Home

Download

Statistics

Examples

Help

Contact

Editing gene: GLS (CAeditome ID:2744)

Gene summary for GLS

Gene summary

Gene information	Gene symbol	GLS
	Gene ID	2744
	Gene name	glutaminase
	Synonyms	AAD20\|CASGID\|DEE71\|EIEE71\|GAC\|GAM\|GDPAG\|GLS1\|KGA
	Cytomap	2q32.2
	Type of gene	protein-coding
	Description	glutaminase kidney isoform, mitochondrialK-glutaminaseL-glutamine amidohydrolaseglutaminase Cglutaminase, phosphate-activated
	Modification date	20210529
	UniProtAcc	O94925
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GLS	GO:0004359	Glutaminase kidney isoform, mitochondrial	22049910
GLS	GO:0006537	Glutaminase kidney isoform, mitochondrial	16899818
GLS	GO:0006537	Glutaminase kidney isoform, mitochondrial	22049910
GLS	GO:0006543	Glutaminase kidney isoform, mitochondrial	22049910
GLS	GO:0051289	Glutaminase kidney isoform, mitochondrial	22049910
GLS	GO:0005739	Glutaminase kidney isoform, mitochondrial	0000052
GLS	GO:0005739	Glutaminase kidney isoform, mitochondrial	16899818

Top

RNA A-to-I events for GLS

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000115419.11

RNA A-to-I editing events in Cancer.

CAediting_229558(190885211, +), CAediting_229559(190885256, +), CAediting_229560(190885271, +), CAediting_229561(190885272, +), CAediting_229562(190885331, +), CAediting_229563(190885357, +), CAediting_229564(190885387, +), CAediting_229565(190885412, +), CAediting_229566(190885424, +), CAediting_229567(190885452, +), CAediting_229568(190885464, +), CAediting_229569(190885466, +), CAediting_229570(190885904, +), CAediting_229571(190886013, +), CAediting_229572(190886019, +), CAediting_229573(190886026, +), CAediting_229574(190886031, +), CAediting_229575(190886078, +), CAediting_229576(190886112, +), CAediting_229577(190886145, +), CAediting_229578(190886147, +), CAediting_229579(190886660, +), CAediting_229580(190886661, +), CAediting_229581(190886683, +), CAediting_229582(190886684, +), CAediting_229583(190886687, +), CAediting_229584(190886717, +), CAediting_229585(190886720, +), CAediting_229586(190886730, +), CAediting_229587(190886738, +), CAediting_229588(190886739, +), CAediting_229589(190886740, +), CAediting_229590(190886765, +), CAediting_229591(190886766, +), CAediting_229592(190886769, +), CAediting_229593(190886866, +), CAediting_229594(190886886, +), CAediting_229595(190887246, +), CAediting_229596(190897141, +), CAediting_229597(190897157, +), CAediting_229598(190897206, +), CAediting_229599(190909784, +), CAediting_229600(190909787, +), CAediting_229601(190909877, +), CAediting_229602(190909953, +), CAediting_229603(190909957, +), CAediting_229604(190909958, +), CAediting_229605(190913824, +), CAediting_229606(190913929, +), CAediting_229607(190913939, +), CAediting_229608(190913977, +), CAediting_229609(190914013, +), CAediting_229610(190914014, +), CAediting_229611(190914038, +), CAediting_229612(190914054, +), CAediting_229613(190914055, +), CAediting_229614(190914072, +), CAediting_229615(190915187, +), CAediting_229616(190915252, +), CAediting_229617(190915262, +), CAediting_229618(190915274, +), CAediting_229619(190915283, +), CAediting_229620(190917825, +), CAediting_229621(190917827, +), CAediting_229622(190917850, +), CAediting_229623(190917860, +), CAediting_229624(190917906, +), CAediting_229625(190924662, +), CAediting_229626(190924706, +), CAediting_229627(190924712, +), CAediting_229628(190924731, +), CAediting_229629(190924744, +), CAediting_229630(190924794, +), CAediting_229631(190924856, +), CAediting_229632(190924867, +), CAediting_229633(190924870, +), CAediting_229634(190929513, +), CAediting_229635(190929625, +), CAediting_229636(190929869, +), CAediting_229637(190930170, +), CAediting_229638(190930196, +), CAediting_229639(190930248, +), CAediting_229640(190930263, +), CAediting_229641(190930320, +), CAediting_229642(190930327, +), CAediting_229643(190933944, +), CAediting_229644(190934060, +), CAediting_229645(190934852, +), CAediting_229646(190934853, +), CAediting_229647(190934854, +), CAediting_229648(190934865, +), CAediting_229649(190934869, +), CAediting_229650(190934889, +), CAediting_229651(190945389, +), CAediting_229652(190945424, +), CAediting_229653(190945432, +), CAediting_229654(190945479, +), CAediting_229655(190945522, +), CAediting_229656(190945558, +), CAediting_229657(190945580, +), CAediting_229658(190945585, +), CAediting_229659(190945640, +), CAediting_229660(190949469, +), CAediting_229661(190949512, +), CAediting_229662(190952023, +), CAediting_229663(190960434, +), CAediting_229664(190960450, +), CAediting_229665(190960477, +), CAediting_229666(190960494, +), CAediting_229667(190960561, +), CAediting_229668(190960597, +), CAediting_229669(190960647, +), CAediting_229670(190960667, +), CAediting_229671(190961242, +), CAediting_229672(190961315, +), CAediting_229673(190961319, +), CAediting_229674(190961327, +), CAediting_229675(190961359, +), CAediting_229676(190961444, +), CAediting_229677(190961468, +), CAediting_229678(190961471, +), CAediting_229679(190963376, +),

Top

RNA editing positional annotations for GLS using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_229558	chr2_190885211_+	ncRNA_intronic
CAediting_229559	chr2_190885256_+	ncRNA_intronic
CAediting_229560	chr2_190885271_+	ncRNA_intronic
CAediting_229561	chr2_190885272_+	ncRNA_intronic
CAediting_229562	chr2_190885331_+	ncRNA_intronic
CAediting_229563	chr2_190885357_+	ncRNA_intronic
CAediting_229564	chr2_190885387_+	ncRNA_intronic
CAediting_229565	chr2_190885412_+	ncRNA_intronic
CAediting_229566	chr2_190885424_+	ncRNA_intronic
CAediting_229567	chr2_190885452_+	ncRNA_intronic
CAediting_229568	chr2_190885464_+	ncRNA_intronic
CAediting_229569	chr2_190885466_+	ncRNA_intronic
CAediting_229570	chr2_190885904_+	ncRNA_intronic
CAediting_229571	chr2_190886013_+	ncRNA_intronic
CAediting_229572	chr2_190886019_+	ncRNA_intronic
CAediting_229573	chr2_190886026_+	ncRNA_intronic
CAediting_229574	chr2_190886031_+	ncRNA_intronic
CAediting_229575	chr2_190886078_+	ncRNA_intronic
CAediting_229576	chr2_190886112_+	ncRNA_intronic
CAediting_229577	chr2_190886145_+	ncRNA_intronic
CAediting_229578	chr2_190886147_+	ncRNA_intronic
CAediting_229579	chr2_190886660_+	ncRNA_intronic
CAediting_229580	chr2_190886661_+	ncRNA_intronic
CAediting_229581	chr2_190886683_+	ncRNA_intronic
CAediting_229582	chr2_190886684_+	ncRNA_intronic
CAediting_229583	chr2_190886687_+	ncRNA_intronic
CAediting_229584	chr2_190886717_+	ncRNA_intronic
CAediting_229585	chr2_190886720_+	ncRNA_intronic
CAediting_229586	chr2_190886730_+	ncRNA_intronic
CAediting_229587	chr2_190886738_+	ncRNA_intronic
CAediting_229588	chr2_190886739_+	ncRNA_intronic
CAediting_229589	chr2_190886740_+	ncRNA_intronic
CAediting_229590	chr2_190886765_+	ncRNA_intronic
CAediting_229591	chr2_190886766_+	ncRNA_intronic
CAediting_229592	chr2_190886769_+	ncRNA_intronic
CAediting_229593	chr2_190886866_+	ncRNA_intronic
CAediting_229594	chr2_190886886_+	ncRNA_intronic
CAediting_229595	chr2_190887246_+	ncRNA_intronic
CAediting_229596	chr2_190897141_+	ncRNA_intronic
CAediting_229597	chr2_190897157_+	ncRNA_intronic
CAediting_229598	chr2_190897206_+	ncRNA_intronic
CAediting_229599	chr2_190909784_+	intronic
CAediting_229600	chr2_190909787_+	intronic
CAediting_229601	chr2_190909877_+	intronic
CAediting_229602	chr2_190909953_+	intronic
CAediting_229603	chr2_190909957_+	intronic
CAediting_229604	chr2_190909958_+	intronic
CAediting_229605	chr2_190913824_+	ncRNA_intronic
CAediting_229606	chr2_190913929_+	ncRNA_intronic
CAediting_229607	chr2_190913939_+	ncRNA_intronic
CAediting_229608	chr2_190913977_+	ncRNA_intronic
CAediting_229609	chr2_190914013_+	ncRNA_intronic
CAediting_229610	chr2_190914014_+	ncRNA_intronic
CAediting_229611	chr2_190914038_+	ncRNA_intronic
CAediting_229612	chr2_190914054_+	ncRNA_intronic
CAediting_229613	chr2_190914055_+	ncRNA_intronic
CAediting_229614	chr2_190914072_+	ncRNA_intronic
CAediting_229615	chr2_190915187_+	ncRNA_intronic
CAediting_229616	chr2_190915252_+	ncRNA_intronic
CAediting_229617	chr2_190915262_+	ncRNA_intronic
CAediting_229618	chr2_190915274_+	ncRNA_intronic
CAediting_229619	chr2_190915283_+	ncRNA_intronic
CAediting_229620	chr2_190917825_+	ncRNA_intronic
CAediting_229621	chr2_190917827_+	ncRNA_intronic
CAediting_229622	chr2_190917850_+	ncRNA_intronic
CAediting_229623	chr2_190917860_+	ncRNA_intronic
CAediting_229624	chr2_190917906_+	ncRNA_intronic
CAediting_229625	chr2_190924662_+	ncRNA_exonic
CAediting_229626	chr2_190924706_+	ncRNA_exonic
CAediting_229627	chr2_190924712_+	ncRNA_exonic
CAediting_229628	chr2_190924731_+	ncRNA_exonic
CAediting_229629	chr2_190924744_+	ncRNA_exonic
CAediting_229630	chr2_190924794_+	ncRNA_intronic
CAediting_229631	chr2_190924856_+	ncRNA_intronic
CAediting_229632	chr2_190924867_+	ncRNA_intronic
CAediting_229633	chr2_190924870_+	ncRNA_intronic
CAediting_229634	chr2_190929513_+	intronic
CAediting_229635	chr2_190929625_+	intronic
CAediting_229636	chr2_190929869_+	intronic
CAediting_229637	chr2_190930170_+	intronic
CAediting_229638	chr2_190930196_+	intronic
CAediting_229639	chr2_190930248_+	intronic
CAediting_229640	chr2_190930263_+	intronic
CAediting_229641	chr2_190930320_+	intronic
CAediting_229642	chr2_190930327_+	intronic
CAediting_229643	chr2_190933944_+	UTR3
CAediting_229644	chr2_190934060_+	UTR3
CAediting_229645	chr2_190934852_+	UTR3
CAediting_229646	chr2_190934853_+	UTR3
CAediting_229647	chr2_190934854_+	UTR3
CAediting_229648	chr2_190934865_+	UTR3
CAediting_229649	chr2_190934869_+	UTR3
CAediting_229650	chr2_190934889_+	UTR3
CAediting_229651	chr2_190945389_+	intronic
CAediting_229652	chr2_190945424_+	intronic
CAediting_229653	chr2_190945432_+	intronic
CAediting_229654	chr2_190945479_+	intronic
CAediting_229655	chr2_190945522_+	intronic
CAediting_229656	chr2_190945558_+	intronic
CAediting_229657	chr2_190945580_+	intronic
CAediting_229658	chr2_190945585_+	intronic
CAediting_229659	chr2_190945640_+	intronic
CAediting_229660	chr2_190949469_+	intronic
CAediting_229661	chr2_190949512_+	intronic
CAediting_229662	chr2_190952023_+	intronic
CAediting_229663	chr2_190960434_+	intronic
CAediting_229664	chr2_190960450_+	intronic
CAediting_229665	chr2_190960477_+	intronic
CAediting_229666	chr2_190960494_+	intronic
CAediting_229667	chr2_190960561_+	intronic
CAediting_229668	chr2_190960597_+	intronic
CAediting_229669	chr2_190960647_+	intronic
CAediting_229670	chr2_190960667_+	intronic
CAediting_229671	chr2_190961242_+	intronic
CAediting_229672	chr2_190961315_+	intronic
CAediting_229673	chr2_190961319_+	intronic
CAediting_229674	chr2_190961327_+	intronic
CAediting_229675	chr2_190961359_+	intronic
CAediting_229676	chr2_190961444_+	intronic
CAediting_229677	chr2_190961468_+	intronic
CAediting_229678	chr2_190961471_+	intronic
CAediting_229679	chr2_190963376_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_229558	chr2_190885211_+	SINE	Alu	AluSx1
CAediting_229559	chr2_190885256_+	SINE	Alu	AluSx1
CAediting_229560	chr2_190885271_+	SINE	Alu	AluSx1
CAediting_229561	chr2_190885272_+	SINE	Alu	AluSx1
CAediting_229562	chr2_190885331_+	SINE	Alu	AluSx1
CAediting_229563	chr2_190885357_+	SINE	Alu	AluSx1
CAediting_229564	chr2_190885387_+	SINE	Alu	AluSx1
CAediting_229565	chr2_190885412_+	SINE	Alu	AluSx1
CAediting_229566	chr2_190885424_+	SINE	Alu	AluSx1
CAediting_229567	chr2_190885452_+	SINE	Alu	AluSx1
CAediting_229568	chr2_190885464_+	SINE	Alu	AluSx1
CAediting_229569	chr2_190885466_+	SINE	Alu	AluSx1
CAediting_229570	chr2_190885904_+	SINE	Alu	AluSc8
CAediting_229571	chr2_190886013_+	SINE	Alu	AluSc8
CAediting_229572	chr2_190886019_+	SINE	Alu	AluSc8
CAediting_229573	chr2_190886026_+	SINE	Alu	AluSc8
CAediting_229574	chr2_190886031_+	SINE	Alu	AluSc8
CAediting_229575	chr2_190886078_+	SINE	Alu	AluSc8
CAediting_229576	chr2_190886112_+	SINE	Alu	AluSc8
CAediting_229577	chr2_190886145_+	SINE	Alu	AluSc8
CAediting_229578	chr2_190886147_+	SINE	Alu	AluSc8
CAediting_229579	chr2_190886660_+	SINE	Alu	AluSx1
CAediting_229580	chr2_190886661_+	SINE	Alu	AluSx1
CAediting_229581	chr2_190886683_+	SINE	Alu	AluSx1
CAediting_229582	chr2_190886684_+	SINE	Alu	AluSx1
CAediting_229583	chr2_190886687_+	SINE	Alu	AluSx1
CAediting_229584	chr2_190886717_+	SINE	Alu	AluSx1
CAediting_229585	chr2_190886720_+	SINE	Alu	AluSx1
CAediting_229586	chr2_190886730_+	SINE	Alu	AluSx1
CAediting_229587	chr2_190886738_+	SINE	Alu	AluSx1
CAediting_229588	chr2_190886739_+	SINE	Alu	AluSx1
CAediting_229589	chr2_190886740_+	SINE	Alu	AluSx1
CAediting_229590	chr2_190886765_+	SINE	Alu	AluSx1
CAediting_229591	chr2_190886766_+	SINE	Alu	AluSx1
CAediting_229592	chr2_190886769_+	SINE	Alu	AluSx1
CAediting_229593	chr2_190886866_+	SINE	Alu	AluSx1
CAediting_229594	chr2_190886886_+	SINE	Alu	AluSx1
CAediting_229596	chr2_190897141_+	SINE	Alu	AluSx1
CAediting_229597	chr2_190897157_+	SINE	Alu	AluSx1
CAediting_229598	chr2_190897206_+	SINE	Alu	AluSx1
CAediting_229599	chr2_190909784_+	SINE	Alu	AluJo
CAediting_229600	chr2_190909787_+	SINE	Alu	AluJo
CAediting_229601	chr2_190909877_+	SINE	Alu	AluJo
CAediting_229602	chr2_190909953_+	SINE	Alu	AluJo
CAediting_229603	chr2_190909957_+	SINE	Alu	AluJo
CAediting_229604	chr2_190909958_+	SINE	Alu	AluJo
CAediting_229605	chr2_190913824_+	SINE	Alu	AluJr
CAediting_229606	chr2_190913929_+	SINE	Alu	AluJr
CAediting_229607	chr2_190913939_+	SINE	Alu	AluJr
CAediting_229608	chr2_190913977_+	SINE	Alu	AluJr
CAediting_229609	chr2_190914013_+	SINE	Alu	AluJr
CAediting_229610	chr2_190914014_+	SINE	Alu	AluJr
CAediting_229611	chr2_190914038_+	SINE	Alu	AluJr
CAediting_229612	chr2_190914054_+	SINE	Alu	AluJr
CAediting_229613	chr2_190914055_+	SINE	Alu	AluJr
CAediting_229614	chr2_190914072_+	SINE	Alu	AluJr
CAediting_229615	chr2_190915187_+	SINE	Alu	AluY
CAediting_229616	chr2_190915252_+	SINE	Alu	AluY
CAediting_229617	chr2_190915262_+	SINE	Alu	AluY
CAediting_229618	chr2_190915274_+	SINE	Alu	AluY
CAediting_229619	chr2_190915283_+	SINE	Alu	AluY
CAediting_229620	chr2_190917825_+	DNA	TcMar-Tigger	Tigger1
CAediting_229621	chr2_190917827_+	DNA	TcMar-Tigger	Tigger1
CAediting_229622	chr2_190917850_+	DNA	TcMar-Tigger	Tigger1
CAediting_229623	chr2_190917860_+	DNA	TcMar-Tigger	Tigger1
CAediting_229624	chr2_190917906_+	DNA	TcMar-Tigger	Tigger1
CAediting_229625	chr2_190924662_+	SINE	Alu	AluSc
CAediting_229626	chr2_190924706_+	SINE	Alu	AluSc
CAediting_229627	chr2_190924712_+	SINE	Alu	AluSc
CAediting_229628	chr2_190924731_+	SINE	Alu	AluSc
CAediting_229629	chr2_190924744_+	SINE	Alu	AluSc
CAediting_229630	chr2_190924794_+	SINE	Alu	AluSc
CAediting_229631	chr2_190924856_+	SINE	Alu	AluSc
CAediting_229632	chr2_190924867_+	SINE	Alu	AluSc
CAediting_229633	chr2_190924870_+	SINE	Alu	AluSc
CAediting_229634	chr2_190929513_+	SINE	Alu	AluSx1
CAediting_229635	chr2_190929625_+	SINE	Alu	AluSx1
CAediting_229636	chr2_190929869_+	SINE	Alu	AluYc
CAediting_229637	chr2_190930170_+	SINE	Alu	AluJo
CAediting_229638	chr2_190930196_+	SINE	Alu	AluJo
CAediting_229639	chr2_190930248_+	SINE	Alu	AluJo
CAediting_229640	chr2_190930263_+	SINE	Alu	AluJo
CAediting_229641	chr2_190930320_+	SINE	Alu	AluJo
CAediting_229642	chr2_190930327_+	SINE	Alu	AluJo
CAediting_229651	chr2_190945389_+	SINE	Alu	AluJb
CAediting_229652	chr2_190945424_+	SINE	Alu	AluJb
CAediting_229653	chr2_190945432_+	SINE	Alu	AluJb
CAediting_229654	chr2_190945479_+	SINE	Alu	AluJb
CAediting_229655	chr2_190945522_+	SINE	Alu	AluJb
CAediting_229656	chr2_190945558_+	SINE	Alu	AluJb
CAediting_229657	chr2_190945580_+	SINE	Alu	AluJb
CAediting_229658	chr2_190945585_+	SINE	Alu	AluJb
CAediting_229659	chr2_190945640_+	SINE	Alu	AluJb
CAediting_229660	chr2_190949469_+	SINE	Alu	AluSz
CAediting_229661	chr2_190949512_+	SINE	Alu	AluSz
CAediting_229662	chr2_190952023_+	SINE	Alu	AluJr
CAediting_229663	chr2_190960434_+	SINE	Alu	AluJo
CAediting_229664	chr2_190960450_+	SINE	Alu	AluJo
CAediting_229665	chr2_190960477_+	SINE	Alu	AluJo
CAediting_229666	chr2_190960494_+	SINE	Alu	AluJo
CAediting_229667	chr2_190960561_+	SINE	Alu	AluJo
CAediting_229668	chr2_190960597_+	SINE	Alu	AluJo
CAediting_229669	chr2_190960647_+	SINE	Alu	AluJo
CAediting_229670	chr2_190960667_+	SINE	Alu	AluJo
CAediting_229671	chr2_190961242_+	SINE	Alu	AluSz6
CAediting_229672	chr2_190961315_+	SINE	Alu	AluSz6
CAediting_229673	chr2_190961319_+	SINE	Alu	AluSz6
CAediting_229674	chr2_190961327_+	SINE	Alu	AluSz6
CAediting_229675	chr2_190961359_+	SINE	Alu	AluSz6
CAediting_229676	chr2_190961444_+	SINE	Alu	AluSz6
CAediting_229677	chr2_190961468_+	SINE	Alu	AluSz6
CAediting_229678	chr2_190961471_+	SINE	Alu	AluSz6

Top

RNA A-to-I editing events in the alternative splicing sites for GLS

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_229667	chr2_190960561_+	190960540:190960562	3SS	2+0i	TTTATTTTTTATTTTTTGTAGAG	-13.02	TTTATTTTTTATTTTTTGTAGGG	-18.32

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000115419.11.GLS.

Correlation between RNA A-to-I editing and PSI for ENSG00000115419.11.GLS.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for GLS

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for GLS

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for GLS

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_229645	chr2_190934852_+	ENSG00000115419.11	ENST00000338435	hsa-miR-3682-5p	190934850	190934856	7mer-m8	190934838	190934857	144.00	-9.36
CAediting_229645	chr2_190934852_+	ENSG00000115419.11	ENST00000338435	hsa-miR-942-5p	190934848	190934854	7mer-m8	190934834	190934855	146.00	-13.46
CAediting_229647	chr2_190934854_+	ENSG00000115419.11	ENST00000338435	hsa-miR-3144-3p	190934852	190934859	8mer-1a	190934839	190934859	149.00	-8.78
CAediting_229648	chr2_190934865_+	ENSG00000115419.11	ENST00000338435	hsa-miR-629-3p	190934862	190934868	7mer-m8	190934848	190934869	140.00	-10.87
CAediting_229649	chr2_190934869_+	ENSG00000115419.11	ENST00000338435	hsa-miR-4279	190934866	190934872	7mer-m8	190934856	190934873	142.00	-15.79
CAediting_229649	chr2_190934869_+	ENSG00000115419.11	ENST00000338435	hsa-miR-6881-3p	190934864	190934870	7mer-m8	190934850	190934871	156.00	-18.17
CAediting_229649	chr2_190934869_+	ENSG00000115419.11	ENST00000338435	hsa-miR-877-3p	190934863	190934870	8mer-1a	190934850	190934870	141.00	-13.40
CAediting_229679	chr2_190963376_+	ENSG00000115419.11	ENST00000320717	hsa-miR-2115-5p	190963374	190963381	8mer-1a	190963357	190963381	142.00	-15.95

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_229679	chr2_190963376_+	ENSG00000115419.11	ENST00000320717	hsa-miR-4509	190963370	190963377	8mer-1a	190963354	190963377	142	-10.39
CAediting_229679	chr2_190963376_+	ENSG00000115419.11	ENST00000320717	hsa-miR-4509	190963370	190963377	8mer-1a	190963354	190963377	142	-10.39
CAediting_229679	chr2_190963376_+	ENSG00000115419.11	ENST00000320717	hsa-miR-4509	190963370	190963377	8mer-1a	190963354	190963377	142	-10.39
CAediting_229648	chr2_190934865_+	ENSG00000115419.11	ENST00000338435	hsa-miR-1468-5p	190934858	190934865	8mer-1a	190934845	190934865	153	-13.72
CAediting_229648	chr2_190934865_+	ENSG00000115419.11	ENST00000338435	hsa-miR-4778-3p	190934863	190934870	8mer-1a	190934848	190934870	155	-15.9
CAediting_229649	chr2_190934869_+	ENSG00000115419.11	ENST00000338435	hsa-miR-4778-3p	190934863	190934870	8mer-1a	190934848	190934870	155	-15.9
CAediting_229645	chr2_190934852_+	ENSG00000115419.11	ENST00000338435	hsa-miR-5003-3p	190934849	190934856	8mer-1a	190934836	190934856	150	-11.33
CAediting_229646	chr2_190934853_+	ENSG00000115419.11	ENST00000338435	hsa-miR-5003-3p	190934849	190934856	8mer-1a	190934836	190934856	150	-11.33
CAediting_229647	chr2_190934854_+	ENSG00000115419.11	ENST00000338435	hsa-miR-5003-3p	190934849	190934856	8mer-1a	190934836	190934856	150	-11.33
CAediting_229644	chr2_190934060_+	ENSG00000115419.11	ENST00000338435	hsa-miR-5585-3p	190934053	190934059	7mer-m8	190934042	190934060	152	-16.77
CAediting_229644	chr2_190934060_+	ENSG00000115419.11	ENST00000338435	hsa-miR-595	190934058	190934064	7mer-m8	190934045	190934065	143	-16.76
CAediting_229648	chr2_190934865_+	ENSG00000115419.11	ENST00000338435	hsa-miR-6875-3p	190934862	190934868	7mer-m8	190934848	190934869	140	-9.96
CAediting_229649	chr2_190934869_+	ENSG00000115419.11	ENST00000338435	hsa-miR-6875-3p	190934862	190934868	7mer-m8	190934848	190934869	140	-9.96

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000115419.11	ENST00000320717	hsa-miR-605-3p	190964555	190964561	7mer-m8	190964541	190964562	143	-18.97
CAediting_393	chr1_1167164_+	ENSG00000115419.11	ENST00000320717	hsa-miR-200b-3p	190964716	190964721	6mer	190964701	190964722	144	-20.11
CAediting_393	chr1_1167164_+	ENSG00000115419.11	ENST00000320717	hsa-miR-200b-3p	190964742	190964749	8mer-1a	190964727	190964749	149	-18.4
CAediting_1306324	chr19_13836464_-	ENSG00000115419.11	ENST00000338435	hsa-miR-27a-3p	190934879	190934886	8mer-1a	190934866	190934886	158	-18.35
CAediting_1229414	chr17_67471546_+	ENSG00000115419.11	ENST00000320717	hsa-miR-548aa	190963255	190963261	7mer-m8	190963240	190963262	155	-18.03
CAediting_1229415	chr17_67471547_+	ENSG00000115419.11	ENST00000320717	hsa-miR-548aa	190965151	190965158	8mer-1a	190965134	190965158	150	-9.47
CAediting_1351755	chr19_40282625_-	ENSG00000115419.11	ENST00000320717	hsa-miR-641	190963465	190963471	7mer-m8	190963449	190963472	146	-15.8
CAediting_604450	chr7_133034877_-	ENSG00000115419.11	ENST00000320717	hsa-miR-3654	190963658	190963664	7mer-m8	190963646	190963665	150	-20.74
CAediting_1229414	chr17_67471546_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190933046	190933052	7mer-m8	190933026	190933053	161	-18.86
CAediting_1229415	chr17_67471547_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190933421	190933428	8mer-1a	190933402	190933428	151	-14.04
CAediting_117844	chr1_162342605_+	ENSG00000115419.11	ENST00000338435	hsa-miR-556-3p	190933286	190933292	7mer-m8	190933271	190933293	162	-19.65
CAediting_1229414	chr17_67471546_+	ENSG00000115419.11	ENST00000409215	hsa-miR-548aa	190933046	190933052	7mer-m8	190933026	190933053	161	-18.86

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000115419.11	ENST00000320717	hsa-miR-556-3p	190965070	190965077	8mer-1a	190965055	190965077	149	-11.16
CAediting_117844	chr1_162342605_+	ENSG00000115419.11	ENST00000320717	hsa-miR-556-3p	190965254	190965260	7mer-m8	190965241	190965261	147	-10.96
CAediting_1351755	chr19_40282625_-	ENSG00000115419.11	ENST00000320717	hsa-miR-641	190964174	190964179	6mer	190964155	190964180	143	-19.4
CAediting_393	chr1_1167164_+	ENSG00000115419.11	ENST00000338435	hsa-miR-200b-3p	190934949	190934955	7mer-m8	190934934	190934956	143	-8.08
CAediting_396018	chr5_1062918_-	ENSG00000115419.11	ENST00000338435	hsa-miR-4635	190933989	190933994	6mer	190933975	190933995	144	-16.33
CAediting_396018	chr5_1062918_-	ENSG00000115419.11	ENST00000338435	hsa-miR-4635	190933647	190933653	7mer-m8	190933634	190933654	147	-13.65
CAediting_1229413	chr17_67471544_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934088	190934094	7mer-m8	190934070	190934095	143	-5.51
CAediting_1229414	chr17_67471546_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934088	190934094	7mer-m8	190934070	190934095	143	-5.51
CAediting_1229415	chr17_67471547_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934088	190934094	7mer-m8	190934070	190934095	143	-5.51
CAediting_1229413	chr17_67471544_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934654	190934661	8mer-1a	190934638	190934661	143	-7.85
CAediting_1229414	chr17_67471546_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934654	190934661	8mer-1a	190934638	190934661	143	-7.85
CAediting_1229415	chr17_67471547_+	ENSG00000115419.11	ENST00000338435	hsa-miR-548aa	190934654	190934661	8mer-1a	190934638	190934661	143	-7.85
CAediting_524911	chr7_5495852_-	ENSG00000115419.11	ENST00000338435	hsa-miR-589-3p	190933506	190933512	7mer-m8	190933492	190933513	151	-10.42
CAediting_1351755	chr19_40282625_-	ENSG00000115419.11	ENST00000338435	hsa-miR-641	190933275	190933281	7mer-m8	190933260	190933282	148	-10.86

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for GLS

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000320717.6	protein_coding
ENST00000338435.7	protein_coding
ENST00000495444.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_229679	ENST00000320717.6	chr2_190963376_+	-1425.50	-1425.50	-1425.50
CAediting_229643	ENST00000338435.7	chr2_190933944_+	-1250.00	-1250.00	-1259.40
CAediting_229644	ENST00000338435.7	chr2_190934060_+	-1255.40	-1250.00	-1259.40
CAediting_229645	ENST00000338435.7	chr2_190934852_+	-1256.40	-1250.00	-1259.40
CAediting_229646	ENST00000338435.7	chr2_190934853_+	-1250.40	-1250.00	-1259.40
CAediting_229647	ENST00000338435.7	chr2_190934854_+	-1249.70	-1250.00	-1259.40
CAediting_229648	ENST00000338435.7	chr2_190934865_+	-1249.50	-1250.00	-1259.40
CAediting_229649	ENST00000338435.7	chr2_190934869_+	-1249.70	-1250.00	-1259.40
CAediting_229650	ENST00000338435.7	chr2_190934889_+	-1249.70	-1250.00	-1259.40
CAediting_229625	ENST00000495444.1	chr2_190924662_+	-97.90	-97.00	-103.70
CAediting_229626	ENST00000495444.1	chr2_190924706_+	-103.60	-97.00	-103.70
CAediting_229627	ENST00000495444.1	chr2_190924712_+	-102.10	-97.00	-103.70
CAediting_229628	ENST00000495444.1	chr2_190924731_+	-96.60	-97.00	-103.70
CAediting_229629	ENST00000495444.1	chr2_190924744_+	-96.10	-97.00	-103.70

Top

Relation with ADAR for GLS

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for GLS

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for GLS

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for GLS

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GLS	O94925	DB00142	Glutamic acid	Glutaminase kidney isoform, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

Top

RelatedDiseases for GLS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GLS	C0000786	Spontaneous abortion	1	CTD_human
GLS	C0000822	Abortion, Tubal	1	CTD_human
GLS	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
GLS	C0029408	Degenerative polyarthritis	1	CTD_human
GLS	C0086743	Osteoarthrosis Deformans	1	CTD_human
GLS	C3830362	Early Pregnancy Loss	1	CTD_human
GLS	C4552766	Miscarriage	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene