factor 1-alpha | 8756616 |
| HIF1A | GO:0001666 | Hypoxia-inducible factor 1-alpha | 9887100 |
| HIF1A | GO:0001678 | Hypoxia-inducible factor 1-alpha | 30125331 |
| HIF1A | GO:0006110 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:0006355 | Hypoxia-inducible factor 1-alpha | 15261140 |
| HIF1A | GO:0010468 | Hypoxia-inducible factor 1-alpha | 18419598 |
| HIF1A | GO:0010468 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:0010573 | Hypoxia-inducible factor 1-alpha | 12958148 |
| HIF1A | GO:0010575 | Hypoxia-inducible factor 1-alpha | 8756616 |
| HIF1A | GO:0010628 | Hypoxia-inducible factor 1-alpha | 15459207 |
| HIF1A | GO:0010628 | Hypoxia-inducible factor 1-alpha | 24244340 |
| HIF1A | GO:0032364 | Hypoxia-inducible factor 1-alpha | 16956324 |
| HIF1A | GO:0043619 | Hypoxia-inducible factor 1-alpha | 8089148 |
| HIF1A | GO:0043619 | Hypoxia-inducible factor 1-alpha | 8387214 |
| HIF1A | GO:0045893 | Hypoxia-inducible factor 1-alpha | 25043030 |
| HIF1A | GO:0045893 | Hypoxia-inducible factor 1-alpha | 9887100 |
| HIF1A | GO:0045944 | Hypoxia-inducible factor 1-alpha | 11573933 |
| HIF1A | GO:0045944 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:0045944 | Hypoxia-inducible factor 1-alpha | 7539918 |
| HIF1A | GO:0045944 | Hypoxia-inducible factor 1-alpha | 8089148 |
| HIF1A | GO:0046886 | Hypoxia-inducible factor 1-alpha | 1448077 |
| HIF1A | GO:0061419 | Hypoxia-inducible factor 1-alpha | 22735262 |
| HIF1A | GO:0071456 | Hypoxia-inducible factor 1-alpha | 11573933 |
| HIF1A | GO:0071456 | Hypoxia-inducible factor 1-alpha | 19528298 |
| HIF1A | GO:0071456 | Hypoxia-inducible factor 1-alpha | 20889502 |
| HIF1A | GO:0098586 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:1900017 | Hypoxia-inducible factor 1-alpha | 32697943 |
| HIF1A | GO:1902895 | Hypoxia-inducible factor 1-alpha | 19782034 |
| HIF1A | GO:1903377 | Hypoxia-inducible factor 1-alpha | 24899725 |
| HIF1A | GO:0000785 | Hypoxia-inducible factor 1-alpha | 19782034 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 15261140 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 18658046 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 20810912 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 20972335 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 24048733 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 25043030 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 8089148 |
| HIF1A | GO:0005654 | Hypoxia-inducible factor 1-alpha | 0000052 |
| HIF1A | GO:0005737 | Hypoxia-inducible factor 1-alpha | 19651758 |
| HIF1A | GO:0005737 | Hypoxia-inducible factor 1-alpha | 24048733 |
| HIF1A | GO:0005829 | Hypoxia-inducible factor 1-alpha | 24681946 |
| HIF1A | GO:0016604 | Hypoxia-inducible factor 1-alpha | 0000052 |
| HIF1A | GO:0005634 | Hypoxia-inducible factor 1-alpha | 22848707 |
| HIF1A | GO:0090575 | Hypoxia-inducible factor 1-alpha | 7539918 |
| HIF1A | GO:0090575 | Hypoxia-inducible factor 1-alpha | 8756616 |
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RNA A-to-I events for HIF1A |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
 |
| RNA editing frequencies across 33 cancers of gene: ENSG00000100644.15 |
| RNA A-to-I editing events in Cancer. |
| CAediting_995934(61701841, +), CAediting_995935(61701881, +), CAediting_995936(61701938, +), CAediting_995937(61701976, +), CAediting_995938(61702199, +), CAediting_995939(61702226, +), CAediting_995940(61702238, +), CAediting_995941(61702346, +), CAediting_995942(61703111, +), CAediting_995943(61703116, +), CAediting_995944(61708967, +), CAediting_995945(61708975, +), CAediting_995946(61708991, +), CAediting_995947(61710783, +), CAediting_995948(61710805, +), CAediting_995949(61710806, +), CAediting_995950(61710849, +), CAediting_995951(61710857, +), CAediting_995952(61710877, +), CAediting_995953(61710913, +), CAediting_995954(61710929, +), CAediting_995955(61710939, +), CAediting_995956(61710940, +), CAediting_995957(61710953, +), CAediting_995958(61710957, +), CAediting_995959(61710967, +), CAediting_995960(61710968, +), CAediting_995961(61710992, +), CAediting_995962(61710997, +), CAediting_995963(61711004, +), CAediting_995964(61711038, +), CAediting_995965(61711266, +), CAediting_995966(61711269, +), CAediting_995967(61711272, +), CAediting_995968(61711274, +), CAediting_995969(61711279, +), CAediting_995970(61711284, +), CAediting_995971(61711291, +), CAediting_995972(61711292, +), CAediting_995973(61711308, +), CAediting_995974(61711334, +), CAediting_995975(61711357, +), CAediting_995976(61711360, +), CAediting_995977(61714785, +), CAediting_995978(61714795, +), CAediting_995979(61714809, +), |
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RNA editing positional annotations for HIF1A using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_995934 | chr14_61701841_+ | ncRNA_intronic |
| CAediting_995935 | chr14_61701881_+ | ncRNA_intronic |
| CAediting_995936 | chr14_61701938_+ | ncRNA_intronic |
| CAediting_995937 | chr14_61701976_+ | ncRNA_intronic |
| CAediting_995938 | chr14_61702199_+ | ncRNA_intronic |
| CAediting_995939 | chr14_61702226_+ | ncRNA_intronic |
| CAediting_995940 | chr14_61702238_+ | ncRNA_intronic |
| CAediting_995941 | chr14_61702346_+ | ncRNA_intronic |
| CAediting_995942 | chr14_61703111_+ | ncRNA_intronic |
| CAediting_995943 | chr14_61703116_+ | ncRNA_intronic |
| CAediting_995944 | chr14_61708967_+ | ncRNA_intronic |
| CAediting_995945 | chr14_61708975_+ | ncRNA_intronic |
| CAediting_995946 | chr14_61708991_+ | ncRNA_intronic |
| CAediting_995947 | chr14_61710783_+ | ncRNA_intronic |
| CAediting_995948 | chr14_61710805_+ | ncRNA_intronic |
| CAediting_995949 | chr14_61710806_+ | ncRNA_intronic |
| CAediting_995950 | chr14_61710849_+ | ncRNA_intronic |
| CAediting_995951 | chr14_61710857_+ | ncRNA_intronic |
| CAediting_995952 | chr14_61710877_+ | ncRNA_intronic |
| CAediting_995953 | chr14_61710913_+ | ncRNA_intronic |
| CAediting_995954 | chr14_61710929_+ | ncRNA_intronic |
| CAediting_995955 | chr14_61710939_+ | ncRNA_intronic |
| CAediting_995956 | chr14_61710940_+ | ncRNA_intronic |
| CAediting_995957 | chr14_61710953_+ | ncRNA_intronic |
| CAediting_995958 | chr14_61710957_+ | ncRNA_intronic |
| CAediting_995959 | chr14_61710967_+ | ncRNA_intronic |
| CAediting_995960 | chr14_61710968_+ | ncRNA_intronic |
| CAediting_995961 | chr14_61710992_+ | ncRNA_intronic |
| CAediting_995962 | chr14_61710997_+ | ncRNA_intronic |
| CAediting_995963 | chr14_61711004_+ | ncRNA_intronic |
| CAediting_995964 | chr14_61711038_+ | ncRNA_intronic |
| CAediting_995965 | chr14_61711266_+ | ncRNA_intronic |
| CAediting_995966 | chr14_61711269_+ | ncRNA_intronic |
| CAediting_995967 | chr14_61711272_+ | ncRNA_intronic |
| CAediting_995968 | chr14_61711274_+ | ncRNA_intronic |
| CAediting_995969 | chr14_61711279_+ | ncRNA_intronic |
| CAediting_995970 | chr14_61711284_+ | ncRNA_intronic |
| CAediting_995971 | chr14_61711291_+ | ncRNA_intronic |
| CAediting_995972 | chr14_61711292_+ | ncRNA_intronic |
| CAediting_995973 | chr14_61711308_+ | ncRNA_intronic |
| CAediting_995974 | chr14_61711334_+ | ncRNA_intronic |
| CAediting_995975 | chr14_61711357_+ | ncRNA_intronic |
| CAediting_995976 | chr14_61711360_+ | ncRNA_intronic |
| CAediting_995977 | chr14_61714785_+ | ncRNA_intronic |
| CAediting_995978 | chr14_61714795_+ | ncRNA_intronic |
| CAediting_995979 | chr14_61714809_+ | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_995934 | chr14_61701841_+ | SINE | Alu | AluSx1 |
| CAediting_995935 | chr14_61701881_+ | SINE | Alu | AluSx1 |
| CAediting_995936 | chr14_61701938_+ | SINE | Alu | AluSx1 |
| CAediting_995937 | chr14_61701976_+ | SINE | Alu | AluSx1 |
| CAediting_995938 | chr14_61702199_+ | SINE | Alu | AluSx |
| CAediting_995939 | chr14_61702226_+ | SINE | Alu | AluSx |
| CAediting_995940 | chr14_61702238_+ | SINE | Alu | AluSx |
| CAediting_995941 | chr14_61702346_+ | SINE | Alu | AluSx |
| CAediting_995942 | chr14_61703111_+ | SINE | Alu | Alu |
| CAediting_995943 | chr14_61703116_+ | SINE | Alu | Alu |
| CAediting_995944 | chr14_61708967_+ | SINE | Alu | AluSp |
| CAediting_995945 | chr14_61708975_+ | SINE | Alu | AluSp |
| CAediting_995946 | chr14_61708991_+ | SINE | Alu | AluSp |
| CAediting_995947 | chr14_61710783_+ | SINE | Alu | AluSx3 |
| CAediting_995948 | chr14_61710805_+ | SINE | Alu | AluSx3 |
| CAediting_995949 | chr14_61710806_+ | SINE | Alu | AluSx3 |
| CAediting_995950 | chr14_61710849_+ | SINE | Alu | AluSx3 |
| CAediting_995951 | chr14_61710857_+ | SINE | Alu | AluSx3 |
| CAediting_995952 | chr14_61710877_+ | SINE | Alu | AluSx3 |
| CAediting_995953 | chr14_61710913_+ | SINE | Alu | AluSx3 |
| CAediting_995954 | chr14_61710929_+ | SINE | Alu | AluSx3 |
| CAediting_995955 | chr14_61710939_+ | SINE | Alu | AluSx3 |
| CAediting_995956 | chr14_61710940_+ | SINE | Alu | AluSx3 |
| CAediting_995957 | chr14_61710953_+ | SINE | Alu | AluSx3 |
| CAediting_995958 | chr14_61710957_+ | SINE | Alu | AluSx3 |
| CAediting_995959 | chr14_61710967_+ | SINE | Alu | AluSx3 |
| CAediting_995960 | chr14_61710968_+ | SINE | Alu | AluSx3 |
| CAediting_995961 | chr14_61710992_+ | SINE | Alu | AluSx3 |
| CAediting_995962 | chr14_61710997_+ | SINE | Alu | AluSx3 |
| CAediting_995963 | chr14_61711004_+ | SINE | Alu | AluSx3 |
| CAediting_995964 | chr14_61711038_+ | SINE | Alu | AluSx3 |
| CAediting_995965 | chr14_61711266_+ | SINE | Alu | AluJo |
| CAediting_995966 | chr14_61711269_+ | SINE | Alu | AluJo |
| CAediting_995967 | chr14_61711272_+ | SINE | Alu | AluJo |
| CAediting_995968 | chr14_61711274_+ | SINE | Alu | AluJo |
| CAediting_995969 | chr14_61711279_+ | SINE | Alu | AluJo |
| CAediting_995970 | chr14_61711284_+ | SINE | Alu | AluJo |
| CAediting_995971 | chr14_61711291_+ | SINE | Alu | AluJo |
| CAediting_995972 | chr14_61711292_+ | SINE | Alu | AluJo |
| CAediting_995973 | chr14_61711308_+ | SINE | Alu | AluJo |
| CAediting_995974 | chr14_61711334_+ | SINE | Alu | AluJo |
| CAediting_995975 | chr14_61711357_+ | SINE | Alu | AluJo |
| CAediting_995976 | chr14_61711360_+ | SINE | Alu | AluJo |
| CAediting_995977 | chr14_61714785_+ | SINE | Alu | AluSq2 |
| CAediting_995978 | chr14_61714795_+ | SINE | Alu | AluSq2 |
| CAediting_995979 | chr14_61714809_+ | SINE | Alu | AluSq2 |
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RNA A-to-I editing events in the alternative splicing sites for HIF1A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000100644.15.HIF1A. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000100644.15.HIF1A. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HIF1A |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for HIF1A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for HIF1A |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_980496 | chr14_31014685_- | ENSG00000100644.15 | ENST00000337138 | hsa-miR-624-3p | 61747926 | 61747932 | 7mer-m8 | 61747915 | 61747933 | 152 | -17.13 |
| CAediting_980496 | chr14_31014685_- | ENSG00000100644.15 | ENST00000394997 | hsa-miR-624-3p | 61747926 | 61747932 | 7mer-m8 | 61747915 | 61747933 | 152 | -17.13 |
| CAediting_980496 | chr14_31014685_- | ENSG00000100644.15 | ENST00000323441 | hsa-miR-624-3p | 61747926 | 61747932 | 7mer-m8 | 61747915 | 61747933 | 152 | -17.13 |
| CAediting_980496 | chr14_31014685_- | ENSG00000100644.15 | ENST00000539097 | hsa-miR-624-3p | 61747926 | 61747932 | 7mer-m8 | 61747915 | 61747933 | 152 | -17.13 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000100644.15 | ENST00000337138 | hsa-miR-320e | 61747839 | 61747846 | 8mer-1a | 61747829 | 61747846 | 140 | -14.37 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000100644.15 | ENST00000394997 | hsa-miR-320e | 61747839 | 61747846 | 8mer-1a | 61747829 | 61747846 | 140 | -14.37 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000100644.15 | ENST00000323441 | hsa-miR-320e | 61747839 | 61747846 | 8mer-1a | 61747829 | 61747846 | 140 | -14.37 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000100644.15 | ENST00000539097 | hsa-miR-320e | 61747839 | 61747846 | 8mer-1a | 61747829 | 61747846 | 140 | -14.37 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for HIF1A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for HIF1A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for HIF1A |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for HIF1A |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for HIF1A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| HIF1A | Q16665 | DB01275 | Hydralazine | Hypoxia-inducible factor 1-alpha | SmallMoleculeDrug | approved |
| HIF1A | Q16665 | DB01136 | Carvedilol | Hypoxia-inducible factor 1-alpha | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for HIF1A |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HIF1A | C0027055 | Myocardial Reperfusion Injury | 2 | CTD_human |
| HIF1A | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
| HIF1A | C0002793 | Anaplasia | 1 | CTD_human |
| HIF1A | C0004114 | Astrocytoma | 1 | CTD_human |
| HIF1A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| HIF1A | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| HIF1A | C0007097 | Carcinoma | 1 | CTD_human |
| HIF1A | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
| HIF1A | C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | CTD_human |
| HIF1A | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| HIF1A | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| HIF1A | C0007786 | Brain Ischemia | 1 | CTD_human |
| HIF1A | C0008312 | Primary biliary cirrhosis | 1 | CTD_human |
| HIF1A | C0008313 | Cholangitis, Sclerosing | 1 | CTD_human |
| HIF1A | C0011570 | Mental Depression | 1 | PSYGENET |
| HIF1A | C0017636 | Glioblastoma | 1 | CTD_human |
| HIF1A | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| HIF1A | C0018800 | Cardiomegaly | 1 | CTD_human |
| HIF1A | C0018801 | Heart failure | 1 | CTD_human |
| HIF1A | C0018802 | Congestive heart failure | 1 | CTD_human |
| HIF1A | C0020507 | Hyperplasia | 1 | CTD_human |
| HIF1A | C0020538 | Hypertensive disease | 1 | CTD_human |
| HIF1A | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| HIF1A | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
| HIF1A | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| HIF1A | C0024115 | Lung diseases | 1 | CTD_human |
| HIF1A | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| HIF1A | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| HIF1A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| HIF1A | C0037286 | Skin Neoplasms | 1 | CTD_human |
| HIF1A | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| HIF1A | C0041696 | Unipolar Depression | 1 | PSYGENET |
| HIF1A | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
| HIF1A | C0178540 | Cerebral Hypoxia-Ischemia | 1 | CTD_human |
| HIF1A | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| HIF1A | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| HIF1A | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| HIF1A | C0205699 | Carcinomatosis | 1 | CTD_human |
| HIF1A | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
| HIF1A | C0206734 | Hemangioblastoma | 1 | CTD_human |
| HIF1A | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
| HIF1A | C0235874 | Disease Exacerbation | 1 | CTD_human |
| HIF1A | C0238065 | Secondary Biliary Cholangitis | 1 | CTD_human |
| HIF1A | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| HIF1A | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
| HIF1A | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
| HIF1A | C0334579 | Anaplastic astrocytoma | 1 | CTD_human |
| HIF1A | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
| HIF1A | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
| HIF1A | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
| HIF1A | C0334583 | Pilocytic Astrocytoma | 1 | CTD_human |
| HIF1A | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
| HIF1A | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
| HIF1A | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human |
| HIF1A | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
| HIF1A | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| HIF1A | C0525045 | Mood Disorders | 1 | PSYGENET |
| HIF1A | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
| HIF1A | C0549473 | Thyroid carcinoma | 1 | CTD_human |
| HIF1A | C0566602 | Primary sclerosing cholangitis | 1 | CTD_human |
| HIF1A | C0678222 | Breast Carcinoma | 1 | CTD_human |
| HIF1A | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
| HIF1A | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
| HIF1A | C0751692 | Multiple Hemangioblastomas | 1 | CTD_human |
| HIF1A | C0752304 | Hypoxic-Ischemic Encephalopathy | 1 | CTD_human |
| HIF1A | C0752305 | Anoxic-Ischemic Encephalopathy | 1 | CTD_human |
| HIF1A | C0752306 | Anoxia-Ischemia, Brain | 1 | CTD_human |
| HIF1A | C0752307 | Anoxia-Ischemia, Cerebral | 1 | CTD_human |
| HIF1A | C0752308 | Hypoxia-Ischemia, Brain | 1 | CTD_human |
| HIF1A | C0917798 | Cerebral Ischemia | 1 | CTD_human |
| HIF1A | C1176475 | Ductal Carcinoma | 1 | CTD_human |
| HIF1A | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| HIF1A | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| HIF1A | C1332347 | Atypical Ductal Breast Hyperplasia | 1 | CTD_human |
| HIF1A | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
| HIF1A | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
| HIF1A | C1449862 | Micronuclei, Genotoxicant-Induced | 1 | CTD_human |
| HIF1A | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| HIF1A | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
| HIF1A | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
| HIF1A | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human |
| HIF1A | C1959583 | Myocardial Failure | 1 | CTD_human |
| HIF1A | C1961112 | Heart Decompensation | 1 | CTD_human |
| HIF1A | C4551595 | Biliary Cirrhosis, Primary, 1 | 1 | CTD_human |
| HIF1A | C4551637 | Erythrocytosis familial, 1 | 1 | GENOMICS_ENGLAND |
| HIF1A | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| HIF1A | C4721508 | Hamman-Rich Disease | 1 | CTD_human |
| HIF1A | C4721509 | Usual Interstitial Pneumonia | 1 | CTD_human |
| HIF1A | C4721952 | Familial Idiopathic Pulmonary Fibrosis | 1 | CTD_human |
