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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: GSTM5 (CAeditome ID:2949)

Gene summary for GSTM5

check button Gene summary
Gene informationGene symbol

GSTM5

Gene ID

2949

Gene nameglutathione S-transferase mu 5
SynonymsGSTM5-5|GTM5
Cytomap

1p13.3

Type of geneprotein-coding
Descriptionglutathione S-transferase Mu 5GST class-mu 5S-(hydroxyalkyl)glutathione lyase M5epididymis secretory sperm binding proteinglutathione S-alkyltransferase M5glutathione S-aralkyltransferase M5glutathione S-aryltransferase M5glutathione S-transferase
Modification date20210518
UniProtAcc

P46439

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
GSTM5

GO:0004364

Glutathione S-transferase Mu 5

10587441

GSTM5

GO:0006749

Glutathione S-transferase Mu 5

10587441

GSTM5

GO:0005829

Glutathione S-transferase Mu 5

0000052

GSTM5

GO:0045171

Glutathione S-transferase Mu 5

0000052


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RNA A-to-I events for GSTM5

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000134201.9
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_86466(109713512, +), CAediting_86467(109713674, +), CAediting_86468(109713682, +), CAediting_86469(109713684, +), CAediting_86470(109713837, +), CAediting_86471(109728586, +), CAediting_86472(109728626, +),

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RNA editing positional annotations for GSTM5 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_86466chr1_109713512_+nonsynonymous SNVENST00000256593.6c.A206Gp.K69RDBD
CAediting_86466chr1_109713512_+nonsynonymous SNVENST00000369812.6c.A206Gp.K69RDBD
CAediting_86469chr1_109713684_+nonsynonymous SNVENST00000256593.6c.A283Gp.I95VDBN
CAediting_86469chr1_109713684_+nonsynonymous SNVENST00000369812.6c.A283Gp.I95VDBN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_86466chr1_109713512_+exonic
CAediting_86467chr1_109713674_+exonic
CAediting_86468chr1_109713682_+exonic
CAediting_86469chr1_109713684_+exonic
CAediting_86470chr1_109713837_+ncRNA_exonic
CAediting_86471chr1_109728586_+ncRNA_intronic
CAediting_86472chr1_109728626_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_86471chr1_109728586_+SINEAluAluSc
CAediting_86472chr1_109728626_+SINEAluAluSc

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RNA A-to-I editing events in the alternative splicing sites for GSTM5

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000134201.9.GSTM5.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000134201.9.GSTM5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GSTM5

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GSTM5

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for GSTM5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GSTM5

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000256593.6protein_codingSoverviewSoverview
ENST00000369812.6protein_codingSoverviewSoverview
ENST00000369813.4protein_codingSoverviewSoverview
ENST00000492718.1processed_transcriptSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_86466ENST00000256593.6chr1_109713512_+-491.70-490.50-493.00
CAediting_86467ENST00000256593.6chr1_109713674_+-493.60-490.50-493.00
CAediting_86468ENST00000256593.6chr1_109713682_+-490.20-490.50-493.00
CAediting_86469ENST00000256593.6chr1_109713684_+-489.70-490.50-493.00
CAediting_86466ENST00000369812.6chr1_109713512_+-193.80-192.60-199.80
CAediting_86467ENST00000369812.6chr1_109713674_+-194.80-192.60-199.80
CAediting_86468ENST00000369812.6chr1_109713682_+-194.80-192.60-199.80
CAediting_86469ENST00000369812.6chr1_109713684_+-193.60-192.60-199.80
CAediting_86466ENST00000369813.4chr1_109713512_+-1595.90-1593.40-1602.70
CAediting_86467ENST00000369813.4chr1_109713674_+-1595.00-1593.40-1602.70
CAediting_86468ENST00000369813.4chr1_109713682_+-1595.20-1593.40-1602.70
CAediting_86469ENST00000369813.4chr1_109713684_+-1598.20-1593.40-1602.70
CAediting_86467ENST00000492718.1chr1_109713674_+-1533.50-1533.80-1536.80
CAediting_86468ENST00000492718.1chr1_109713682_+-1533.50-1533.80-1536.80
CAediting_86469ENST00000492718.1chr1_109713684_+-1533.20-1533.80-1536.80
CAediting_86470ENST00000492718.1chr1_109713837_+-1538.00-1533.80-1536.80

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Relation with ADAR for GSTM5

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for GSTM5

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for GSTM5

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for GSTM5

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
GSTM5P46439DB03310Glutathione disulfideGlutathione S-transferase Mu 5 SmallMoleculeDrugapproved|experimental|investigational
GSTM5P46439DB00143GlutathioneGlutathione S-transferase Mu 5 SmallMoleculeDrugapproved|investigational|nutraceutical

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RelatedDiseases for GSTM5

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
GSTM5C0007102Malignant tumor of colon1CTD_human
GSTM5C0009375Colonic Neoplasms1CTD_human
GSTM5C0270715Degenerative Diseases, Central Nervous System1CTD_human
GSTM5C0524851Neurodegenerative Disorders1CTD_human
GSTM5C0751733Degenerative Diseases, Spinal Cord1CTD_human