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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CES4A (CAeditome ID:283848)

Gene summary for CES4A

check button Gene summary
Gene informationGene symbol

CES4A

Gene ID

283848

Gene namecarboxylesterase 4A
SynonymsCES6|CES8
Cytomap

16q22.1

Type of geneprotein-coding
Descriptioncarboxylesterase 4Acarboxylesterase 6carboxylesterase 8 (putative)
Modification date20210522
UniProtAcc

Q5XG92

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for CES4A

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000172824.13

check button RNA A-to-I editing events in Cancer.
CAediting_1120812(66990315, +), CAediting_1120813(66990515, +), CAediting_1120814(66990516, +), CAediting_1120815(66992700, +), CAediting_1120816(66995195, +), CAediting_1120817(66996081, +), CAediting_1120818(66996112, +), CAediting_1120819(66996118, +), CAediting_1120820(66996155, +), CAediting_1120821(66996166, +), CAediting_1120822(66996202, +), CAediting_1120823(66996297, +), CAediting_1120824(66996309, +), CAediting_1120825(66996852, +), CAediting_1120826(66996945, +), CAediting_1120827(66996951, +), CAediting_1120828(66997005, +), CAediting_1120829(66997716, +), CAediting_1120830(66997866, +), CAediting_1120831(66997870, +), CAediting_1120832(66998786, +), CAediting_1120833(66998810, +), CAediting_1120834(66999733, +), CAediting_1120835(67005562, +), CAediting_1120836(67005569, +), CAediting_1120837(67005573, +), CAediting_1120838(67005583, +), CAediting_1120839(67005591, +), CAediting_1120840(67005592, +), CAediting_1120841(67005597, +), CAediting_1120842(67005609, +), CAediting_1120843(67005615, +), CAediting_1120844(67005632, +), CAediting_1120845(67005637, +), CAediting_1120846(67005640, +), CAediting_1120847(67005646, +), CAediting_1120848(67005657, +), CAediting_1120849(67005660, +), CAediting_1120850(67005661, +), CAediting_1120851(67005671, +), CAediting_1120852(67005672, +), CAediting_1120853(67005676, +), CAediting_1120854(67005682, +), CAediting_1120855(67005685, +), CAediting_1120856(67005686, +), CAediting_1120857(67005687, +), CAediting_1120858(67005688, +), CAediting_1120859(67005691, +), CAediting_1120860(67005694, +), CAediting_1120861(67005695, +), CAediting_1120862(67005696, +), CAediting_1120863(67005697, +), CAediting_1120864(67005698, +), CAediting_1120865(67005699, +), CAediting_1120866(67005702, +), CAediting_1120867(67005706, +), CAediting_1120868(67005712, +), CAediting_1120869(67005726, +), CAediting_1120870(67005734, +), CAediting_1120871(67005738, +), CAediting_1120872(67005742, +), CAediting_1120873(67005745, +), CAediting_1120874(67005755, +), CAediting_1120875(67005761, +), CAediting_1120876(67005769, +), CAediting_1120877(67005770, +), CAediting_1120878(67005777, +), CAediting_1120879(67005794, +), CAediting_1120880(67005806, +), CAediting_1120881(67005809, +), CAediting_1120882(67005814, +), CAediting_1120883(67005819, +), CAediting_1120884(67005829, +), CAediting_1120885(67005833, +),

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RNA editing positional annotations for CES4A using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1120812chr16_66990315_+intronic
CAediting_1120813chr16_66990515_+intronic
CAediting_1120814chr16_66990516_+intronic
CAediting_1120815chr16_66992700_+intronic
CAediting_1120816chr16_66995195_+intronic
CAediting_1120817chr16_66996081_+exonic
CAediting_1120818chr16_66996112_+exonic
CAediting_1120819chr16_66996118_+exonic
CAediting_1120820chr16_66996155_+exonic
CAediting_1120821chr16_66996166_+exonic
CAediting_1120822chr16_66996202_+intronic
CAediting_1120823chr16_66996297_+intronic
CAediting_1120824chr16_66996309_+intronic
CAediting_1120825chr16_66996852_+intronic
CAediting_1120826chr16_66996945_+intronic
CAediting_1120827chr16_66996951_+intronic
CAediting_1120828chr16_66997005_+intronic
CAediting_1120829chr16_66997716_+intronic
CAediting_1120830chr16_66997866_+intronic
CAediting_1120831chr16_66997870_+intronic
CAediting_1120832chr16_66998786_+intronic
CAediting_1120833chr16_66998810_+intronic
CAediting_1120834chr16_66999733_+intronic
CAediting_1120835chr16_67005562_+ncRNA_exonic
CAediting_1120836chr16_67005569_+ncRNA_exonic
CAediting_1120837chr16_67005573_+ncRNA_exonic
CAediting_1120838chr16_67005583_+ncRNA_exonic
CAediting_1120839chr16_67005591_+ncRNA_exonic
CAediting_1120840chr16_67005592_+ncRNA_exonic
CAediting_1120841chr16_67005597_+ncRNA_exonic
CAediting_1120842chr16_67005609_+ncRNA_exonic
CAediting_1120843chr16_67005615_+ncRNA_exonic
CAediting_1120844chr16_67005632_+ncRNA_exonic
CAediting_1120845chr16_67005637_+ncRNA_exonic
CAediting_1120846chr16_67005640_+ncRNA_exonic
CAediting_1120847chr16_67005646_+ncRNA_exonic
CAediting_1120848chr16_67005657_+ncRNA_exonic
CAediting_1120849chr16_67005660_+ncRNA_exonic
CAediting_1120850chr16_67005661_+ncRNA_exonic
CAediting_1120851chr16_67005671_+ncRNA_exonic
CAediting_1120852chr16_67005672_+ncRNA_exonic
CAediting_1120853chr16_67005676_+ncRNA_exonic
CAediting_1120854chr16_67005682_+ncRNA_exonic
CAediting_1120855chr16_67005685_+ncRNA_exonic
CAediting_1120856chr16_67005686_+ncRNA_exonic
CAediting_1120857chr16_67005687_+ncRNA_exonic
CAediting_1120858chr16_67005688_+ncRNA_exonic
CAediting_1120859chr16_67005691_+ncRNA_exonic
CAediting_1120860chr16_67005694_+ncRNA_exonic
CAediting_1120861chr16_67005695_+ncRNA_exonic
CAediting_1120862chr16_67005696_+ncRNA_exonic
CAediting_1120863chr16_67005697_+ncRNA_exonic
CAediting_1120864chr16_67005698_+ncRNA_exonic
CAediting_1120865chr16_67005699_+ncRNA_exonic
CAediting_1120866chr16_67005702_+ncRNA_exonic
CAediting_1120867chr16_67005706_+ncRNA_exonic
CAediting_1120868chr16_67005712_+ncRNA_exonic
CAediting_1120869chr16_67005726_+ncRNA_exonic
CAediting_1120870chr16_67005734_+ncRNA_exonic
CAediting_1120871chr16_67005738_+ncRNA_exonic
CAediting_1120872chr16_67005742_+ncRNA_exonic
CAediting_1120873chr16_67005745_+ncRNA_exonic
CAediting_1120874chr16_67005755_+ncRNA_exonic
CAediting_1120875chr16_67005761_+ncRNA_exonic
CAediting_1120876chr16_67005769_+ncRNA_exonic
CAediting_1120877chr16_67005770_+ncRNA_exonic
CAediting_1120878chr16_67005777_+ncRNA_exonic
CAediting_1120879chr16_67005794_+ncRNA_exonic
CAediting_1120880chr16_67005806_+ncRNA_exonic
CAediting_1120881chr16_67005809_+ncRNA_exonic
CAediting_1120882chr16_67005814_+ncRNA_exonic
CAediting_1120883chr16_67005819_+ncRNA_exonic
CAediting_1120884chr16_67005829_+ncRNA_exonic
CAediting_1120885chr16_67005833_+ncRNA_exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1120812chr16_66990315_+SINEAluAluSx
CAediting_1120813chr16_66990515_+SINEAluAluJr
CAediting_1120814chr16_66990516_+SINEAluAluJr
CAediting_1120815chr16_66992700_+SINEAluAluSx
CAediting_1120816chr16_66995195_+SINEAluAluY
CAediting_1120817chr16_66996081_+SINEAluAluSc
CAediting_1120818chr16_66996112_+SINEAluAluSc
CAediting_1120819chr16_66996118_+SINEAluAluSc
CAediting_1120820chr16_66996155_+SINEAluAluSc
CAediting_1120821chr16_66996166_+SINEAluAluSc
CAediting_1120822chr16_66996202_+SINEAluAluSc
CAediting_1120823chr16_66996297_+SINEAluAluSc
CAediting_1120824chr16_66996309_+SINEAluAluSc
CAediting_1120825chr16_66996852_+SINEAluAluJr
CAediting_1120826chr16_66996945_+SINEAluAluJr
CAediting_1120827chr16_66996951_+SINEAluAluJr
CAediting_1120828chr16_66997005_+SINEAluAluJr
CAediting_1120829chr16_66997716_+SINEAluAluJr4
CAediting_1120830chr16_66997866_+SINEAluAluJr4
CAediting_1120831chr16_66997870_+SINEAluAluJr4
CAediting_1120832chr16_66998786_+SINEAluAluSg
CAediting_1120833chr16_66998810_+SINEAluAluSg
CAediting_1120834chr16_66999733_+SINEAluAluSz
CAediting_1120836chr16_67005569_+SINEAluAluSz
CAediting_1120837chr16_67005573_+SINEAluAluSz
CAediting_1120838chr16_67005583_+SINEAluAluSz
CAediting_1120839chr16_67005591_+SINEAluAluSz
CAediting_1120840chr16_67005592_+SINEAluAluSz
CAediting_1120841chr16_67005597_+SINEAluAluSz
CAediting_1120842chr16_67005609_+SINEAluAluSz
CAediting_1120843chr16_67005615_+SINEAluAluSz
CAediting_1120844chr16_67005632_+SINEAluAluSz
CAediting_1120845chr16_67005637_+SINEAluAluSz
CAediting_1120846chr16_67005640_+SINEAluAluSz
CAediting_1120847chr16_67005646_+SINEAluAluSz
CAediting_1120848chr16_67005657_+SINEAluAluSz
CAediting_1120849chr16_67005660_+SINEAluAluSz
CAediting_1120850chr16_67005661_+SINEAluAluSz
CAediting_1120851chr16_67005671_+SINEAluAluSz
CAediting_1120852chr16_67005672_+SINEAluAluSz
CAediting_1120853chr16_67005676_+SINEAluAluSz
CAediting_1120854chr16_67005682_+SINEAluAluSz
CAediting_1120855chr16_67005685_+SINEAluAluSz
CAediting_1120856chr16_67005686_+SINEAluAluSz
CAediting_1120857chr16_67005687_+SINEAluAluSz
CAediting_1120858chr16_67005688_+SINEAluAluSz
CAediting_1120859chr16_67005691_+SINEAluAluSz
CAediting_1120860chr16_67005694_+SINEAluAluSz
CAediting_1120861chr16_67005695_+SINEAluAluSz
CAediting_1120862chr16_67005696_+SINEAluAluSz
CAediting_1120863chr16_67005697_+SINEAluAluSz
CAediting_1120864chr16_67005698_+SINEAluAluSz
CAediting_1120865chr16_67005699_+SINEAluAluSz
CAediting_1120866chr16_67005702_+SINEAluAluSz
CAediting_1120867chr16_67005706_+SINEAluAluSz
CAediting_1120868chr16_67005712_+SINEAluAluSz
CAediting_1120869chr16_67005726_+SINEAluAluSz
CAediting_1120870chr16_67005734_+SINEAluAluSz
CAediting_1120871chr16_67005738_+SINEAluAluSz
CAediting_1120872chr16_67005742_+SINEAluAluSz
CAediting_1120873chr16_67005745_+SINEAluAluSz
CAediting_1120874chr16_67005755_+SINEAluAluSz
CAediting_1120875chr16_67005761_+SINEAluAluSz
CAediting_1120876chr16_67005769_+SINEAluAluSz
CAediting_1120877chr16_67005770_+SINEAluAluSz
CAediting_1120878chr16_67005777_+SINEAluAluSz
CAediting_1120879chr16_67005794_+SINEAluAluSz
CAediting_1120880chr16_67005806_+SINEAluAluSz
CAediting_1120881chr16_67005809_+SINEAluAluSz
CAediting_1120882chr16_67005814_+SINEAluAluSz
CAediting_1120883chr16_67005819_+SINEAluAluSz
CAediting_1120884chr16_67005829_+SINEAluAluSz
CAediting_1120885chr16_67005833_+SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for CES4A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172824.13.CES4A.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000172824.13.CES4A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CES4A

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CES4A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CES4A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000540947hsa-miR-624-3p67009387670093926mer6700937467009393141-18.17
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000567587hsa-miR-624-3p67001416670014227mer-m86700140367001423140-16.38
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000567587hsa-miR-624-3p67009387670093926mer6700937467009393141-18.17
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000538199hsa-miR-624-3p67009387670093926mer6700937467009393141-18.17
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000535543hsa-miR-624-3p67004864670048707mer-m86700485167004871163-20.78
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000535543hsa-miR-624-3p67009387670093926mer6700937467009393141-18.17
CAediting_1229415chr17_67471547_+ENSG00000172824.13ENST00000540947hsa-miR-548aa67009083670090897mer-m86700906867009090150-14.82
CAediting_1351755chr19_40282625_-ENSG00000172824.13ENST00000540947hsa-miR-64167009470670094767mer-m86700945467009477149-14.17
CAediting_1399425chr20_1392958_-ENSG00000172824.13ENST00000540947hsa-miR-6869-5p67009235670092417mer-m86700922267009242141-17.66
CAediting_1229415chr17_67471547_+ENSG00000172824.13ENST00000567587hsa-miR-548aa67009083670090897mer-m86700906867009090150-14.82
CAediting_1351755chr19_40282625_-ENSG00000172824.13ENST00000567587hsa-miR-64167009470670094767mer-m86700945467009477149-14.17
CAediting_1399425chr20_1392958_-ENSG00000172824.13ENST00000567587hsa-miR-6869-5p67009235670092417mer-m86700922267009242141-17.66
CAediting_1351755chr19_40282625_-ENSG00000172824.13ENST00000538199hsa-miR-64167009470670094767mer-m86700945467009477149-14.17
CAediting_1399425chr20_1392958_-ENSG00000172824.13ENST00000538199hsa-miR-6869-5p67009235670092417mer-m86700922267009242141-17.66
CAediting_524911chr7_5495852_-ENSG00000172824.13ENST00000535543hsa-miR-589-3p67004847670048537mer-m86700482767004854152-19.29
CAediting_1229415chr17_67471547_+ENSG00000172824.13ENST00000535543hsa-miR-548aa67009083670090897mer-m86700906867009090150-14.82
CAediting_1351755chr19_40282625_-ENSG00000172824.13ENST00000535543hsa-miR-64167009470670094767mer-m86700945467009477149-14.17
CAediting_1399425chr20_1392958_-ENSG00000172824.13ENST00000535543hsa-miR-6869-5p67009235670092417mer-m86700922267009242141-17.66
CAediting_1229415chr17_67471547_+ENSG00000172824.13ENST00000535696hsa-miR-548aa67009083670090897mer-m86700906867009090150-14.82
CAediting_1399425chr20_1392958_-ENSG00000172824.13ENST00000535696hsa-miR-6869-5p67009235670092417mer-m86700922267009242141-17.66
CAediting_1524209chrX_134546392_-ENSG00000172824.13ENST00000540947hsa-miR-503-5p67009270670092756mer6700925567009276147-30.64
CAediting_1524209chrX_134546392_-ENSG00000172824.13ENST00000567587hsa-miR-503-5p67009270670092756mer6700925567009276147-30.64
CAediting_1524209chrX_134546392_-ENSG00000172824.13ENST00000538199hsa-miR-503-5p67009270670092756mer6700925567009276147-30.64
CAediting_1524209chrX_134546392_-ENSG00000172824.13ENST00000535543hsa-miR-503-5p67009270670092756mer6700925567009276147-30.64
CAediting_1524209chrX_134546392_-ENSG00000172824.13ENST00000535696hsa-miR-503-5p67009270670092756mer6700925567009276147-30.64

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000172824.13ENST00000540947hsa-miR-320e67009535670095417mer-m86700952567009542154-17.32
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000540947hsa-miR-624-3p67009566670095727mer-m86700955467009573145-14.05
CAediting_1368054chr19_46709310_-ENSG00000172824.13ENST00000567587hsa-miR-320e67009535670095417mer-m86700952567009542154-17.32
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000567587hsa-miR-624-3p67009566670095727mer-m86700955467009573145-14.05
CAediting_1368054chr19_46709310_-ENSG00000172824.13ENST00000538199hsa-miR-320e67009535670095417mer-m86700952567009542154-17.32
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000538199hsa-miR-624-3p67009566670095727mer-m86700955467009573145-14.05
CAediting_1368054chr19_46709310_-ENSG00000172824.13ENST00000535543hsa-miR-320e67009535670095417mer-m86700952567009542154-17.32
CAediting_980496chr14_31014685_-ENSG00000172824.13ENST00000535543hsa-miR-624-3p67009566670095727mer-m86700955467009573145-14.05

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CES4A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CES4A

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
KIRCCAediting_1120842chr16_67005609_+0.01803315830886250.231538870312094....
KIRCCAediting_1120877chr16_67005770_+0.0456652758399380.2013493039505....

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Relation with cancer stages for CES4A

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
KIRCpathologic_stageCAediting_1120872chr16_67005742_+0.02310826377985640.184195393357889

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Relation with survival for CES4A

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
KIRCCAediting_1120857chr16_67005687_+0.03366919589724850.00169876238.668

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RelatedDrugs for CES4A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CES4A

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource