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Editing gene: TMEM14A (CAeditome ID:28978)

Gene summary for TMEM14A

Gene summary

Gene information	Gene symbol	TMEM14A
	Gene ID	28978
	Gene name	transmembrane protein 14A
	Synonyms	C6orf73\|PTD011
	Cytomap	6p12.2
	Type of gene	protein-coding
	Description	transmembrane protein 14A
	Modification date	20210518
	UniProtAcc	Q9Y6G1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TMEM14A	GO:0005789	Transmembrane protein 14A	21723035
TMEM14A	GO:0031966	Transmembrane protein 14A	21723035

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RNA A-to-I events for TMEM14A

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000096092.5

RNA A-to-I editing events in Cancer.

CAediting_486712(52683178, +), CAediting_486713(52683182, +), CAediting_486714(52683205, +), CAediting_486715(52683213, +), CAediting_486716(52683245, +), CAediting_486717(52683250, +), CAediting_486718(52683258, +), CAediting_486719(52683259, +), CAediting_486720(52683273, +), CAediting_486721(52683274, +), CAediting_486722(52683276, +), CAediting_486723(52683278, +), CAediting_486724(52683281, +), CAediting_486725(52683282, +), CAediting_486726(52683300, +), CAediting_486727(52683310, +), CAediting_486728(52683313, +), CAediting_486729(52683319, +), CAediting_486730(52683339, +), CAediting_486731(52683340, +), CAediting_486732(52683345, +), CAediting_486733(52683366, +), CAediting_486734(52683401, +), CAediting_486735(52683420, +), CAediting_486736(52683681, +), CAediting_486737(52683689, +), CAediting_486738(52683692, +), CAediting_486739(52683715, +), CAediting_486740(52683741, +), CAediting_486741(52683751, +), CAediting_486742(52683777, +), CAediting_486743(52683798, +), CAediting_486744(52683805, +), CAediting_486745(52683815, +), CAediting_486746(52683835, +), CAediting_486747(52683836, +), CAediting_486748(52683843, +), CAediting_486749(52683849, +), CAediting_486750(52683876, +), CAediting_486751(52683877, +), CAediting_486752(52685347, +), CAediting_486753(52685392, +), CAediting_486754(52685403, +), CAediting_486755(52685464, +), CAediting_486756(52685604, +),

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RNA editing positional annotations for TMEM14A using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_486712	chr6_52683178_+	intronic
CAediting_486713	chr6_52683182_+	intronic
CAediting_486714	chr6_52683205_+	intronic
CAediting_486715	chr6_52683213_+	intronic
CAediting_486716	chr6_52683245_+	intronic
CAediting_486717	chr6_52683250_+	intronic
CAediting_486718	chr6_52683258_+	intronic
CAediting_486719	chr6_52683259_+	intronic
CAediting_486720	chr6_52683273_+	intronic
CAediting_486721	chr6_52683274_+	intronic
CAediting_486722	chr6_52683276_+	intronic
CAediting_486723	chr6_52683278_+	intronic
CAediting_486724	chr6_52683281_+	intronic
CAediting_486725	chr6_52683282_+	intronic
CAediting_486726	chr6_52683300_+	intronic
CAediting_486727	chr6_52683310_+	intronic
CAediting_486728	chr6_52683313_+	intronic
CAediting_486729	chr6_52683319_+	intronic
CAediting_486730	chr6_52683339_+	intronic
CAediting_486731	chr6_52683340_+	intronic
CAediting_486732	chr6_52683345_+	intronic
CAediting_486733	chr6_52683366_+	intronic
CAediting_486734	chr6_52683401_+	intronic
CAediting_486735	chr6_52683420_+	intronic
CAediting_486736	chr6_52683681_+	intronic
CAediting_486737	chr6_52683689_+	intronic
CAediting_486738	chr6_52683692_+	intronic
CAediting_486739	chr6_52683715_+	intronic
CAediting_486740	chr6_52683741_+	intronic
CAediting_486741	chr6_52683751_+	intronic
CAediting_486742	chr6_52683777_+	intronic
CAediting_486743	chr6_52683798_+	intronic
CAediting_486744	chr6_52683805_+	intronic
CAediting_486745	chr6_52683815_+	intronic
CAediting_486746	chr6_52683835_+	intronic
CAediting_486747	chr6_52683836_+	intronic
CAediting_486748	chr6_52683843_+	intronic
CAediting_486749	chr6_52683849_+	intronic
CAediting_486750	chr6_52683876_+	intronic
CAediting_486751	chr6_52683877_+	intronic
CAediting_486752	chr6_52685347_+	intronic
CAediting_486753	chr6_52685392_+	intronic
CAediting_486754	chr6_52685403_+	intronic
CAediting_486755	chr6_52685464_+	intronic
CAediting_486756	chr6_52685604_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_486713	chr6_52683182_+	SINE	Alu	AluSz6
CAediting_486714	chr6_52683205_+	SINE	Alu	AluSz6
CAediting_486715	chr6_52683213_+	SINE	Alu	AluSz6
CAediting_486716	chr6_52683245_+	SINE	Alu	AluSz6
CAediting_486717	chr6_52683250_+	SINE	Alu	AluSz6
CAediting_486718	chr6_52683258_+	SINE	Alu	AluSz6
CAediting_486719	chr6_52683259_+	SINE	Alu	AluSz6
CAediting_486720	chr6_52683273_+	SINE	Alu	AluSz6
CAediting_486721	chr6_52683274_+	SINE	Alu	AluSz6
CAediting_486722	chr6_52683276_+	SINE	Alu	AluSz6
CAediting_486723	chr6_52683278_+	SINE	Alu	AluSz6
CAediting_486724	chr6_52683281_+	SINE	Alu	AluSz6
CAediting_486725	chr6_52683282_+	SINE	Alu	AluSz6
CAediting_486726	chr6_52683300_+	SINE	Alu	AluSz6
CAediting_486727	chr6_52683310_+	SINE	Alu	AluSz6
CAediting_486728	chr6_52683313_+	SINE	Alu	AluSz6
CAediting_486729	chr6_52683319_+	SINE	Alu	AluSz6
CAediting_486730	chr6_52683339_+	SINE	Alu	AluSz6
CAediting_486731	chr6_52683340_+	SINE	Alu	AluSz6
CAediting_486732	chr6_52683345_+	SINE	Alu	AluSz6
CAediting_486733	chr6_52683366_+	SINE	Alu	AluSz6
CAediting_486734	chr6_52683401_+	SINE	Alu	AluSz6
CAediting_486735	chr6_52683420_+	SINE	Alu	AluSz6
CAediting_486736	chr6_52683681_+	SINE	Alu	AluSp
CAediting_486737	chr6_52683689_+	SINE	Alu	AluSp
CAediting_486738	chr6_52683692_+	SINE	Alu	AluSp
CAediting_486739	chr6_52683715_+	SINE	Alu	AluSp
CAediting_486740	chr6_52683741_+	SINE	Alu	AluSp
CAediting_486741	chr6_52683751_+	SINE	Alu	AluSp
CAediting_486742	chr6_52683777_+	SINE	Alu	AluSp
CAediting_486743	chr6_52683798_+	SINE	Alu	AluSp
CAediting_486744	chr6_52683805_+	SINE	Alu	AluSp
CAediting_486745	chr6_52683815_+	SINE	Alu	AluSp
CAediting_486746	chr6_52683835_+	SINE	Alu	AluSp
CAediting_486747	chr6_52683836_+	SINE	Alu	AluSp
CAediting_486748	chr6_52683843_+	SINE	Alu	AluSp
CAediting_486749	chr6_52683849_+	SINE	Alu	AluSp
CAediting_486750	chr6_52683876_+	SINE	Alu	AluSp
CAediting_486751	chr6_52683877_+	SINE	Alu	AluSp
CAediting_486752	chr6_52685347_+	SINE	Alu	AluSx1
CAediting_486753	chr6_52685392_+	SINE	Alu	AluSx1
CAediting_486754	chr6_52685403_+	SINE	Alu	AluSx1
CAediting_486755	chr6_52685464_+	SINE	Alu	AluSx1
CAediting_486756	chr6_52685604_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for TMEM14A

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000096092.5.TMEM14A.

Correlation between RNA A-to-I editing and PSI for ENSG00000096092.5.TMEM14A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM14A

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM14A

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM14A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1351755	chr19_40282625_-	ENSG00000096092.5	ENST00000211314	hsa-miR-641	52686344	52686351	8mer-1a	52686327	52686351	148	-13.03
CAediting_414656	chr5_72878640_+	ENSG00000096092.5	ENST00000211314	hsa-miR-4804-3p	52686237	52686244	8mer-1a	52686224	52686244	140	-11.58

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM14A

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for TMEM14A

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TMEM14A

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TMEM14A

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TMEM14A

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM14A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene