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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SNX12 (CAeditome ID:29934)

Gene summary for SNX12

check button Gene summary
Gene informationGene symbol

SNX12

Gene ID

29934

Gene namesorting nexin 12
Synonyms-
Cytomap

Xq13.1

Type of geneprotein-coding
Descriptionsorting nexin-12
Modification date20210518
UniProtAcc

Q9UMY4

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SNX12

GO:0035091

Sorting nexin-12

22719997

SNX12

GO:0010955

Sorting nexin-12

22709416

SNX12

GO:0042177

Sorting nexin-12

22719997

SNX12

GO:0051224

Sorting nexin-12

22719997

SNX12

GO:2000642

Sorting nexin-12

22719997

SNX12

GO:0005769

Sorting nexin-12

22709416

SNX12

GO:0005769

Sorting nexin-12

22719997


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RNA A-to-I events for SNX12

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000147164.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1510726(71056346, -), CAediting_1510727(71056353, -), CAediting_1510728(71057714, -), CAediting_1510729(71057724, -), CAediting_1510730(71057727, -), CAediting_1510731(71057735, -), CAediting_1510732(71057739, -), CAediting_1510733(71057743, -), CAediting_1510734(71057747, -), CAediting_1510735(71057767, -), CAediting_1510736(71057780, -), CAediting_1510737(71057783, -), CAediting_1510738(71057789, -), CAediting_1510739(71057790, -), CAediting_1510740(71057796, -), CAediting_1510741(71057807, -), CAediting_1510742(71057813, -), CAediting_1510743(71057815, -), CAediting_1510744(71057828, -), CAediting_1510745(71057832, -), CAediting_1510746(71057841, -), CAediting_1510747(71057842, -), CAediting_1510748(71057847, -), CAediting_1510749(71057848, -), CAediting_1510750(71057849, -), CAediting_1510751(71057862, -), CAediting_1510752(71057864, -), CAediting_1510753(71057865, -), CAediting_1510754(71057869, -), CAediting_1510755(71057875, -), CAediting_1510756(71057886, -), CAediting_1510757(71057890, -), CAediting_1510758(71057891, -), CAediting_1510759(71057900, -), CAediting_1510760(71057911, -), CAediting_1510761(71057914, -), CAediting_1510762(71057919, -), CAediting_1510763(71057930, -), CAediting_1510764(71057941, -), CAediting_1510765(71057946, -), CAediting_1510766(71057947, -), CAediting_1510767(71057955, -), CAediting_1510768(71057973, -), CAediting_1510769(71058401, -), CAediting_1510770(71058411, -), CAediting_1510771(71058429, -), CAediting_1510772(71058433, -), CAediting_1510773(71058435, -), CAediting_1510774(71058447, -), CAediting_1510775(71058461, -), CAediting_1510776(71058466, -), CAediting_1510777(71058480, -), CAediting_1510778(71058484, -), CAediting_1510779(71058490, -), CAediting_1510780(71058506, -), CAediting_1510781(71058507, -), CAediting_1510782(71058515, -), CAediting_1510783(71058528, -), CAediting_1510784(71058529, -), CAediting_1510785(71062510, -),

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RNA editing positional annotations for SNX12 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1510726chrX_71056346_-exonic
CAediting_1510727chrX_71056353_-exonic
CAediting_1510728chrX_71057714_-intronic
CAediting_1510729chrX_71057724_-intronic
CAediting_1510730chrX_71057727_-intronic
CAediting_1510731chrX_71057735_-intronic
CAediting_1510732chrX_71057739_-intronic
CAediting_1510733chrX_71057743_-intronic
CAediting_1510734chrX_71057747_-intronic
CAediting_1510735chrX_71057767_-intronic
CAediting_1510736chrX_71057780_-intronic
CAediting_1510737chrX_71057783_-intronic
CAediting_1510738chrX_71057789_-intronic
CAediting_1510739chrX_71057790_-intronic
CAediting_1510740chrX_71057796_-intronic
CAediting_1510741chrX_71057807_-intronic
CAediting_1510742chrX_71057813_-intronic
CAediting_1510743chrX_71057815_-intronic
CAediting_1510744chrX_71057828_-intronic
CAediting_1510745chrX_71057832_-intronic
CAediting_1510746chrX_71057841_-intronic
CAediting_1510747chrX_71057842_-intronic
CAediting_1510748chrX_71057847_-intronic
CAediting_1510749chrX_71057848_-intronic
CAediting_1510750chrX_71057849_-intronic
CAediting_1510751chrX_71057862_-intronic
CAediting_1510752chrX_71057864_-intronic
CAediting_1510753chrX_71057865_-intronic
CAediting_1510754chrX_71057869_-intronic
CAediting_1510755chrX_71057875_-intronic
CAediting_1510756chrX_71057886_-intronic
CAediting_1510757chrX_71057890_-intronic
CAediting_1510758chrX_71057891_-intronic
CAediting_1510759chrX_71057900_-intronic
CAediting_1510760chrX_71057911_-intronic
CAediting_1510761chrX_71057914_-intronic
CAediting_1510762chrX_71057919_-intronic
CAediting_1510763chrX_71057930_-intronic
CAediting_1510764chrX_71057941_-intronic
CAediting_1510765chrX_71057946_-intronic
CAediting_1510766chrX_71057947_-intronic
CAediting_1510767chrX_71057955_-intronic
CAediting_1510768chrX_71057973_-intronic
CAediting_1510769chrX_71058401_-intronic
CAediting_1510770chrX_71058411_-intronic
CAediting_1510771chrX_71058429_-intronic
CAediting_1510772chrX_71058433_-intronic
CAediting_1510773chrX_71058435_-intronic
CAediting_1510774chrX_71058447_-intronic
CAediting_1510775chrX_71058461_-intronic
CAediting_1510776chrX_71058466_-intronic
CAediting_1510777chrX_71058480_-intronic
CAediting_1510778chrX_71058484_-intronic
CAediting_1510779chrX_71058490_-intronic
CAediting_1510780chrX_71058506_-intronic
CAediting_1510781chrX_71058507_-intronic
CAediting_1510782chrX_71058515_-intronic
CAediting_1510783chrX_71058528_-intronic
CAediting_1510784chrX_71058529_-intronic
CAediting_1510785chrX_71062510_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1510726chrX_71056346_-SINEAluAluSz
CAediting_1510727chrX_71056353_-SINEAluAluSz
CAediting_1510728chrX_71057714_-SINEAluAluJo
CAediting_1510729chrX_71057724_-SINEAluAluJo
CAediting_1510730chrX_71057727_-SINEAluAluJo
CAediting_1510731chrX_71057735_-SINEAluAluJo
CAediting_1510732chrX_71057739_-SINEAluAluJo
CAediting_1510733chrX_71057743_-SINEAluAluJo
CAediting_1510734chrX_71057747_-SINEAluAluJo
CAediting_1510735chrX_71057767_-SINEAluAluJo
CAediting_1510736chrX_71057780_-SINEAluAluJo
CAediting_1510737chrX_71057783_-SINEAluAluJo
CAediting_1510738chrX_71057789_-SINEAluAluJo
CAediting_1510739chrX_71057790_-SINEAluAluJo
CAediting_1510740chrX_71057796_-SINEAluAluJo
CAediting_1510741chrX_71057807_-SINEAluAluJo
CAediting_1510742chrX_71057813_-SINEAluAluJo
CAediting_1510743chrX_71057815_-SINEAluAluJo
CAediting_1510744chrX_71057828_-SINEAluAluJo
CAediting_1510745chrX_71057832_-SINEAluAluJo
CAediting_1510746chrX_71057841_-SINEAluAluJo
CAediting_1510747chrX_71057842_-SINEAluAluJo
CAediting_1510748chrX_71057847_-SINEAluAluJo
CAediting_1510749chrX_71057848_-SINEAluAluJo
CAediting_1510750chrX_71057849_-SINEAluAluJo
CAediting_1510751chrX_71057862_-SINEAluAluJo
CAediting_1510752chrX_71057864_-SINEAluAluJo
CAediting_1510753chrX_71057865_-SINEAluAluJo
CAediting_1510754chrX_71057869_-SINEAluAluJo
CAediting_1510755chrX_71057875_-SINEAluAluJo
CAediting_1510756chrX_71057886_-SINEAluAluJo
CAediting_1510757chrX_71057890_-SINEAluAluJo
CAediting_1510758chrX_71057891_-SINEAluAluJo
CAediting_1510759chrX_71057900_-SINEAluAluJo
CAediting_1510760chrX_71057911_-SINEAluAluJo
CAediting_1510761chrX_71057914_-SINEAluAluJo
CAediting_1510762chrX_71057919_-SINEAluAluJo
CAediting_1510763chrX_71057930_-SINEAluAluJo
CAediting_1510764chrX_71057941_-SINEAluAluJo
CAediting_1510765chrX_71057946_-SINEAluAluJo
CAediting_1510766chrX_71057947_-SINEAluAluJo
CAediting_1510767chrX_71057955_-SINEAluAluJo
CAediting_1510769chrX_71058401_-SINEAluAluJr4
CAediting_1510770chrX_71058411_-SINEAluAluJr4
CAediting_1510771chrX_71058429_-SINEAluAluJr4
CAediting_1510772chrX_71058433_-SINEAluAluJr4
CAediting_1510773chrX_71058435_-SINEAluAluJr4
CAediting_1510774chrX_71058447_-SINEAluAluJr4
CAediting_1510775chrX_71058461_-SINEAluAluJr4
CAediting_1510776chrX_71058466_-SINEAluAluJr4
CAediting_1510777chrX_71058480_-SINEAluAluJr4
CAediting_1510778chrX_71058484_-SINEAluAluJr4
CAediting_1510779chrX_71058490_-SINEAluAluJr4
CAediting_1510780chrX_71058506_-SINEAluAluJr4
CAediting_1510781chrX_71058507_-SINEAluAluJr4
CAediting_1510782chrX_71058515_-SINEAluAluJr4
CAediting_1510783chrX_71058528_-SINEAluAluJr4
CAediting_1510784chrX_71058529_-SINEAluAluJr4
CAediting_1510785chrX_71062510_-SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for SNX12

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000147164.10.SNX12.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000147164.10.SNX12.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SNX12

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SNX12

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SNX12

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000147164.10ENST00000622277hsa-miR-605-3p71059954710599607mer-m87105995371059974155-16.96
CAediting_748296chr10_51299626_+ENSG00000147164.10ENST00000622277hsa-miR-605-3p71060992710609987mer-m87106099171061014146-19.14
CAediting_393chr1_1167164_+ENSG00000147164.10ENST00000622277hsa-miR-200b-3p71059893710598997mer-m87105989271059913144-12.44
CAediting_688081chr9_63819627_+ENSG00000147164.10ENST00000622277hsa-miR-4477b71060241710602477mer-m87106024071060261140-12.63
CAediting_748296chr10_51299626_+ENSG00000147164.10ENST00000276105hsa-miR-605-3p71060992710609987mer-m87106099171061014146-19.14
CAediting_1054808chr15_66496985_-ENSG00000147164.10ENST00000622277hsa-miR-451271059359710593668mer-1a7105935971059380156-22.2
CAediting_1229413chr17_67471544_+ENSG00000147164.10ENST00000622277hsa-miR-548aa71059796710598027mer-m87105979571059818147-14.86
CAediting_1524209chrX_134546392_-ENSG00000147164.10ENST00000622277hsa-miR-503-5p71059957710599626mer7105995671059976146-21.3
CAediting_1524209chrX_134546392_-ENSG00000147164.10ENST00000622277hsa-miR-503-5p71059446710594516mer7105944571059467148-22.66

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SNX12

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SNX12

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1510732chrX_71057739_-0.003087249041753650.176859732901082....
LGGCAediting_1510735chrX_71057767_-0.004969761604188630.23956215840439....
BRCACAediting_1510735chrX_71057767_-7.95629112333524e-150.392097396321973....
LUADCAediting_1510735chrX_71057767_-4.68921992698598e-050.362657336985994....
LUSCCAediting_1510735chrX_71057767_-0.0002914700516752340.406899935182449....
STADCAediting_1510735chrX_71057767_-0.003825208706943450.227429712948926....
THCACAediting_1510735chrX_71057767_-0.01615333496144480.248859849181502....
ESCACAediting_1510735chrX_71057767_-0.003904814901820510.321143926084404..0.01617912541190790.269828490942375
SKCMCAediting_1510735chrX_71057767_-0.01889927674360810.260365509485861....
BLCACAediting_1510738chrX_71057789_-0.0003480374031277750.348975881589308....
LGGCAediting_1510738chrX_71057789_-4.48384377765873e-070.235489551766756....
BRCACAediting_1510738chrX_71057789_-3.09762866009569e-180.343346757700631....
CESCCAediting_1510738chrX_71057789_-0.0002249235222167630.379529321278904....
LUADCAediting_1510738chrX_71057789_-0.0008112233693384070.220747008299009....
COADCAediting_1510738chrX_71057789_-2.47435785593299e-050.292034294115884....
LUSCCAediting_1510738chrX_71057789_-4.89791652305911e-080.343838664511229....
GBMCAediting_1510738chrX_71057789_-0.03961708347697310.190535461217165....
PRADCAediting_1510738chrX_71057789_-0.0008000909484314490.218168308993576....
HNSCCAediting_1510738chrX_71057789_-6.02783226645853e-050.282499573598904....
STADCAediting_1510738chrX_71057789_-3.72820121033502e-050.233802165258444....
THCACAediting_1510738chrX_71057789_-9.04611535562089e-110.354691900101188....
KIRCCAediting_1510738chrX_71057789_-8.76784240878643e-050.206369485422965....
KIRPCAediting_1510738chrX_71057789_-0.001861768236372070.244916531824499....
ESCACAediting_1510738chrX_71057789_-0.0006896218982843070.269700345031239....
OVCAediting_1510738chrX_71057789_-3.28981754343644e-050.239656389002481....
SKCMCAediting_1510738chrX_71057789_-2.15920114549956e-160.453805859365292....
READCAediting_1510738chrX_71057789_-0.04047031081231980.235611774868836....
SARCCAediting_1510738chrX_71057789_-0.006208709445806820.311225194772395....
STADCAediting_1510739chrX_71057790_-0.02773201137801170.281905780792982....
STADCAediting_1510745chrX_71057832_-0.00431676199412380.253632806996356....
ESCACAediting_1510745chrX_71057832_-0.0006673604912887840.414217394424281....
BRCACAediting_1510761chrX_71057914_-0.0002710740048570260.294170643195117....
ESCACAediting_1510765chrX_71057946_-..0.01254838307594680.350617096657318..
STADCAediting_1510768chrX_71057973_-....0.01801194425638490.301994233686781
BRCACAediting_1510775chrX_71058461_-0.008040621323779220.23700843796472....
STADCAediting_1510775chrX_71058461_-0.0001649919382855020.299986832756922....
OVCAediting_1510775chrX_71058461_-0.04976223100281050.158393590798881....
BRCACAediting_1510780chrX_71058506_-0.0003932382798663950.189243681107199....
LUADCAediting_1510780chrX_71058506_-0.001151945550504870.363611520932739....
COADCAediting_1510780chrX_71058506_-0.01697721456463620.332930912917549....
STADCAediting_1510780chrX_71058506_-4.28504234800397e-050.265787926209489....
KIRCCAediting_1510780chrX_71058506_-..0.03870129188539440.143122839500098..

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Relation with cancer stages for SNX12

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_1510735chrX_71057767_-0.04360091148257530.106718198356324
BRCApathologic_stageCAediting_1510775chrX_71058461_-0.0342565045147877-0.192651126363803
ESCApathologic_stageCAediting_1510765chrX_71057946_-0.0252053885865242-0.326275010066488
HNSCpathologic_stageCAediting_1510738chrX_71057789_-0.03953320374478580.158527110068874
KIRCpathologic_stageCAediting_1510735chrX_71057767_-0.03416237681582470.17194237152714
KIRCpathologic_stageCAediting_1510738chrX_71057789_-4.30716973316785e-050.215301423633128
KIRPpathologic_stageCAediting_1510738chrX_71057789_-0.001209510220263250.267128467295114
LUADpathologic_stageCAediting_1510732chrX_71057739_-0.0475311219498813-0.236020666860856
LUSCpathologic_stageCAediting_1510738chrX_71057789_-0.04143471710027950.132572954219891
STADpathologic_stageCAediting_1510781chrX_71058507_-0.009157741321234480.237971122338655
THCApathologic_stageCAediting_1510732chrX_71057739_-0.03914680172857870.286965908975441

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Relation with survival for SNX12

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LGGCAediting_1510761chrX_71057914_-0.03067034679198970.018366123551100
STADCAediting_1510780chrX_71058506_-0.0004261438180728220.01791115.69711
SKCMCAediting_1510732chrX_71057739_-0.004377608799310820.0284928496.38

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RelatedDrugs for SNX12

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX12

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource