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Editing gene: DROSHA (CAeditome ID:29102)

Gene summary for DROSHA

Gene summary

Gene information	Gene symbol	DROSHA
	Gene ID	29102
	Gene name	drosha ribonuclease III
	Synonyms	ETOHI2\|HSA242976\|RANSE3L\|RN3\|RNASE3L\|RNASEN
	Cytomap	5p13.3
	Type of gene	protein-coding
	Description	ribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclear
	Modification date	20210529
	UniProtAcc	Q9NRR4
	Context	- 33437394(Influence of variants of the drosha, mir499a, and mir938 genes on susceptibility to acute lymphoblastic leukemia in an admixed population from the brazilian amazon)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DROSHA	GO:0001530	Ribonuclease 3	20180804
DROSHA	GO:0004525	Ribonuclease 3	14508493
DROSHA	GO:0004525	Ribonuclease 3	15574589
DROSHA	GO:0042803	Ribonuclease 3	15574589
DROSHA	GO:0070878	Ribonuclease 3	31507089
DROSHA	GO:0031053	Ribonuclease 3	14508493
DROSHA	GO:0031053	Ribonuclease 3	15574589
DROSHA	GO:0050829	Ribonuclease 3	20180804
DROSHA	GO:0050830	Ribonuclease 3	20180804
DROSHA	GO:0005654	Ribonuclease 3	0000052
DROSHA	GO:0005829	Ribonuclease 3	0000052
DROSHA	GO:0070877	Ribonuclease 3	15574589

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RNA A-to-I events for DROSHA

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000113360.15

RNA A-to-I editing events in Cancer.

CAediting_399407(31402921, -), CAediting_399408(31402960, -), CAediting_399409(31403990, -), CAediting_399410(31404039, -), CAediting_399411(31404056, -), CAediting_399412(31404058, -), CAediting_399413(31405187, -), CAediting_399414(31412534, -), CAediting_399415(31443116, -), CAediting_399416(31443131, -), CAediting_399417(31443135, -), CAediting_399418(31443157, -), CAediting_399419(31443158, -), CAediting_399420(31455920, -), CAediting_399421(31455921, -), CAediting_399422(31456854, -), CAediting_399423(31456864, -), CAediting_399424(31457220, -), CAediting_399425(31457221, -), CAediting_399426(31457235, -), CAediting_399427(31457256, -), CAediting_399428(31457262, -), CAediting_399429(31457288, -), CAediting_399430(31457291, -), CAediting_399431(31457292, -), CAediting_399432(31457293, -), CAediting_399433(31457307, -), CAediting_399434(31457357, -), CAediting_399435(31457672, -), CAediting_399436(31457679, -), CAediting_399437(31457741, -), CAediting_399438(31457768, -), CAediting_399439(31457778, -), CAediting_399440(31457781, -), CAediting_399441(31457814, -), CAediting_399442(31457840, -), CAediting_399443(31457857, -), CAediting_399444(31457871, -), CAediting_399445(31474435, -), CAediting_399446(31474455, -), CAediting_399447(31474460, -), CAediting_399448(31474471, -), CAediting_399449(31474476, -), CAediting_399450(31474478, -), CAediting_399451(31474491, -), CAediting_399452(31474495, -), CAediting_399453(31474501, -), CAediting_399454(31474511, -), CAediting_399455(31474527, -), CAediting_399456(31474530, -), CAediting_399457(31474531, -), CAediting_399458(31474532, -), CAediting_399459(31474538, -), CAediting_399460(31474540, -), CAediting_399461(31474541, -), CAediting_399462(31474542, -), CAediting_399463(31474543, -), CAediting_399464(31474544, -), CAediting_399465(31474559, -), CAediting_399466(31474563, -), CAediting_399467(31474567, -), CAediting_399468(31474568, -), CAediting_399469(31474591, -), CAediting_399470(31474636, -), CAediting_399471(31474637, -), CAediting_399472(31475151, -), CAediting_399473(31475170, -), CAediting_399474(31475196, -), CAediting_399475(31475206, -), CAediting_399476(31475250, -), CAediting_399477(31476289, -),

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RNA editing positional annotations for DROSHA using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_399407	chr5_31402921_-	ncRNA_intronic
CAediting_399408	chr5_31402960_-	ncRNA_intronic
CAediting_399409	chr5_31403990_-	ncRNA_intronic
CAediting_399410	chr5_31404039_-	ncRNA_intronic
CAediting_399411	chr5_31404056_-	ncRNA_intronic
CAediting_399412	chr5_31404058_-	ncRNA_intronic
CAediting_399413	chr5_31405187_-	ncRNA_intronic
CAediting_399414	chr5_31412534_-	ncRNA_intronic
CAediting_399415	chr5_31443116_-	intronic
CAediting_399416	chr5_31443131_-	intronic
CAediting_399417	chr5_31443135_-	intronic
CAediting_399418	chr5_31443157_-	intronic
CAediting_399419	chr5_31443158_-	intronic
CAediting_399420	chr5_31455920_-	ncRNA_intronic
CAediting_399421	chr5_31455921_-	ncRNA_intronic
CAediting_399422	chr5_31456854_-	ncRNA_intronic
CAediting_399423	chr5_31456864_-	ncRNA_intronic
CAediting_399424	chr5_31457220_-	ncRNA_intronic
CAediting_399425	chr5_31457221_-	ncRNA_intronic
CAediting_399426	chr5_31457235_-	ncRNA_intronic
CAediting_399427	chr5_31457256_-	ncRNA_intronic
CAediting_399428	chr5_31457262_-	ncRNA_intronic
CAediting_399429	chr5_31457288_-	ncRNA_intronic
CAediting_399430	chr5_31457291_-	ncRNA_intronic
CAediting_399431	chr5_31457292_-	ncRNA_intronic
CAediting_399432	chr5_31457293_-	ncRNA_intronic
CAediting_399433	chr5_31457307_-	ncRNA_intronic
CAediting_399434	chr5_31457357_-	ncRNA_intronic
CAediting_399435	chr5_31457672_-	ncRNA_intronic
CAediting_399436	chr5_31457679_-	ncRNA_intronic
CAediting_399437	chr5_31457741_-	ncRNA_intronic
CAediting_399438	chr5_31457768_-	ncRNA_intronic
CAediting_399439	chr5_31457778_-	ncRNA_intronic
CAediting_399440	chr5_31457781_-	ncRNA_intronic
CAediting_399441	chr5_31457814_-	ncRNA_intronic
CAediting_399442	chr5_31457840_-	ncRNA_intronic
CAediting_399443	chr5_31457857_-	ncRNA_intronic
CAediting_399444	chr5_31457871_-	ncRNA_intronic
CAediting_399445	chr5_31474435_-	ncRNA_intronic
CAediting_399446	chr5_31474455_-	ncRNA_intronic
CAediting_399447	chr5_31474460_-	ncRNA_intronic
CAediting_399448	chr5_31474471_-	ncRNA_intronic
CAediting_399449	chr5_31474476_-	ncRNA_intronic
CAediting_399450	chr5_31474478_-	ncRNA_intronic
CAediting_399451	chr5_31474491_-	ncRNA_intronic
CAediting_399452	chr5_31474495_-	ncRNA_intronic
CAediting_399453	chr5_31474501_-	ncRNA_intronic
CAediting_399454	chr5_31474511_-	ncRNA_intronic
CAediting_399455	chr5_31474527_-	ncRNA_intronic
CAediting_399456	chr5_31474530_-	ncRNA_intronic
CAediting_399457	chr5_31474531_-	ncRNA_intronic
CAediting_399458	chr5_31474532_-	ncRNA_intronic
CAediting_399459	chr5_31474538_-	ncRNA_intronic
CAediting_399460	chr5_31474540_-	ncRNA_intronic
CAediting_399461	chr5_31474541_-	ncRNA_intronic
CAediting_399462	chr5_31474542_-	ncRNA_intronic
CAediting_399463	chr5_31474543_-	ncRNA_intronic
CAediting_399464	chr5_31474544_-	ncRNA_intronic
CAediting_399465	chr5_31474559_-	ncRNA_intronic
CAediting_399466	chr5_31474563_-	ncRNA_intronic
CAediting_399467	chr5_31474567_-	ncRNA_intronic
CAediting_399468	chr5_31474568_-	ncRNA_intronic
CAediting_399469	chr5_31474591_-	ncRNA_intronic
CAediting_399470	chr5_31474636_-	ncRNA_intronic
CAediting_399471	chr5_31474637_-	ncRNA_intronic
CAediting_399472	chr5_31475151_-	ncRNA_intronic
CAediting_399473	chr5_31475170_-	ncRNA_intronic
CAediting_399474	chr5_31475196_-	ncRNA_intronic
CAediting_399475	chr5_31475206_-	ncRNA_intronic
CAediting_399476	chr5_31475250_-	ncRNA_intronic
CAediting_399477	chr5_31476289_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_399407	chr5_31402921_-	SINE	Alu	AluSz6
CAediting_399408	chr5_31402960_-	SINE	Alu	AluSz6
CAediting_399409	chr5_31403990_-	SINE	Alu	AluJo
CAediting_399410	chr5_31404039_-	SINE	Alu	AluJo
CAediting_399411	chr5_31404056_-	SINE	Alu	AluJo
CAediting_399412	chr5_31404058_-	SINE	Alu	AluJo
CAediting_399413	chr5_31405187_-	SINE	Alu	AluSq
CAediting_399415	chr5_31443116_-	SINE	Alu	AluSx1
CAediting_399416	chr5_31443131_-	SINE	Alu	AluSx1
CAediting_399417	chr5_31443135_-	SINE	Alu	AluSx1
CAediting_399418	chr5_31443157_-	SINE	Alu	AluSx1
CAediting_399419	chr5_31443158_-	SINE	Alu	AluSx1
CAediting_399420	chr5_31455920_-	SINE	Alu	AluJb
CAediting_399421	chr5_31455921_-	SINE	Alu	AluJb
CAediting_399422	chr5_31456854_-	SINE	Alu	AluJr
CAediting_399423	chr5_31456864_-	SINE	Alu	AluJr
CAediting_399424	chr5_31457220_-	SINE	Alu	AluSx
CAediting_399425	chr5_31457221_-	SINE	Alu	AluSx
CAediting_399426	chr5_31457235_-	SINE	Alu	AluSx
CAediting_399427	chr5_31457256_-	SINE	Alu	AluSx
CAediting_399428	chr5_31457262_-	SINE	Alu	AluSx
CAediting_399429	chr5_31457288_-	SINE	Alu	AluSx
CAediting_399430	chr5_31457291_-	SINE	Alu	AluSx
CAediting_399431	chr5_31457292_-	SINE	Alu	AluSx
CAediting_399432	chr5_31457293_-	SINE	Alu	AluSx
CAediting_399433	chr5_31457307_-	SINE	Alu	AluSx
CAediting_399434	chr5_31457357_-	SINE	Alu	AluSx
CAediting_399435	chr5_31457672_-	SINE	Alu	AluJo
CAediting_399436	chr5_31457679_-	SINE	Alu	AluJo
CAediting_399437	chr5_31457741_-	SINE	Alu	AluJo
CAediting_399438	chr5_31457768_-	SINE	Alu	AluJo
CAediting_399439	chr5_31457778_-	SINE	Alu	AluJo
CAediting_399440	chr5_31457781_-	SINE	Alu	AluJo
CAediting_399441	chr5_31457814_-	SINE	Alu	AluJo
CAediting_399442	chr5_31457840_-	SINE	Alu	AluJo
CAediting_399443	chr5_31457857_-	SINE	Alu	AluJo
CAediting_399444	chr5_31457871_-	SINE	Alu	AluJo
CAediting_399445	chr5_31474435_-	SINE	Alu	AluJb
CAediting_399446	chr5_31474455_-	SINE	Alu	AluJb
CAediting_399447	chr5_31474460_-	SINE	Alu	AluJb
CAediting_399448	chr5_31474471_-	SINE	Alu	AluJb
CAediting_399449	chr5_31474476_-	SINE	Alu	AluJb
CAediting_399450	chr5_31474478_-	SINE	Alu	AluJb
CAediting_399451	chr5_31474491_-	SINE	Alu	AluJb
CAediting_399452	chr5_31474495_-	SINE	Alu	AluJb
CAediting_399453	chr5_31474501_-	SINE	Alu	AluJb
CAediting_399454	chr5_31474511_-	SINE	Alu	AluJb
CAediting_399455	chr5_31474527_-	SINE	Alu	AluJb
CAediting_399456	chr5_31474530_-	SINE	Alu	AluJb
CAediting_399457	chr5_31474531_-	SINE	Alu	AluJb
CAediting_399458	chr5_31474532_-	SINE	Alu	AluJb
CAediting_399459	chr5_31474538_-	SINE	Alu	AluJb
CAediting_399460	chr5_31474540_-	SINE	Alu	AluJb
CAediting_399461	chr5_31474541_-	SINE	Alu	AluJb
CAediting_399462	chr5_31474542_-	SINE	Alu	AluJb
CAediting_399463	chr5_31474543_-	SINE	Alu	AluJb
CAediting_399464	chr5_31474544_-	SINE	Alu	AluJb
CAediting_399465	chr5_31474559_-	SINE	Alu	AluJb
CAediting_399466	chr5_31474563_-	SINE	Alu	AluJb
CAediting_399467	chr5_31474567_-	SINE	Alu	AluJb
CAediting_399468	chr5_31474568_-	SINE	Alu	AluJb
CAediting_399469	chr5_31474591_-	SINE	Alu	AluJb
CAediting_399470	chr5_31474636_-	SINE	Alu	AluJb
CAediting_399471	chr5_31474637_-	SINE	Alu	AluJb
CAediting_399472	chr5_31475151_-	SINE	Alu	AluJb
CAediting_399473	chr5_31475170_-	SINE	Alu	AluJb
CAediting_399474	chr5_31475196_-	SINE	Alu	AluJb
CAediting_399475	chr5_31475206_-	SINE	Alu	AluJb
CAediting_399476	chr5_31475250_-	SINE	Alu	AluJb
CAediting_399477	chr5_31476289_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for DROSHA

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000113360.15.DROSHA.

Correlation between RNA A-to-I editing and PSI for ENSG00000113360.15.DROSHA.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DROSHA

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for DROSHA

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for DROSHA

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000113360.15	ENST00000511367	hsa-miR-548aa	31400529	31400535	7mer-m8	31400528	31400556	144	-9.6
CAediting_1229414	chr17_67471546_+	ENSG00000113360.15	ENST00000511367	hsa-miR-548aa	31401261	31401267	7mer-m8	31401260	31401286	145	-13.31
CAediting_1229414	chr17_67471546_+	ENSG00000113360.15	ENST00000513349	hsa-miR-548aa	31401261	31401267	7mer-m8	31401260	31401286	145	-13.31

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DROSHA

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for DROSHA

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_399451	chr5_31474491_-	0.0231348622603941	0.314563358661858	.	.	.	.

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Relation with cancer stages for DROSHA

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for DROSHA

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for DROSHA

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DROSHA

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
DROSHA	C0021364	Male infertility	1	CTD_human
DROSHA	C0027708	Nephroblastoma	1	CTD_human
DROSHA	C0848676	Subfertility, Male	1	CTD_human
DROSHA	C0917731	Male sterility	1	CTD_human
DROSHA	C2930471	Bilateral Wilms Tumor	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene