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Editing gene: IGHV2-26 (CAeditome ID:28455)

Gene summary for IGHV2-26

Gene summary

Gene information	Gene symbol	IGHV2-26
	Gene ID	28455
	Gene name	immunoglobulin heavy variable 2-26
	Synonyms	IGHV226\|VH
	Cytomap	14q32.33
	Type of gene	other
	Description	immunogloblin heavy chain variable region
	Modification date	20210518
	UniProtAcc	A0A0B4J1V2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for IGHV2-26

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000211951.2

RNA A-to-I editing events in Cancer.

CAediting_1022960(106301396, -), CAediting_1022961(106301402, -), CAediting_1022962(106301420, -), CAediting_1022963(106301437, -), CAediting_1022964(106301439, -), CAediting_1022965(106301446, -), CAediting_1022966(106301460, -), CAediting_1022967(106301465, -), CAediting_1022968(106301466, -), CAediting_1022969(106301473, -), CAediting_1022970(106301475, -), CAediting_1022971(106301478, -), CAediting_1022972(106301479, -), CAediting_1022973(106301488, -), CAediting_1022974(106301494, -), CAediting_1022975(106301497, -), CAediting_1022976(106301500, -), CAediting_1022977(106301519, -), CAediting_1022978(106301522, -), CAediting_1022979(106301523, -), CAediting_1022980(106301526, -), CAediting_1022981(106301530, -), CAediting_1022982(106301543, -), CAediting_1022983(106301563, -), CAediting_1022984(106301567, -), CAediting_1022985(106301581, -), CAediting_1022986(106301597, -), CAediting_1022987(106301653, -),

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RNA editing positional annotations for IGHV2-26 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1022960	chr14_106301396_-	exonic
CAediting_1022961	chr14_106301402_-	exonic
CAediting_1022962	chr14_106301420_-	exonic
CAediting_1022963	chr14_106301437_-	exonic
CAediting_1022964	chr14_106301439_-	exonic
CAediting_1022965	chr14_106301446_-	exonic
CAediting_1022966	chr14_106301460_-	exonic
CAediting_1022967	chr14_106301465_-	exonic
CAediting_1022968	chr14_106301466_-	exonic
CAediting_1022969	chr14_106301473_-	exonic
CAediting_1022970	chr14_106301475_-	exonic
CAediting_1022971	chr14_106301478_-	exonic
CAediting_1022972	chr14_106301479_-	exonic
CAediting_1022973	chr14_106301488_-	exonic
CAediting_1022974	chr14_106301494_-	exonic
CAediting_1022975	chr14_106301497_-	exonic
CAediting_1022976	chr14_106301500_-	exonic
CAediting_1022977	chr14_106301519_-	exonic
CAediting_1022978	chr14_106301522_-	exonic
CAediting_1022979	chr14_106301523_-	exonic
CAediting_1022980	chr14_106301526_-	exonic
CAediting_1022981	chr14_106301530_-	exonic
CAediting_1022982	chr14_106301543_-	exonic
CAediting_1022983	chr14_106301563_-	exonic
CAediting_1022984	chr14_106301567_-	exonic
CAediting_1022985	chr14_106301581_-	exonic
CAediting_1022986	chr14_106301597_-	exonic
CAediting_1022987	chr14_106301653_-	exonic

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for IGHV2-26

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000211951.2.IGHV2-26.

Correlation between RNA A-to-I editing and PSI for ENSG00000211951.2.IGHV2-26.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IGHV2-26

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for IGHV2-26

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for IGHV2-26

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IGHV2-26

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for IGHV2-26

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUSC	CAediting_1022961	chr14_106301402_-	.	.	.	.	0.00110831063919331	0.447877127647251
LUAD	CAediting_1022963	chr14_106301437_-	.	.	.	.	0.00840196133210928	0.221943008845846
LUAD	CAediting_1022968	chr14_106301466_-	.	.	.	.	0.00669370591729331	0.343664809400953
LUSC	CAediting_1022968	chr14_106301466_-	.	.	0.0427803329086598	0.266969165656229	.	.
LUAD	CAediting_1022971	chr14_106301478_-	.	.	.	.	2.87646481582556e-08	0.690506350472854
LUSC	CAediting_1022977	chr14_106301519_-	.	.	.	.	0.0211390631167686	0.231493681986705
LUSC	CAediting_1022980	chr14_106301526_-	.	.	.	.	0.0122432482035845	0.329769695383059
LUSC	CAediting_1022981	chr14_106301530_-	.	.	.	.	0.00192401665054598	0.331757874581257

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Relation with cancer stages for IGHV2-26

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
LUAD	pathologic_stage	CAediting_1022963	chr14_106301437_-	0.0246466128431552	0.190550328723381
LUAD	pathologic_stage	CAediting_1022980	chr14_106301526_-	0.0479288842639112	0.226182958680282

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Relation with survival for IGHV2-26

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for IGHV2-26

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IGHV2-26

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene