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Editing gene: GRIA2 (CAeditome ID:2891)

Gene summary for GRIA2

Gene summary

Gene information	Gene symbol	GRIA2
	Gene ID	2891
	Gene name	glutamate ionotropic receptor AMPA type subunit 2
	Synonyms	GLUR2\|GLURB\|GluA2\|GluR-K2\|HBGR2\|NEDLIB\|gluR-2\|gluR-B
	Cytomap	4q32.1
	Type of gene	protein-coding
	Description	glutamate receptor 2AMPA-selective glutamate receptor 2glutamate receptor, ionotropic, AMPA 2
	Modification date	20210518
	UniProtAcc	P42262
	Context	- 30524204(ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2(Q607R))

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GRIA2	GO:0004970	Glutamate receptor 2	20614889
GRIA2	GO:0035235	Glutamate receptor 2	20614889

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RNA A-to-I events for GRIA2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000120251.17

RNA A-to-I editing events in Cancer.

CAediting_390693(157228537, +), CAediting_390694(157228591, +), CAediting_390695(157228597, +), CAediting_390696(157228628, +), CAediting_390697(157228631, +), CAediting_390698(157228633, +), CAediting_390699(157228634, +), CAediting_390700(157228672, +), CAediting_390701(157228686, +), CAediting_390702(157228695, +), CAediting_390703(157228699, +), CAediting_390704(157228713, +), CAediting_390705(157228714, +), CAediting_390706(157228725, +), CAediting_390707(157228738, +), CAediting_390708(157228813, +), CAediting_390709(157336727, +), CAediting_390710(157336984, +), CAediting_390711(157336985, +), CAediting_390712(157336986, +), CAediting_390713(157337091, +), CAediting_390714(157360142, +),

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RNA editing positional annotations for GRIA2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_390714	chr4_157360142_+	nonsynonymous SNV	ENST00000264426.12	c.A2290G	p.R764G	T	B	D
CAediting_390714	chr4_157360142_+	nonsynonymous SNV	ENST00000296526.10	c.A2290G	p.R764G	T	B	D
CAediting_390714	chr4_157360142_+	nonsynonymous SNV	ENST00000323661.9	c.A2149G	p.S717G	T	B	D
CAediting_390714	chr4_157360142_+	nonsynonymous SNV	ENST00000393815.5	c.A2149G	p.R717G	T	B	D
CAediting_390714	chr4_157360142_+	nonsynonymous SNV	ENST00000507898.4	c.A2149G	p.R717G	T	B	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_390693	chr4_157228537_+	ncRNA_intronic
CAediting_390694	chr4_157228591_+	ncRNA_intronic
CAediting_390695	chr4_157228597_+	ncRNA_intronic
CAediting_390696	chr4_157228628_+	ncRNA_intronic
CAediting_390697	chr4_157228631_+	ncRNA_intronic
CAediting_390698	chr4_157228633_+	ncRNA_intronic
CAediting_390699	chr4_157228634_+	ncRNA_intronic
CAediting_390700	chr4_157228672_+	ncRNA_intronic
CAediting_390701	chr4_157228686_+	ncRNA_intronic
CAediting_390702	chr4_157228695_+	ncRNA_intronic
CAediting_390703	chr4_157228699_+	ncRNA_intronic
CAediting_390704	chr4_157228713_+	ncRNA_intronic
CAediting_390705	chr4_157228714_+	ncRNA_intronic
CAediting_390706	chr4_157228725_+	ncRNA_intronic
CAediting_390707	chr4_157228738_+	ncRNA_intronic
CAediting_390708	chr4_157228813_+	ncRNA_intronic
CAediting_390709	chr4_157336727_+	exonic
CAediting_390710	chr4_157336984_+	ncRNA_intronic
CAediting_390711	chr4_157336985_+	ncRNA_intronic
CAediting_390712	chr4_157336986_+	ncRNA_intronic
CAediting_390713	chr4_157337091_+	ncRNA_intronic
CAediting_390714	chr4_157360142_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_390693	chr4_157228537_+	SINE	Alu	AluSx
CAediting_390694	chr4_157228591_+	SINE	Alu	AluSx
CAediting_390695	chr4_157228597_+	SINE	Alu	AluSx
CAediting_390696	chr4_157228628_+	SINE	Alu	AluSx
CAediting_390697	chr4_157228631_+	SINE	Alu	AluSx
CAediting_390698	chr4_157228633_+	SINE	Alu	AluSx
CAediting_390699	chr4_157228634_+	SINE	Alu	AluSx
CAediting_390700	chr4_157228672_+	SINE	Alu	AluSx
CAediting_390701	chr4_157228686_+	SINE	Alu	AluSx
CAediting_390702	chr4_157228695_+	SINE	Alu	AluSx
CAediting_390703	chr4_157228699_+	SINE	Alu	AluSx
CAediting_390704	chr4_157228713_+	SINE	Alu	AluSx
CAediting_390705	chr4_157228714_+	SINE	Alu	AluSx
CAediting_390706	chr4_157228725_+	SINE	Alu	AluSx
CAediting_390707	chr4_157228738_+	SINE	Alu	AluSx
CAediting_390708	chr4_157228813_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for GRIA2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_390714	chr4_157360142_+	157360141:157360149	5SS	2+0i	AAGGTGGGT	8.23	AGGGTGGGT	5.37

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000120251.17.GRIA2.

Correlation between RNA A-to-I editing and PSI for ENSG00000120251.17.GRIA2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRIA2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

GBM.CAediting_390710.ENSG00000120251.GRIA2.png
Soverview

LGG.CAediting_390710.ENSG00000120251.GRIA2.png
Soverview

PCPG.CAediting_390714.ENSG00000120251.GRIA2.png
Soverview

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Protein coding region RNA A-to-I editings for GRIA2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GRIA2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000120251.17	ENST00000393815	hsa-miR-4477b	157364813	157364818	6mer	157364798	157364819	148	-18.68
CAediting_688081	chr9_63819627_+	ENSG00000120251.17	ENST00000393815	hsa-miR-4477b	157365239	157365245	7mer-m8	157365226	157365246	161	-17.2
CAediting_688081	chr9_63819627_+	ENSG00000120251.17	ENST00000296526	hsa-miR-4477b	157364813	157364818	6mer	157364798	157364819	148	-18.68
CAediting_688081	chr9_63819627_+	ENSG00000120251.17	ENST00000296526	hsa-miR-4477b	157365239	157365245	7mer-m8	157365226	157365246	161	-17.2
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000393815	hsa-miR-548aa	157366011	157366017	7mer-m8	157365990	157366018	148	-10.27
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000393815	hsa-miR-548aa	157364011	157364017	7mer-m8	157363995	157364018	148	-10.03
CAediting_77128	chr1_85133844_+	ENSG00000120251.17	ENST00000393815	hsa-miR-4423-3p	157364368	157364374	7mer-m8	157364355	157364375	160	-21.62
CAediting_414656	chr5_72878640_+	ENSG00000120251.17	ENST00000393815	hsa-miR-4804-3p	157365487	157365493	7mer-m8	157365474	157365494	140	-12.06
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000296526	hsa-miR-548aa	157366011	157366017	7mer-m8	157365990	157366018	148	-10.27
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000296526	hsa-miR-548aa	157364011	157364017	7mer-m8	157363995	157364018	148	-10.03
CAediting_77128	chr1_85133844_+	ENSG00000120251.17	ENST00000296526	hsa-miR-4423-3p	157364368	157364374	7mer-m8	157364355	157364375	160	-21.62
CAediting_414656	chr5_72878640_+	ENSG00000120251.17	ENST00000296526	hsa-miR-4804-3p	157365487	157365493	7mer-m8	157365474	157365494	140	-12.06

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000120251.17	ENST00000393815	hsa-miR-195-3p	157364179	157364185	7mer-m8	157364166	157364186	146	-7.14
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000393815	hsa-miR-548aa	157363630	157363636	7mer-m8	157363613	157363637	140	-10.21
CAediting_117844	chr1_162342605_+	ENSG00000120251.17	ENST00000393815	hsa-miR-556-3p	157365259	157365265	7mer-m8	157365248	157365266	155	-14.09
CAediting_228905	chr2_188297554_+	ENSG00000120251.17	ENST00000393815	hsa-miR-561-3p	157364192	157364199	8mer-1a	157364174	157364199	146	-5.09
CAediting_1160181	chr17_7017644_-	ENSG00000120251.17	ENST00000296526	hsa-miR-195-3p	157364179	157364185	7mer-m8	157364166	157364186	146	-7.14
CAediting_1229415	chr17_67471547_+	ENSG00000120251.17	ENST00000296526	hsa-miR-548aa	157363630	157363636	7mer-m8	157363613	157363637	140	-10.21
CAediting_117844	chr1_162342605_+	ENSG00000120251.17	ENST00000296526	hsa-miR-556-3p	157365259	157365265	7mer-m8	157365248	157365266	155	-14.09
CAediting_228905	chr2_188297554_+	ENSG00000120251.17	ENST00000296526	hsa-miR-561-3p	157364192	157364199	8mer-1a	157364174	157364199	146	-5.09

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GRIA2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000264426.12	protein_coding
ENST00000296526.10	protein_coding
ENST00000323661.9	nonsense_mediated_decay
ENST00000393815.5	protein_coding
ENST00000471736.4	retained_intron
ENST00000507898.4	protein_coding
ENST00000510854.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_390709	ENST00000264426.12	chr4_157336727_+	-1007.10	-1001.80	-1008.70
CAediting_390714	ENST00000264426.12	chr4_157360142_+	-1003.40	-1001.80	-1008.70
CAediting_390709	ENST00000296526.10	chr4_157336727_+	-1472.60	-1469.70	-1473.30
CAediting_390714	ENST00000296526.10	chr4_157360142_+	-1470.40	-1469.70	-1473.30
CAediting_390709	ENST00000323661.9	chr4_157336727_+	-793.30	-791.80	-797.90
CAediting_390714	ENST00000323661.9	chr4_157360142_+	-796.40	-791.80	-797.90
CAediting_390709	ENST00000393815.5	chr4_157336727_+	-1343.60	-1341.70	-1344.30
CAediting_390714	ENST00000393815.5	chr4_157360142_+	-1342.40	-1341.70	-1344.30
CAediting_390709	ENST00000471736.4	chr4_157336727_+	-1499.30	-1497.70	-1500.00
CAediting_390714	ENST00000471736.4	chr4_157360142_+	-1498.40	-1497.70	-1500.00
CAediting_390709	ENST00000507898.4	chr4_157336727_+	-899.70	-896.50	-900.40
CAediting_390714	ENST00000507898.4	chr4_157360142_+	-897.20	-896.50	-900.40
CAediting_390714	ENST00000510854.1	chr4_157360142_+	-218.50	-217.80	-218.50

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Relation with ADAR for GRIA2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_390709	chr4_157336727_+	0.00247043705057847	0.188408555257689	.	.	.	.
BRCA	CAediting_390709	chr4_157336727_+	8.02408982445583e-06	0.413125423835657	.	.	.	.
PCPG	CAediting_390709	chr4_157336727_+	0.0467679959055778	0.18583050885724	.	.	.	.
LGG	CAediting_390710	chr4_157336984_+	.	.	6.59261566316379e-15	0.3947069356958	2.10407595597743e-09	0.308584106095948
BRCA	CAediting_390710	chr4_157336984_+	.	.	4.04818846837315e-05	0.408052808078867	.	.
LGG	CAediting_390711	chr4_157336985_+	.	.	8.11260402398963e-21	0.625388110535322	.	.
LGG	CAediting_390714	chr4_157360142_+	.	.	1.37583449628224e-59	0.736823491635299	.	.
BRCA	CAediting_390714	chr4_157360142_+	6.44551875414919e-13	0.53041096725997	.	.	.	.
GBM	CAediting_390714	chr4_157360142_+	.	.	0.00301050753224431	0.33169850276288	0.00291886647548812	0.332698866240068
PCPG	CAediting_390714	chr4_157360142_+	1.99038890702299e-05	0.345111213387144	2.88294093676155e-08	0.439392618545829	.	.

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Relation with cancer stages for GRIA2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_390709	chr4_157336727_+	0.0407076703841721	0.197279918780566

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Relation with survival for GRIA2

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
UCEC	CAediting_390714	chr4_157360142_+	0.0482098696638136	0.00962948	2329240

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RelatedDrugs for GRIA2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GRIA2	P42262	DB00849	Methylphenobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved
GRIA2	P42262	DB00898	Ethanol	Glutamate receptor 2	SmallMoleculeDrug	approved
GRIA2	P42262	DB01346	Quinidine barbiturate	Glutamate receptor 2	SmallMoleculeDrug	approved
GRIA2	P42262	DB13146	Fluciclovine (18F)	Glutamate receptor 2	SmallMoleculeDrug	approved
GRIA2	P42262	DB00237	Butabarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|illicit
GRIA2	P42262	DB00241	Butalbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|illicit
GRIA2	P42262	DB00306	Talbutal	Glutamate receptor 2	SmallMoleculeDrug	approved\|illicit
GRIA2	P42262	DB01351	Amobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|illicit
GRIA2	P42262	DB01353	Butobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|illicit
GRIA2	P42262	DB01174	Phenobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|investigational
GRIA2	P42262	DB00312	Pentobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|investigational\|vet_approved
GRIA2	P42262	DB00142	Glutamic acid	Glutamate receptor 2	SmallMoleculeDrug	approved\|nutraceutical
GRIA2	P42262	DB00418	Secobarbital	Glutamate receptor 2	SmallMoleculeDrug	approved\|vet_approved
GRIA2	P42262	DB00599	Thiopental	Glutamate receptor 2	SmallMoleculeDrug	approved\|vet_approved
GRIA2	P42262	DB00794	Primidone	Glutamate receptor 2	SmallMoleculeDrug	approved\|vet_approved

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RelatedDiseases for GRIA2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GRIA2	C0005586	Bipolar Disorder	3	PSYGENET
GRIA2	C0036341	Schizophrenia	2	PSYGENET
GRIA2	C0038220	Status Epilepticus	2	CTD_human;GENOMICS_ENGLAND
GRIA2	C0041696	Unipolar Depression	2	PSYGENET
GRIA2	C1269683	Major Depressive Disorder	2	PSYGENET
GRIA2	C0009171	Cocaine Abuse	1	CTD_human
GRIA2	C0036572	Seizures	1	GENOMICS_ENGLAND
GRIA2	C0038587	Substance Withdrawal Syndrome	1	CTD_human
GRIA2	C0086189	Drug Withdrawal Symptoms	1	CTD_human
GRIA2	C0087169	Withdrawal Symptoms	1	CTD_human
GRIA2	C0236736	Cocaine-Related Disorders	1	CTD_human
GRIA2	C0270823	Petit mal status	1	CTD_human
GRIA2	C0311335	Grand Mal Status Epilepticus	1	CTD_human
GRIA2	C0393734	Complex Partial Status Epilepticus	1	CTD_human
GRIA2	C0494475	Tonic - clonic seizures	1	GENOMICS_ENGLAND
GRIA2	C0600427	Cocaine Dependence	1	CTD_human
GRIA2	C0751217	Hyperkinesia, Generalized	1	CTD_human
GRIA2	C0751495	Seizures, Focal	1	GENOMICS_ENGLAND
GRIA2	C0751522	Status Epilepticus, Subclinical	1	CTD_human
GRIA2	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
GRIA2	C0751524	Simple Partial Status Epilepticus	1	CTD_human
GRIA2	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
GRIA2	C3887506	Hyperkinesia	1	CTD_human
GRIA2	C4317123	Myoclonic Seizures	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene