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Editing gene: MCAT (CAeditome ID:27349)

Gene summary for MCAT

Gene summary

Gene information	Gene symbol	MCAT
	Gene ID	27349
	Gene name	malonyl-CoA-acyl carrier protein transacylase
	Synonyms	FASN2C\|MCT\|MCT1\|MT\|NET62\|fabD
	Cytomap	22q13.2
	Type of gene	protein-coding
	Description	malonyl-CoA-acyl carrier protein transacylase, mitochondrial[Acyl-carrier-protein] malonyltransferase[acyl-carrier-protein] S-malonyltransferasemalonyl CoA:ACP acyltransferase (mitochondrial)mitochondrial malonyl CoA:ACP acyltransferasemitochondrial
	Modification date	20210518
	UniProtAcc	Q8IVS2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MCAT	GO:0004312	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	12882974
MCAT	GO:0004314	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	12882974
MCAT	GO:0006633	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	12882974
MCAT	GO:0005739	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	0000052
MCAT	GO:0005739	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	12882974

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RNA A-to-I events for MCAT

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000100294.11

RNA A-to-I editing events in Cancer.

CAediting_1491059(43133944, -), CAediting_1491060(43134038, -), CAediting_1491061(43134370, -), CAediting_1491062(43134377, -), CAediting_1491063(43134378, -), CAediting_1491064(43134383, -), CAediting_1491065(43134415, -), CAediting_1491066(43134437, -), CAediting_1491067(43134444, -), CAediting_1491068(43134445, -), CAediting_1491069(43134459, -), CAediting_1491070(43134463, -), CAediting_1491071(43134476, -), CAediting_1491072(43134480, -), CAediting_1491073(43134486, -), CAediting_1491074(43134488, -), CAediting_1491075(43134494, -), CAediting_1491076(43134496, -), CAediting_1491077(43134508, -), CAediting_1491078(43134512, -), CAediting_1491079(43134516, -), CAediting_1491080(43134518, -), CAediting_1491081(43134528, -), CAediting_1491082(43134533, -), CAediting_1491083(43134543, -), CAediting_1491084(43134547, -), CAediting_1491085(43134553, -), CAediting_1491086(43134556, -), CAediting_1491087(43134558, -), CAediting_1491088(43134559, -), CAediting_1491089(43134564, -), CAediting_1491090(43134567, -), CAediting_1491091(43134572, -), CAediting_1491092(43134586, -), CAediting_1491093(43134589, -), CAediting_1491094(43134590, -), CAediting_1491095(43134591, -), CAediting_1491096(43134721, -), CAediting_1491097(43135337, -), CAediting_1491098(43135360, -), CAediting_1491099(43135392, -), CAediting_1491100(43135964, -), CAediting_1491101(43135984, -), CAediting_1491102(43135986, -), CAediting_1491103(43135999, -), CAediting_1491104(43136008, -), CAediting_1491105(43136013, -), CAediting_1491106(43136025, -), CAediting_1491107(43136039, -), CAediting_1491108(43136051, -), CAediting_1491109(43136063, -), CAediting_1491110(43136104, -), CAediting_1491111(43136120, -), CAediting_1491112(43136122, -), CAediting_1491113(43136144, -), CAediting_1491114(43136149, -), CAediting_1491115(43136161, -), CAediting_1491116(43136162, -), CAediting_1491117(43136182, -), CAediting_1491118(43136187, -), CAediting_1491119(43136194, -), CAediting_1491120(43136200, -), CAediting_1491121(43136208, -), CAediting_1491122(43136211, -), CAediting_1491123(43136230, -), CAediting_1491124(43136238, -), CAediting_1491125(43136242, -), CAediting_1491126(43138144, -), CAediting_1491127(43138565, -), CAediting_1491128(43139062, -), CAediting_1491129(43139079, -), CAediting_1491130(43139309, -), CAediting_1491131(43139310, -), CAediting_1491132(43139372, -), CAediting_1491133(43139378, -), CAediting_1491134(43139402, -), CAediting_1491135(43139699, -), CAediting_1491136(43140509, -), CAediting_1491137(43140513, -), CAediting_1491138(43140622, -),

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RNA editing positional annotations for MCAT using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1491059	chr22_43133944_-	intronic
CAediting_1491060	chr22_43134038_-	intronic
CAediting_1491061	chr22_43134370_-	intronic
CAediting_1491062	chr22_43134377_-	intronic
CAediting_1491063	chr22_43134378_-	intronic
CAediting_1491064	chr22_43134383_-	intronic
CAediting_1491065	chr22_43134415_-	intronic
CAediting_1491066	chr22_43134437_-	intronic
CAediting_1491067	chr22_43134444_-	intronic
CAediting_1491068	chr22_43134445_-	intronic
CAediting_1491069	chr22_43134459_-	intronic
CAediting_1491070	chr22_43134463_-	intronic
CAediting_1491071	chr22_43134476_-	intronic
CAediting_1491072	chr22_43134480_-	intronic
CAediting_1491073	chr22_43134486_-	intronic
CAediting_1491074	chr22_43134488_-	intronic
CAediting_1491075	chr22_43134494_-	intronic
CAediting_1491076	chr22_43134496_-	intronic
CAediting_1491077	chr22_43134508_-	intronic
CAediting_1491078	chr22_43134512_-	intronic
CAediting_1491079	chr22_43134516_-	intronic
CAediting_1491080	chr22_43134518_-	intronic
CAediting_1491081	chr22_43134528_-	intronic
CAediting_1491082	chr22_43134533_-	intronic
CAediting_1491083	chr22_43134543_-	intronic
CAediting_1491084	chr22_43134547_-	intronic
CAediting_1491085	chr22_43134553_-	intronic
CAediting_1491086	chr22_43134556_-	intronic
CAediting_1491087	chr22_43134558_-	intronic
CAediting_1491088	chr22_43134559_-	intronic
CAediting_1491089	chr22_43134564_-	intronic
CAediting_1491090	chr22_43134567_-	intronic
CAediting_1491091	chr22_43134572_-	intronic
CAediting_1491092	chr22_43134586_-	intronic
CAediting_1491093	chr22_43134589_-	intronic
CAediting_1491094	chr22_43134590_-	intronic
CAediting_1491095	chr22_43134591_-	intronic
CAediting_1491096	chr22_43134721_-	intronic
CAediting_1491097	chr22_43135337_-	intronic
CAediting_1491098	chr22_43135360_-	intronic
CAediting_1491099	chr22_43135392_-	intronic
CAediting_1491100	chr22_43135964_-	intronic
CAediting_1491101	chr22_43135984_-	intronic
CAediting_1491102	chr22_43135986_-	intronic
CAediting_1491103	chr22_43135999_-	intronic
CAediting_1491104	chr22_43136008_-	intronic
CAediting_1491105	chr22_43136013_-	intronic
CAediting_1491106	chr22_43136025_-	intronic
CAediting_1491107	chr22_43136039_-	intronic
CAediting_1491108	chr22_43136051_-	intronic
CAediting_1491109	chr22_43136063_-	intronic
CAediting_1491110	chr22_43136104_-	intronic
CAediting_1491111	chr22_43136120_-	intronic
CAediting_1491112	chr22_43136122_-	intronic
CAediting_1491113	chr22_43136144_-	intronic
CAediting_1491114	chr22_43136149_-	intronic
CAediting_1491115	chr22_43136161_-	intronic
CAediting_1491116	chr22_43136162_-	intronic
CAediting_1491117	chr22_43136182_-	intronic
CAediting_1491118	chr22_43136187_-	intronic
CAediting_1491119	chr22_43136194_-	intronic
CAediting_1491120	chr22_43136200_-	intronic
CAediting_1491121	chr22_43136208_-	intronic
CAediting_1491122	chr22_43136211_-	intronic
CAediting_1491123	chr22_43136230_-	intronic
CAediting_1491124	chr22_43136238_-	intronic
CAediting_1491125	chr22_43136242_-	intronic
CAediting_1491126	chr22_43138144_-	intronic
CAediting_1491127	chr22_43138565_-	intronic
CAediting_1491128	chr22_43139062_-	intronic
CAediting_1491129	chr22_43139079_-	intronic
CAediting_1491130	chr22_43139309_-	intronic
CAediting_1491131	chr22_43139310_-	intronic
CAediting_1491132	chr22_43139372_-	intronic
CAediting_1491133	chr22_43139378_-	intronic
CAediting_1491134	chr22_43139402_-	intronic
CAediting_1491135	chr22_43139699_-	intronic
CAediting_1491136	chr22_43140509_-	intronic
CAediting_1491137	chr22_43140513_-	intronic
CAediting_1491138	chr22_43140622_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1491059	chr22_43133944_-	SINE	Alu	AluYc
CAediting_1491060	chr22_43134038_-	SINE	Alu	AluYc
CAediting_1491061	chr22_43134370_-	SINE	Alu	AluSz
CAediting_1491062	chr22_43134377_-	SINE	Alu	AluSz
CAediting_1491063	chr22_43134378_-	SINE	Alu	AluSz
CAediting_1491064	chr22_43134383_-	SINE	Alu	AluSz
CAediting_1491065	chr22_43134415_-	SINE	Alu	AluSz
CAediting_1491066	chr22_43134437_-	SINE	Alu	AluSz
CAediting_1491067	chr22_43134444_-	SINE	Alu	AluSz
CAediting_1491068	chr22_43134445_-	SINE	Alu	AluSz
CAediting_1491069	chr22_43134459_-	SINE	Alu	AluSz
CAediting_1491070	chr22_43134463_-	SINE	Alu	AluSz
CAediting_1491071	chr22_43134476_-	SINE	Alu	AluSz
CAediting_1491072	chr22_43134480_-	SINE	Alu	AluSz
CAediting_1491073	chr22_43134486_-	SINE	Alu	AluSz
CAediting_1491074	chr22_43134488_-	SINE	Alu	AluSz
CAediting_1491075	chr22_43134494_-	SINE	Alu	AluSz
CAediting_1491076	chr22_43134496_-	SINE	Alu	AluSz
CAediting_1491077	chr22_43134508_-	SINE	Alu	AluSz
CAediting_1491078	chr22_43134512_-	SINE	Alu	AluSz
CAediting_1491079	chr22_43134516_-	SINE	Alu	AluSz
CAediting_1491080	chr22_43134518_-	SINE	Alu	AluSz
CAediting_1491081	chr22_43134528_-	SINE	Alu	AluSz
CAediting_1491082	chr22_43134533_-	SINE	Alu	AluSz
CAediting_1491083	chr22_43134543_-	SINE	Alu	AluSz
CAediting_1491084	chr22_43134547_-	SINE	Alu	AluSz
CAediting_1491085	chr22_43134553_-	SINE	Alu	AluSz
CAediting_1491086	chr22_43134556_-	SINE	Alu	AluSz
CAediting_1491087	chr22_43134558_-	SINE	Alu	AluSz
CAediting_1491088	chr22_43134559_-	SINE	Alu	AluSz
CAediting_1491089	chr22_43134564_-	SINE	Alu	AluSz
CAediting_1491090	chr22_43134567_-	SINE	Alu	AluSz
CAediting_1491091	chr22_43134572_-	SINE	Alu	AluSz
CAediting_1491092	chr22_43134586_-	SINE	Alu	AluSz
CAediting_1491093	chr22_43134589_-	SINE	Alu	AluSz
CAediting_1491094	chr22_43134590_-	SINE	Alu	AluSz
CAediting_1491095	chr22_43134591_-	SINE	Alu	AluSz
CAediting_1491096	chr22_43134721_-	LTR	ERVL-MaLR	MLT1I
CAediting_1491097	chr22_43135337_-	SINE	Alu	AluSx
CAediting_1491098	chr22_43135360_-	SINE	Alu	AluSx
CAediting_1491099	chr22_43135392_-	SINE	Alu	AluSx
CAediting_1491100	chr22_43135964_-	SINE	Alu	AluJb
CAediting_1491101	chr22_43135984_-	SINE	Alu	AluJb
CAediting_1491102	chr22_43135986_-	SINE	Alu	AluJb
CAediting_1491103	chr22_43135999_-	SINE	Alu	AluJb
CAediting_1491104	chr22_43136008_-	SINE	Alu	AluJb
CAediting_1491105	chr22_43136013_-	SINE	Alu	AluJb
CAediting_1491106	chr22_43136025_-	SINE	Alu	AluJb
CAediting_1491107	chr22_43136039_-	SINE	Alu	AluJb
CAediting_1491108	chr22_43136051_-	SINE	Alu	AluJb
CAediting_1491109	chr22_43136063_-	SINE	Alu	AluJb
CAediting_1491110	chr22_43136104_-	SINE	Alu	AluJb
CAediting_1491111	chr22_43136120_-	SINE	Alu	AluJb
CAediting_1491112	chr22_43136122_-	SINE	Alu	AluJb
CAediting_1491113	chr22_43136144_-	SINE	Alu	AluJb
CAediting_1491114	chr22_43136149_-	SINE	Alu	AluJb
CAediting_1491115	chr22_43136161_-	SINE	Alu	AluJb
CAediting_1491116	chr22_43136162_-	SINE	Alu	AluJb
CAediting_1491117	chr22_43136182_-	SINE	Alu	AluJb
CAediting_1491118	chr22_43136187_-	SINE	Alu	AluJb
CAediting_1491119	chr22_43136194_-	SINE	Alu	AluJb
CAediting_1491120	chr22_43136200_-	SINE	Alu	AluJb
CAediting_1491121	chr22_43136208_-	SINE	Alu	AluJb
CAediting_1491122	chr22_43136211_-	SINE	Alu	AluJb
CAediting_1491123	chr22_43136230_-	SINE	Alu	AluJb
CAediting_1491124	chr22_43136238_-	SINE	Alu	AluJb
CAediting_1491125	chr22_43136242_-	SINE	Alu	AluJb
CAediting_1491126	chr22_43138144_-	SINE	Alu	AluJo
CAediting_1491127	chr22_43138565_-	SINE	Alu	AluJb
CAediting_1491128	chr22_43139062_-	SINE	Alu	AluJo
CAediting_1491129	chr22_43139079_-	SINE	Alu	AluJo
CAediting_1491130	chr22_43139309_-	SINE	Alu	AluJo
CAediting_1491131	chr22_43139310_-	SINE	Alu	AluJo
CAediting_1491132	chr22_43139372_-	SINE	Alu	AluJo
CAediting_1491133	chr22_43139378_-	SINE	Alu	AluJo
CAediting_1491134	chr22_43139402_-	SINE	Alu	AluJo
CAediting_1491135	chr22_43139699_-	SINE	Alu	AluSz6
CAediting_1491136	chr22_43140509_-	SINE	Alu	AluJb
CAediting_1491137	chr22_43140513_-	SINE	Alu	AluJb
CAediting_1491138	chr22_43140622_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for MCAT

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000100294.11.MCAT.

Correlation between RNA A-to-I editing and PSI for ENSG00000100294.11.MCAT.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MCAT

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

PRAD.CAediting_1491067.ENSG00000100294.MCAT.png
Soverview

PRAD.CAediting_1491074.ENSG00000100294.MCAT.png
Soverview

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Protein coding region RNA A-to-I editings for MCAT

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MCAT

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000100294.11	ENST00000327555	hsa-miR-548aa	43133329	43133335	7mer-m8	43133328	43133353	148	-12.44
CAediting_580943	chr7_100356700_+	ENSG00000100294.11	ENST00000327555	hsa-miR-6840-3p	43133286	43133292	7mer-m8	43133285	43133307	146	-26.26
CAediting_468389	chr6_31355314_-	ENSG00000100294.11	ENST00000327555	hsa-miR-6891-5p	43132950	43132955	6mer	43132946	43132965	156	-22.75
CAediting_468389	chr6_31355314_-	ENSG00000100294.11	ENST00000327555	hsa-miR-6891-5p	43132947	43132953	7mer-m8	43132946	43132965	156	-22.75

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MCAT

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for MCAT

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for MCAT

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for MCAT

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MCAT

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MCAT

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MCAT	C0036341	Schizophrenia	1	PSYGENET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene