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Editing gene: FHOD1 (CAeditome ID:29109)

Gene summary for FHOD1

Gene summary

Gene information	Gene symbol	FHOD1
	Gene ID	29109
	Gene name	formin homology 2 domain containing 1
	Synonyms	FHOS
	Cytomap	16q22.1
	Type of gene	protein-coding
	Description	FH1/FH2 domain-containing protein 1formin homolog overexpressed in spleen 1
	Modification date	20210518
	UniProtAcc	Q9Y613
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
FHOD1	GO:0001725	FH1/FH2 domain-containing protein 1	15095401
FHOD1	GO:0045944	FH1/FH2 domain-containing protein 1	15095401
FHOD1	GO:0051496	FH1/FH2 domain-containing protein 1	15095401
FHOD1	GO:0005634	FH1/FH2 domain-containing protein 1	15095401
FHOD1	GO:0005654	FH1/FH2 domain-containing protein 1	0000052
FHOD1	GO:0005829	FH1/FH2 domain-containing protein 1	0000052

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RNA A-to-I events for FHOD1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000135723.12

RNA A-to-I editing events in Cancer.

CAediting_1121577(67230363, -), CAediting_1121578(67232703, -), CAediting_1121579(67233029, -), CAediting_1121580(67234832, -), CAediting_1121581(67234838, -), CAediting_1121582(67234842, -), CAediting_1121583(67234897, -), CAediting_1121584(67234907, -), CAediting_1121585(67234959, -), CAediting_1121586(67234979, -), CAediting_1121587(67234983, -), CAediting_1121588(67235019, -), CAediting_1121589(67235032, -), CAediting_1121590(67235039, -), CAediting_1121591(67235308, -), CAediting_1121592(67235421, -), CAediting_1121593(67235504, -),

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RNA editing positional annotations for FHOD1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1121577	chr16_67230363_-	exonic
CAediting_1121578	chr16_67232703_-	ncRNA_intronic
CAediting_1121579	chr16_67233029_-	ncRNA_intronic
CAediting_1121580	chr16_67234832_-	ncRNA_intronic
CAediting_1121581	chr16_67234838_-	ncRNA_intronic
CAediting_1121582	chr16_67234842_-	ncRNA_intronic
CAediting_1121583	chr16_67234897_-	ncRNA_intronic
CAediting_1121584	chr16_67234907_-	ncRNA_intronic
CAediting_1121585	chr16_67234959_-	ncRNA_intronic
CAediting_1121586	chr16_67234979_-	ncRNA_intronic
CAediting_1121587	chr16_67234983_-	ncRNA_intronic
CAediting_1121588	chr16_67235019_-	ncRNA_intronic
CAediting_1121589	chr16_67235032_-	ncRNA_intronic
CAediting_1121590	chr16_67235039_-	ncRNA_intronic
CAediting_1121591	chr16_67235308_-	ncRNA_intronic
CAediting_1121592	chr16_67235421_-	ncRNA_intronic
CAediting_1121593	chr16_67235504_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1121578	chr16_67232703_-	SINE	Alu	AluJr
CAediting_1121579	chr16_67233029_-	SINE	Alu	AluSz
CAediting_1121580	chr16_67234832_-	SINE	Alu	AluJr
CAediting_1121581	chr16_67234838_-	SINE	Alu	AluJr
CAediting_1121582	chr16_67234842_-	SINE	Alu	AluJr
CAediting_1121583	chr16_67234897_-	SINE	Alu	AluJr
CAediting_1121584	chr16_67234907_-	SINE	Alu	AluJr
CAediting_1121585	chr16_67234959_-	SINE	Alu	AluJr
CAediting_1121586	chr16_67234979_-	SINE	Alu	AluJr
CAediting_1121587	chr16_67234983_-	SINE	Alu	AluJr
CAediting_1121588	chr16_67235019_-	SINE	Alu	AluJr
CAediting_1121589	chr16_67235032_-	SINE	Alu	AluJr
CAediting_1121590	chr16_67235039_-	SINE	Alu	AluJr
CAediting_1121591	chr16_67235308_-	SINE	Alu	AluSz
CAediting_1121592	chr16_67235421_-	SINE	Alu	AluSz
CAediting_1121593	chr16_67235504_-	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for FHOD1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000135723.12.FHOD1.

Correlation between RNA A-to-I editing and PSI for ENSG00000135723.12.FHOD1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FHOD1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for FHOD1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for FHOD1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1121577	chr16_67230363_-	ENSG00000135723.12	ENST00000567561	hsa-miR-1538	67230358	67230364	7mer-1a	67230358	67230381	147.00	-34.75

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000135723.12	ENST00000567561	hsa-miR-4477b	67231440	67231446	7mer-m8	67231439	67231459	149	-14.97
CAediting_846604	chr11_93733708_-	ENSG00000135723.12	ENST00000561922	hsa-miR-1304-3p	67236570	67236577	8mer-1a	67236570	67236591	147	-17.31
CAediting_980496	chr14_31014685_-	ENSG00000135723.12	ENST00000561922	hsa-miR-624-3p	67233724	67233730	7mer-m8	67233723	67233742	144	-14.6
CAediting_77128	chr1_85133844_+	ENSG00000135723.12	ENST00000258201	hsa-miR-4423-3p	67229531	67229537	7mer-m8	67229530	67229550	140	-12.1
CAediting_1306323	chr19_13836462_-	ENSG00000135723.12	ENST00000567561	hsa-miR-27a-3p	67230348	67230354	7mer-m8	67230347	67230367	141	-18.15
CAediting_604450	chr7_133034877_-	ENSG00000135723.12	ENST00000561922	hsa-miR-3654	67237298	67237304	7mer-m8	67237297	67237315	152	-17.08
CAediting_1054808	chr15_66496985_-	ENSG00000135723.12	ENST00000561922	hsa-miR-4512	67236702	67236709	8mer-1a	67236702	67236723	147	-19.8
CAediting_1054808	chr15_66496985_-	ENSG00000135723.12	ENST00000561922	hsa-miR-4512	67236667	67236673	7mer-m8	67236666	67236687	151	-22.5
CAediting_442554	chr5_154685830_+	ENSG00000135723.12	ENST00000561922	hsa-miR-1303	67236631	67236637	7mer-m8	67236630	67236651	153	-21.68
CAediting_1054808	chr15_66496985_-	ENSG00000135723.12	ENST00000561922	hsa-miR-4512	67233912	67233918	7mer-m8	67233911	67233932	140	-13.99
CAediting_1368054	chr19_46709310_-	ENSG00000135723.12	ENST00000561922	hsa-miR-320e	67233989	67233995	7mer-m8	67233988	67234005	152	-18.37
CAediting_1368054	chr19_46709310_-	ENSG00000135723.12	ENST00000568595	hsa-miR-320e	67233989	67233995	7mer-m8	67233988	67234005	152	-18.37

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FHOD1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for FHOD1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for FHOD1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for FHOD1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for FHOD1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FHOD1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene