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Editing gene: GNG5 (CAeditome ID:2787)

Gene summary for GNG5

Gene summary

Gene information	Gene symbol	GNG5
	Gene ID	2787
	Gene name	G protein subunit gamma 5
	Synonyms	-
	Cytomap	1p22.3
	Type of gene	protein-coding
	Description	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5guanine nucleotide binding protein (G protein), gamma 5
	Modification date	20210522
	UniProtAcc	P63218
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GNG5	GO:0030165	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	23209302

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RNA A-to-I events for GNG5

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000174021.9

RNA A-to-I editing events in Cancer.

CAediting_76988(84499870, -), CAediting_76989(84499871, -), CAediting_76990(84499881, -), CAediting_76991(84499971, -), CAediting_76992(84499973, -), CAediting_76993(84499983, -), CAediting_76994(84500046, -), CAediting_76995(84502194, -), CAediting_76996(84502197, -), CAediting_76997(84502255, -), CAediting_76998(84502258, -), CAediting_76999(84502262, -), CAediting_77000(84502266, -), CAediting_77001(84502272, -), CAediting_77002(84502301, -), CAediting_77003(84502302, -), CAediting_77004(84502307, -), CAediting_77005(84502316, -), CAediting_77006(84502360, -), CAediting_77007(84502399, -), CAediting_77008(84502411, -), CAediting_77009(84506047, -),

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RNA editing positional annotations for GNG5 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_76988	chr1_84499870_-	ncRNA_intronic
CAediting_76989	chr1_84499871_-	ncRNA_intronic
CAediting_76990	chr1_84499881_-	ncRNA_intronic
CAediting_76991	chr1_84499971_-	ncRNA_intronic
CAediting_76992	chr1_84499973_-	ncRNA_intronic
CAediting_76993	chr1_84499983_-	ncRNA_intronic
CAediting_76994	chr1_84500046_-	ncRNA_intronic
CAediting_76995	chr1_84502194_-	ncRNA_intronic
CAediting_76996	chr1_84502197_-	ncRNA_intronic
CAediting_76997	chr1_84502255_-	ncRNA_intronic
CAediting_76998	chr1_84502258_-	ncRNA_intronic
CAediting_76999	chr1_84502262_-	ncRNA_intronic
CAediting_77000	chr1_84502266_-	ncRNA_intronic
CAediting_77001	chr1_84502272_-	ncRNA_intronic
CAediting_77002	chr1_84502301_-	ncRNA_intronic
CAediting_77003	chr1_84502302_-	ncRNA_intronic
CAediting_77004	chr1_84502307_-	ncRNA_intronic
CAediting_77005	chr1_84502316_-	ncRNA_intronic
CAediting_77006	chr1_84502360_-	ncRNA_intronic
CAediting_77007	chr1_84502399_-	ncRNA_intronic
CAediting_77008	chr1_84502411_-	ncRNA_intronic
CAediting_77009	chr1_84506047_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_76988	chr1_84499870_-	SINE	Alu	AluSx
CAediting_76989	chr1_84499871_-	SINE	Alu	AluSx
CAediting_76990	chr1_84499881_-	SINE	Alu	AluSx
CAediting_76991	chr1_84499971_-	SINE	Alu	AluSx
CAediting_76992	chr1_84499973_-	SINE	Alu	AluSx
CAediting_76993	chr1_84499983_-	SINE	Alu	AluSx
CAediting_76994	chr1_84500046_-	SINE	Alu	Alu
CAediting_76995	chr1_84502194_-	SINE	Alu	AluSc
CAediting_76996	chr1_84502197_-	SINE	Alu	AluSc
CAediting_76997	chr1_84502255_-	SINE	Alu	AluSc
CAediting_76998	chr1_84502258_-	SINE	Alu	AluSc
CAediting_76999	chr1_84502262_-	SINE	Alu	AluSc
CAediting_77000	chr1_84502266_-	SINE	Alu	AluSc
CAediting_77001	chr1_84502272_-	SINE	Alu	AluSc
CAediting_77002	chr1_84502301_-	SINE	Alu	AluSc
CAediting_77003	chr1_84502302_-	SINE	Alu	AluSc
CAediting_77004	chr1_84502307_-	SINE	Alu	AluSc
CAediting_77005	chr1_84502316_-	SINE	Alu	AluSc
CAediting_77006	chr1_84502360_-	SINE	Alu	AluSc
CAediting_77007	chr1_84502399_-	SINE	Alu	AluSc
CAediting_77008	chr1_84502411_-	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for GNG5

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000174021.9.GNG5.

Correlation between RNA A-to-I editing and PSI for ENSG00000174021.9.GNG5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GNG5

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GNG5

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GNG5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GNG5

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000370641.3	protein_coding
ENST00000370645.7	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_77009	ENST00000370641.3	chr1_84506047_-	-284.40	-283.30	-284.40
CAediting_77009	ENST00000370645.7	chr1_84506047_-	-244.80	-243.70	-244.80

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Relation with ADAR for GNG5

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for GNG5

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GNG5

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GNG5

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GNG5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GNG5	C0033578	Prostatic Neoplasms	1	CTD_human
GNG5	C0376358	Malignant neoplasm of prostate	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene