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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: NR3C1 (CAeditome ID:2908) |
Gene summary for NR3C1 |
 Gene summary |
| Gene information | Gene symbol | NR3C1 | Gene ID | 2908 |
| Gene name | nuclear receptor subfamily 3 group C member 1 | |
| Synonyms | GCCR|GCR|GCRST|GR|GRL | |
| Cytomap | 5q31.3 | |
| Type of gene | protein-coding | |
| Description | glucocorticoid receptorglucocorticoid nuclear receptor variant 1nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)nuclear receptor subfamily 3 group C member 1 variant hGR-B(9 | |
| Modification date | 20210531 | |
| UniProtAcc | P04150 | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NR3C1 | GO:0000977 | Glucocorticoid receptor | 1894621 |
| NR3C1 | GO:0000978 | Glucocorticoid receptor | 16728402 |
| NR3C1 | GO:0001046 | Glucocorticoid receptor | 17081986 |
| NR3C1 | GO:0001227 | Glucocorticoid receptor | 1894621 |
| NR3C1 | GO:0001228 | Glucocorticoid receptor | 16728402 |
| NR3C1 | GO:0001228 | Glucocorticoid receptor | 23823477 |
| NR3C1 | GO:0003700 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:0004879 | Glucocorticoid receptor | 17635946 |
| NR3C1 | GO:0005496 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:1990239 | Glucocorticoid receptor | 17635946 |
| NR3C1 | GO:1990837 | Glucocorticoid receptor | 28473536 |
| NR3C1 | GO:0000122 | Glucocorticoid receptor | 1894621 |
| NR3C1 | GO:0006355 | Glucocorticoid receptor | 17081986 |
| NR3C1 | GO:0006355 | Glucocorticoid receptor | 19141540 |
| NR3C1 | GO:0045892 | Glucocorticoid receptor | 1894621 |
| NR3C1 | GO:0045944 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:0045944 | Glucocorticoid receptor | 16728402 |
| NR3C1 | GO:0045944 | Glucocorticoid receptor | 23823477 |
| NR3C1 | GO:0071383 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:0071383 | Glucocorticoid receptor | 17635946 |
| NR3C1 | GO:0071385 | Glucocorticoid receptor | 9353307 |
| NR3C1 | GO:0071560 | Glucocorticoid receptor | 12902338 |
| NR3C1 | GO:1902895 | Glucocorticoid receptor | 27334923 |
| NR3C1 | GO:0005634 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:0005634 | Glucocorticoid receptor | 17635946 |
| NR3C1 | GO:0005634 | Glucocorticoid receptor | 22022502 |
| NR3C1 | GO:0005634 | Glucocorticoid receptor | 23878391 |
| NR3C1 | GO:0005634 | Glucocorticoid receptor | 9353307 |
| NR3C1 | GO:0005654 | Glucocorticoid receptor | 0000052 |
| NR3C1 | GO:0005737 | Glucocorticoid receptor | 15769988 |
| NR3C1 | GO:0005737 | Glucocorticoid receptor | 17635946 |
| NR3C1 | GO:0005737 | Glucocorticoid receptor | 22022502 |
| NR3C1 | GO:0005829 | Glucocorticoid receptor | 0000052 |
| NR3C1 | GO:0016607 | Glucocorticoid receptor | 9353307 |
| NR3C1 | GO:0032991 | Glucocorticoid receptor | 26593036 |
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RNA A-to-I events for NR3C1 |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000113580.13 |
| RNA A-to-I editing events in Cancer. |
| CAediting_438770(143282918, -), CAediting_438771(143282920, -), CAediting_438772(143288191, -), CAediting_438773(143288192, -), CAediting_438774(143288195, -), CAediting_438775(143288283, -), CAediting_438776(143288567, -), CAediting_438777(143288574, -), CAediting_438778(143288575, -), CAediting_438779(143288584, -), CAediting_438780(143288636, -), CAediting_438781(143288655, -), CAediting_438782(143288675, -), CAediting_438783(143288689, -), CAediting_438784(143288759, -), CAediting_438785(143289004, -), CAediting_438786(143306964, -), CAediting_438787(143306989, -), CAediting_438788(143306994, -), CAediting_438789(143308204, -), CAediting_438790(143308216, -), CAediting_438791(143308356, -), CAediting_438792(143308369, -), CAediting_438793(143308402, -), CAediting_438794(143308451, -), CAediting_438795(143308452, -), CAediting_438796(143308459, -), CAediting_438797(143309170, -), CAediting_438798(143309171, -), CAediting_438799(143309185, -), CAediting_438800(143309198, -), CAediting_438801(143310187, -), CAediting_438802(143311829, -), CAediting_438803(143312441, -), CAediting_438804(143312452, -), CAediting_438805(143312455, -), CAediting_438806(143312465, -), CAediting_438807(143312467, -), CAediting_438808(143312472, -), CAediting_438809(143312484, -), CAediting_438810(143312501, -), CAediting_438811(143312506, -), CAediting_438812(143312514, -), CAediting_438813(143312518, -), CAediting_438814(143312896, -), CAediting_438815(143312900, -), CAediting_438816(143312902, -), CAediting_438817(143312909, -), CAediting_438818(143312926, -), CAediting_438819(143312929, -), CAediting_438820(143312934, -), CAediting_438821(143312952, -), CAediting_438822(143312969, -), CAediting_438823(143333576, -), CAediting_438824(143333659, -), CAediting_438825(143333668, -), CAediting_438826(143340620, -), CAediting_438827(143340753, -), CAediting_438828(143340754, -), CAediting_438829(143345347, -), CAediting_438830(143345348, -), CAediting_438831(143345456, -), |
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RNA editing positional annotations for NR3C1 using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000231509.6 | c.A1381G | p.R461G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000343796.5 | c.A1378G | p.R460G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000394464.5 | c.A1378G | p.R460G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000394466.5 | c.A1381G | p.R461G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000415690.5 | c.A1378G | p.R460G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000424646.5 | c.A1300G | p.R434G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000503201.1 | c.A1378G | p.R460G | D | D | D |
| CAediting_438801 | chr5_143310187_- | nonsynonymous SNV | ENST00000504572.4 | c.A1381G | p.R461G | D | D | D |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_438770 | chr5_143282918_- | intronic |
| CAediting_438771 | chr5_143282920_- | intronic |
| CAediting_438772 | chr5_143288191_- | intronic |
| CAediting_438773 | chr5_143288192_- | intronic |
| CAediting_438774 | chr5_143288195_- | intronic |
| CAediting_438775 | chr5_143288283_- | intronic |
| CAediting_438776 | chr5_143288567_- | intronic |
| CAediting_438777 | chr5_143288574_- | intronic |
| CAediting_438778 | chr5_143288575_- | intronic |
| CAediting_438779 | chr5_143288584_- | intronic |
| CAediting_438780 | chr5_143288636_- | intronic |
| CAediting_438781 | chr5_143288655_- | intronic |
| CAediting_438782 | chr5_143288675_- | intronic |
| CAediting_438783 | chr5_143288689_- | intronic |
| CAediting_438784 | chr5_143288759_- | intronic |
| CAediting_438785 | chr5_143289004_- | intronic |
| CAediting_438786 | chr5_143306964_- | ncRNA_intronic |
| CAediting_438787 | chr5_143306989_- | ncRNA_intronic |
| CAediting_438788 | chr5_143306994_- | ncRNA_intronic |
| CAediting_438789 | chr5_143308204_- | ncRNA_intronic |
| CAediting_438790 | chr5_143308216_- | ncRNA_intronic |
| CAediting_438791 | chr5_143308356_- | ncRNA_intronic |
| CAediting_438792 | chr5_143308369_- | ncRNA_intronic |
| CAediting_438793 | chr5_143308402_- | ncRNA_intronic |
| CAediting_438794 | chr5_143308451_- | ncRNA_intronic |
| CAediting_438795 | chr5_143308452_- | ncRNA_intronic |
| CAediting_438796 | chr5_143308459_- | ncRNA_intronic |
| CAediting_438797 | chr5_143309170_- | ncRNA_intronic |
| CAediting_438798 | chr5_143309171_- | ncRNA_intronic |
| CAediting_438799 | chr5_143309185_- | ncRNA_intronic |
| CAediting_438800 | chr5_143309198_- | ncRNA_intronic |
| CAediting_438801 | chr5_143310187_- | exonic |
| CAediting_438802 | chr5_143311829_- | ncRNA_intronic |
| CAediting_438803 | chr5_143312441_- | ncRNA_intronic |
| CAediting_438804 | chr5_143312452_- | ncRNA_intronic |
| CAediting_438805 | chr5_143312455_- | ncRNA_intronic |
| CAediting_438806 | chr5_143312465_- | ncRNA_intronic |
| CAediting_438807 | chr5_143312467_- | ncRNA_intronic |
| CAediting_438808 | chr5_143312472_- | ncRNA_intronic |
| CAediting_438809 | chr5_143312484_- | ncRNA_intronic |
| CAediting_438810 | chr5_143312501_- | ncRNA_intronic |
| CAediting_438811 | chr5_143312506_- | ncRNA_intronic |
| CAediting_438812 | chr5_143312514_- | ncRNA_intronic |
| CAediting_438813 | chr5_143312518_- | ncRNA_intronic |
| CAediting_438814 | chr5_143312896_- | ncRNA_intronic |
| CAediting_438815 | chr5_143312900_- | ncRNA_intronic |
| CAediting_438816 | chr5_143312902_- | ncRNA_intronic |
| CAediting_438817 | chr5_143312909_- | ncRNA_intronic |
| CAediting_438818 | chr5_143312926_- | ncRNA_intronic |
| CAediting_438819 | chr5_143312929_- | ncRNA_intronic |
| CAediting_438820 | chr5_143312934_- | ncRNA_intronic |
| CAediting_438821 | chr5_143312952_- | ncRNA_intronic |
| CAediting_438822 | chr5_143312969_- | ncRNA_intronic |
| CAediting_438823 | chr5_143333576_- | ncRNA_intronic |
| CAediting_438824 | chr5_143333659_- | ncRNA_intronic |
| CAediting_438825 | chr5_143333668_- | ncRNA_intronic |
| CAediting_438826 | chr5_143340620_- | ncRNA_intronic |
| CAediting_438827 | chr5_143340753_- | ncRNA_intronic |
| CAediting_438828 | chr5_143340754_- | ncRNA_intronic |
| CAediting_438829 | chr5_143345347_- | ncRNA_intronic |
| CAediting_438830 | chr5_143345348_- | ncRNA_intronic |
| CAediting_438831 | chr5_143345456_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_438770 | chr5_143282918_- | SINE | Alu | AluJr |
| CAediting_438771 | chr5_143282920_- | SINE | Alu | AluJr |
| CAediting_438772 | chr5_143288191_- | SINE | Alu | AluSx3 |
| CAediting_438773 | chr5_143288192_- | SINE | Alu | AluSx3 |
| CAediting_438774 | chr5_143288195_- | SINE | Alu | AluSx3 |
| CAediting_438775 | chr5_143288283_- | SINE | Alu | AluSx3 |
| CAediting_438776 | chr5_143288567_- | SINE | Alu | AluJb |
| CAediting_438777 | chr5_143288574_- | SINE | Alu | AluJb |
| CAediting_438778 | chr5_143288575_- | SINE | Alu | AluJb |
| CAediting_438779 | chr5_143288584_- | SINE | Alu | AluJb |
| CAediting_438780 | chr5_143288636_- | SINE | Alu | AluJb |
| CAediting_438781 | chr5_143288655_- | SINE | Alu | AluJb |
| CAediting_438782 | chr5_143288675_- | SINE | Alu | AluJb |
| CAediting_438783 | chr5_143288689_- | SINE | Alu | AluJb |
| CAediting_438784 | chr5_143288759_- | SINE | Alu | AluJb |
| CAediting_438785 | chr5_143289004_- | SINE | Alu | AluSq |
| CAediting_438786 | chr5_143306964_- | SINE | Alu | AluY |
| CAediting_438787 | chr5_143306989_- | SINE | Alu | AluY |
| CAediting_438788 | chr5_143306994_- | SINE | Alu | AluY |
| CAediting_438789 | chr5_143308204_- | SINE | Alu | AluJr |
| CAediting_438790 | chr5_143308216_- | SINE | Alu | AluJr |
| CAediting_438791 | chr5_143308356_- | SINE | Alu | AluJr |
| CAediting_438792 | chr5_143308369_- | SINE | Alu | AluJr |
| CAediting_438793 | chr5_143308402_- | SINE | Alu | AluJr |
| CAediting_438794 | chr5_143308451_- | SINE | Alu | AluJr |
| CAediting_438795 | chr5_143308452_- | SINE | Alu | AluJr |
| CAediting_438796 | chr5_143308459_- | SINE | Alu | AluJr |
| CAediting_438797 | chr5_143309170_- | SINE | Alu | AluSc |
| CAediting_438798 | chr5_143309171_- | SINE | Alu | AluSc |
| CAediting_438799 | chr5_143309185_- | SINE | Alu | AluSc |
| CAediting_438800 | chr5_143309198_- | SINE | Alu | AluSc |
| CAediting_438802 | chr5_143311829_- | SINE | Alu | AluJr |
| CAediting_438823 | chr5_143333576_- | SINE | Alu | AluSc |
| CAediting_438824 | chr5_143333659_- | SINE | Alu | AluSc |
| CAediting_438825 | chr5_143333668_- | SINE | Alu | AluSc |
| CAediting_438826 | chr5_143340620_- | SINE | Alu | AluSg |
| CAediting_438827 | chr5_143340753_- | SINE | Alu | AluSg |
| CAediting_438828 | chr5_143340754_- | SINE | Alu | AluSg |
| CAediting_438829 | chr5_143345347_- | SINE | Alu | AluSz |
| CAediting_438830 | chr5_143345348_- | SINE | Alu | AluSz |
| CAediting_438831 | chr5_143345456_- | SINE | Alu | AluSz |
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RNA A-to-I editing events in the alternative splicing sites for NR3C1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000113580.13.NR3C1. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000113580.13.NR3C1. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NR3C1 |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for NR3C1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for NR3C1 |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_980496 | chr14_31014685_- | ENSG00000113580.13 | ENST00000343796 | hsa-miR-624-3p | 143280959 | 143280964 | 6mer | 143280958 | 143280981 | 144 | -19.35 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-200b-3p | 143281460 | 143281465 | 6mer | 143281459 | 143281481 | 141 | -14.64 |
| CAediting_688080 | chr9_63819626_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-4477b | 143278368 | 143278375 | 8mer-1a | 143278368 | 143278391 | 143 | -9.12 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-4477b | 143280606 | 143280612 | 7mer-m8 | 143280605 | 143280624 | 152 | -14.94 |
| CAediting_688080 | chr9_63819626_+ | ENSG00000113580.13 | ENST00000415690 | hsa-miR-4477b | 143278368 | 143278375 | 8mer-1a | 143278368 | 143278391 | 143 | -9.12 |
| CAediting_980496 | chr14_31014685_- | ENSG00000113580.13 | ENST00000424646 | hsa-miR-624-3p | 143280959 | 143280964 | 6mer | 143280958 | 143280981 | 144 | -19.35 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-200b-3p | 143281460 | 143281465 | 6mer | 143281459 | 143281481 | 141 | -14.64 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-4477b | 143280606 | 143280612 | 7mer-m8 | 143280605 | 143280624 | 152 | -14.94 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000504572 | hsa-miR-200b-3p | 143281460 | 143281465 | 6mer | 143281459 | 143281481 | 141 | -14.64 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000394466 | hsa-miR-200b-3p | 143281460 | 143281465 | 6mer | 143281459 | 143281481 | 141 | -14.64 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000231509 | hsa-miR-200b-3p | 143281460 | 143281465 | 6mer | 143281459 | 143281481 | 141 | -14.64 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-197-5p | 143278472 | 143278479 | 8mer-1a | 143278472 | 143278494 | 149 | -23.86 |
| CAediting_117844 | chr1_162342605_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-556-3p | 143279778 | 143279784 | 7mer-m8 | 143279777 | 143279794 | 150 | -12.48 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-4423-3p | 143281568 | 143281575 | 8mer-1a | 143281568 | 143281588 | 140 | -12.47 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-561-3p | 143281244 | 143281251 | 8mer-1a | 143281244 | 143281265 | 145 | -8.28 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000113580.13 | ENST00000415690 | hsa-miR-197-5p | 143278472 | 143278479 | 8mer-1a | 143278472 | 143278494 | 149 | -23.86 |
| CAediting_117844 | chr1_162342605_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-556-3p | 143279778 | 143279784 | 7mer-m8 | 143279777 | 143279794 | 150 | -12.48 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-4423-3p | 143281568 | 143281575 | 8mer-1a | 143281568 | 143281588 | 140 | -12.47 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-561-3p | 143281244 | 143281251 | 8mer-1a | 143281244 | 143281265 | 145 | -8.28 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000113580.13 | ENST00000504572 | hsa-miR-4423-3p | 143281568 | 143281575 | 8mer-1a | 143281568 | 143281588 | 140 | -12.47 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000504572 | hsa-miR-561-3p | 143281244 | 143281251 | 8mer-1a | 143281244 | 143281265 | 145 | -8.28 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000113580.13 | ENST00000394466 | hsa-miR-4423-3p | 143281568 | 143281575 | 8mer-1a | 143281568 | 143281588 | 140 | -12.47 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000394466 | hsa-miR-561-3p | 143281244 | 143281251 | 8mer-1a | 143281244 | 143281265 | 145 | -8.28 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000113580.13 | ENST00000231509 | hsa-miR-4423-3p | 143281568 | 143281575 | 8mer-1a | 143281568 | 143281588 | 140 | -12.47 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000231509 | hsa-miR-561-3p | 143281244 | 143281251 | 8mer-1a | 143281244 | 143281265 | 145 | -8.28 |
| CAediting_468389 | chr6_31355314_- | ENSG00000113580.13 | ENST00000343796 | hsa-miR-6891-5p | 143278370 | 143278377 | 8mer-1a | 143278370 | 143278388 | 145 | -19.84 |
| CAediting_468389 | chr6_31355314_- | ENSG00000113580.13 | ENST00000415690 | hsa-miR-6891-5p | 143278370 | 143278377 | 8mer-1a | 143278370 | 143278388 | 145 | -19.84 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_442554 | chr5_154685830_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-1303 | 143280758 | 143280764 | 7mer-m8 | 143280757 | 143280778 | 149 | -10.63 |
| CAediting_442554 | chr5_154685830_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-1303 | 143279554 | 143279561 | 8mer-1a | 143279554 | 143279574 | 141 | -11.06 |
| CAediting_1160181 | chr17_7017644_- | ENSG00000113580.13 | ENST00000343796 | hsa-miR-195-3p | 143278700 | 143278706 | 7mer-m8 | 143278699 | 143278720 | 142 | -6.37 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-200b-3p | 143279609 | 143279615 | 7mer-m8 | 143279608 | 143279628 | 149 | -9.62 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-200b-3p | 143281144 | 143281150 | 7mer-m8 | 143281143 | 143281164 | 140 | -9.35 |
| CAediting_688080 | chr9_63819626_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-4477b | 143279863 | 143279870 | 8mer-1a | 143279863 | 143279884 | 140 | -8.19 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-4477b | 143279863 | 143279870 | 8mer-1a | 143279863 | 143279884 | 140 | -8.19 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-548aa | 143278571 | 143278578 | 8mer-1a | 143278571 | 143278595 | 154 | -11.23 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-548aa | 143281803 | 143281808 | 6mer | 143281794 | 143281817 | 144 | -14.6 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000343796 | hsa-miR-561-3p | 143280778 | 143280785 | 8mer-1a | 143280778 | 143280799 | 145 | -5.2 |
| CAediting_524911 | chr7_5495852_- | ENSG00000113580.13 | ENST00000343796 | hsa-miR-589-3p | 143278038 | 143278044 | 7mer-m8 | 143278037 | 143278057 | 142 | -11.36 |
| CAediting_980496 | chr14_31014685_- | ENSG00000113580.13 | ENST00000343796 | hsa-miR-624-3p | 143278084 | 143278090 | 7mer-m8 | 143278083 | 143278105 | 154 | -14.99 |
| CAediting_1160181 | chr17_7017644_- | ENSG00000113580.13 | ENST00000415690 | hsa-miR-195-3p | 143278700 | 143278706 | 7mer-m8 | 143278699 | 143278720 | 142 | -6.37 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000415690 | hsa-miR-548aa | 143278571 | 143278578 | 8mer-1a | 143278571 | 143278595 | 154 | -11.23 |
| CAediting_524911 | chr7_5495852_- | ENSG00000113580.13 | ENST00000415690 | hsa-miR-589-3p | 143278038 | 143278044 | 7mer-m8 | 143278037 | 143278057 | 142 | -11.36 |
| CAediting_442554 | chr5_154685830_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-1303 | 143280758 | 143280764 | 7mer-m8 | 143280757 | 143280778 | 149 | -10.63 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-200b-3p | 143279609 | 143279615 | 7mer-m8 | 143279608 | 143279628 | 149 | -9.62 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-200b-3p | 143281144 | 143281150 | 7mer-m8 | 143281143 | 143281164 | 140 | -9.35 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-4477b | 143279863 | 143279870 | 8mer-1a | 143279863 | 143279884 | 140 | -8.19 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-548aa | 143281803 | 143281808 | 6mer | 143281794 | 143281817 | 144 | -14.6 |
| CAediting_228905 | chr2_188297554_+ | ENSG00000113580.13 | ENST00000424646 | hsa-miR-561-3p | 143280778 | 143280785 | 8mer-1a | 143280778 | 143280799 | 145 | -5.2 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000504572 | hsa-miR-200b-3p | 143281144 | 143281150 | 7mer-m8 | 143281143 | 143281164 | 140 | -9.35 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000504572 | hsa-miR-548aa | 143281803 | 143281808 | 6mer | 143281794 | 143281817 | 144 | -14.6 |
| CAediting_393 | chr1_1167164_+ | ENSG00000113580.13 | ENST00000394466 | hsa-miR-200b-3p | 143281144 | 143281150 | 7mer-m8 | 143281143 | 143281164 | 140 | -9.35 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000394466 | hsa-miR-548aa | 143281803 | 143281808 | 6mer | 143281794 | 143281817 | 144 | -14.6 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000113580.13 | ENST00000231509 | hsa-miR-548aa | 143281803 | 143281808 | 6mer | 143281794 | 143281817 | 144 | -14.6 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for NR3C1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000231509.6 | protein_coding |  |  |
| ENST00000343796.5 | protein_coding |  |  |
| ENST00000394464.5 | protein_coding |  |  |
| ENST00000394466.5 | protein_coding |  |  |
| ENST00000415690.5 | protein_coding |  |  |
| ENST00000424646.5 | protein_coding |  |  |
| ENST00000503201.1 | protein_coding |  |  |
| ENST00000504572.4 | protein_coding |  |  |
| ENST00000504336.1 | processed_transcript |  |  |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| CAediting_438801 | ENST00000231509.6 | chr5_143310187_- | -1082.40 | -1080.70 | -1082.40 |
| CAediting_438801 | ENST00000343796.5 | chr5_143310187_- | -1966.70 | -1966.70 | -1966.70 |
| CAediting_438801 | ENST00000394464.5 | chr5_143310187_- | -1887.80 | -1887.80 | -1887.80 |
| CAediting_438801 | ENST00000394466.5 | chr5_143310187_- | -925.70 | -924.00 | -925.70 |
| CAediting_438801 | ENST00000415690.5 | chr5_143310187_- | -1048.90 | -1048.90 | -1048.90 |
| CAediting_438801 | ENST00000424646.5 | chr5_143310187_- | -1222.60 | -1222.60 | -1222.60 |
| CAediting_438801 | ENST00000503201.1 | chr5_143310187_- | -762.90 | -762.90 | -762.90 |
| CAediting_438801 | ENST00000504572.4 | chr5_143310187_- | -948.80 | -947.10 | -948.80 |
| CAediting_438801 | ENST00000504336.1 | chr5_143310187_- | -148.10 | -146.90 | -148.10 |
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Relation with ADAR for NR3C1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for NR3C1 |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for NR3C1 |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for NR3C1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| NR3C1 | P04150 | DB00223 | Diflorasone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00240 | Alclometasone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00253 | Medrysone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00288 | Amcinonide | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00421 | Spironolactone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00547 | Desoximetasone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00588 | Fluticasone propionate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00596 | Ulobetasol | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00717 | Norethisterone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00769 | Hydrocortamate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00838 | Clocortolone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00846 | Flurandrenolide | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB14596 | Loteprednol etabonate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB00896 | Rimexolone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB01013 | Clobetasol propionate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB01222 | Budesonide | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB01395 | Drospirenone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB06781 | Difluprednate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB08867 | Ulipristal | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB08906 | Fluticasone furoate | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB11619 | Gestrinone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB13158 | Clobetasone | Glucocorticoid receptor | SmallMoleculeDrug | approved |
| NR3C1 | P04150 | DB13867 | Fluticasone | Glucocorticoid receptor | SmallMoleculeDrug | approved|experimental |
| NR3C1 | P04150 | DB14583 | Segesterone acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|experimental|investigational |
| NR3C1 | P04150 | DB01185 | Fluoxymesterone | Glucocorticoid receptor | SmallMoleculeDrug | approved|illicit |
| NR3C1 | P04150 | DB00180 | Flunisolide | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00324 | Fluorometholone | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00367 | Levonorgestrel | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00394 | Beclomethasone dipropionate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00687 | Fludrocortisone | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00834 | Mifepristone | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB01047 | Fluocinonide | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB01130 | Prednicarbate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB01260 | Desonide | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB01380 | Cortisone acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB01410 | Ciclesonide | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB11921 | Deflazacort | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational |
| NR3C1 | P04150 | DB00351 | Megestrol acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB00591 | Fluocinolone acetonide | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB01234 | Dexamethasone | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB14512 | Mometasone furoate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB14541 | Hydrocortisone cypionate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB14649 | Dexamethasone acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|vet_approved |
| NR3C1 | P04150 | DB09095 | Difluocortolone | Glucocorticoid receptor | SmallMoleculeDrug | approved|investigational|withdrawn |
| NR3C1 | P04150 | DB00396 | Progesterone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00443 | Betamethasone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00620 | Triamcinolone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00635 | Prednisone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00663 | Flumethasone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00741 | Hydrocortisone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00860 | Prednisolone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB00959 | Methylprednisolone | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14539 | Hydrocortisone acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14540 | Hydrocortisone butyrate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14542 | Hydrocortisone phosphate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14543 | Hydrocortisone probutate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14544 | Hydrocortisone valerate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14631 | Prednisolone phosphate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB14669 | Betamethasone phosphate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB15566 | Prednisolone acetate | Glucocorticoid receptor | SmallMoleculeDrug | approved|vet_approved |
| NR3C1 | P04150 | DB09091 | Tixocortol | Glucocorticoid receptor | SmallMoleculeDrug | approved|withdrawn |
| NR3C1 | P04150 | DB14538 | Hydrocortisone aceponate | Glucocorticoid receptor | SmallMoleculeDrug | experimental|vet_approved |
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RelatedDiseases for NR3C1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| NR3C1 | C1841972 | Glucocorticoid Receptor Deficiency | 16 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| NR3C1 | C0005586 | Bipolar Disorder | 6 | CTD_human;PSYGENET |
| NR3C1 | C0011581 | Depressive disorder | 6 | CTD_human;PSYGENET |
| NR3C1 | C0041696 | Unipolar Depression | 6 | CTD_human;PSYGENET |
| NR3C1 | C0525045 | Mood Disorders | 6 | CTD_human;PSYGENET |
| NR3C1 | C0011570 | Mental Depression | 5 | PSYGENET |
| NR3C1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| NR3C1 | C0001969 | Alcoholic Intoxication | 2 | PSYGENET |
| NR3C1 | C0009171 | Cocaine Abuse | 2 | CTD_human |
| NR3C1 | C0020538 | Hypertensive disease | 2 | CTD_human |
| NR3C1 | C0036341 | Schizophrenia | 2 | CTD_human |
| NR3C1 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
| NR3C1 | C0600427 | Cocaine Dependence | 2 | CTD_human |
| NR3C1 | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| NR3C1 | C0005587 | Depression, Bipolar | 1 | CTD_human |
| NR3C1 | C0011573 | Endogenous depression | 1 | CTD_human |
| NR3C1 | C0013221 | Drug toxicity | 1 | CTD_human |
| NR3C1 | C0014175 | Endometriosis | 1 | CTD_human |
| NR3C1 | C0017614 | Glaucoma, Suspect | 1 | CTD_human |
| NR3C1 | C0020621 | Hypokalemia | 1 | CTD_human |
| NR3C1 | C0024713 | Manic Disorder | 1 | CTD_human |
| NR3C1 | C0025193 | Melancholia | 1 | CTD_human |
| NR3C1 | C0028840 | Ocular Hypertension | 1 | CTD_human |
| NR3C1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| NR3C1 | C0033958 | Psychosis, Brief Reactive | 1 | CTD_human |
| NR3C1 | C0033975 | Psychotic Disorders | 1 | CTD_human |
| NR3C1 | C0036337 | Schizoaffective Disorder | 1 | CTD_human |
| NR3C1 | C0036358 | Schizophreniform Disorders | 1 | CTD_human |
| NR3C1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| NR3C1 | C0086133 | Depressive Syndrome | 1 | CTD_human |
| NR3C1 | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
| NR3C1 | C0238394 | Female Pseudohermaphroditism | 1 | CTD_human |
| NR3C1 | C0269102 | Endometrioma | 1 | CTD_human |
| NR3C1 | C0282126 | Depression, Neurotic | 1 | CTD_human |
| NR3C1 | C0338831 | Manic | 1 | CTD_human |
| NR3C1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| NR3C1 | C0600260 | Lung Diseases, Obstructive | 1 | CTD_human |
| NR3C1 | C1257958 | Glucose Metabolism Disorders | 1 | CTD_human |
| NR3C1 | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
| NR3C1 | C2936403 | 46, XX Disorders of Sex Development | 1 | CTD_human |
| NR3C1 | C3468561 | familial atrial fibrillation | 1 | CTD_human |
