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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: CFH (CAeditome ID:3075) |
Gene summary for CFH |
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Gene information | Gene symbol | CFH | Gene ID | 3075 |
Gene name | complement factor H | |
Synonyms | AHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS | |
Cytomap | 1q31.3 | |
Type of gene | protein-coding | |
Description | complement factor HH factor 1 (complement)H factor 2 (complement)adrenomedullin binding proteinage-related maculopathy susceptibility 1beta-1-H-globulinbeta-1Hfactor Hfactor H-like 1 | |
Modification date | 20210531 | |
UniProtAcc | P08603 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
CFH | GO:0030449 | Complement factor H | 25284781 |
CFH | GO:1903659 | Complement factor H | 25284781 |
CFH | GO:0008201 | Complement factor H | 22471560 |
CFH | GO:0043395 | Complement factor H | 22471560 |
CFH | GO:0006956 | Complement factor H | 24835392 |
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RNA A-to-I events for CFH |
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CAediting_128181(196656224, +), CAediting_128182(196666691, +), CAediting_128183(196666733, +), CAediting_128184(196666737, +), CAediting_128185(196695109, +), CAediting_128186(196695408, +), CAediting_128187(196696650, +), CAediting_128188(196696762, +), CAediting_128189(196696772, +), CAediting_128190(196696844, +), CAediting_128191(196696858, +), CAediting_128192(196696860, +), CAediting_128193(196696861, +), CAediting_128194(196697565, +), CAediting_128195(196698066, +), CAediting_128196(196698108, +), CAediting_128197(196700412, +), CAediting_128198(196700566, +), CAediting_128199(196700569, +), CAediting_128200(196700673, +), CAediting_128201(196703721, +), CAediting_128202(196703729, +), CAediting_128203(196703730, +), CAediting_128204(196703735, +), CAediting_128205(196703738, +), CAediting_128206(196703746, +), CAediting_128207(196703760, +), CAediting_128208(196703765, +), CAediting_128209(196703768, +), CAediting_128210(196703797, +), CAediting_128211(196703799, +), CAediting_128212(196703801, +), CAediting_128213(196703805, +), CAediting_128214(196703806, +), CAediting_128215(196703807, +), CAediting_128216(196703829, +), CAediting_128217(196703837, +), CAediting_128218(196703869, +), CAediting_128219(196703873, +), CAediting_128220(196703916, +), CAediting_128221(196703935, +), CAediting_128222(196704097, +), CAediting_128223(196704101, +), CAediting_128224(196704139, +), CAediting_128225(196704142, +), CAediting_128226(196704152, +), CAediting_128227(196704212, +), CAediting_128228(196704224, +), CAediting_128229(196704234, +), CAediting_128230(196704260, +), CAediting_128231(196704261, +), CAediting_128232(196704267, +), CAediting_128233(196704269, +), CAediting_128234(196704278, +), CAediting_128235(196704280, +), CAediting_128236(196704292, +), CAediting_128237(196704333, +), CAediting_128238(196704334, +), CAediting_128239(196704357, +), CAediting_128240(196737639, +), |
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RNA editing positional annotations for CFH using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_128240 | chr1_196737639_+ | nonsynonymous SNV | ENST00000367429.7 | c.A2761G | p.S921G | D | . | D |
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CAeditome ID | Position | Variant type |
CAediting_128181 | chr1_196656224_+ | ncRNA_intronic |
CAediting_128182 | chr1_196666691_+ | ncRNA_intronic |
CAediting_128183 | chr1_196666733_+ | ncRNA_intronic |
CAediting_128184 | chr1_196666737_+ | ncRNA_intronic |
CAediting_128185 | chr1_196695109_+ | ncRNA_intronic |
CAediting_128186 | chr1_196695408_+ | ncRNA_intronic |
CAediting_128187 | chr1_196696650_+ | ncRNA_intronic |
CAediting_128188 | chr1_196696762_+ | ncRNA_intronic |
CAediting_128189 | chr1_196696772_+ | ncRNA_intronic |
CAediting_128190 | chr1_196696844_+ | ncRNA_intronic |
CAediting_128191 | chr1_196696858_+ | ncRNA_intronic |
CAediting_128192 | chr1_196696860_+ | ncRNA_intronic |
CAediting_128193 | chr1_196696861_+ | ncRNA_intronic |
CAediting_128194 | chr1_196697565_+ | ncRNA_intronic |
CAediting_128195 | chr1_196698066_+ | ncRNA_intronic |
CAediting_128196 | chr1_196698108_+ | ncRNA_intronic |
CAediting_128197 | chr1_196700412_+ | ncRNA_intronic |
CAediting_128198 | chr1_196700566_+ | ncRNA_intronic |
CAediting_128199 | chr1_196700569_+ | ncRNA_intronic |
CAediting_128200 | chr1_196700673_+ | ncRNA_intronic |
CAediting_128201 | chr1_196703721_+ | ncRNA_intronic |
CAediting_128202 | chr1_196703729_+ | ncRNA_intronic |
CAediting_128203 | chr1_196703730_+ | ncRNA_intronic |
CAediting_128204 | chr1_196703735_+ | ncRNA_intronic |
CAediting_128205 | chr1_196703738_+ | ncRNA_intronic |
CAediting_128206 | chr1_196703746_+ | ncRNA_intronic |
CAediting_128207 | chr1_196703760_+ | ncRNA_intronic |
CAediting_128208 | chr1_196703765_+ | ncRNA_intronic |
CAediting_128209 | chr1_196703768_+ | ncRNA_intronic |
CAediting_128210 | chr1_196703797_+ | ncRNA_intronic |
CAediting_128211 | chr1_196703799_+ | ncRNA_intronic |
CAediting_128212 | chr1_196703801_+ | ncRNA_intronic |
CAediting_128213 | chr1_196703805_+ | ncRNA_intronic |
CAediting_128214 | chr1_196703806_+ | ncRNA_intronic |
CAediting_128215 | chr1_196703807_+ | ncRNA_intronic |
CAediting_128216 | chr1_196703829_+ | ncRNA_intronic |
CAediting_128217 | chr1_196703837_+ | ncRNA_intronic |
CAediting_128218 | chr1_196703869_+ | ncRNA_intronic |
CAediting_128219 | chr1_196703873_+ | ncRNA_intronic |
CAediting_128220 | chr1_196703916_+ | ncRNA_intronic |
CAediting_128221 | chr1_196703935_+ | ncRNA_intronic |
CAediting_128222 | chr1_196704097_+ | ncRNA_intronic |
CAediting_128223 | chr1_196704101_+ | ncRNA_intronic |
CAediting_128224 | chr1_196704139_+ | ncRNA_intronic |
CAediting_128225 | chr1_196704142_+ | ncRNA_intronic |
CAediting_128226 | chr1_196704152_+ | ncRNA_intronic |
CAediting_128227 | chr1_196704212_+ | ncRNA_intronic |
CAediting_128228 | chr1_196704224_+ | ncRNA_intronic |
CAediting_128229 | chr1_196704234_+ | ncRNA_intronic |
CAediting_128230 | chr1_196704260_+ | ncRNA_intronic |
CAediting_128231 | chr1_196704261_+ | ncRNA_intronic |
CAediting_128232 | chr1_196704267_+ | ncRNA_intronic |
CAediting_128233 | chr1_196704269_+ | ncRNA_intronic |
CAediting_128234 | chr1_196704278_+ | ncRNA_intronic |
CAediting_128235 | chr1_196704280_+ | ncRNA_intronic |
CAediting_128236 | chr1_196704292_+ | ncRNA_intronic |
CAediting_128237 | chr1_196704333_+ | ncRNA_intronic |
CAediting_128238 | chr1_196704334_+ | ncRNA_intronic |
CAediting_128239 | chr1_196704357_+ | ncRNA_intronic |
CAediting_128240 | chr1_196737639_+ | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_128181 | chr1_196656224_+ | SINE | Alu | AluSg |
CAediting_128182 | chr1_196666691_+ | SINE | Alu | AluY |
CAediting_128183 | chr1_196666733_+ | SINE | Alu | AluY |
CAediting_128184 | chr1_196666737_+ | SINE | Alu | AluY |
CAediting_128185 | chr1_196695109_+ | LINE | L1 | L1PA8 |
CAediting_128186 | chr1_196695408_+ | LINE | L1 | L1PA8 |
CAediting_128187 | chr1_196696650_+ | LINE | L1 | L1PA4 |
CAediting_128188 | chr1_196696762_+ | LINE | L1 | L1PA4 |
CAediting_128189 | chr1_196696772_+ | LINE | L1 | L1PA4 |
CAediting_128190 | chr1_196696844_+ | LINE | L1 | L1PA4 |
CAediting_128191 | chr1_196696858_+ | LINE | L1 | L1PA4 |
CAediting_128192 | chr1_196696860_+ | LINE | L1 | L1PA4 |
CAediting_128193 | chr1_196696861_+ | LINE | L1 | L1PA4 |
CAediting_128194 | chr1_196697565_+ | LINE | L1 | L1PA4 |
CAediting_128195 | chr1_196698066_+ | LINE | L1 | L1PA4 |
CAediting_128196 | chr1_196698108_+ | LINE | L1 | L1PA4 |
CAediting_128197 | chr1_196700412_+ | SINE | Alu | AluSz |
CAediting_128198 | chr1_196700566_+ | SINE | Alu | AluSz |
CAediting_128199 | chr1_196700569_+ | SINE | Alu | AluSz |
CAediting_128200 | chr1_196700673_+ | SINE | Alu | AluSz |
CAediting_128201 | chr1_196703721_+ | SINE | Alu | AluY |
CAediting_128202 | chr1_196703729_+ | SINE | Alu | AluY |
CAediting_128203 | chr1_196703730_+ | SINE | Alu | AluY |
CAediting_128204 | chr1_196703735_+ | SINE | Alu | AluY |
CAediting_128205 | chr1_196703738_+ | SINE | Alu | AluY |
CAediting_128206 | chr1_196703746_+ | SINE | Alu | AluY |
CAediting_128207 | chr1_196703760_+ | SINE | Alu | AluY |
CAediting_128208 | chr1_196703765_+ | SINE | Alu | AluY |
CAediting_128209 | chr1_196703768_+ | SINE | Alu | AluY |
CAediting_128210 | chr1_196703797_+ | SINE | Alu | AluY |
CAediting_128211 | chr1_196703799_+ | SINE | Alu | AluY |
CAediting_128212 | chr1_196703801_+ | SINE | Alu | AluY |
CAediting_128213 | chr1_196703805_+ | SINE | Alu | AluY |
CAediting_128214 | chr1_196703806_+ | SINE | Alu | AluY |
CAediting_128215 | chr1_196703807_+ | SINE | Alu | AluY |
CAediting_128216 | chr1_196703829_+ | SINE | Alu | AluY |
CAediting_128217 | chr1_196703837_+ | SINE | Alu | AluY |
CAediting_128218 | chr1_196703869_+ | SINE | Alu | AluY |
CAediting_128219 | chr1_196703873_+ | SINE | Alu | AluY |
CAediting_128220 | chr1_196703916_+ | SINE | Alu | AluY |
CAediting_128221 | chr1_196703935_+ | SINE | Alu | AluY |
CAediting_128222 | chr1_196704097_+ | SINE | Alu | AluSx |
CAediting_128223 | chr1_196704101_+ | SINE | Alu | AluSx |
CAediting_128224 | chr1_196704139_+ | SINE | Alu | AluSx |
CAediting_128225 | chr1_196704142_+ | SINE | Alu | AluSx |
CAediting_128226 | chr1_196704152_+ | SINE | Alu | AluSx |
CAediting_128227 | chr1_196704212_+ | SINE | Alu | AluSx |
CAediting_128228 | chr1_196704224_+ | SINE | Alu | AluSx |
CAediting_128229 | chr1_196704234_+ | SINE | Alu | AluSx |
CAediting_128230 | chr1_196704260_+ | SINE | Alu | AluSx |
CAediting_128231 | chr1_196704261_+ | SINE | Alu | AluSx |
CAediting_128232 | chr1_196704267_+ | SINE | Alu | AluSx |
CAediting_128233 | chr1_196704269_+ | SINE | Alu | AluSx |
CAediting_128234 | chr1_196704278_+ | SINE | Alu | AluSx |
CAediting_128235 | chr1_196704280_+ | SINE | Alu | AluSx |
CAediting_128236 | chr1_196704292_+ | SINE | Alu | AluSx |
CAediting_128237 | chr1_196704333_+ | SINE | Alu | AluSx |
CAediting_128238 | chr1_196704334_+ | SINE | Alu | AluSx |
CAediting_128239 | chr1_196704357_+ | SINE | Alu | AluSx |
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RNA A-to-I editing events in the alternative splicing sites for CFH |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CFH |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for CFH |
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The effects of the RNA editing to the miRNA binding sites for CFH |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229415 | chr17_67471547_+ | ENSG00000000971.14 | ENST00000630130 | hsa-miR-548aa | 196701529 | 196701535 | 7mer-m8 | 196701512 | 196701536 | 160 | -21.84 |
CAediting_228905 | chr2_188297554_+ | ENSG00000000971.14 | ENST00000630130 | hsa-miR-561-3p | 196701545 | 196701551 | 7mer-m8 | 196701531 | 196701552 | 168 | -15.18 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000000971.14 | ENST00000359637 | hsa-miR-548aa | 196701529 | 196701535 | 7mer-m8 | 196701512 | 196701536 | 160 | -21.84 |
CAediting_228905 | chr2_188297554_+ | ENSG00000000971.14 | ENST00000359637 | hsa-miR-561-3p | 196701545 | 196701551 | 7mer-m8 | 196701531 | 196701552 | 168 | -15.18 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1368054 | chr19_46709310_- | ENSG00000000971.14 | ENST00000630130 | hsa-miR-320e | 196701356 | 196701362 | 7mer-m8 | 196701346 | 196701363 | 147 | -15.06 |
CAediting_1368054 | chr19_46709310_- | ENSG00000000971.14 | ENST00000359637 | hsa-miR-320e | 196701356 | 196701362 | 7mer-m8 | 196701346 | 196701363 | 147 | -15.06 |
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The effects of the RNA editing to the stability of the RNA structures for CFH |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000367429.7 | protein_coding | ![]() | ![]() |
ENST00000466229.4 | retained_intron | ![]() | ![]() |
ENST00000470918.1 | retained_intron | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_128240 | ENST00000367429.7 | chr1_196737639_+ | -1046.40 | -1044.10 | -1046.40 |
CAediting_128240 | ENST00000466229.4 | chr1_196737639_+ | -1686.40 | -1685.40 | -1686.40 |
CAediting_128240 | ENST00000470918.1 | chr1_196737639_+ | -168.60 | -169.50 | -168.60 |
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Relation with ADAR for CFH |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for CFH |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for CFH |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for CFH |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
CFH | P08603 | DB14548 | Zinc sulfate, unspecified form | Complement factor H | SmallMoleculeDrug | approved|experimental |
CFH | P08603 | DB01593 | Zinc | Complement factor H | SmallMoleculeDrug | approved|investigational |
CFH | P08603 | DB09130 | Copper | Complement factor H | SmallMoleculeDrug | approved|investigational |
CFH | P08603 | DB14487 | Zinc acetate | Complement factor H | SmallMoleculeDrug | approved|investigational |
CFH | P08603 | DB14533 | Zinc chloride | Complement factor H | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for CFH |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
CFH | C2749604 | HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 | 11 | GENOMICS_ENGLAND;UNIPROT |
CFH | C0398777 | Complement Factor H Deficiency | 9 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
CFH | C0242383 | Age related macular degeneration | 6 | CTD_human |
CFH | C0268743 | Membranoproliferative Glomerulonephritis, Type II | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
CFH | C0162739 | HELLP Syndrome | 2 | ORPHANET |
CFH | C0268742 | Membranoproliferative Glomerulonephritis, Type I | 2 | CTD_human;ORPHANET |
CFH | C1720821 | Membranoproliferative Glomerulonephritis, Type III | 2 | CTD_human;ORPHANET |
CFH | C2931788 | Atypical Hemolytic Uremic Syndrome | 2 | CTD_human |
CFH | C0003257 | Antibody Deficiency Syndrome | 1 | CTD_human |
CFH | C0017662 | Glomerulonephritis, Membranoproliferative | 1 | CTD_human |
CFH | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
CFH | C0021051 | Immunologic Deficiency Syndromes | 1 | CTD_human |
CFH | C0025303 | Meningococcal Infections | 1 | CTD_human |
CFH | C0272242 | Complement deficiency disease | 1 | GENOMICS_ENGLAND |
CFH | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
CFH | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
CFH | C1832174 | DOYNE HONEYCOMB RETINAL DYSTROPHY | 1 | ORPHANET |
CFH | C1852020 | Malattia Leventinese | 1 | ORPHANET |
CFH | C1852021 | Drusen, Radial, Autosomal Dominant | 1 | ORPHANET |
CFH | C1853147 | MACULAR DEGENERATION, AGE-RELATED, 4 (disorder) | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
CFH | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
CFH | C4087273 | C3 glomerulopathy | 1 | GENOMICS_ENGLAND |
CFH | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
CFH | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |