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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ANXA1 (CAeditome ID:301)

Gene summary for ANXA1

check button Gene summary
Gene informationGene symbol

ANXA1

Gene ID

301

Gene nameannexin A1
SynonymsANX1|LPC1
Cytomap

9q21.13

Type of geneprotein-coding
Descriptionannexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9epididymis secretory sperm binding proteinphospholipase A2 inhibitory protein
Modification date20210518
UniProtAcc

P04083

Context- 33948376(New insight into the role of ANXA1 in melanoma progression: involvement of stromal expression in dissemination)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ANXA1

GO:0005884

Annexin A1

22773844

ANXA1

GO:0005544

Annexin A1

2138016

ANXA1

GO:0019834

Annexin A1

2936963

ANXA1

GO:0019834

Annexin A1

3013422

ANXA1

GO:0002548

Annexin A1

15187149

ANXA1

GO:0007187

Annexin A1

25664854

ANXA1

GO:0008360

Annexin A1

15187149

ANXA1

GO:0018149

Annexin A1

10908733

ANXA1

GO:0030216

Annexin A1

10908733

ANXA1

GO:0031340

Annexin A1

2138016

ANXA1

GO:0031532

Annexin A1

15187149

ANXA1

GO:0032743

Annexin A1

17008549

ANXA1

GO:0035924

Annexin A1

22773844

ANXA1

GO:0042102

Annexin A1

17008549

ANXA1

GO:0045627

Annexin A1

17008549

ANXA1

GO:0045629

Annexin A1

17008549

ANXA1

GO:0071385

Annexin A1

2936963

ANXA1

GO:0071621

Annexin A1

15187149

ANXA1

GO:0090050

Annexin A1

22773844

ANXA1

GO:0090303

Annexin A1

25664854

ANXA1

GO:0001533

Annexin A1

10908733

ANXA1

GO:0005615

Annexin A1

17008549

ANXA1

GO:0005615

Annexin A1

19625660

ANXA1

GO:0005615

Annexin A1

25664854

ANXA1

GO:0005634

Annexin A1

22056994

ANXA1

GO:0005654

Annexin A1

0000052

ANXA1

GO:0005737

Annexin A1

17008549

ANXA1

GO:0005737

Annexin A1

19625660

ANXA1

GO:0005737

Annexin A1

22056994

ANXA1

GO:0005768

Annexin A1

18767904

ANXA1

GO:0005829

Annexin A1

0000052

ANXA1

GO:0005886

Annexin A1

0000052

ANXA1

GO:0009986

Annexin A1

22056994

ANXA1

GO:0019898

Annexin A1

17008549

ANXA1

GO:0031232

Annexin A1

19625660

ANXA1

GO:0070062

Annexin A1

25664854


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RNA A-to-I events for ANXA1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000135046.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_689995(73154459, +), CAediting_689996(73154491, +), CAediting_689997(73154515, +), CAediting_689998(73154538, +), CAediting_689999(73154556, +), CAediting_690000(73154565, +), CAediting_690001(73154578, +), CAediting_690002(73154613, +), CAediting_690003(73154622, +), CAediting_690004(73154626, +), CAediting_690005(73154639, +), CAediting_690006(73154648, +), CAediting_690007(73154660, +), CAediting_690008(73154661, +), CAediting_690009(73154674, +), CAediting_690010(73154677, +), CAediting_690011(73154678, +), CAediting_690012(73154686, +), CAediting_690013(73154701, +), CAediting_690014(73154726, +), CAediting_690015(73157385, +), CAediting_690016(73157429, +), CAediting_690017(73157434, +), CAediting_690018(73157452, +), CAediting_690019(73157453, +), CAediting_690020(73157454, +), CAediting_690021(73157468, +), CAediting_690022(73157478, +), CAediting_690023(73157489, +), CAediting_690024(73157493, +), CAediting_690025(73157494, +), CAediting_690026(73157495, +), CAediting_690027(73157496, +), CAediting_690028(73157498, +), CAediting_690029(73157501, +), CAediting_690030(73157502, +), CAediting_690031(73157503, +), CAediting_690032(73157504, +), CAediting_690033(73157533, +), CAediting_690034(73157534, +), CAediting_690035(73157539, +), CAediting_690036(73157560, +), CAediting_690037(73157566, +), CAediting_690038(73157574, +), CAediting_690039(73157575, +), CAediting_690040(73157611, +),

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RNA editing positional annotations for ANXA1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_689995chr9_73154459_+ncRNA_intronic
CAediting_689996chr9_73154491_+ncRNA_intronic
CAediting_689997chr9_73154515_+ncRNA_intronic
CAediting_689998chr9_73154538_+ncRNA_intronic
CAediting_689999chr9_73154556_+ncRNA_intronic
CAediting_690000chr9_73154565_+ncRNA_intronic
CAediting_690001chr9_73154578_+ncRNA_intronic
CAediting_690002chr9_73154613_+ncRNA_intronic
CAediting_690003chr9_73154622_+ncRNA_intronic
CAediting_690004chr9_73154626_+ncRNA_intronic
CAediting_690005chr9_73154639_+ncRNA_intronic
CAediting_690006chr9_73154648_+ncRNA_intronic
CAediting_690007chr9_73154660_+ncRNA_intronic
CAediting_690008chr9_73154661_+ncRNA_intronic
CAediting_690009chr9_73154674_+ncRNA_intronic
CAediting_690010chr9_73154677_+ncRNA_intronic
CAediting_690011chr9_73154678_+ncRNA_intronic
CAediting_690012chr9_73154686_+ncRNA_intronic
CAediting_690013chr9_73154701_+ncRNA_intronic
CAediting_690014chr9_73154726_+ncRNA_intronic
CAediting_690015chr9_73157385_+ncRNA_intronic
CAediting_690016chr9_73157429_+ncRNA_intronic
CAediting_690017chr9_73157434_+ncRNA_intronic
CAediting_690018chr9_73157452_+ncRNA_intronic
CAediting_690019chr9_73157453_+ncRNA_intronic
CAediting_690020chr9_73157454_+ncRNA_intronic
CAediting_690021chr9_73157468_+ncRNA_intronic
CAediting_690022chr9_73157478_+ncRNA_intronic
CAediting_690023chr9_73157489_+ncRNA_intronic
CAediting_690024chr9_73157493_+ncRNA_intronic
CAediting_690025chr9_73157494_+ncRNA_intronic
CAediting_690026chr9_73157495_+ncRNA_intronic
CAediting_690027chr9_73157496_+ncRNA_intronic
CAediting_690028chr9_73157498_+ncRNA_intronic
CAediting_690029chr9_73157501_+ncRNA_intronic
CAediting_690030chr9_73157502_+ncRNA_intronic
CAediting_690031chr9_73157503_+ncRNA_intronic
CAediting_690032chr9_73157504_+ncRNA_intronic
CAediting_690033chr9_73157533_+ncRNA_intronic
CAediting_690034chr9_73157534_+ncRNA_intronic
CAediting_690035chr9_73157539_+ncRNA_intronic
CAediting_690036chr9_73157560_+ncRNA_intronic
CAediting_690037chr9_73157566_+ncRNA_intronic
CAediting_690038chr9_73157574_+ncRNA_intronic
CAediting_690039chr9_73157575_+ncRNA_intronic
CAediting_690040chr9_73157611_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_689995chr9_73154459_+SINEAluAluSz6
CAediting_689996chr9_73154491_+SINEAluAluSz6
CAediting_689997chr9_73154515_+SINEAluAluSz6
CAediting_689998chr9_73154538_+SINEAluAluSz6
CAediting_689999chr9_73154556_+SINEAluAluSz6
CAediting_690000chr9_73154565_+SINEAluAluSz6
CAediting_690001chr9_73154578_+SINEAluAluSz6
CAediting_690002chr9_73154613_+SINEAluAluSz6
CAediting_690003chr9_73154622_+SINEAluAluSz6
CAediting_690004chr9_73154626_+SINEAluAluSz6
CAediting_690005chr9_73154639_+SINEAluAluSz6
CAediting_690006chr9_73154648_+SINEAluAluSz6
CAediting_690007chr9_73154660_+SINEAluAluSz6
CAediting_690008chr9_73154661_+SINEAluAluSz6
CAediting_690009chr9_73154674_+SINEAluAluSz6
CAediting_690010chr9_73154677_+SINEAluAluSz6
CAediting_690011chr9_73154678_+SINEAluAluSz6
CAediting_690012chr9_73154686_+SINEAluAluSz6
CAediting_690013chr9_73154701_+SINEAluAluSz6
CAediting_690014chr9_73154726_+SINEAluAluSz6
CAediting_690015chr9_73157385_+SINEAluAluSx1
CAediting_690016chr9_73157429_+SINEAluAluSx1
CAediting_690017chr9_73157434_+SINEAluAluSx1
CAediting_690018chr9_73157452_+SINEAluAluSx1
CAediting_690019chr9_73157453_+SINEAluAluSx1
CAediting_690020chr9_73157454_+SINEAluAluSx1
CAediting_690021chr9_73157468_+SINEAluAluSx1
CAediting_690022chr9_73157478_+SINEAluAluSx1
CAediting_690023chr9_73157489_+SINEAluAluSx1
CAediting_690024chr9_73157493_+SINEAluAluSx1
CAediting_690025chr9_73157494_+SINEAluAluSx1
CAediting_690026chr9_73157495_+SINEAluAluSx1
CAediting_690027chr9_73157496_+SINEAluAluSx1
CAediting_690028chr9_73157498_+SINEAluAluSx1
CAediting_690029chr9_73157501_+SINEAluAluSx1
CAediting_690030chr9_73157502_+SINEAluAluSx1
CAediting_690031chr9_73157503_+SINEAluAluSx1
CAediting_690032chr9_73157504_+SINEAluAluSx1
CAediting_690033chr9_73157533_+SINEAluAluSx1
CAediting_690034chr9_73157534_+SINEAluAluSx1
CAediting_690035chr9_73157539_+SINEAluAluSx1
CAediting_690036chr9_73157560_+SINEAluAluSx1
CAediting_690037chr9_73157566_+SINEAluAluSx1
CAediting_690038chr9_73157574_+SINEAluAluSx1
CAediting_690039chr9_73157575_+SINEAluAluSx1
CAediting_690040chr9_73157611_+SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for ANXA1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_689995chr9_73154459_+73154440:731544623SS0+1iTTCTTTCTTTCTTCCCGACAGAG-8.25TTCTTTCTTTCTTCCCGACGGAG0.5
MEX_2CAediting_689995chr9_73154459_+73154440:731544623SS0+1iTTCTTTCTTTCTTCCCGACAGAG-8.25TTCTTTCTTTCTTCCCGACGGAG0.5
ESCAediting_689998chr9_73154538_+73154531:731545395SS0+5iTGGGTTCAA-10.77TGGGTTCGA-3.14
ESCAediting_689998chr9_73154538_+73154537:731545455SS2+0iCAAGTGATT0.45CGAGTGATT-1.81
IRCAediting_689998chr9_73154538_+73154531:731545395SS0+5iTGGGTTCAA-10.77TGGGTTCGA-3.14
IRCAediting_689998chr9_73154538_+73154537:731545455SS2+0iCAAGTGATT0.45CGAGTGATT-1.81
MEX_2CAediting_689998chr9_73154538_+73154531:731545395SS0+5iTGGGTTCAA-10.77TGGGTTCGA-3.14
MEX_2CAediting_689998chr9_73154538_+73154537:731545455SS2+0iCAAGTGATT0.45CGAGTGATT-1.81
ESCAediting_690003chr9_73154622_+73154617:731546255SS0+3iTTGGTAGAG-1.36TTGGTGGAG-6.9
IRCAediting_690003chr9_73154622_+73154617:731546255SS0+3iTTGGTAGAG-1.36TTGGTGGAG-6.9
MEX_2CAediting_690003chr9_73154622_+73154617:731546255SS0+3iTTGGTAGAG-1.36TTGGTGGAG-6.9
ESCAediting_690009chr9_73154674_+73154672:731546805SS1+0iCAAGTAATC0.66CAGGTAATC6.99
IRCAediting_690009chr9_73154674_+73154672:731546805SS1+0iCAAGTAATC0.66CAGGTAATC6.99
MEX_2CAediting_690009chr9_73154674_+73154672:731546805SS1+0iCAAGTAATC0.66CAGGTAATC6.99
ESCAediting_690010chr9_73154677_+73154672:731546805SS0+3iCAAGTAATC0.66CAAGTGATC-2.84
IRCAediting_690010chr9_73154677_+73154672:731546805SS0+3iCAAGTAATC0.66CAAGTGATC-2.84
MEX_2CAediting_690010chr9_73154677_+73154672:731546805SS0+3iCAAGTAATC0.66CAAGTGATC-2.84
ESCAediting_690011chr9_73154678_+73154672:731546805SS0+4iCAAGTAATC0.66CAAGTAGTC-3.19
IRCAediting_690011chr9_73154678_+73154672:731546805SS0+4iCAAGTAATC0.66CAAGTAGTC-3.19
MEX_2CAediting_690011chr9_73154678_+73154672:731546805SS0+4iCAAGTAATC0.66CAAGTAGTC-3.19

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000135046.12.ANXA1.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000135046.12.ANXA1.
boxplot

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ANXA1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
OV.CAediting_690015.ENSG00000135046.ANXA1.png
Soverview

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Protein coding region RNA A-to-I editings for ANXA1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ANXA1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ANXA1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ANXA1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for ANXA1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for ANXA1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
ESCACAediting_690015chr9_73157385_+0.02355949791553570.04718569.30567

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RelatedDrugs for ANXA1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
ANXA1P04083DB00288AmcinonideAnnexin A1 SmallMoleculeDrugapproved
ANXA1P04083DB01013Clobetasol propionateAnnexin A1 SmallMoleculeDrugapproved
ANXA1P04083DB01222BudesonideAnnexin A1 SmallMoleculeDrugapproved
ANXA1P04083DB00591Fluocinolone acetonideAnnexin A1 SmallMoleculeDrugapproved|investigational|vet_approved
ANXA1P04083DB01234DexamethasoneAnnexin A1 SmallMoleculeDrugapproved|investigational|vet_approved
ANXA1P04083DB14541Hydrocortisone cypionateAnnexin A1 SmallMoleculeDrugapproved|investigational|vet_approved
ANXA1P04083DB14649Dexamethasone acetateAnnexin A1 SmallMoleculeDrugapproved|investigational|vet_approved
ANXA1P04083DB00741HydrocortisoneAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB00959MethylprednisoloneAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14539Hydrocortisone acetateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14540Hydrocortisone butyrateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14542Hydrocortisone phosphateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14543Hydrocortisone probutateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14544Hydrocortisone valerateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14631Prednisolone phosphateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14669Betamethasone phosphateAnnexin A1 SmallMoleculeDrugapproved|vet_approved
ANXA1P04083DB14538Hydrocortisone aceponateAnnexin A1 SmallMoleculeDrugexperimental|vet_approved

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RelatedDiseases for ANXA1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
ANXA1C0024667Animal Mammary Neoplasms3CTD_human
ANXA1C1257925Mammary Carcinoma, Animal3CTD_human
ANXA1C0007097Carcinoma2CTD_human
ANXA1C0024668Mammary Neoplasms, Experimental2CTD_human
ANXA1C0205696Anaplastic carcinoma2CTD_human
ANXA1C0205697Carcinoma, Spindle-Cell2CTD_human
ANXA1C0205698Undifferentiated carcinoma2CTD_human
ANXA1C0205699Carcinomatosis2CTD_human
ANXA1C0007137Squamous cell carcinoma1CTD_human
ANXA1C0020538Hypertensive disease1CTD_human
ANXA1C0022658Kidney Diseases1CTD_human
ANXA1C0023893Liver Cirrhosis, Experimental1CTD_human
ANXA1C0024232Lymphatic Metastasis1CTD_human
ANXA1C0026640Mouth Neoplasms1CTD_human
ANXA1C0027626Neoplasm Invasiveness1CTD_human
ANXA1C0027627Neoplasm Metastasis1CTD_human
ANXA1C0033578Prostatic Neoplasms1CTD_human
ANXA1C0038354Stomach Diseases1CTD_human
ANXA1C0152013Adenocarcinoma of lung (disorder)1CTD_human
ANXA1C0153381Malignant neoplasm of mouth1CTD_human
ANXA1C0279626Squamous cell carcinoma of esophagus1CTD_human
ANXA1C0376358Malignant neoplasm of prostate1CTD_human
ANXA1C0376634Craniofacial Abnormalities1CTD_human