CAeditome Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: RSPO1 (CAeditome ID:284654)

Gene summary for RSPO1

check button Gene summary
Gene informationGene symbol

RSPO1

Gene ID

284654

Gene nameR-spondin 1
SynonymsCRISTIN3|RSPO
Cytomap

1p34.3

Type of geneprotein-coding
DescriptionR-spondin-1R-spondin homologroof plate-specific spondin-1
Modification date20210518
UniProtAcc

Q2MKA7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
RSPO1

GO:0001934

R-spondin-1

22615920

RSPO1

GO:0002090

R-spondin-1

17804805

RSPO1

GO:0030177

R-spondin-1

22575959

RSPO1

GO:0030177

R-spondin-1

29769720

RSPO1

GO:0090263

R-spondin-1

17804805

RSPO1

GO:0090263

R-spondin-1

22815884


Top

RNA A-to-I events for RSPO1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000169218.12

check button RNA A-to-I editing events in Cancer.
CAediting_47183(37617537, -), CAediting_47184(37617598, -), CAediting_47185(37617610, -), CAediting_47186(37617615, -), CAediting_47187(37617623, -), CAediting_47188(37619065, -), CAediting_47189(37619075, -), CAediting_47190(37619101, -), CAediting_47191(37619111, -), CAediting_47192(37619123, -), CAediting_47193(37619136, -), CAediting_47194(37619140, -), CAediting_47195(37619147, -), CAediting_47196(37619161, -), CAediting_47197(37619171, -), CAediting_47198(37619179, -), CAediting_47199(37619185, -), CAediting_47200(37619815, -), CAediting_47201(37619837, -), CAediting_47202(37619844, -), CAediting_47203(37619859, -), CAediting_47204(37619876, -), CAediting_47205(37619880, -), CAediting_47206(37619885, -), CAediting_47207(37619886, -), CAediting_47208(37619942, -), CAediting_47209(37619943, -), CAediting_47210(37619944, -), CAediting_47211(37620021, -), CAediting_47212(37620030, -), CAediting_47213(37620256, -), CAediting_47214(37620341, -), CAediting_47215(37620389, -), CAediting_47216(37620404, -), CAediting_47217(37620439, -), CAediting_47218(37620446, -), CAediting_47219(37620451, -), CAediting_47220(37620465, -), CAediting_47221(37620468, -), CAediting_47222(37620509, -), CAediting_47223(37620519, -), CAediting_47224(37620522, -), CAediting_47225(37620549, -), CAediting_47226(37620626, -), CAediting_47227(37621894, -), CAediting_47228(37621899, -), CAediting_47229(37621913, -), CAediting_47230(37621916, -), CAediting_47231(37621926, -), CAediting_47232(37621930, -), CAediting_47233(37621940, -), CAediting_47234(37621961, -), CAediting_47235(37621966, -), CAediting_47236(37622386, -), CAediting_47237(37622393, -), CAediting_47238(37622400, -), CAediting_47239(37622402, -), CAediting_47240(37622429, -), CAediting_47241(37622459, -), CAediting_47242(37623624, -), CAediting_47243(37623634, -), CAediting_47244(37623638, -), CAediting_47245(37623646, -), CAediting_47246(37623667, -), CAediting_47247(37623685, -), CAediting_47248(37623695, -), CAediting_47249(37623710, -), CAediting_47250(37623773, -), CAediting_47251(37623828, -), CAediting_47252(37623852, -), CAediting_47253(37623875, -), CAediting_47254(37623884, -), CAediting_47255(37623888, -), CAediting_47256(37623897, -), CAediting_47257(37623898, -), CAediting_47258(37623966, -), CAediting_47259(37623989, -), CAediting_47260(37624032, -), CAediting_47261(37625733, -), CAediting_47262(37625817, -), CAediting_47263(37625843, -), CAediting_47264(37625872, -), CAediting_47265(37625906, -), CAediting_47266(37625950, -), CAediting_47267(37627484, -),

Top

RNA editing positional annotations for RSPO1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_47183chr1_37617537_-intronic
CAediting_47184chr1_37617598_-intronic
CAediting_47185chr1_37617610_-intronic
CAediting_47186chr1_37617615_-intronic
CAediting_47187chr1_37617623_-intronic
CAediting_47188chr1_37619065_-intronic
CAediting_47189chr1_37619075_-intronic
CAediting_47190chr1_37619101_-intronic
CAediting_47191chr1_37619111_-intronic
CAediting_47192chr1_37619123_-intronic
CAediting_47193chr1_37619136_-intronic
CAediting_47194chr1_37619140_-intronic
CAediting_47195chr1_37619147_-intronic
CAediting_47196chr1_37619161_-intronic
CAediting_47197chr1_37619171_-intronic
CAediting_47198chr1_37619179_-intronic
CAediting_47199chr1_37619185_-intronic
CAediting_47200chr1_37619815_-intronic
CAediting_47201chr1_37619837_-intronic
CAediting_47202chr1_37619844_-intronic
CAediting_47203chr1_37619859_-intronic
CAediting_47204chr1_37619876_-intronic
CAediting_47205chr1_37619880_-intronic
CAediting_47206chr1_37619885_-intronic
CAediting_47207chr1_37619886_-intronic
CAediting_47208chr1_37619942_-intronic
CAediting_47209chr1_37619943_-intronic
CAediting_47210chr1_37619944_-intronic
CAediting_47211chr1_37620021_-intronic
CAediting_47212chr1_37620030_-intronic
CAediting_47213chr1_37620256_-intronic
CAediting_47214chr1_37620341_-intronic
CAediting_47215chr1_37620389_-intronic
CAediting_47216chr1_37620404_-intronic
CAediting_47217chr1_37620439_-intronic
CAediting_47218chr1_37620446_-intronic
CAediting_47219chr1_37620451_-intronic
CAediting_47220chr1_37620465_-intronic
CAediting_47221chr1_37620468_-intronic
CAediting_47222chr1_37620509_-intronic
CAediting_47223chr1_37620519_-intronic
CAediting_47224chr1_37620522_-intronic
CAediting_47225chr1_37620549_-intronic
CAediting_47226chr1_37620626_-intronic
CAediting_47227chr1_37621894_-intronic
CAediting_47228chr1_37621899_-intronic
CAediting_47229chr1_37621913_-intronic
CAediting_47230chr1_37621916_-intronic
CAediting_47231chr1_37621926_-intronic
CAediting_47232chr1_37621930_-intronic
CAediting_47233chr1_37621940_-intronic
CAediting_47234chr1_37621961_-intronic
CAediting_47235chr1_37621966_-intronic
CAediting_47236chr1_37622386_-intronic
CAediting_47237chr1_37622393_-intronic
CAediting_47238chr1_37622400_-intronic
CAediting_47239chr1_37622402_-intronic
CAediting_47240chr1_37622429_-intronic
CAediting_47241chr1_37622459_-intronic
CAediting_47242chr1_37623624_-intronic
CAediting_47243chr1_37623634_-intronic
CAediting_47244chr1_37623638_-intronic
CAediting_47245chr1_37623646_-intronic
CAediting_47246chr1_37623667_-intronic
CAediting_47247chr1_37623685_-intronic
CAediting_47248chr1_37623695_-intronic
CAediting_47249chr1_37623710_-intronic
CAediting_47250chr1_37623773_-intronic
CAediting_47251chr1_37623828_-intronic
CAediting_47252chr1_37623852_-intronic
CAediting_47253chr1_37623875_-intronic
CAediting_47254chr1_37623884_-intronic
CAediting_47255chr1_37623888_-intronic
CAediting_47256chr1_37623897_-intronic
CAediting_47257chr1_37623898_-intronic
CAediting_47258chr1_37623966_-intronic
CAediting_47259chr1_37623989_-intronic
CAediting_47260chr1_37624032_-intronic
CAediting_47261chr1_37625733_-intronic
CAediting_47262chr1_37625817_-intronic
CAediting_47263chr1_37625843_-intronic
CAediting_47264chr1_37625872_-intronic
CAediting_47265chr1_37625906_-intronic
CAediting_47266chr1_37625950_-intronic
CAediting_47267chr1_37627484_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_47183chr1_37617537_-SINEAluAluSx
CAediting_47184chr1_37617598_-SINEAluAluSx
CAediting_47185chr1_37617610_-SINEAluAluSx
CAediting_47186chr1_37617615_-SINEAluAluSx
CAediting_47187chr1_37617623_-SINEAluAluSx
CAediting_47188chr1_37619065_-SINEAluAluSx1
CAediting_47189chr1_37619075_-SINEAluAluSx1
CAediting_47190chr1_37619101_-SINEAluAluSx1
CAediting_47191chr1_37619111_-SINEAluAluSx1
CAediting_47192chr1_37619123_-SINEAluAluSx1
CAediting_47193chr1_37619136_-SINEAluAluSx1
CAediting_47194chr1_37619140_-SINEAluAluSx1
CAediting_47195chr1_37619147_-SINEAluAluSx1
CAediting_47196chr1_37619161_-SINEAluAluSx1
CAediting_47197chr1_37619171_-SINEAluAluSx1
CAediting_47198chr1_37619179_-SINEAluAluSx1
CAediting_47199chr1_37619185_-SINEAluAluSx1
CAediting_47200chr1_37619815_-SINEAluAluSx1
CAediting_47201chr1_37619837_-SINEAluAluSx1
CAediting_47202chr1_37619844_-SINEAluAluSx1
CAediting_47203chr1_37619859_-SINEAluAluSx1
CAediting_47204chr1_37619876_-SINEAluAluSx1
CAediting_47205chr1_37619880_-SINEAluAluSx1
CAediting_47206chr1_37619885_-SINEAluAluSx1
CAediting_47207chr1_37619886_-SINEAluAluSx1
CAediting_47208chr1_37619942_-SINEAluAluSx1
CAediting_47209chr1_37619943_-SINEAluAluSx1
CAediting_47210chr1_37619944_-SINEAluAluSx1
CAediting_47211chr1_37620021_-SINEAluAluSx1
CAediting_47212chr1_37620030_-SINEAluAluSx1
CAediting_47213chr1_37620256_-SINEAluAluJo
CAediting_47214chr1_37620341_-SINEAluAluJo
CAediting_47215chr1_37620389_-SINEAluAluSx4
CAediting_47216chr1_37620404_-SINEAluAluSx4
CAediting_47217chr1_37620439_-SINEAluAluSx4
CAediting_47218chr1_37620446_-SINEAluAluSx4
CAediting_47219chr1_37620451_-SINEAluAluSx4
CAediting_47220chr1_37620465_-SINEAluAluSx4
CAediting_47221chr1_37620468_-SINEAluAluSx4
CAediting_47222chr1_37620509_-SINEAluAluSx4
CAediting_47223chr1_37620519_-SINEAluAluSx4
CAediting_47224chr1_37620522_-SINEAluAluSx4
CAediting_47225chr1_37620549_-SINEAluAluSx4
CAediting_47226chr1_37620626_-SINEAluAluSx4
CAediting_47227chr1_37621894_-SINEAluFRAM
CAediting_47228chr1_37621899_-SINEAluFRAM
CAediting_47229chr1_37621913_-SINEAluFRAM
CAediting_47230chr1_37621916_-SINEAluFRAM
CAediting_47231chr1_37621926_-SINEAluFRAM
CAediting_47232chr1_37621930_-SINEAluFRAM
CAediting_47233chr1_37621940_-SINEAluFRAM
CAediting_47234chr1_37621961_-SINEAluFRAM
CAediting_47235chr1_37621966_-LINEL2L2a
CAediting_47236chr1_37622386_-SINEAluAluJr
CAediting_47237chr1_37622393_-SINEAluAluJr
CAediting_47238chr1_37622400_-SINEAluAluJr
CAediting_47239chr1_37622402_-SINEAluAluJr
CAediting_47240chr1_37622429_-SINEAluAluJr
CAediting_47241chr1_37622459_-SINEAluAluJr
CAediting_47242chr1_37623624_-SINEAluFLAM_A
CAediting_47243chr1_37623634_-SINEAluFLAM_A
CAediting_47244chr1_37623638_-SINEAluFLAM_A
CAediting_47245chr1_37623646_-SINEAluFLAM_A
CAediting_47246chr1_37623667_-SINEAluFLAM_A
CAediting_47247chr1_37623685_-SINEAluFLAM_A
CAediting_47248chr1_37623695_-SINEAluFLAM_A
CAediting_47249chr1_37623710_-SINEAluFLAM_A
CAediting_47250chr1_37623773_-SINEAluAluSx3
CAediting_47251chr1_37623828_-SINEAluAluSx3
CAediting_47252chr1_37623852_-SINEAluAluSx3
CAediting_47253chr1_37623875_-SINEAluAluSx3
CAediting_47254chr1_37623884_-SINEAluAluSx3
CAediting_47255chr1_37623888_-SINEAluAluSx3
CAediting_47256chr1_37623897_-SINEAluAluSx3
CAediting_47257chr1_37623898_-SINEAluAluSx3
CAediting_47258chr1_37623966_-SINEAluAluSx3
CAediting_47259chr1_37623989_-SINEAluAluSx3
CAediting_47260chr1_37624032_-SINEAluAluSx3
CAediting_47261chr1_37625733_-SINEAluAluSx
CAediting_47262chr1_37625817_-SINEAluAluSx
CAediting_47263chr1_37625843_-SINEAluAluSx
CAediting_47264chr1_37625872_-SINEAluAluSx
CAediting_47265chr1_37625906_-SINEAluAluSx
CAediting_47266chr1_37625950_-SINEAluAluSx
CAediting_47267chr1_37627484_-SINEAluAluSx

Top

RNA A-to-I editing events in the alternative splicing sites for RSPO1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000169218.12.RSPO1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000169218.12.RSPO1.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for RSPO1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for RSPO1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for RSPO1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000169218.12ENST00000615459hsa-miR-548aa37612443376124497mer-m83761244237612468149-15.75
CAediting_524911chr7_5495852_-ENSG00000169218.12ENST00000615459hsa-miR-589-3p37611988376119958mer-1a3761198837612012141-17.48
CAediting_1229413chr17_67471544_+ENSG00000169218.12ENST00000612451hsa-miR-548aa37612443376124497mer-m83761244237612468149-15.75
CAediting_524911chr7_5495852_-ENSG00000169218.12ENST00000612451hsa-miR-589-3p37611988376119958mer-1a3761198837612012141-17.48
CAediting_1229413chr17_67471544_+ENSG00000169218.12ENST00000401068hsa-miR-548aa37612443376124497mer-m83761244237612468149-15.75
CAediting_524911chr7_5495852_-ENSG00000169218.12ENST00000401068hsa-miR-589-3p37611988376119958mer-1a3761198837612012141-17.48

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for RSPO1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for RSPO1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

Top

Relation with cancer stages for RSPO1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

Top

Relation with survival for RSPO1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
OVCAediting_47235chr1_37621966_-0.009259534016575980.018793818.4887

Top

RelatedDrugs for RSPO1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RSPO1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
RSPO1C3149931PALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND 46,XX SEX REVERSAL2GENOMICS_ENGLAND;ORPHANET
RSPO1C2674504Palmoplantar Hyperkeratosis And True Hermaphroditism1ORPHANET
RSPO1C4721610Carcinoma, Ovarian Epithelial1CTD_human