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Editing gene: GRIK2 (CAeditome ID:2898)

Gene summary for GRIK2

Gene summary

Gene information	Gene symbol	GRIK2
	Gene ID	2898
	Gene name	glutamate ionotropic receptor kainate type subunit 2
	Synonyms	EAA4\|GLR6\|GLUK6\|GLUR6\|GluK2\|MRT6
	Cytomap	6q16.3
	Type of gene	protein-coding
	Description	glutamate receptor ionotropic, kainate 2bA487F5.1excitatory amino acid receptor 4gluR-6glutamate receptor 6glutamate receptor form Aglutamate receptor form Bglutamate receptor form Cglutamate receptor form Dglutamate receptor form E
	Modification date	20210518
	UniProtAcc	Q13002
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GRIK2	GO:0015277	Glutamate receptor ionotropic, kainate 2	15537878
GRIK2	GO:0050804	Glutamate receptor ionotropic, kainate 2	15537878

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RNA A-to-I events for GRIK2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000164418.18

RNA A-to-I editing events in Cancer.

CAediting_495934(101470121, +), CAediting_495935(101470122, +), CAediting_495936(101482403, +), CAediting_495937(101493792, +), CAediting_495938(101598960, +), CAediting_495939(101598973, +), CAediting_495940(101599007, +), CAediting_495941(101599049, +), CAediting_495942(101599050, +), CAediting_495943(101599117, +), CAediting_495944(101599136, +), CAediting_495945(101599151, +), CAediting_495946(101599153, +), CAediting_495947(101599154, +), CAediting_495948(101599268, +), CAediting_495949(101691933, +), CAediting_495950(101889814, +), CAediting_495951(101889827, +), CAediting_495952(101924697, +), CAediting_495953(101924714, +), CAediting_495954(101924755, +), CAediting_495955(101925040, +), CAediting_495956(101925056, +), CAediting_495957(101926678, +), CAediting_495958(101926684, +), CAediting_495959(101926697, +), CAediting_495960(101926724, +), CAediting_495961(101926741, +), CAediting_495962(101926759, +), CAediting_495963(101926768, +),

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RNA editing positional annotations for GRIK2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000369134.7	c.A1598G	p.Y533C	T	B	D
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000369137.6	c.A1598G	p.Y533C	T	B	D
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000369138.4	c.A1712G	p.Y571C	T	B	D
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000413795.4	c.A1712G	p.Y571C	T	B	D
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000421544.4	c.A1712G	p.Y571C	T	B	D
CAediting_495951	chr6_101889827_+	nonsynonymous SNV	ENST00000436862.1	c.A509G	p.Y170C	T	B	D
CAediting_495953	chr6_101924714_+	nonsynonymous SNV	ENST00000369134.7	c.A1748G	p.Q583R	T	B	D
CAediting_495953	chr6_101924714_+	nonsynonymous SNV	ENST00000369137.6	c.A1748G	p.Q583R	T	B	D
CAediting_495953	chr6_101924714_+	nonsynonymous SNV	ENST00000369138.4	c.A1862G	p.Q621R	T	B	D
CAediting_495953	chr6_101924714_+	nonsynonymous SNV	ENST00000413795.4	c.A1862G	p.Q621R	T	B	D
CAediting_495953	chr6_101924714_+	nonsynonymous SNV	ENST00000421544.4	c.A1862G	p.Q621R	T	B	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_495934	chr6_101470121_+	intronic
CAediting_495935	chr6_101470122_+	intronic
CAediting_495936	chr6_101482403_+	intronic
CAediting_495937	chr6_101493792_+	intronic
CAediting_495938	chr6_101598960_+	intronic
CAediting_495939	chr6_101598973_+	intronic
CAediting_495940	chr6_101599007_+	intronic
CAediting_495941	chr6_101599049_+	intronic
CAediting_495942	chr6_101599050_+	intronic
CAediting_495943	chr6_101599117_+	intronic
CAediting_495944	chr6_101599136_+	intronic
CAediting_495945	chr6_101599151_+	intronic
CAediting_495946	chr6_101599153_+	intronic
CAediting_495947	chr6_101599154_+	intronic
CAediting_495948	chr6_101599268_+	intronic
CAediting_495949	chr6_101691933_+	intronic
CAediting_495950	chr6_101889814_+	exonic
CAediting_495951	chr6_101889827_+	exonic
CAediting_495952	chr6_101924697_+	exonic
CAediting_495953	chr6_101924714_+	exonic
CAediting_495954	chr6_101924755_+	intronic
CAediting_495955	chr6_101925040_+	intronic
CAediting_495956	chr6_101925056_+	intronic
CAediting_495957	chr6_101926678_+	intronic
CAediting_495958	chr6_101926684_+	intronic
CAediting_495959	chr6_101926697_+	intronic
CAediting_495960	chr6_101926724_+	intronic
CAediting_495961	chr6_101926741_+	intronic
CAediting_495962	chr6_101926759_+	intronic
CAediting_495963	chr6_101926768_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_495934	chr6_101470121_+	LTR	ERV1	LTR78B
CAediting_495935	chr6_101470122_+	LTR	ERV1	LTR78B
CAediting_495936	chr6_101482403_+	LINE	L2	L2c
CAediting_495938	chr6_101598960_+	LINE	L1	L1PA16
CAediting_495939	chr6_101598973_+	LINE	L1	L1PA16
CAediting_495940	chr6_101599007_+	LINE	L1	L1PA16
CAediting_495941	chr6_101599049_+	LINE	L1	L1PA16
CAediting_495942	chr6_101599050_+	LINE	L1	L1PA16
CAediting_495943	chr6_101599117_+	LINE	L1	L1PA16
CAediting_495944	chr6_101599136_+	LINE	L1	L1PA16
CAediting_495945	chr6_101599151_+	LINE	L1	L1PA16
CAediting_495946	chr6_101599153_+	LINE	L1	L1PA16
CAediting_495947	chr6_101599154_+	LINE	L1	L1PA16
CAediting_495948	chr6_101599268_+	LINE	L1	L1PA16
CAediting_495949	chr6_101691933_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for GRIK2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164418.18.GRIK2.

Correlation between RNA A-to-I editing and PSI for ENSG00000164418.18.GRIK2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRIK2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LGG.CAediting_495951.ENSG00000164418.GRIK2.png
Soverview

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Protein coding region RNA A-to-I editings for GRIK2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GRIK2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000164418.18	ENST00000421544	hsa-miR-4477b	102069211	102069217	7mer-m8	102069198	102069218	155	-12.5
CAediting_688081	chr9_63819627_+	ENSG00000164418.18	ENST00000369134	hsa-miR-4477b	102069211	102069217	7mer-m8	102069198	102069218	155	-12.5
CAediting_688081	chr9_63819627_+	ENSG00000164418.18	ENST00000369138	hsa-miR-4477b	102069211	102069217	7mer-m8	102069198	102069218	155	-12.5
CAediting_688081	chr9_63819627_+	ENSG00000164418.18	ENST00000413795	hsa-miR-4477b	102069211	102069217	7mer-m8	102069198	102069218	155	-12.5
CAediting_1229413	chr17_67471544_+	ENSG00000164418.18	ENST00000421544	hsa-miR-548aa	102069912	102069918	7mer-m8	102069895	102069919	140	-8.48
CAediting_1160181	chr17_7017644_-	ENSG00000164418.18	ENST00000421544	hsa-miR-195-3p	102069987	102069993	7mer-m8	102069973	102069994	147	-13.53
CAediting_414656	chr5_72878640_+	ENSG00000164418.18	ENST00000421544	hsa-miR-4804-3p	102069761	102069768	8mer-1a	102069748	102069768	157	-20.11
CAediting_1229413	chr17_67471544_+	ENSG00000164418.18	ENST00000369134	hsa-miR-548aa	102069912	102069918	7mer-m8	102069895	102069919	140	-8.48
CAediting_1160181	chr17_7017644_-	ENSG00000164418.18	ENST00000369134	hsa-miR-195-3p	102069987	102069993	7mer-m8	102069973	102069994	147	-13.53
CAediting_414656	chr5_72878640_+	ENSG00000164418.18	ENST00000369134	hsa-miR-4804-3p	102069761	102069768	8mer-1a	102069748	102069768	157	-20.11
CAediting_1054808	chr15_66496985_-	ENSG00000164418.18	ENST00000369138	hsa-miR-4512	102068422	102068429	8mer-1a	102068408	102068429	140	-14.62
CAediting_1229413	chr17_67471544_+	ENSG00000164418.18	ENST00000369138	hsa-miR-548aa	102069912	102069918	7mer-m8	102069895	102069919	140	-8.48
CAediting_1160181	chr17_7017644_-	ENSG00000164418.18	ENST00000369138	hsa-miR-195-3p	102069987	102069993	7mer-m8	102069973	102069994	147	-13.53
CAediting_414656	chr5_72878640_+	ENSG00000164418.18	ENST00000369138	hsa-miR-4804-3p	102069761	102069768	8mer-1a	102069748	102069768	157	-20.11
CAediting_1054808	chr15_66496985_-	ENSG00000164418.18	ENST00000413795	hsa-miR-4512	102068422	102068429	8mer-1a	102068408	102068429	140	-14.62
CAediting_1229413	chr17_67471544_+	ENSG00000164418.18	ENST00000413795	hsa-miR-548aa	102069912	102069918	7mer-m8	102069895	102069919	140	-8.48
CAediting_1160181	chr17_7017644_-	ENSG00000164418.18	ENST00000413795	hsa-miR-195-3p	102069987	102069993	7mer-m8	102069973	102069994	147	-13.53
CAediting_414656	chr5_72878640_+	ENSG00000164418.18	ENST00000413795	hsa-miR-4804-3p	102069761	102069768	8mer-1a	102069748	102069768	157	-20.11

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GRIK2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000369138.4	protein_coding
ENST00000413795.4	protein_coding
ENST00000421544.4	protein_coding
ENST00000318991.9	protein_coding
ENST00000369134.7	protein_coding
ENST00000369137.6	protein_coding
ENST00000436862.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_495950	ENST00000369138.4	chr6_101889814_+	-1362.70	-1361.20	-1367.30
CAediting_495951	ENST00000369138.4	chr6_101889827_+	-1361.30	-1361.20	-1367.30
CAediting_495952	ENST00000369138.4	chr6_101924697_+	-1364.40	-1361.20	-1367.30
CAediting_495953	ENST00000369138.4	chr6_101924714_+	-1362.80	-1361.20	-1367.30
CAediting_495950	ENST00000413795.4	chr6_101889814_+	-1356.30	-1354.80	-1360.70
CAediting_495951	ENST00000413795.4	chr6_101889827_+	-1356.00	-1354.80	-1360.70
CAediting_495952	ENST00000413795.4	chr6_101924697_+	-1357.80	-1354.80	-1360.70
CAediting_495953	ENST00000413795.4	chr6_101924714_+	-1356.40	-1354.80	-1360.70
CAediting_495950	ENST00000421544.4	chr6_101889814_+	-1339.00	-1337.50	-1343.40
CAediting_495951	ENST00000421544.4	chr6_101889827_+	-1337.60	-1337.50	-1343.40
CAediting_495952	ENST00000421544.4	chr6_101924697_+	-1340.50	-1337.50	-1343.40
CAediting_495953	ENST00000421544.4	chr6_101924714_+	-1339.10	-1337.50	-1343.40
CAediting_495950	ENST00000318991.9	chr6_101889814_+	-1154.44	-1152.94	-1159.04
CAediting_495951	ENST00000318991.9	chr6_101889827_+	-1153.04	-1152.94	-1159.04
CAediting_495952	ENST00000318991.9	chr6_101924697_+	-1156.14	-1152.94	-1159.04
CAediting_495953	ENST00000318991.9	chr6_101924714_+	-1154.54	-1152.94	-1159.04
CAediting_495950	ENST00000369134.7	chr6_101889814_+	-1130.74	-1129.24	-1135.14
CAediting_495951	ENST00000369134.7	chr6_101889827_+	-1129.34	-1129.24	-1135.14
CAediting_495952	ENST00000369134.7	chr6_101924697_+	-1132.24	-1129.24	-1135.14
CAediting_495953	ENST00000369134.7	chr6_101924714_+	-1130.84	-1129.24	-1135.14
CAediting_495950	ENST00000369137.6	chr6_101889814_+	-1148.04	-1146.54	-1152.44
CAediting_495951	ENST00000369137.6	chr6_101889827_+	-1147.74	-1146.54	-1152.44
CAediting_495952	ENST00000369137.6	chr6_101924697_+	-1149.54	-1146.54	-1152.44
CAediting_495953	ENST00000369137.6	chr6_101924714_+	-1148.14	-1146.54	-1152.44
CAediting_495950	ENST00000436862.1	chr6_101889814_+	-254.40	-253.40	-254.40
CAediting_495951	ENST00000436862.1	chr6_101889827_+	-253.90	-253.40	-254.40

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Relation with ADAR for GRIK2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_495950	chr6_101889814_+	.	.	8.99492634304455e-16	0.621291122412048	.	.
PCPG	CAediting_495950	chr6_101889814_+	0.000164499692492676	0.447585013415109	0.0172842064036994	0.292189110114604	.	.
LGG	CAediting_495951	chr6_101889827_+	.	.	1.21386828447887e-13	0.685795151376532	0.0492983804730968	0.209042383014061
LGG	CAediting_495952	chr6_101924697_+	.	.	0.0379043946007558	0.258109713799759	.	.
LGG	CAediting_495953	chr6_101924714_+	.	.	5.74330221928797e-41	0.739971061726409	.	.
PCPG	CAediting_495953	chr6_101924714_+	.	.	3.06124367935063e-06	0.486819542707474	.	.
LGG	CAediting_495959	chr6_101926697_+	0.000139185833085344	0.370123202851243	.	.	0.0367786437264119	0.208094719978662
LGG	CAediting_495963	chr6_101926768_+	0.0036958107722568	0.256828613074142	0.00109123690694275	0.287640383052344	.	.

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Relation with cancer stages for GRIK2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GRIK2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GRIK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GRIK2	Q13002	DB00273	Topiramate	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved
GRIK2	Q13002	DB00849	Methylphenobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved
GRIK2	Q13002	DB00237	Butabarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|illicit
GRIK2	Q13002	DB00241	Butalbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|illicit
GRIK2	Q13002	DB00306	Talbutal	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|illicit
GRIK2	Q13002	DB01351	Amobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|illicit
GRIK2	Q13002	DB01353	Butobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|illicit
GRIK2	Q13002	DB01174	Phenobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|investigational
GRIK2	Q13002	DB00312	Pentobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|investigational\|vet_approved
GRIK2	Q13002	DB00142	Glutamic acid	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|nutraceutical
GRIK2	Q13002	DB00418	Secobarbital	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|vet_approved
GRIK2	Q13002	DB00599	Thiopental	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|vet_approved
GRIK2	Q13002	DB00794	Primidone	Glutamate receptor ionotropic, kainate 2	SmallMoleculeDrug	approved\|vet_approved

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RelatedDiseases for GRIK2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GRIK2	C0005586	Bipolar Disorder	3	CTD_human;PSYGENET
GRIK2	C0004352	Autistic Disorder	2	CTD_human
GRIK2	C0005587	Depression, Bipolar	1	CTD_human
GRIK2	C0006142	Malignant neoplasm of breast	1	CTD_human;UNIPROT
GRIK2	C0007102	Malignant tumor of colon	1	CTD_human
GRIK2	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
GRIK2	C0009375	Colonic Neoplasms	1	CTD_human
GRIK2	C0013146	Drug abuse	1	CTD_human
GRIK2	C0013170	Drug habituation	1	CTD_human
GRIK2	C0013222	Drug Use Disorders	1	CTD_human
GRIK2	C0014859	Esophageal Neoplasms	1	CTD_human
GRIK2	C0016722	Frigidity	1	CTD_human
GRIK2	C0017636	Glioblastoma	1	CTD_human
GRIK2	C0020594	Hypoactive Sexual Desire Disorder	1	CTD_human
GRIK2	C0023903	Liver neoplasms	1	CTD_human
GRIK2	C0024232	Lymphatic Metastasis	1	CTD_human
GRIK2	C0024713	Manic Disorder	1	CTD_human
GRIK2	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
GRIK2	C0029261	Orgasmic Disorder	1	CTD_human
GRIK2	C0033953	Psychosexual Disorders	1	CTD_human
GRIK2	C0036341	Schizophrenia	1	CTD_human
GRIK2	C0036902	Sexual Arousal Disorder	1	CTD_human
GRIK2	C0038580	Substance Dependence	1	CTD_human
GRIK2	C0038586	Substance Use Disorders	1	CTD_human
GRIK2	C0236969	Substance-Related Disorders	1	CTD_human
GRIK2	C0334588	Giant Cell Glioblastoma	1	CTD_human
GRIK2	C0338831	Manic	1	CTD_human
GRIK2	C0345904	Malignant neoplasm of liver	1	CTD_human
GRIK2	C0525045	Mood Disorders	1	PSYGENET
GRIK2	C0546837	Malignant neoplasm of esophagus	1	CTD_human
GRIK2	C0678222	Breast Carcinoma	1	CTD_human
GRIK2	C0740858	Substance abuse problem	1	CTD_human
GRIK2	C0919267	ovarian neoplasm	1	CTD_human
GRIK2	C1140680	Malignant neoplasm of ovary	1	CTD_human
GRIK2	C1257931	Mammary Neoplasms, Human	1	CTD_human
GRIK2	C1458155	Mammary Neoplasms	1	CTD_human
GRIK2	C1510472	Drug Dependence	1	CTD_human
GRIK2	C1621958	Glioblastoma Multiforme	1	CTD_human
GRIK2	C1970198	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 6	1	CTD_human;GENOMICS_ENGLAND
GRIK2	C4316881	Prescription Drug Abuse	1	CTD_human
GRIK2	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene