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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: STK32C (CAeditome ID:282974)

Gene summary for STK32C

check button Gene summary
Gene informationGene symbol

STK32C

Gene ID

282974

Gene nameserine/threonine kinase 32C
SynonymsPKE|YANK3
Cytomap

10q26.3

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase 32CPKE protein kinasetesticular tissue protein Li 187yet another novel kinase 3
Modification date20210518
UniProtAcc

Q86UX6

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for STK32C

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000165752.15
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_790118(132278697, -), CAediting_790119(132321650, -), CAediting_790120(132326434, -), CAediting_790121(132326565, -), CAediting_790122(132327591, -), CAediting_790123(132327592, -), CAediting_790124(132329338, -), CAediting_790125(132330543, -), CAediting_790126(132330565, -), CAediting_790127(132330591, -), CAediting_790128(132330600, -), CAediting_790129(132330605, -), CAediting_790130(132330618, -), CAediting_790131(132330619, -), CAediting_790132(132330623, -), CAediting_790133(132330629, -), CAediting_790134(132330640, -), CAediting_790135(132330646, -), CAediting_790136(132330652, -), CAediting_790137(132330654, -), CAediting_790138(132330656, -), CAediting_790139(132330696, -), CAediting_790140(132330699, -), CAediting_790141(132330702, -), CAediting_790142(132330737, -), CAediting_790143(132330742, -), CAediting_790144(132330752, -), CAediting_790145(132330753, -), CAediting_790146(132330761, -), CAediting_790147(132330774, -), CAediting_790148(132330777, -), CAediting_790149(132330782, -), CAediting_790150(132330783, -), CAediting_790151(132330791, -), CAediting_790152(132330798, -), CAediting_790153(132330801, -), CAediting_790154(132330819, -), CAediting_790155(132330937, -), CAediting_790156(132330944, -), CAediting_790157(132330946, -), CAediting_790158(132330958, -), CAediting_790159(132330959, -), CAediting_790160(132330981, -), CAediting_790161(132330989, -), CAediting_790162(132331035, -), CAediting_790163(132331077, -), CAediting_790164(132331079, -), CAediting_790165(132331089, -), CAediting_790166(132331115, -), CAediting_790167(132331119, -), CAediting_790168(132331125, -),

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RNA editing positional annotations for STK32C using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_790118chr10_132278697_-intronic
CAediting_790119chr10_132321650_-intronic
CAediting_790120chr10_132326434_-intronic
CAediting_790121chr10_132326565_-intronic
CAediting_790122chr10_132327591_-intronic
CAediting_790123chr10_132327592_-intronic
CAediting_790124chr10_132329338_-intronic
CAediting_790125chr10_132330543_-intronic
CAediting_790126chr10_132330565_-intronic
CAediting_790127chr10_132330591_-intronic
CAediting_790128chr10_132330600_-intronic
CAediting_790129chr10_132330605_-intronic
CAediting_790130chr10_132330618_-intronic
CAediting_790131chr10_132330619_-intronic
CAediting_790132chr10_132330623_-intronic
CAediting_790133chr10_132330629_-intronic
CAediting_790134chr10_132330640_-intronic
CAediting_790135chr10_132330646_-intronic
CAediting_790136chr10_132330652_-intronic
CAediting_790137chr10_132330654_-intronic
CAediting_790138chr10_132330656_-intronic
CAediting_790139chr10_132330696_-intronic
CAediting_790140chr10_132330699_-intronic
CAediting_790141chr10_132330702_-intronic
CAediting_790142chr10_132330737_-intronic
CAediting_790143chr10_132330742_-intronic
CAediting_790144chr10_132330752_-intronic
CAediting_790145chr10_132330753_-intronic
CAediting_790146chr10_132330761_-intronic
CAediting_790147chr10_132330774_-intronic
CAediting_790148chr10_132330777_-intronic
CAediting_790149chr10_132330782_-intronic
CAediting_790150chr10_132330783_-intronic
CAediting_790151chr10_132330791_-intronic
CAediting_790152chr10_132330798_-intronic
CAediting_790153chr10_132330801_-intronic
CAediting_790154chr10_132330819_-intronic
CAediting_790155chr10_132330937_-intronic
CAediting_790156chr10_132330944_-intronic
CAediting_790157chr10_132330946_-intronic
CAediting_790158chr10_132330958_-intronic
CAediting_790159chr10_132330959_-intronic
CAediting_790160chr10_132330981_-intronic
CAediting_790161chr10_132330989_-intronic
CAediting_790162chr10_132331035_-intronic
CAediting_790163chr10_132331077_-intronic
CAediting_790164chr10_132331079_-intronic
CAediting_790165chr10_132331089_-intronic
CAediting_790166chr10_132331115_-intronic
CAediting_790167chr10_132331119_-intronic
CAediting_790168chr10_132331125_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_790118chr10_132278697_-SINEAluAluY
CAediting_790119chr10_132321650_-SINEAluAluSx1
CAediting_790120chr10_132326434_-SINEAluAluSz6
CAediting_790121chr10_132326565_-SINEAluAluSz6
CAediting_790122chr10_132327591_-SINEAluAluSx
CAediting_790123chr10_132327592_-SINEAluAluSx
CAediting_790124chr10_132329338_-SINEAluAluJb
CAediting_790125chr10_132330543_-SINEAluAluJr
CAediting_790126chr10_132330565_-SINEAluAluJr
CAediting_790127chr10_132330591_-SINEAluAluJr
CAediting_790128chr10_132330600_-SINEAluAluJr
CAediting_790129chr10_132330605_-SINEAluAluJr
CAediting_790130chr10_132330618_-SINEAluAluJr
CAediting_790131chr10_132330619_-SINEAluAluJr
CAediting_790132chr10_132330623_-SINEAluAluJr
CAediting_790133chr10_132330629_-SINEAluAluJr
CAediting_790134chr10_132330640_-SINEAluAluJr
CAediting_790135chr10_132330646_-SINEAluAluJr
CAediting_790136chr10_132330652_-SINEAluAluJr
CAediting_790137chr10_132330654_-SINEAluAluJr
CAediting_790138chr10_132330656_-SINEAluAluJr
CAediting_790139chr10_132330696_-SINEAluAluJr
CAediting_790140chr10_132330699_-SINEAluAluJr
CAediting_790141chr10_132330702_-SINEAluAluJr
CAediting_790142chr10_132330737_-SINEAluAluJr
CAediting_790143chr10_132330742_-SINEAluAluJr
CAediting_790144chr10_132330752_-SINEAluAluJr
CAediting_790145chr10_132330753_-SINEAluAluJr
CAediting_790146chr10_132330761_-SINEAluAluJr
CAediting_790147chr10_132330774_-SINEAluAluJr
CAediting_790148chr10_132330777_-SINEAluAluJr
CAediting_790149chr10_132330782_-SINEAluAluJr
CAediting_790150chr10_132330783_-SINEAluAluJr
CAediting_790151chr10_132330791_-SINEAluAluJr
CAediting_790152chr10_132330798_-SINEAluAluJr
CAediting_790153chr10_132330801_-SINEAluAluJr
CAediting_790155chr10_132330937_-SINEAluAluSg
CAediting_790156chr10_132330944_-SINEAluAluSg
CAediting_790157chr10_132330946_-SINEAluAluSg
CAediting_790158chr10_132330958_-SINEAluAluSg
CAediting_790159chr10_132330959_-SINEAluAluSg
CAediting_790160chr10_132330981_-SINEAluAluSg
CAediting_790161chr10_132330989_-SINEAluAluSg
CAediting_790162chr10_132331035_-SINEAluAluSg
CAediting_790163chr10_132331077_-SINEAluAluSg
CAediting_790164chr10_132331079_-SINEAluAluSg
CAediting_790165chr10_132331089_-SINEAluAluSg
CAediting_790166chr10_132331115_-SINEAluAluSg
CAediting_790167chr10_132331119_-SINEAluAluSg
CAediting_790168chr10_132331125_-SINEAluAluSg

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RNA A-to-I editing events in the alternative splicing sites for STK32C

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000165752.15.STK32C.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000165752.15.STK32C.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STK32C

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
UCEC.CAediting_790128.ENSG00000165752.STK32C.png
Soverview

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Protein coding region RNA A-to-I editings for STK32C

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for STK32C

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000165752.15ENST00000456004hsa-miR-200b-3p1323303291323303357mer-m8132330328132330352147-9.48
CAediting_77128chr1_85133844_+ENSG00000165752.15ENST00000368622hsa-miR-4423-3p1322078921322078987mer-m8132207891132207911145-19.6
CAediting_77128chr1_85133844_+ENSG00000165752.15ENST00000298630hsa-miR-4423-3p1322078921322078987mer-m8132207891132207911145-19.6
CAediting_1368054chr19_46709310_-ENSG00000165752.15ENST00000368619hsa-miR-320e1323241511323241577mer-m8132324150132324168153-24.27

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1524209chrX_134546392_-ENSG00000165752.15ENST00000368622hsa-miR-503-5p1322077591322077657mer-m8132207758132207780140-18.33
CAediting_1524209chrX_134546392_-ENSG00000165752.15ENST00000298630hsa-miR-503-5p1322077591322077657mer-m8132207758132207780140-18.33

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for STK32C

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for STK32C

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LUADCAediting_790128chr10_132330600_-0.002355153648552890.282147645348914....
PRADCAediting_790128chr10_132330600_-..0.0004618473336471050.441680063629107..
KIRPCAediting_790128chr10_132330600_-..0.006855609670085150.2770977502944990.01778069551078290.244019854220215
SKCMCAediting_790128chr10_132330600_-..0.001798624265653130.394796453582024..
THYMCAediting_790128chr10_132330600_-..5.68627381490585e-060.4626009965754880.01599274393629890.256170803039105
BLCACAediting_790130chr10_132330618_-..0.002428217580727970.2345338074570530.01815054852186460.183750955065528
LUADCAediting_790130chr10_132330618_-..0.04029067464383130.19860729269355..
UCECCAediting_790130chr10_132330618_-0.01602647033172570.220374414494879....
KIRPCAediting_790130chr10_132330618_-..0.02735842425627640.24520718810125..
THYMCAediting_790130chr10_132330618_-..0.03135926832171080.235075806772414..
UCECCAediting_790144chr10_132330752_-....0.04986756738321660.22729235315645
THYMCAediting_790144chr10_132330752_-0.007300760759216890.348727706354537..0.04211099909450840.267803569834294
CESCCAediting_790150chr10_132330783_-0.01658061728712210.293980302612969....
THYMCAediting_790150chr10_132330783_-..0.00906925559507410.323724967626351..

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Relation with cancer stages for STK32C

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BLCApathologic_stageCAediting_790128chr10_132330600_-0.02762855847957340.169455097346809
KIRCpathologic_stageCAediting_790130chr10_132330618_-0.006830898948310890.302006240815068
THCApathologic_stageCAediting_790128chr10_132330600_-0.007526524898965030.246963450421587

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Relation with survival for STK32C

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LUADCAediting_790130chr10_132330618_-0.01337789304692580.038674812.3666

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RelatedDrugs for STK32C

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK32C

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource