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Editing gene: GRM4 (CAeditome ID:2914)

Gene summary for GRM4

Gene summary

Gene information	Gene symbol	GRM4
	Gene ID	2914
	Gene name	glutamate metabotropic receptor 4
	Synonyms	GPRC1D\|MGLUR4\|mGlu4
	Cytomap	6p21.31
	Type of gene	protein-coding
	Description	metabotropic glutamate receptor 4glutamate receptor, metabotropic 4
	Modification date	20210518
	UniProtAcc	Q14833
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GRM4	GO:0000187	Metabotropic glutamate receptor 4	15102938
GRM4	GO:0005887	Metabotropic glutamate receptor 4	15102938
GRM4	GO:0031410	Metabotropic glutamate receptor 4	15102938

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RNA A-to-I events for GRM4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000124493.12

RNA A-to-I editing events in Cancer.

CAediting_470043(34129294, -), CAediting_470044(34133126, -),

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RNA editing positional annotations for GRM4 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_470044	chr6_34133126_-	nonsynonymous SNV	ENST00000374181.7	c.A371G	p.Q124R	T	D	N
CAediting_470044	chr6_34133126_-	nonsynonymous SNV	ENST00000538487.5	c.A371G	p.Q124R	T	D	N
CAediting_470044	chr6_34133126_-	nonsynonymous SNV	ENST00000609278.1	c.A371G	p.Q124R	T	D	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_470043	chr6_34129294_-	ncRNA_intronic
CAediting_470044	chr6_34133126_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_470043	chr6_34129294_-	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for GRM4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000124493.12.GRM4.

Correlation between RNA A-to-I editing and PSI for ENSG00000124493.12.GRM4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRM4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GRM4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GRM4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000124493.12	ENST00000535756	hsa-miR-605-3p	34020183	34020190	8mer-1a	34020183	34020207	143	-15.41
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000535756	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_688080	chr9_63819626_+	ENSG00000124493.12	ENST00000535756	hsa-miR-4477b	34019796	34019802	7mer-m8	34019795	34019816	140	-11.42
CAediting_688080	chr9_63819626_+	ENSG00000124493.12	ENST00000535756	hsa-miR-4477b	34019631	34019637	7mer-m8	34019630	34019651	140	-12.85
CAediting_748296	chr10_51299626_+	ENSG00000124493.12	ENST00000374181	hsa-miR-605-3p	34020183	34020190	8mer-1a	34020183	34020207	143	-15.41
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000374181	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_688080	chr9_63819626_+	ENSG00000124493.12	ENST00000374181	hsa-miR-4477b	34019796	34019802	7mer-m8	34019795	34019816	140	-11.42
CAediting_688080	chr9_63819626_+	ENSG00000124493.12	ENST00000374181	hsa-miR-4477b	34019631	34019637	7mer-m8	34019630	34019651	140	-12.85
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000374177	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000609222	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000544773	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000455714	hsa-miR-624-3p	34022776	34022782	7mer-m8	34022775	34022795	147	-24.3
CAediting_980496	chr14_31014685_-	ENSG00000124493.12	ENST00000609278	hsa-miR-624-3p	34040594	34040601	8mer-1a	34040594	34040614	140	-13.25
CAediting_1306324	chr19_13836464_-	ENSG00000124493.12	ENST00000609278	hsa-miR-27a-3p	34036482	34036488	7mer-m8	34036481	34036501	147	-19.43
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000535756	hsa-miR-4512	34020311	34020316	6mer	34020310	34020330	142	-21.88
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000535756	hsa-miR-641	34022372	34022377	6mer	34022371	34022393	154	-22.61
CAediting_1368054	chr19_46709310_-	ENSG00000124493.12	ENST00000535756	hsa-miR-320e	34020488	34020494	7mer-m8	34020487	34020504	142	-17.04
CAediting_86358	chr1_109598906_+	ENSG00000124493.12	ENST00000535756	hsa-miR-197-5p	34021494	34021500	7mer-m8	34021493	34021514	171	-32.03
CAediting_86358	chr1_109598906_+	ENSG00000124493.12	ENST00000535756	hsa-miR-197-5p	34020616	34020623	8mer-1a	34020616	34020645	142	-28.81
CAediting_77128	chr1_85133844_+	ENSG00000124493.12	ENST00000535756	hsa-miR-4423-3p	34019386	34019392	7mer-m8	34019385	34019405	140	-12.65
CAediting_442554	chr5_154685830_+	ENSG00000124493.12	ENST00000535756	hsa-miR-1303	34020277	34020283	7mer-m8	34020276	34020297	160	-20.87
CAediting_580943	chr7_100356700_+	ENSG00000124493.12	ENST00000535756	hsa-miR-6840-3p	34021424	34021430	7mer-m8	34021423	34021444	141	-20.39
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000535756	hsa-miR-3654	34021237	34021243	7mer-m8	34021236	34021254	144	-15
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000535756	hsa-miR-3654	34022240	34022246	7mer-m8	34022239	34022258	156	-23.73
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000535756	hsa-miR-589-3p	34021584	34021590	7mer-m8	34021583	34021606	150	-18.94
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000535756	hsa-miR-589-3p	34020435	34020441	7mer-m8	34020434	34020456	156	-26.5
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000535756	hsa-miR-589-3p	34020399	34020406	8mer-1a	34020399	34020422	151	-18.05
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000374181	hsa-miR-4512	34020311	34020316	6mer	34020310	34020330	142	-21.88
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374181	hsa-miR-641	34022372	34022377	6mer	34022371	34022393	154	-22.61
CAediting_1368054	chr19_46709310_-	ENSG00000124493.12	ENST00000374181	hsa-miR-320e	34020488	34020494	7mer-m8	34020487	34020504	142	-17.04
CAediting_86358	chr1_109598906_+	ENSG00000124493.12	ENST00000374181	hsa-miR-197-5p	34021494	34021500	7mer-m8	34021493	34021514	171	-32.03
CAediting_86358	chr1_109598906_+	ENSG00000124493.12	ENST00000374181	hsa-miR-197-5p	34020616	34020623	8mer-1a	34020616	34020645	142	-28.81
CAediting_77128	chr1_85133844_+	ENSG00000124493.12	ENST00000374181	hsa-miR-4423-3p	34019386	34019392	7mer-m8	34019385	34019405	140	-12.65
CAediting_442554	chr5_154685830_+	ENSG00000124493.12	ENST00000374181	hsa-miR-1303	34020277	34020283	7mer-m8	34020276	34020297	160	-20.87
CAediting_580943	chr7_100356700_+	ENSG00000124493.12	ENST00000374181	hsa-miR-6840-3p	34021424	34021430	7mer-m8	34021423	34021444	141	-20.39
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000374181	hsa-miR-3654	34021237	34021243	7mer-m8	34021236	34021254	144	-15
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000374181	hsa-miR-3654	34022240	34022246	7mer-m8	34022239	34022258	156	-23.73
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000374181	hsa-miR-589-3p	34021584	34021590	7mer-m8	34021583	34021606	150	-18.94
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000374181	hsa-miR-589-3p	34020435	34020441	7mer-m8	34020434	34020456	156	-26.5
CAediting_524911	chr7_5495852_-	ENSG00000124493.12	ENST00000374181	hsa-miR-589-3p	34020399	34020406	8mer-1a	34020399	34020422	151	-18.05
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374177	hsa-miR-641	34022372	34022377	6mer	34022371	34022393	154	-22.61
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000374177	hsa-miR-3654	34022240	34022246	7mer-m8	34022239	34022258	156	-23.73
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000609222	hsa-miR-641	34022372	34022377	6mer	34022371	34022393	154	-22.61
CAediting_604450	chr7_133034877_-	ENSG00000124493.12	ENST00000609222	hsa-miR-3654	34022240	34022246	7mer-m8	34022239	34022258	156	-23.73
CAediting_396018	chr5_1062918_-	ENSG00000124493.12	ENST00000609278	hsa-miR-4635	34056571	34056578	8mer-1a	34056571	34056591	142	-13.91
CAediting_1306323	chr19_13836462_-	ENSG00000124493.12	ENST00000609278	hsa-miR-27a-3p	34040640	34040646	7mer-m8	34040639	34040659	145	-14.75
CAediting_86358	chr1_109598906_+	ENSG00000124493.12	ENST00000609278	hsa-miR-197-5p	34028263	34028269	7mer-m8	34028262	34028286	159	-32.56
CAediting_77128	chr1_85133844_+	ENSG00000124493.12	ENST00000609278	hsa-miR-4423-3p	34028245	34028252	8mer-1a	34028245	34028265	140	-12.53
CAediting_468389	chr6_31355314_-	ENSG00000124493.12	ENST00000535756	hsa-miR-6891-5p	34019632	34019639	8mer-1a	34019632	34019650	146	-24.74
CAediting_468389	chr6_31355314_-	ENSG00000124493.12	ENST00000374181	hsa-miR-6891-5p	34019632	34019639	8mer-1a	34019632	34019650	146	-24.74
CAediting_1524209	chrX_134546392_-	ENSG00000124493.12	ENST00000609278	hsa-miR-503-5p	34036306	34036313	8mer-1a	34036306	34036329	148	-22.32

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306323	chr19_13836462_-	ENSG00000124493.12	ENST00000535756	hsa-miR-27a-3p	34018838	34018844	7mer-m8	34018837	34018862	153	-25.31
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000535756	hsa-miR-4512	34020231	34020236	6mer	34020230	34020251	140	-23.31
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000535756	hsa-miR-4512	34020006	34020013	8mer-1a	34020006	34020027	141	-17.22
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000535756	hsa-miR-4512	34019159	34019165	7mer-m8	34019158	34019179	142	-18.45
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000535756	hsa-miR-4512	34018699	34018705	7mer-m8	34018698	34018719	140	-19.27
CAediting_1229413	chr17_67471544_+	ENSG00000124493.12	ENST00000535756	hsa-miR-548aa	34021854	34021860	7mer-m8	34021853	34021879	151	-7.02
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000535756	hsa-miR-641	34020819	34020825	7mer-m8	34020818	34020844	152	-12.22
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000535756	hsa-miR-641	34019194	34019201	8mer-1a	34019194	34019220	153	-19.24
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000535756	hsa-miR-641	34022028	34022033	6mer	34022027	34022050	144	-14.82
CAediting_580943	chr7_100356700_+	ENSG00000124493.12	ENST00000535756	hsa-miR-6840-3p	34020451	34020457	7mer-m8	34020450	34020472	141	-30.58
CAediting_468389	chr6_31355314_-	ENSG00000124493.12	ENST00000535756	hsa-miR-6891-5p	34021465	34021470	6mer	34021464	34021483	140	-20.49
CAediting_1306323	chr19_13836462_-	ENSG00000124493.12	ENST00000374181	hsa-miR-27a-3p	34018838	34018844	7mer-m8	34018837	34018862	153	-25.31
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000374181	hsa-miR-4512	34020231	34020236	6mer	34020230	34020251	140	-23.31
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000374181	hsa-miR-4512	34020006	34020013	8mer-1a	34020006	34020027	141	-17.22
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000374181	hsa-miR-4512	34019159	34019165	7mer-m8	34019158	34019179	142	-18.45
CAediting_1054808	chr15_66496985_-	ENSG00000124493.12	ENST00000374181	hsa-miR-4512	34018699	34018705	7mer-m8	34018698	34018719	140	-19.27
CAediting_1229413	chr17_67471544_+	ENSG00000124493.12	ENST00000374181	hsa-miR-548aa	34021854	34021860	7mer-m8	34021853	34021879	151	-7.02
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374181	hsa-miR-641	34020819	34020825	7mer-m8	34020818	34020844	152	-12.22
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374181	hsa-miR-641	34019194	34019201	8mer-1a	34019194	34019220	153	-19.24
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374181	hsa-miR-641	34022028	34022033	6mer	34022027	34022050	144	-14.82
CAediting_580943	chr7_100356700_+	ENSG00000124493.12	ENST00000374181	hsa-miR-6840-3p	34020451	34020457	7mer-m8	34020450	34020472	141	-30.58
CAediting_468389	chr6_31355314_-	ENSG00000124493.12	ENST00000374181	hsa-miR-6891-5p	34021465	34021470	6mer	34021464	34021483	140	-20.49
CAediting_1351755	chr19_40282625_-	ENSG00000124493.12	ENST00000374177	hsa-miR-641	34022028	34022033	6mer	34022027	34022050	144	-14.82
CAediting_1524209	chrX_134546392_-	ENSG00000124493.12	ENST00000609278	hsa-miR-503-5p	34036221	34036226	6mer	34036220	34036245	141	-22.23

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GRM4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000374181.7	protein_coding
ENST00000538487.5	protein_coding
ENST00000607916.1	retained_intron
ENST00000609278.1	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_470044	ENST00000374181.7	chr6_34133126_-	-3149.40	-3143.20	-3149.40
CAediting_470044	ENST00000538487.5	chr6_34133126_-	-1683.70	-1677.50	-1683.70
CAediting_470044	ENST00000607916.1	chr6_34133126_-	-477.90	-471.70	-477.90
CAediting_470044	ENST00000609278.1	chr6_34133126_-	-1276.10	-1269.90	-1276.10

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Relation with ADAR for GRM4

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for GRM4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GRM4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GRM4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GRM4	Q14833	DB00142	Glutamic acid	Metabotropic glutamate receptor 4	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for GRM4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GRM4	C0036341	Schizophrenia	3	PSYGENET
GRM4	C0005586	Bipolar Disorder	2	PSYGENET
GRM4	C0014556	Epilepsy, Temporal Lobe	1	CTD_human
GRM4	C0014558	Uncinate Epilepsy	1	CTD_human
GRM4	C0027746	Nerve Degeneration	1	CTD_human
GRM4	C0029463	Osteosarcoma	1	CTD_human
GRM4	C0393672	Epilepsy, Benign Psychomotor, Childhood	1	CTD_human
GRM4	C0393682	Epilepsy, Lateral Temporal	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene