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Editing gene: GRIA4 (CAeditome ID:2893)

Gene summary for GRIA4

Gene summary

Gene information	Gene symbol	GRIA4
	Gene ID	2893
	Gene name	glutamate ionotropic receptor AMPA type subunit 4
	Synonyms	GLUR4\|GLUR4C\|GLURD\|GluA4\|NEDSGA
	Cytomap	11q22.3
	Type of gene	protein-coding
	Description	glutamate receptor 4AMPA-selective glutamate receptor 4gluR-4gluR-Dglutamate receptor, ionotrophic, AMPA 4glutamate receptor, ionotropic, AMPA 4
	Modification date	20210518
	UniProtAcc	P48058
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GRIA4	GO:0004971	Glutamate receptor 4	21172611

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RNA A-to-I events for GRIA4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000152578.11

RNA A-to-I editing events in Cancer.

CAediting_849219(105634226, +), CAediting_849220(105634371, +), CAediting_849221(105634372, +), CAediting_849222(105634375, +), CAediting_849223(105688381, +), CAediting_849224(105785980, +), CAediting_849225(105785983, +), CAediting_849226(105785984, +), CAediting_849227(105786042, +), CAediting_849228(105786047, +), CAediting_849229(105786051, +), CAediting_849230(105786095, +), CAediting_849231(105786108, +), CAediting_849232(105933967, +), CAediting_849233(105933968, +), CAediting_849234(105933981, +), CAediting_849235(105934586, +), CAediting_849236(105944330, +), CAediting_849237(105944331, +), CAediting_849238(105944332, +), CAediting_849239(105944336, +), CAediting_849240(105944346, +), CAediting_849241(105945383, +), CAediting_849242(105945402, +), CAediting_849243(105945418, +), CAediting_849244(105945433, +), CAediting_849245(105945504, +), CAediting_849246(105946328, +), CAediting_849247(105946439, +), CAediting_849248(105951811, +),

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RNA editing positional annotations for GRIA4 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_849233	chr11_105933968_+	nonsynonymous SNV	ENST00000282499.8	c.A2293G	p.R765G	T	B	D
CAediting_849233	chr11_105933968_+	nonsynonymous SNV	ENST00000393127.5	c.A2293G	p.R765G	T	B	D
CAediting_849233	chr11_105933968_+	nonsynonymous SNV	ENST00000525187.4	c.A2293G	p.R765G	T	B	D
CAediting_849233	chr11_105933968_+	nonsynonymous SNV	ENST00000530497.1	c.A2293G	p.R765G	T	B	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_849219	chr11_105634226_+	ncRNA_intronic
CAediting_849220	chr11_105634371_+	ncRNA_intronic
CAediting_849221	chr11_105634372_+	ncRNA_intronic
CAediting_849222	chr11_105634375_+	ncRNA_intronic
CAediting_849223	chr11_105688381_+	ncRNA_intronic
CAediting_849224	chr11_105785980_+	ncRNA_intronic
CAediting_849225	chr11_105785983_+	ncRNA_intronic
CAediting_849226	chr11_105785984_+	ncRNA_intronic
CAediting_849227	chr11_105786042_+	ncRNA_intronic
CAediting_849228	chr11_105786047_+	ncRNA_intronic
CAediting_849229	chr11_105786051_+	ncRNA_intronic
CAediting_849230	chr11_105786095_+	ncRNA_intronic
CAediting_849231	chr11_105786108_+	ncRNA_intronic
CAediting_849232	chr11_105933967_+	exonic
CAediting_849233	chr11_105933968_+	exonic
CAediting_849234	chr11_105933981_+	ncRNA_exonic
CAediting_849235	chr11_105934586_+	ncRNA_intronic
CAediting_849236	chr11_105944330_+	ncRNA_intronic
CAediting_849237	chr11_105944331_+	ncRNA_intronic
CAediting_849238	chr11_105944332_+	ncRNA_intronic
CAediting_849239	chr11_105944336_+	ncRNA_intronic
CAediting_849240	chr11_105944346_+	ncRNA_intronic
CAediting_849241	chr11_105945383_+	ncRNA_intronic
CAediting_849242	chr11_105945402_+	ncRNA_intronic
CAediting_849243	chr11_105945418_+	ncRNA_intronic
CAediting_849244	chr11_105945433_+	ncRNA_intronic
CAediting_849245	chr11_105945504_+	ncRNA_intronic
CAediting_849246	chr11_105946328_+	ncRNA_intronic
CAediting_849247	chr11_105946439_+	ncRNA_intronic
CAediting_849248	chr11_105951811_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_849219	chr11_105634226_+	SINE	Alu	AluSg
CAediting_849220	chr11_105634371_+	SINE	Alu	AluSg
CAediting_849221	chr11_105634372_+	SINE	Alu	AluSg
CAediting_849222	chr11_105634375_+	SINE	Alu	AluSg
CAediting_849223	chr11_105688381_+	SINE	Alu	AluY
CAediting_849224	chr11_105785980_+	SINE	Alu	AluSx
CAediting_849225	chr11_105785983_+	SINE	Alu	AluSx
CAediting_849226	chr11_105785984_+	SINE	Alu	AluSx
CAediting_849227	chr11_105786042_+	SINE	Alu	AluSx
CAediting_849228	chr11_105786047_+	SINE	Alu	AluSx
CAediting_849229	chr11_105786051_+	SINE	Alu	AluSx
CAediting_849230	chr11_105786095_+	SINE	Alu	AluSx
CAediting_849231	chr11_105786108_+	SINE	Alu	AluSx
CAediting_849246	chr11_105946328_+	SINE	Alu	AluJb
CAediting_849247	chr11_105946439_+	SINE	Alu	AluJb
CAediting_849248	chr11_105951811_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for GRIA4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_849245	chr11_105945504_+	105945499:105945507	5SS	0+3i	AAGGTAAGA	10.57	AAGGTGAGA	8.68
MEX_1	CAediting_849245	chr11_105945504_+	105945499:105945507	5SS	0+3i	AAGGTAAGA	10.57	AAGGTGAGA	8.68

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000152578.11.GRIA4.

Correlation between RNA A-to-I editing and PSI for ENSG00000152578.11.GRIA4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRIA4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GRIA4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GRIA4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000152578.11	ENST00000527669	hsa-miR-200b-3p	105614007	105614013	7mer-m8	105613993	105614014	142	-10.63
CAediting_1160181	chr17_7017644_-	ENSG00000152578.11	ENST00000393127	hsa-miR-195-3p	105980654	105980660	7mer-m8	105980642	105980661	147	-10.41
CAediting_1351755	chr19_40282625_-	ENSG00000152578.11	ENST00000393127	hsa-miR-641	105980157	105980162	6mer	105980140	105980163	154	-24.26
CAediting_573001	chr7_92204086_-	ENSG00000152578.11	ENST00000393127	hsa-miR-1285-5p	105981876	105981882	7mer-m8	105981863	105981883	140	-15.28
CAediting_1229413	chr17_67471544_+	ENSG00000152578.11	ENST00000527669	hsa-miR-548aa	105612550	105612557	8mer-1a	105612531	105612557	148	-10.66
CAediting_1351755	chr19_40282625_-	ENSG00000152578.11	ENST00000527669	hsa-miR-641	105614083	105614089	7mer-m8	105614067	105614090	156	-16.22
CAediting_1351755	chr19_40282625_-	ENSG00000152578.11	ENST00000527669	hsa-miR-641	105613013	105613019	7mer-m8	105612997	105613020	140	-17.92
CAediting_1160181	chr17_7017644_-	ENSG00000152578.11	ENST00000530497	hsa-miR-195-3p	105980654	105980660	7mer-m8	105980642	105980661	147	-10.41
CAediting_1351755	chr19_40282625_-	ENSG00000152578.11	ENST00000530497	hsa-miR-641	105980157	105980162	6mer	105980140	105980163	154	-24.26
CAediting_573001	chr7_92204086_-	ENSG00000152578.11	ENST00000530497	hsa-miR-1285-5p	105981876	105981882	7mer-m8	105981863	105981883	140	-15.28
CAediting_1229415	chr17_67471547_+	ENSG00000152578.11	ENST00000525942	hsa-miR-548aa	105974391	105974397	7mer-m8	105974377	105974398	153	-14.7
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000393127	hsa-miR-6891-5p	105981765	105981770	6mer	105981762	105981782	143	-25.06
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000393127	hsa-miR-6891-5p	105981776	105981781	6mer	105981762	105981782	143	-25.06
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000527669	hsa-miR-6891-5p	105613351	105613358	8mer-1a	105613340	105613358	149	-20.56
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000530497	hsa-miR-6891-5p	105981765	105981770	6mer	105981762	105981782	143	-25.06
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000530497	hsa-miR-6891-5p	105981776	105981781	6mer	105981762	105981782	143	-25.06

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306323	chr19_13836462_-	ENSG00000152578.11	ENST00000393127	hsa-miR-27a-3p	105980073	105980080	8mer-1a	105980060	105980080	140	-15.29
CAediting_1306324	chr19_13836464_-	ENSG00000152578.11	ENST00000393127	hsa-miR-27a-3p	105980073	105980080	8mer-1a	105980060	105980080	140	-15.29
CAediting_1306323	chr19_13836462_-	ENSG00000152578.11	ENST00000393127	hsa-miR-27a-3p	105980218	105980224	7mer-m8	105980205	105980225	140	-10.27
CAediting_1306324	chr19_13836464_-	ENSG00000152578.11	ENST00000393127	hsa-miR-27a-3p	105980218	105980224	7mer-m8	105980205	105980225	140	-10.27
CAediting_1229414	chr17_67471546_+	ENSG00000152578.11	ENST00000393127	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_1229413	chr17_67471544_+	ENSG00000152578.11	ENST00000393127	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_1229415	chr17_67471547_+	ENSG00000152578.11	ENST00000393127	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000152578.11	ENST00000393127	hsa-miR-561-3p	105980428	105980435	8mer-1a	105980415	105980435	149	-6.36
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000393127	hsa-miR-6891-5p	105980850	105980856	7mer-m8	105980839	105980857	152	-20.7
CAediting_1229413	chr17_67471544_+	ENSG00000152578.11	ENST00000527669	hsa-miR-548aa	105612808	105612814	7mer-m8	105612791	105612815	142	-6.79
CAediting_1229414	chr17_67471546_+	ENSG00000152578.11	ENST00000527669	hsa-miR-548aa	105612808	105612814	7mer-m8	105612791	105612815	142	-6.79
CAediting_1306323	chr19_13836462_-	ENSG00000152578.11	ENST00000530497	hsa-miR-27a-3p	105980073	105980080	8mer-1a	105980060	105980080	140	-15.29
CAediting_1306324	chr19_13836464_-	ENSG00000152578.11	ENST00000530497	hsa-miR-27a-3p	105980073	105980080	8mer-1a	105980060	105980080	140	-15.29
CAediting_1306323	chr19_13836462_-	ENSG00000152578.11	ENST00000530497	hsa-miR-27a-3p	105980218	105980224	7mer-m8	105980205	105980225	140	-10.27
CAediting_1306324	chr19_13836464_-	ENSG00000152578.11	ENST00000530497	hsa-miR-27a-3p	105980218	105980224	7mer-m8	105980205	105980225	140	-10.27
CAediting_1229414	chr17_67471546_+	ENSG00000152578.11	ENST00000530497	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_1229413	chr17_67471544_+	ENSG00000152578.11	ENST00000530497	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_1229415	chr17_67471547_+	ENSG00000152578.11	ENST00000530497	hsa-miR-548aa	105979961	105979966	6mer	105979940	105979967	140	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000152578.11	ENST00000530497	hsa-miR-561-3p	105980428	105980435	8mer-1a	105980415	105980435	149	-6.36
CAediting_468389	chr6_31355314_-	ENSG00000152578.11	ENST00000530497	hsa-miR-6891-5p	105980850	105980856	7mer-m8	105980839	105980857	152	-20.7

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GRIA4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GRIA4

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_849233	chr11_105933968_+	7.64792827335207e-08	0.238466675161653	1.37124591497667e-35	0.519227262118314	0.00153838413962208	0.141856009124686
GBM	CAediting_849233	chr11_105933968_+	0.0239647107660077	0.211386617527844	0.00348347069160639	0.271458004986828	.	.
KIRC	CAediting_849233	chr11_105933968_+	0.00812456408994038	0.229478382754518	0.0166312823393887	0.208128691471666	.	.
PCPG	CAediting_849233	chr11_105933968_+	1.24013183731143e-08	0.534163941407633	2.80308421784897e-09	0.553563687288443	.	.

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Relation with cancer stages for GRIA4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GRIA4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GRIA4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GRIA4	P48058	DB00898	Ethanol	Glutamate receptor 4	SmallMoleculeDrug	approved
GRIA4	P48058	DB13146	Fluciclovine (18F)	Glutamate receptor 4	SmallMoleculeDrug	approved
GRIA4	P48058	DB00237	Butabarbital	Glutamate receptor 4	SmallMoleculeDrug	approved\|illicit
GRIA4	P48058	DB00142	Glutamic acid	Glutamate receptor 4	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for GRIA4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GRIA4	C0036341	Schizophrenia	4	PSYGENET
GRIA4	C4693391	NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT SEIZURES AND GAIT ABNORMALITIES	2	GENOMICS_ENGLAND;UNIPROT
GRIA4	C0013146	Drug abuse	1	CTD_human
GRIA4	C0013170	Drug habituation	1	CTD_human
GRIA4	C0013222	Drug Use Disorders	1	CTD_human
GRIA4	C0027092	Myopia	1	CTD_human
GRIA4	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
GRIA4	C0038580	Substance Dependence	1	CTD_human
GRIA4	C0038586	Substance Use Disorders	1	CTD_human
GRIA4	C0236969	Substance-Related Disorders	1	CTD_human
GRIA4	C0740858	Substance abuse problem	1	CTD_human
GRIA4	C1510472	Drug Dependence	1	CTD_human
GRIA4	C4316881	Prescription Drug Abuse	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene