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Editing gene: GM2A (CAeditome ID:2760)

Gene summary for GM2A

Gene summary

Gene information	Gene symbol	GM2A
	Gene ID	2760
	Gene name	GM2 ganglioside activator
	Synonyms	GM2-AP\|SAP-3
	Cytomap	5q33.1
	Type of gene	protein-coding
	Description	ganglioside GM2 activatorcerebroside sulfate activator proteinshingolipid activator protein 3sphingolipid activator protein 3
	Modification date	20210518
	UniProtAcc	P17900
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GM2A	GO:0005829	Ganglioside GM2 activator	0000052
GM2A	GO:0043231	Ganglioside GM2 activator	0000052

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RNA A-to-I events for GM2A

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000196743.7

RNA A-to-I editing events in Cancer.

CAediting_441990(151224717, +), CAediting_441991(151224884, +), CAediting_441992(151224896, +), CAediting_441993(151226452, +), CAediting_441994(151227061, +), CAediting_441995(151227062, +), CAediting_441996(151227107, +), CAediting_441997(151235421, +), CAediting_441998(151235473, +), CAediting_441999(151236544, +), CAediting_442000(151236550, +), CAediting_442001(151236551, +), CAediting_442002(151236641, +), CAediting_442003(151236684, +), CAediting_442004(151236689, +), CAediting_442005(151236753, +), CAediting_442006(151236754, +), CAediting_442007(151236759, +), CAediting_442008(151245524, +), CAediting_442009(151255047, +), CAediting_442010(151255069, +), CAediting_442011(151255228, +), CAediting_442012(151255246, +), CAediting_442013(151266326, +), CAediting_442014(151266327, +), CAediting_442015(151268176, +), CAediting_442016(151268178, +), CAediting_442017(151268180, +), CAediting_442018(151268182, +), CAediting_442019(151268183, +), CAediting_442020(151268235, +), CAediting_442021(151268236, +), CAediting_442022(151268255, +), CAediting_442023(151268259, +), CAediting_442024(151268260, +), CAediting_442025(151268295, +), CAediting_442026(151268297, +), CAediting_442027(151268320, +), CAediting_442028(151268329, +), CAediting_442029(151268335, +), CAediting_442030(151268338, +), CAediting_442031(151268352, +), CAediting_442032(151268355, +), CAediting_442033(151268400, +), CAediting_442034(151268414, +), CAediting_442035(151268415, +), CAediting_442036(151268426, +), CAediting_442037(151268428, +), CAediting_442038(151268432, +), CAediting_442039(151268442, +), CAediting_442040(151268584, +),

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RNA editing positional annotations for GM2A using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_441990	chr5_151224717_+	intronic
CAediting_441991	chr5_151224884_+	intronic
CAediting_441992	chr5_151224896_+	intronic
CAediting_441993	chr5_151226452_+	intronic
CAediting_441994	chr5_151227061_+	intronic
CAediting_441995	chr5_151227062_+	intronic
CAediting_441996	chr5_151227107_+	intronic
CAediting_441997	chr5_151235421_+	intronic
CAediting_441998	chr5_151235473_+	intronic
CAediting_441999	chr5_151236544_+	intronic
CAediting_442000	chr5_151236550_+	intronic
CAediting_442001	chr5_151236551_+	intronic
CAediting_442002	chr5_151236641_+	intronic
CAediting_442003	chr5_151236684_+	intronic
CAediting_442004	chr5_151236689_+	intronic
CAediting_442005	chr5_151236753_+	intronic
CAediting_442006	chr5_151236754_+	intronic
CAediting_442007	chr5_151236759_+	intronic
CAediting_442008	chr5_151245524_+	intronic
CAediting_442009	chr5_151255047_+	intronic
CAediting_442010	chr5_151255069_+	intronic
CAediting_442011	chr5_151255228_+	intronic
CAediting_442012	chr5_151255246_+	intronic
CAediting_442013	chr5_151266326_+	intronic
CAediting_442014	chr5_151266327_+	intronic
CAediting_442015	chr5_151268176_+	UTR3
CAediting_442016	chr5_151268178_+	UTR3
CAediting_442017	chr5_151268180_+	UTR3
CAediting_442018	chr5_151268182_+	UTR3
CAediting_442019	chr5_151268183_+	UTR3
CAediting_442020	chr5_151268235_+	UTR3
CAediting_442021	chr5_151268236_+	UTR3
CAediting_442022	chr5_151268255_+	UTR3
CAediting_442023	chr5_151268259_+	UTR3
CAediting_442024	chr5_151268260_+	UTR3
CAediting_442025	chr5_151268295_+	UTR3
CAediting_442026	chr5_151268297_+	UTR3
CAediting_442027	chr5_151268320_+	UTR3
CAediting_442028	chr5_151268329_+	UTR3
CAediting_442029	chr5_151268335_+	UTR3
CAediting_442030	chr5_151268338_+	UTR3
CAediting_442031	chr5_151268352_+	UTR3
CAediting_442032	chr5_151268355_+	UTR3
CAediting_442033	chr5_151268400_+	UTR3
CAediting_442034	chr5_151268414_+	UTR3
CAediting_442035	chr5_151268415_+	UTR3
CAediting_442036	chr5_151268426_+	UTR3
CAediting_442037	chr5_151268428_+	UTR3
CAediting_442038	chr5_151268432_+	UTR3
CAediting_442039	chr5_151268442_+	UTR3
CAediting_442040	chr5_151268584_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_441990	chr5_151224717_+	SINE	Alu	AluJr
CAediting_441991	chr5_151224884_+	SINE	Alu	AluSx
CAediting_441992	chr5_151224896_+	SINE	Alu	AluSx
CAediting_441993	chr5_151226452_+	SINE	Alu	AluSx
CAediting_441994	chr5_151227061_+	SINE	Alu	AluY
CAediting_441995	chr5_151227062_+	SINE	Alu	AluY
CAediting_441996	chr5_151227107_+	SINE	Alu	AluY
CAediting_441997	chr5_151235421_+	SINE	Alu	AluSg4
CAediting_441998	chr5_151235473_+	SINE	Alu	AluSg4
CAediting_441999	chr5_151236544_+	SINE	Alu	AluSx
CAediting_442000	chr5_151236550_+	SINE	Alu	AluSx
CAediting_442001	chr5_151236551_+	SINE	Alu	AluSx
CAediting_442002	chr5_151236641_+	SINE	Alu	AluSx
CAediting_442003	chr5_151236684_+	SINE	Alu	AluSx
CAediting_442004	chr5_151236689_+	SINE	Alu	AluSx
CAediting_442005	chr5_151236753_+	SINE	Alu	AluSx
CAediting_442006	chr5_151236754_+	SINE	Alu	AluSx
CAediting_442007	chr5_151236759_+	SINE	Alu	AluSx
CAediting_442008	chr5_151245524_+	SINE	Alu	AluSx1
CAediting_442009	chr5_151255047_+	SINE	Alu	AluJb
CAediting_442010	chr5_151255069_+	SINE	Alu	AluJb
CAediting_442011	chr5_151255228_+	SINE	Alu	AluJb
CAediting_442012	chr5_151255246_+	SINE	Alu	AluJb
CAediting_442013	chr5_151266326_+	SINE	Alu	AluJo
CAediting_442014	chr5_151266327_+	SINE	Alu	AluJo
CAediting_442015	chr5_151268176_+	SINE	Alu	AluSc
CAediting_442016	chr5_151268178_+	SINE	Alu	AluSc
CAediting_442017	chr5_151268180_+	SINE	Alu	AluSc
CAediting_442018	chr5_151268182_+	SINE	Alu	AluSc
CAediting_442019	chr5_151268183_+	SINE	Alu	AluSc
CAediting_442020	chr5_151268235_+	SINE	Alu	AluSc
CAediting_442021	chr5_151268236_+	SINE	Alu	AluSc
CAediting_442022	chr5_151268255_+	SINE	Alu	AluSc
CAediting_442023	chr5_151268259_+	SINE	Alu	AluSc
CAediting_442024	chr5_151268260_+	SINE	Alu	AluSc
CAediting_442025	chr5_151268295_+	SINE	Alu	AluSc
CAediting_442026	chr5_151268297_+	SINE	Alu	AluSc
CAediting_442027	chr5_151268320_+	SINE	Alu	AluSc
CAediting_442028	chr5_151268329_+	SINE	Alu	AluSc
CAediting_442029	chr5_151268335_+	SINE	Alu	AluSc
CAediting_442030	chr5_151268338_+	SINE	Alu	AluSc
CAediting_442031	chr5_151268352_+	SINE	Alu	AluSc
CAediting_442032	chr5_151268355_+	SINE	Alu	AluSc
CAediting_442033	chr5_151268400_+	SINE	Alu	AluSc
CAediting_442034	chr5_151268414_+	SINE	Alu	AluSc
CAediting_442035	chr5_151268415_+	SINE	Alu	AluSc
CAediting_442036	chr5_151268426_+	SINE	Alu	AluSc
CAediting_442037	chr5_151268428_+	SINE	Alu	AluSc
CAediting_442038	chr5_151268432_+	SINE	Alu	AluSc
CAediting_442039	chr5_151268442_+	SINE	Alu	AluSc
CAediting_442040	chr5_151268584_+	DNA	hAT-Charlie	MER102a

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RNA A-to-I editing events in the alternative splicing sites for GM2A

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_442017	chr5_151268180_+	151268180:151268202	3SS	0+20i	AGAATCTCACTTTGTCACCAGGC	-10.9	GGAATCTCACTTTGTCACCAGGC	-11.23
IR	CAediting_442018	chr5_151268182_+	151268180:151268202	3SS	0+18i	AGAATCTCACTTTGTCACCAGGC	-10.9	AGGATCTCACTTTGTCACCAGGC	-11.01
IR	CAediting_442019	chr5_151268183_+	151268180:151268202	3SS	0+17i	AGAATCTCACTTTGTCACCAGGC	-10.9	AGAGTCTCACTTTGTCACCAGGC	-11.2

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000196743.7.GM2A.

Correlation between RNA A-to-I editing and PSI for ENSG00000196743.7.GM2A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GM2A

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

BLCA.CAediting_442016.ENSG00000196743.GM2A.png
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BRCA.CAediting_442015.ENSG00000196743.GM2A.png
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BRCA.CAediting_442019.ENSG00000196743.GM2A.png
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CESC.CAediting_442019.ENSG00000196743.GM2A.png
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COAD.CAediting_442015.ENSG00000196743.GM2A.png
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COAD.CAediting_442019.ENSG00000196743.GM2A.png
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KIRC.CAediting_442015.ENSG00000196743.GM2A.png
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KIRC.CAediting_442019.ENSG00000196743.GM2A.png
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LUAD.CAediting_442019.ENSG00000196743.GM2A.png
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READ.CAediting_442015.ENSG00000196743.GM2A.png
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STAD.CAediting_442015.ENSG00000196743.GM2A.png
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STAD.CAediting_442019.ENSG00000196743.GM2A.png
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THCA.CAediting_442015.ENSG00000196743.GM2A.png
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THCA.CAediting_442019.ENSG00000196743.GM2A.png
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UCEC.CAediting_442015.ENSG00000196743.GM2A.png
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UCEC.CAediting_442019.ENSG00000196743.GM2A.png
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Protein coding region RNA A-to-I editings for GM2A

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GM2A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442015	chr5_151268176_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4433b-5p	151268173	151268179	7mer-m8	151268160	151268180	140.00	-10.81
CAediting_442016	chr5_151268178_+	ENSG00000196743.7	ENST00000357164	hsa-miR-5001-3p	151268175	151268182	8mer-1a	151268161	151268182	145.00	-15.23
CAediting_442016	chr5_151268178_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6738-3p	151268176	151268182	7mer-m8	151268161	151268183	146.00	-11.57
CAediting_442017	chr5_151268180_+	ENSG00000196743.7	ENST00000357164	hsa-miR-340-3p	151268174	151268181	8mer-1a	151268160	151268181	146.00	-18.22
CAediting_442017	chr5_151268180_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6827-3p	151268174	151268181	8mer-1a	151268161	151268181	140.00	-14.67
CAediting_442019	chr5_151268183_+	ENSG00000196743.7	ENST00000357164	hsa-miR-3664-5p	151268177	151268183	7mer-m8	151268163	151268184	153.00	-15.28
CAediting_442019	chr5_151268183_+	ENSG00000196743.7	ENST00000357164	hsa-miR-3672	151268181	151268187	7mer-m8	151268164	151268188	156.00	-15.23
CAediting_442019	chr5_151268183_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4522	151268178	151268184	7mer-m8	151268165	151268185	148.00	-12.83
CAediting_442019	chr5_151268183_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6864-3p	151268181	151268187	7mer-m8	151268167	151268188	153.00	-17.84
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-2114-5p	151268582	151268588	7mer-m8	151268568	151268589	147.00	-20.89
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4722-3p	151268578	151268584	7mer-m8	151268564	151268585	142.00	-17.84
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6727-3p	151268578	151268584	7mer-m8	151268566	151268585	151.00	-21.94
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6752-3p	151268579	151268586	8mer-1a	151268565	151268586	155.00	-24.19
CAediting_442021	chr5_151268236_+	ENSG00000196743.7	ENST00000357164	hsa-miR-17-3p	151268229	151268235	7mer-m8	151268214	151268236	155.00	-20.97
CAediting_442021	chr5_151268236_+	ENSG00000196743.7	ENST00000357164	hsa-miR-485-5p	151268233	151268239	7mer-m8	151268217	151268240	156.00	-17.89
CAediting_442021	chr5_151268236_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6884-5p	151268233	151268239	7mer-m8	151268217	151268240	162.00	-26.06
CAediting_442024	chr5_151268260_+	ENSG00000196743.7	ENST00000357164	hsa-miR-146a-5p	151268258	151268264	7mer-m8	151268241	151268265	151.00	-20.69
CAediting_442024	chr5_151268260_+	ENSG00000196743.7	ENST00000357164	hsa-miR-146b-5p	151268258	151268264	7mer-m8	151268239	151268265	152.00	-22.20
CAediting_442024	chr5_151268260_+	ENSG00000196743.7	ENST00000357164	hsa-miR-7153-5p	151268258	151268264	7mer-m8	151268243	151268265	145.00	-17.70
CAediting_442025	chr5_151268295_+	ENSG00000196743.7	ENST00000357164	hsa-miR-17-3p	151268291	151268297	7mer-m8	151268276	151268298	166.00	-23.43
CAediting_442025	chr5_151268295_+	ENSG00000196743.7	ENST00000357164	hsa-miR-455-3p	151268288	151268294	7mer-m8	151268275	151268295	142.00	-19.39
CAediting_442027	chr5_151268320_+	ENSG00000196743.7	ENST00000357164	hsa-miR-34a-3p	151268316	151268322	7mer-m8	151268302	151268323	140.00	-8.35
CAediting_442028	chr5_151268329_+	ENSG00000196743.7	ENST00000357164	hsa-miR-8485	151268323	151268329	7mer-m8	151268310	151268330	142.00	-9.85
CAediting_442030	chr5_151268338_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6509-3p	151268334	151268339	6mer	151268319	151268340	143.00	-13.09
CAediting_442032	chr5_151268355_+	ENSG00000196743.7	ENST00000357164	hsa-miR-433-5p	151268349	151268355	7mer-m8	151268333	151268356	159.00	-23.87
CAediting_442034	chr5_151268414_+	ENSG00000196743.7	ENST00000357164	hsa-miR-2276-3p	151268407	151268414	8mer-1a	151268395	151268414	155.00	-23.39
CAediting_442034	chr5_151268414_+	ENSG00000196743.7	ENST00000357164	hsa-miR-3194-3p	151268410	151268416	7mer-m8	151268395	151268417	141.00	-17.01
CAediting_442035	chr5_151268415_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6841-3p	151268409	151268415	7mer-m8	151268396	151268416	140.00	-13.31
CAediting_442039	chr5_151268442_+	ENSG00000196743.7	ENST00000357164	hsa-miR-143-5p	151268438	151268444	7mer-m8	151268424	151268445	168.00	-27.76
CAediting_442039	chr5_151268442_+	ENSG00000196743.7	ENST00000357164	hsa-miR-5693	151268435	151268441	7mer-m8	151268420	151268442	151.00	-24.46
CAediting_442018	chr5_151268182_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4421	151268175	151268182	8mer-1a	151268161	151268182	159.00	-17.42
CAediting_442018	chr5_151268182_+	ENSG00000196743.7	ENST00000357164	hsa-miR-5699-3p	151268175	151268182	8mer-1a	151268161	151268182	141.00	-16.73

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442033	chr5_151268400_+	ENSG00000196743.7	ENST00000357164	hsa-miR-12114	151268396	151268402	7mer-m8	151268382	151268403	151	-24.64
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-1915-5p	151268579	151268586	8mer-1a	151268565	151268586	145	-19.3
CAediting_442023	chr5_151268259_+	ENSG00000196743.7	ENST00000357164	hsa-miR-219b-3p	151268256	151268262	7mer-m8	151268243	151268263	153	-18.56
CAediting_442024	chr5_151268260_+	ENSG00000196743.7	ENST00000357164	hsa-miR-219b-3p	151268256	151268262	7mer-m8	151268243	151268263	153	-18.56
CAediting_442026	chr5_151268297_+	ENSG00000196743.7	ENST00000357164	hsa-miR-2861	151268295	151268301	7mer-m8	151268284	151268302	140	-19.78
CAediting_442023	chr5_151268259_+	ENSG00000196743.7	ENST00000357164	hsa-miR-302f	151268255	151268261	7mer-m8	151268246	151268262	145	-8.67
CAediting_442024	chr5_151268260_+	ENSG00000196743.7	ENST00000357164	hsa-miR-302f	151268255	151268261	7mer-m8	151268246	151268262	145	-8.67
CAediting_442030	chr5_151268338_+	ENSG00000196743.7	ENST00000357164	hsa-miR-3675-3p	151268336	151268342	7mer-m8	151268321	151268343	146	-12.58
CAediting_442015	chr5_151268176_+	ENSG00000196743.7	ENST00000357164	hsa-miR-371b-5p	151268170	151268177	8mer-1a	151268156	151268177	146	-13.72
CAediting_442015	chr5_151268176_+	ENSG00000196743.7	ENST00000357164	hsa-miR-373-5p	151268170	151268177	8mer-1a	151268156	151268177	142	-14.4
CAediting_442034	chr5_151268414_+	ENSG00000196743.7	ENST00000357164	hsa-miR-450b-5p	151268408	151268414	7mer-m8	151268394	151268415	140	-8.11
CAediting_442035	chr5_151268415_+	ENSG00000196743.7	ENST00000357164	hsa-miR-450b-5p	151268408	151268414	7mer-m8	151268394	151268415	140	-8.11
CAediting_442033	chr5_151268400_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4520-3p	151268393	151268399	7mer-m8	151268382	151268400	155	-23.8
CAediting_442030	chr5_151268338_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4684-5p	151268335	151268341	7mer-m8	151268321	151268342	153	-15.31
CAediting_442016	chr5_151268178_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4743-3p	151268176	151268182	7mer-m8	151268163	151268183	146	-11.81
CAediting_442017	chr5_151268180_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4743-3p	151268176	151268182	7mer-m8	151268163	151268183	146	-11.81
CAediting_442018	chr5_151268182_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4743-3p	151268176	151268182	7mer-m8	151268163	151268183	146	-11.81
CAediting_442019	chr5_151268183_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4743-3p	151268176	151268182	7mer-m8	151268163	151268183	146	-11.81
CAediting_442033	chr5_151268400_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4761-5p	151268398	151268404	7mer-m8	151268384	151268405	150	-15.04
CAediting_442040	chr5_151268584_+	ENSG00000196743.7	ENST00000357164	hsa-miR-502-5p	151268580	151268586	7mer-m8	151268567	151268587	153	-17.5
CAediting_442015	chr5_151268176_+	ENSG00000196743.7	ENST00000357164	hsa-miR-514b-5p	151268172	151268177	6mer	151268157	151268178	148	-12.74
CAediting_442016	chr5_151268178_+	ENSG00000196743.7	ENST00000357164	hsa-miR-514b-5p	151268172	151268177	6mer	151268157	151268178	148	-12.74
CAediting_442020	chr5_151268235_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6086	151268233	151268239	7mer-m8	151268219	151268240	145	-22.26
CAediting_442021	chr5_151268236_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6086	151268233	151268239	7mer-m8	151268219	151268240	145	-22.26
CAediting_442015	chr5_151268176_+	ENSG00000196743.7	ENST00000357164	hsa-miR-616-5p	151268170	151268177	8mer-1a	151268156	151268177	140	-9.79
CAediting_442037	chr5_151268428_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6514-3p	151268425	151268431	7mer-m8	151268412	151268432	146	-16.37
CAediting_442038	chr5_151268432_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6514-3p	151268425	151268431	7mer-m8	151268412	151268432	146	-16.37
CAediting_442026	chr5_151268297_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6735-3p	151268294	151268300	7mer-m8	151268281	151268301	153	-21.84
CAediting_442039	chr5_151268442_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6772-5p	151268440	151268447	8mer-1a	151268424	151268447	153	-23.59
CAediting_442038	chr5_151268432_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6847-3p	151268430	151268436	7mer-m8	151268418	151268437	153	-21.57
CAediting_442016	chr5_151268178_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6888-3p	151268175	151268182	8mer-1a	151268162	151268182	151	-14.21
CAediting_442017	chr5_151268180_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6888-3p	151268175	151268182	8mer-1a	151268162	151268182	151	-14.21
CAediting_442018	chr5_151268182_+	ENSG00000196743.7	ENST00000357164	hsa-miR-6888-3p	151268175	151268182	8mer-1a	151268162	151268182	151	-14.21
CAediting_442031	chr5_151268352_+	ENSG00000196743.7	ENST00000357164	hsa-miR-7855-5p	151268349	151268354	6mer	151268336	151268355	148	-26.03
CAediting_442032	chr5_151268355_+	ENSG00000196743.7	ENST00000357164	hsa-miR-7855-5p	151268349	151268354	6mer	151268336	151268355	148	-26.03
CAediting_442033	chr5_151268400_+	ENSG00000196743.7	ENST00000357164	hsa-miR-8071	151268395	151268401	7mer-m8	151268381	151268402	145	-19.94
CAediting_442033	chr5_151268400_+	ENSG00000196743.7	ENST00000357164	hsa-miR-8071	151268395	151268401	7mer-m8	151268381	151268402	145	-19.94

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000196743.7	ENST00000357164	hsa-miR-624-3p	151269143	151269149	7mer-m8	151269130	151269150	147	-13.92
CAediting_393	chr1_1167164_+	ENSG00000196743.7	ENST00000357164	hsa-miR-200b-3p	151269838	151269844	7mer-m8	151269824	151269845	150	-12.97
CAediting_688081	chr9_63819627_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4477b	151269771	151269777	7mer-m8	151269757	151269778	168	-16.81
CAediting_1306323	chr19_13836462_-	ENSG00000196743.7	ENST00000357164	hsa-miR-27a-3p	151268116	151268122	7mer-m8	151268101	151268123	144	-16.93
CAediting_1368054	chr19_46709310_-	ENSG00000196743.7	ENST00000357164	hsa-miR-320e	151269426	151269432	7mer-m8	151269416	151269433	155	-17.09
CAediting_117844	chr1_162342605_+	ENSG00000196743.7	ENST00000357164	hsa-miR-556-3p	151268641	151268647	7mer-m8	151268627	151268648	159	-10
CAediting_77128	chr1_85133844_+	ENSG00000196743.7	ENST00000357164	hsa-miR-4423-3p	151268520	151268526	7mer-m8	151268507	151268527	140	-13.91
CAediting_524911	chr7_5495852_-	ENSG00000196743.7	ENST00000357164	hsa-miR-589-3p	151270067	151270073	7mer-m8	151270051	151270074	144	-11.7
CAediting_524911	chr7_5495852_-	ENSG00000196743.7	ENST00000357164	hsa-miR-589-3p	151268051	151268057	7mer-m8	151268031	151268058	143	-23.56
CAediting_1351755	chr19_40282625_-	ENSG00000196743.7	ENST00000523004	hsa-miR-641	151267006	151267012	7mer-m8	151266989	151267013	144	-16.78

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442554	chr5_154685830_+	ENSG00000196743.7	ENST00000357164	hsa-miR-1303	151267718	151267725	8mer-1a	151267706	151267725	147	-11.67
CAediting_1054808	chr15_66496985_-	ENSG00000196743.7	ENST00000357164	hsa-miR-4512	151268296	151268302	7mer-m8	151268282	151268303	140	-19.14

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GM2A

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000357164.3	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_442015	ENST00000357164.3	chr5_151268176_+	-1281.10	-1282.00	-1315.50
CAediting_442016	ENST00000357164.3	chr5_151268178_+	-1281.40	-1282.00	-1315.50
CAediting_442017	ENST00000357164.3	chr5_151268180_+	-1281.30	-1282.00	-1315.50
CAediting_442018	ENST00000357164.3	chr5_151268182_+	-1281.10	-1282.00	-1315.50
CAediting_442019	ENST00000357164.3	chr5_151268183_+	-1288.20	-1282.00	-1315.50
CAediting_442020	ENST00000357164.3	chr5_151268235_+	-1282.10	-1282.00	-1315.50
CAediting_442021	ENST00000357164.3	chr5_151268236_+	-1282.40	-1282.00	-1315.50
CAediting_442022	ENST00000357164.3	chr5_151268255_+	-1282.00	-1282.00	-1315.50
CAediting_442023	ENST00000357164.3	chr5_151268259_+	-1282.00	-1282.00	-1315.50
CAediting_442024	ENST00000357164.3	chr5_151268260_+	-1282.00	-1282.00	-1315.50
CAediting_442025	ENST00000357164.3	chr5_151268295_+	-1283.80	-1282.00	-1315.50
CAediting_442026	ENST00000357164.3	chr5_151268297_+	-1282.80	-1282.00	-1315.50
CAediting_442027	ENST00000357164.3	chr5_151268320_+	-1282.00	-1282.00	-1315.50
CAediting_442028	ENST00000357164.3	chr5_151268329_+	-1282.00	-1282.00	-1315.50
CAediting_442029	ENST00000357164.3	chr5_151268335_+	-1282.20	-1282.00	-1315.50
CAediting_442030	ENST00000357164.3	chr5_151268338_+	-1285.80	-1282.00	-1315.50
CAediting_442031	ENST00000357164.3	chr5_151268352_+	-1284.40	-1282.00	-1315.50
CAediting_442032	ENST00000357164.3	chr5_151268355_+	-1282.00	-1282.00	-1315.50
CAediting_442033	ENST00000357164.3	chr5_151268400_+	-1281.30	-1282.00	-1315.50
CAediting_442034	ENST00000357164.3	chr5_151268414_+	-1282.40	-1282.00	-1315.50
CAediting_442035	ENST00000357164.3	chr5_151268415_+	-1284.60	-1282.00	-1315.50
CAediting_442036	ENST00000357164.3	chr5_151268426_+	-1282.00	-1282.00	-1315.50
CAediting_442037	ENST00000357164.3	chr5_151268428_+	-1282.80	-1282.00	-1315.50
CAediting_442038	ENST00000357164.3	chr5_151268432_+	-1282.80	-1282.00	-1315.50
CAediting_442039	ENST00000357164.3	chr5_151268442_+	-1282.00	-1282.00	-1315.50
CAediting_442040	ENST00000357164.3	chr5_151268584_+	-1286.10	-1282.00	-1315.50

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Relation with ADAR for GM2A

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_442015	chr5_151268176_+	8.45175350785924e-12	0.402136705529603	.	.	.	.
LGG	CAediting_442015	chr5_151268176_+	2.70678892701607e-30	0.50938170134978	.	.	.	.
BRCA	CAediting_442015	chr5_151268176_+	1.89039853579813e-67	0.517607678630166	.	.	.	.
LIHC	CAediting_442015	chr5_151268176_+	7.52932796059463e-13	0.403971875304996	.	.	.	.
CESC	CAediting_442015	chr5_151268176_+	3.75208513961164e-09	0.368205537016382	.	.	.	.
LUAD	CAediting_442015	chr5_151268176_+	1.22838613409387e-12	0.323430119396546	.	.	.	.
COAD	CAediting_442015	chr5_151268176_+	5.07408769557151e-05	0.24996292718398	.	.	.	.
LUSC	CAediting_442015	chr5_151268176_+	5.22730792423368e-24	0.47440753798887	.	.	0.0290884244893844	0.108722696066636
GBM	CAediting_442015	chr5_151268176_+	4.27123367203496e-12	0.518163001363092	.	.	.	.
PRAD	CAediting_442015	chr5_151268176_+	1.302016148348e-10	0.348240665199257	.	.	.	.
HNSC	CAediting_442015	chr5_151268176_+	5.99703857784608e-14	0.366634950662292	.	.	.	.
STAD	CAediting_442015	chr5_151268176_+	5.06957049102062e-16	0.438169252192982	.	.	.	.
THCA	CAediting_442015	chr5_151268176_+	1.85906700784808e-05	0.214128976933012	.	.	.	.
KIRC	CAediting_442015	chr5_151268176_+	1.67240759669883e-12	0.323606627520114	.	.	.	.
UCEC	CAediting_442015	chr5_151268176_+	2.56457428839949e-08	0.351954818608314	.	.	.	.
KIRP	CAediting_442015	chr5_151268176_+	0.030270695092097	0.175809004927853	.	.	.	.
ESCA	CAediting_442015	chr5_151268176_+	9.54942486566363e-06	0.365715022958571	.	.	.	.
OV	CAediting_442015	chr5_151268176_+	8.26091289261548e-11	0.344736469858045	.	.	.	.
PAAD	CAediting_442015	chr5_151268176_+	0.000382332968516678	0.285392738314693	.	.	.	.
PCPG	CAediting_442015	chr5_151268176_+	3.88783508133608e-06	0.407335003480295	.	.	.	.
SKCM	CAediting_442015	chr5_151268176_+	4.67322960349344e-26	0.5144969431672	.	.	.	.
UVM	CAediting_442015	chr5_151268176_+	0.0202978854193253	0.318043086944849	.	.	.	.
MESO	CAediting_442015	chr5_151268176_+	0.0163480242759094	0.276465971109262	.	.	.	.
SARC	CAediting_442015	chr5_151268176_+	4.13967704507236e-07	0.351352411594018	.	.	.	.
TGCT	CAediting_442015	chr5_151268176_+	9.91933884708629e-13	0.562824661096942	.	.	.	.
THYM	CAediting_442015	chr5_151268176_+	8.5755280086483e-05	0.429866190917776	.	.	.	.
LGG	CAediting_442016	chr5_151268178_+	6.37396455264693e-08	0.557654297720872	.	.	.	.
BRCA	CAediting_442016	chr5_151268178_+	1.66397053851329e-09	0.294487657341866	.	.	.	.
CESC	CAediting_442016	chr5_151268178_+	0.000554330269924815	0.339267451295876	.	.	.	.
LUAD	CAediting_442016	chr5_151268178_+	3.02383433492153e-05	0.311496614738786	.	.	.	.
LUSC	CAediting_442016	chr5_151268178_+	5.10392545563277e-05	0.332000701977453	.	.	.	.
HNSC	CAediting_442016	chr5_151268178_+	0.000604684721000558	0.277746272091011	.	.	.	.
STAD	CAediting_442016	chr5_151268178_+	0.0138215542661021	0.213025621969491	.	.	.	.
ESCA	CAediting_442016	chr5_151268178_+	0.0178478437444601	0.318356665183651	.	.	.	.
OV	CAediting_442016	chr5_151268178_+	0.0138378579017197	0.176020942731322	.	.	.	.
SKCM	CAediting_442016	chr5_151268178_+	0.00010014659025953	0.342210983266978	.	.	.	.
SARC	CAediting_442016	chr5_151268178_+	0.000402026512423449	0.472724638985657	.	.	.	.
TGCT	CAediting_442016	chr5_151268178_+	3.68303959686034e-05	0.431825152308315	.	.	.	.
BRCA	CAediting_442017	chr5_151268180_+	0.0226810150255622	0.203723233601479	.	.	.	.
OV	CAediting_442017	chr5_151268180_+	0.023224278297609	0.214374003290521	.	.	.	.
BLCA	CAediting_442019	chr5_151268183_+	1.44420512016476e-08	0.362159084402505	.	.	.	.
LGG	CAediting_442019	chr5_151268183_+	4.3346049324726e-34	0.583159721999259	.	.	.	.
BRCA	CAediting_442019	chr5_151268183_+	3.84815503695987e-89	0.593059196170701	.	.	.	.
LIHC	CAediting_442019	chr5_151268183_+	1.92022093852317e-11	0.393689205280625	.	.	.	.
CESC	CAediting_442019	chr5_151268183_+	3.40816424152816e-11	0.419026811970558	.	.	.	.
LUAD	CAediting_442019	chr5_151268183_+	4.06688384886482e-19	0.396213602284654	.	.	.	.
COAD	CAediting_442019	chr5_151268183_+	3.05443223087851e-05	0.287494201679748	.	.	.	.
LUSC	CAediting_442019	chr5_151268183_+	5.49000187115343e-23	0.483792798040615	.	.	0.022243079276239	0.119156443907517
GBM	CAediting_442019	chr5_151268183_+	4.02125595184653e-15	0.562011857666142	.	.	.	.
PRAD	CAediting_442019	chr5_151268183_+	5.77993881586278e-20	0.578366733889693	.	.	.	.
HNSC	CAediting_442019	chr5_151268183_+	1.07608355840767e-14	0.39131454345589	0.00128799877913329	0.168539174426499	.	.
STAD	CAediting_442019	chr5_151268183_+	1.0229496394895e-14	0.402025164557423	.	.	.	.
THCA	CAediting_442019	chr5_151268183_+	4.22847118816351e-06	0.255861171133405	.	.	.	.
KIRC	CAediting_442019	chr5_151268183_+	7.98908948375954e-15	0.354787667798742	.	.	.	.
UCEC	CAediting_442019	chr5_151268183_+	8.03387287574189e-10	0.387902374019416	.	.	.	.
KIRP	CAediting_442019	chr5_151268183_+	0.0328966438373975	0.212489903692777	.	.	.	.
ESCA	CAediting_442019	chr5_151268183_+	1.51976931769258e-06	0.370603885164828	.	.	.	.
OV	CAediting_442019	chr5_151268183_+	1.90071621351889e-22	0.482482361753819	.	.	.	.
PAAD	CAediting_442019	chr5_151268183_+	0.000137079791022916	0.329529083316775	.	.	.	.
PCPG	CAediting_442019	chr5_151268183_+	0.0184275792772708	0.29161235853935	.	.	.	.
SKCM	CAediting_442019	chr5_151268183_+	2.43034244335868e-25	0.553708401406302	.	.	.	.
MESO	CAediting_442019	chr5_151268183_+	0.00339424356721662	0.358179891044412	.	.	.	.
READ	CAediting_442019	chr5_151268183_+	0.0316511640239795	0.287535016145492	.	.	.	.
SARC	CAediting_442019	chr5_151268183_+	2.03797766340793e-07	0.410227564965622	.	.	.	.
TGCT	CAediting_442019	chr5_151268183_+	2.0098152409426e-12	0.553045726537136	.	.	.	.
THYM	CAediting_442019	chr5_151268183_+	5.1004606425883e-08	0.60353619223794	.	.	.	.
BRCA	CAediting_442040	chr5_151268584_+	9.19632296837604e-09	0.352659485446033	.	.	.	.
LIHC	CAediting_442040	chr5_151268584_+	0.0212888908115659	0.254017213108409	.	.	.	.
LUAD	CAediting_442040	chr5_151268584_+	4.34117346221986e-06	0.482858405028923	.	.	.	.
LUSC	CAediting_442040	chr5_151268584_+	2.47384232123798e-06	0.565727855155487	.	.	.	.
OV	CAediting_442040	chr5_151268584_+	0.000584279294583552	0.324173833901537	.	.	.	.
SKCM	CAediting_442040	chr5_151268584_+	0.000931388384996253	0.395271543757169	.	.	.	.

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Relation with cancer stages for GM2A

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_442015	chr5_151268176_+	0.0339378692506867	0.0688534097168269
BRCA	pathologic_stage	CAediting_442016	chr5_151268178_+	0.0121237242460344	0.126593669805467
KIRC	pathologic_stage	CAediting_442015	chr5_151268176_+	0.00212125740066683	0.144330441806114
KIRC	pathologic_stage	CAediting_442019	chr5_151268183_+	0.000282324288982739	0.170575573051833
KIRP	clinical_stage	CAediting_442019	chr5_151268183_+	0.0229212612699292	0.288589409149113
KIRP	pathologic_stage	CAediting_442015	chr5_151268176_+	0.0204513788685934	0.195759232401397
KIRP	pathologic_stage	CAediting_442019	chr5_151268183_+	0.00501065486185696	0.293377060037756
LUSC	pathologic_stage	CAediting_442040	chr5_151268584_+	0.0433051308479307	-0.266322420502438

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Relation with survival for GM2A

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
STAD	CAediting_442019	chr5_151268183_+	0.00894085605532524	0.0192202	3.44182
READ	CAediting_442015	chr5_151268176_+	0.0206259232180167	0.0238039	58642.2

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RelatedDrugs for GM2A

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GM2A	P17900	DB03017	Lauric acid	Ganglioside GM2 activator	SmallMoleculeDrug	approved\|experimental

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RelatedDiseases for GM2A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GM2A	C0268275	Tay-Sachs Disease, AB Variant	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GM2A	C0036572	Seizures	1	GENOMICS_ENGLAND
GM2A	C0039373	Tay-Sachs Disease	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene