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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: FAM78A (CAeditome ID:286336)

Gene summary for FAM78A

check button Gene summary
Gene informationGene symbol

FAM78A

Gene ID

286336

Gene namefamily with sequence similarity 78 member A
SynonymsC9orf59
Cytomap

9q34.13

Type of geneprotein-coding
Descriptionprotein FAM78A
Modification date20210518
UniProtAcc

Q5JUQ0

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for FAM78A

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000126882.11

check button RNA A-to-I editing events in Cancer.
CAediting_719609(131263048, -), CAediting_719610(131263073, -), CAediting_719611(131263117, -), CAediting_719612(131263437, -), CAediting_719613(131263520, -), CAediting_719614(131263521, -), CAediting_719615(131263540, -), CAediting_719616(131263541, -), CAediting_719617(131263546, -), CAediting_719618(131263556, -), CAediting_719619(131264821, -), CAediting_719620(131264826, -), CAediting_719621(131264832, -), CAediting_719622(131264839, -), CAediting_719623(131264848, -), CAediting_719624(131264852, -), CAediting_719625(131264888, -), CAediting_719626(131264926, -), CAediting_719627(131264927, -), CAediting_719628(131264973, -), CAediting_719629(131265294, -), CAediting_719630(131265341, -), CAediting_719631(131265348, -), CAediting_719632(131265393, -), CAediting_719633(131265394, -), CAediting_719634(131265412, -), CAediting_719635(131265450, -), CAediting_719636(131265452, -), CAediting_719637(131265461, -), CAediting_719638(131265486, -), CAediting_719639(131265521, -), CAediting_719640(131265591, -), CAediting_719641(131265600, -), CAediting_719642(131265624, -), CAediting_719643(131265642, -), CAediting_719644(131265658, -), CAediting_719645(131267224, -), CAediting_719646(131267376, -), CAediting_719647(131267377, -), CAediting_719648(131267397, -), CAediting_719649(131267408, -), CAediting_719650(131267420, -), CAediting_719651(131267432, -), CAediting_719652(131267446, -), CAediting_719653(131267449, -), CAediting_719654(131267450, -), CAediting_719655(131267523, -), CAediting_719656(131267528, -), CAediting_719657(131267878, -), CAediting_719658(131268943, -), CAediting_719659(131268982, -), CAediting_719660(131269549, -), CAediting_719661(131269555, -), CAediting_719662(131269574, -), CAediting_719663(131269601, -), CAediting_719664(131269950, -), CAediting_719665(131270094, -), CAediting_719666(131270098, -), CAediting_719667(131270180, -),

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RNA editing positional annotations for FAM78A using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_719613chr9_131263520_-nonsynonymous SNVENST00000372269.6c.A272Gp.K91RDPN
CAediting_719613chr9_131263520_-nonsynonymous SNVENST00000464831.1c.A188Gp.K63RDPN
CAediting_719614chr9_131263521_-nonsynonymous SNVENST00000372269.6c.A271Gp.K91EDPN
CAediting_719614chr9_131263521_-nonsynonymous SNVENST00000464831.1c.A187Gp.K63EDPN
CAediting_719616chr9_131263541_-nonsynonymous SNVENST00000372269.6c.A251Gp.Q84RDBN
CAediting_719616chr9_131263541_-nonsynonymous SNVENST00000464831.1c.A167Gp.Q56RDBN
CAediting_719618chr9_131263556_-nonsynonymous SNVENST00000372269.6c.A236Gp.D79GDPD
CAediting_719618chr9_131263556_-nonsynonymous SNVENST00000464831.1c.A152Gp.D51GDPD

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_719609chr9_131263048_-ncRNA_intronic
CAediting_719610chr9_131263073_-ncRNA_intronic
CAediting_719611chr9_131263117_-ncRNA_intronic
CAediting_719612chr9_131263437_-ncRNA_intronic
CAediting_719613chr9_131263520_-exonic
CAediting_719614chr9_131263521_-exonic
CAediting_719615chr9_131263540_-exonic
CAediting_719616chr9_131263541_-exonic
CAediting_719617chr9_131263546_-exonic
CAediting_719618chr9_131263556_-exonic
CAediting_719619chr9_131264821_-intronic
CAediting_719620chr9_131264826_-intronic
CAediting_719621chr9_131264832_-intronic
CAediting_719622chr9_131264839_-intronic
CAediting_719623chr9_131264848_-intronic
CAediting_719624chr9_131264852_-intronic
CAediting_719625chr9_131264888_-intronic
CAediting_719626chr9_131264926_-intronic
CAediting_719627chr9_131264927_-intronic
CAediting_719628chr9_131264973_-intronic
CAediting_719629chr9_131265294_-intronic
CAediting_719630chr9_131265341_-intronic
CAediting_719631chr9_131265348_-intronic
CAediting_719632chr9_131265393_-intronic
CAediting_719633chr9_131265394_-intronic
CAediting_719634chr9_131265412_-intronic
CAediting_719635chr9_131265450_-intronic
CAediting_719636chr9_131265452_-intronic
CAediting_719637chr9_131265461_-intronic
CAediting_719638chr9_131265486_-intronic
CAediting_719639chr9_131265521_-intronic
CAediting_719640chr9_131265591_-intronic
CAediting_719641chr9_131265600_-intronic
CAediting_719642chr9_131265624_-intronic
CAediting_719643chr9_131265642_-intronic
CAediting_719644chr9_131265658_-intronic
CAediting_719645chr9_131267224_-intronic
CAediting_719646chr9_131267376_-intronic
CAediting_719647chr9_131267377_-intronic
CAediting_719648chr9_131267397_-intronic
CAediting_719649chr9_131267408_-intronic
CAediting_719650chr9_131267420_-intronic
CAediting_719651chr9_131267432_-intronic
CAediting_719652chr9_131267446_-intronic
CAediting_719653chr9_131267449_-intronic
CAediting_719654chr9_131267450_-intronic
CAediting_719655chr9_131267523_-intronic
CAediting_719656chr9_131267528_-intronic
CAediting_719657chr9_131267878_-intronic
CAediting_719658chr9_131268943_-intronic
CAediting_719659chr9_131268982_-intronic
CAediting_719660chr9_131269549_-intronic
CAediting_719661chr9_131269555_-intronic
CAediting_719662chr9_131269574_-intronic
CAediting_719663chr9_131269601_-intronic
CAediting_719664chr9_131269950_-intronic
CAediting_719665chr9_131270094_-intronic
CAediting_719666chr9_131270098_-intronic
CAediting_719667chr9_131270180_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_719609chr9_131263048_-SINEAluAluSx1
CAediting_719610chr9_131263073_-SINEAluAluSx1
CAediting_719611chr9_131263117_-SINEAluAluSx1
CAediting_719612chr9_131263437_-SINEAluAluSx1
CAediting_719613chr9_131263520_-SINEAluAluSx1
CAediting_719614chr9_131263521_-SINEAluAluSx1
CAediting_719615chr9_131263540_-SINEAluAluSx1
CAediting_719616chr9_131263541_-SINEAluAluSx1
CAediting_719617chr9_131263546_-SINEAluAluSx1
CAediting_719618chr9_131263556_-SINEAluAluSx1
CAediting_719619chr9_131264821_-SINEAluAluSx1
CAediting_719620chr9_131264826_-SINEAluAluSx1
CAediting_719621chr9_131264832_-SINEAluAluSx1
CAediting_719622chr9_131264839_-SINEAluAluSx1
CAediting_719623chr9_131264848_-SINEAluAluSx1
CAediting_719624chr9_131264852_-SINEAluAluSx1
CAediting_719625chr9_131264888_-SINEAluAluSx1
CAediting_719626chr9_131264926_-SINEAluAluSx1
CAediting_719627chr9_131264927_-SINEAluAluSx1
CAediting_719628chr9_131264973_-SINEAluAluSx1
CAediting_719629chr9_131265294_-SINEAluAluSq2
CAediting_719630chr9_131265341_-SINEAluAluSq2
CAediting_719631chr9_131265348_-SINEAluAluSq2
CAediting_719632chr9_131265393_-SINEAluAluSq2
CAediting_719633chr9_131265394_-SINEAluAluSq2
CAediting_719634chr9_131265412_-SINEAluAluSq2
CAediting_719635chr9_131265450_-SINEAluAluSq2
CAediting_719636chr9_131265452_-SINEAluAluSq2
CAediting_719637chr9_131265461_-SINEAluAluSq2
CAediting_719638chr9_131265486_-SINEAluAluSq2
CAediting_719639chr9_131265521_-SINEAluAluSq2
CAediting_719640chr9_131265591_-SINEAluAluSx
CAediting_719641chr9_131265600_-SINEAluAluSx
CAediting_719642chr9_131265624_-SINEAluAluSx
CAediting_719643chr9_131265642_-SINEAluAluSx
CAediting_719644chr9_131265658_-SINEAluAluSx
CAediting_719645chr9_131267224_-SINEAluFLAM_C
CAediting_719646chr9_131267376_-SINEAluAluJr
CAediting_719647chr9_131267377_-SINEAluAluJr
CAediting_719648chr9_131267397_-SINEAluAluJr
CAediting_719649chr9_131267408_-SINEAluAluJr
CAediting_719650chr9_131267420_-SINEAluAluJr
CAediting_719651chr9_131267432_-SINEAluAluJr
CAediting_719652chr9_131267446_-SINEAluAluJr
CAediting_719653chr9_131267449_-SINEAluAluJr
CAediting_719654chr9_131267450_-SINEAluAluJr
CAediting_719655chr9_131267523_-SINEAluAluJr
CAediting_719656chr9_131267528_-SINEAluAluJr
CAediting_719657chr9_131267878_-SINEAluAluY
CAediting_719658chr9_131268943_-SINEAluAluSx
CAediting_719659chr9_131268982_-SINEAluAluSx
CAediting_719660chr9_131269549_-SINEAluAluSx
CAediting_719661chr9_131269555_-SINEAluAluSx
CAediting_719662chr9_131269574_-SINEAluAluSx
CAediting_719663chr9_131269601_-SINEAluAluSx
CAediting_719664chr9_131269950_-SINEAluAluSq2
CAediting_719665chr9_131270094_-SINEAluAluSq2
CAediting_719666chr9_131270098_-SINEAluAluSq2
CAediting_719667chr9_131270180_-SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for FAM78A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000126882.11.FAM78A.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000126882.11.FAM78A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FAM78A

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for FAM78A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for FAM78A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000126882.11ENST00000372269hsa-miR-605-3p1312593311312593377mer-m8131259330131259351140-14.36
CAediting_688080chr9_63819626_+ENSG00000126882.11ENST00000372269hsa-miR-4477b1312594751312594828mer-1a131259475131259496150-12.86
CAediting_1054808chr15_66496985_-ENSG00000126882.11ENST00000372269hsa-miR-45121312588761312588816mer131258875131258894144-27.34
CAediting_1054808chr15_66496985_-ENSG00000126882.11ENST00000372269hsa-miR-45121312583171312583248mer-1a131258317131258339141-18.42
CAediting_1229415chr17_67471547_+ENSG00000126882.11ENST00000372269hsa-miR-548aa1312598241312598307mer-m8131259823131259845154-18.18
CAediting_1368054chr19_46709310_-ENSG00000126882.11ENST00000372269hsa-miR-320e1312589441312589507mer-m8131258943131258962154-21.47
CAediting_86358chr1_109598906_+ENSG00000126882.11ENST00000372269hsa-miR-197-5p1312600531312600597mer-m8131260052131260073162-30.53

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_86358chr1_109598906_+ENSG00000126882.11ENST00000372269hsa-miR-197-5p1312607181312607247mer-m8131260717131260739148-18.49
CAediting_1306323chr19_13836462_-ENSG00000126882.11ENST00000372269hsa-miR-27a-3p1312582021312582098mer-1a131258202131258221142-20.26
CAediting_1368054chr19_46709310_-ENSG00000126882.11ENST00000372269hsa-miR-320e1312591921312591987mer-m8131259191131259208150-18.43
CAediting_1054808chr15_66496985_-ENSG00000126882.11ENST00000372269hsa-miR-45121312595941312596007mer-m8131259593131259614144-24.18
CAediting_580943chr7_100356700_+ENSG00000126882.11ENST00000372269hsa-miR-6840-3p1312589221312589298mer-1a131258922131258943151-22.41
CAediting_468389chr6_31355314_-ENSG00000126882.11ENST00000372269hsa-miR-6891-5p1312605741312605796mer131260563131260582144-23.54
CAediting_468389chr6_31355314_-ENSG00000126882.11ENST00000372269hsa-miR-6891-5p1312583511312583566mer131258340131258359151-23.65
CAediting_468389chr6_31355314_-ENSG00000126882.11ENST00000372269hsa-miR-6891-5p1312583411312583477mer-m8131258340131258359151-23.65
CAediting_468389chr6_31355314_-ENSG00000126882.11ENST00000372269hsa-miR-6891-5p1312605641312605696mer131260563131260582144-23.54

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FAM78A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for FAM78A

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for FAM78A

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for FAM78A

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for FAM78A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM78A

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource