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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SNX5 (CAeditome ID:27131)

Gene summary for SNX5

check button Gene summary
Gene informationGene symbol

SNX5

Gene ID

27131

Gene namesorting nexin 5
Synonyms-
Cytomap

20p11.23

Type of geneprotein-coding
Descriptionsorting nexin-5
Modification date20210518
UniProtAcc

Q9Y5X3

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SNX5

GO:0031901

Sorting nexin-5

15561769

SNX5

GO:0034452

Sorting nexin-5

19619496

SNX5

GO:0035091

Sorting nexin-5

15561769

SNX5

GO:0006907

Sorting nexin-5

18854019

SNX5

GO:0005829

Sorting nexin-5

0000052

SNX5

GO:0031234

Sorting nexin-5

15561769

SNX5

GO:0031234

Sorting nexin-5

18854019

SNX5

GO:0031313

Sorting nexin-5

15561769

SNX5

GO:0043231

Sorting nexin-5

0000052

SNX5

GO:0070685

Sorting nexin-5

18854019

SNX5

GO:0097422

Sorting nexin-5

19619496

SNX5

GO:0030904

Sorting nexin-5

19619496

SNX5

GO:0048471

Sorting nexin-5

25825816


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RNA A-to-I events for SNX5

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000089006.15

check button RNA A-to-I editing events in Cancer.
CAediting_1407855(17942866, -), CAediting_1407856(17942875, -), CAediting_1407857(17944579, -), CAediting_1407858(17944583, -), CAediting_1407859(17944817, -), CAediting_1407860(17944818, -), CAediting_1407861(17944826, -), CAediting_1407862(17944834, -), CAediting_1407863(17951979, -), CAediting_1407864(17954784, -), CAediting_1407865(17954839, -), CAediting_1407866(17954849, -), CAediting_1407867(17954878, -), CAediting_1407868(17955883, -), CAediting_1407869(17955891, -), CAediting_1407870(17955920, -), CAediting_1407871(17955934, -), CAediting_1407872(17955947, -), CAediting_1407873(17955989, -), CAediting_1407874(17955991, -), CAediting_1407875(17956056, -), CAediting_1407876(17956592, -), CAediting_1407877(17957177, -), CAediting_1407878(17957179, -), CAediting_1407879(17957191, -), CAediting_1407880(17957192, -), CAediting_1407881(17957193, -), CAediting_1407882(17957210, -), CAediting_1407883(17957246, -), CAediting_1407884(17957271, -), CAediting_1407885(17957313, -), CAediting_1407886(17957323, -), CAediting_1407887(17957404, -), CAediting_1407888(17960295, -), CAediting_1407889(17960339, -), CAediting_1407890(17960428, -), CAediting_1407891(17960499, -), CAediting_1407892(17960593, -), CAediting_1407893(17960594, -), CAediting_1407894(17960665, -), CAediting_1407895(17962251, -), CAediting_1407896(17962266, -), CAediting_1407897(17962271, -), CAediting_1407898(17962295, -), CAediting_1407899(17962296, -), CAediting_1407900(17962329, -), CAediting_1407901(17962333, -), CAediting_1407902(17962337, -), CAediting_1407903(17962342, -), CAediting_1407904(17962369, -), CAediting_1407905(17962372, -), CAediting_1407906(17962373, -), CAediting_1407907(17962374, -), CAediting_1407908(17962375, -), CAediting_1407909(17962378, -), CAediting_1407910(17962380, -), CAediting_1407911(17962381, -), CAediting_1407912(17962382, -), CAediting_1407913(17962383, -), CAediting_1407914(17962398, -), CAediting_1407915(17962399, -), CAediting_1407916(17962408, -), CAediting_1407917(17962409, -), CAediting_1407918(17962423, -), CAediting_1407919(17962425, -), CAediting_1407920(17962432, -), CAediting_1407921(17962445, -), CAediting_1407922(17962453, -), CAediting_1407923(17962459, -), CAediting_1407924(17962470, -), CAediting_1407925(17962475, -), CAediting_1407926(17962484, -), CAediting_1407927(17962512, -), CAediting_1407928(17962784, -), CAediting_1407929(17962796, -), CAediting_1407930(17963322, -), CAediting_1407931(17963336, -), CAediting_1407932(17963338, -), CAediting_1407933(17963342, -), CAediting_1407934(17963350, -), CAediting_1407935(17963389, -), CAediting_1407936(17963467, -), CAediting_1407937(17965558, -), CAediting_1407938(17966263, -), CAediting_1407939(17966273, -), CAediting_1407940(17966323, -), CAediting_1407941(17966333, -),

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RNA editing positional annotations for SNX5 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1407855chr20_17942866_-ncRNA_exonic
CAediting_1407856chr20_17942875_-ncRNA_exonic
CAediting_1407857chr20_17944579_-ncRNA_exonic
CAediting_1407858chr20_17944583_-ncRNA_exonic
CAediting_1407859chr20_17944817_-ncRNA_exonic
CAediting_1407860chr20_17944818_-ncRNA_exonic
CAediting_1407861chr20_17944826_-ncRNA_exonic
CAediting_1407862chr20_17944834_-ncRNA_exonic
CAediting_1407863chr20_17951979_-ncRNA_intronic
CAediting_1407864chr20_17954784_-ncRNA_intronic
CAediting_1407865chr20_17954839_-ncRNA_intronic
CAediting_1407866chr20_17954849_-ncRNA_intronic
CAediting_1407867chr20_17954878_-ncRNA_intronic
CAediting_1407868chr20_17955883_-ncRNA_intronic
CAediting_1407869chr20_17955891_-ncRNA_intronic
CAediting_1407870chr20_17955920_-ncRNA_intronic
CAediting_1407871chr20_17955934_-ncRNA_intronic
CAediting_1407872chr20_17955947_-ncRNA_intronic
CAediting_1407873chr20_17955989_-ncRNA_intronic
CAediting_1407874chr20_17955991_-ncRNA_intronic
CAediting_1407875chr20_17956056_-ncRNA_intronic
CAediting_1407876chr20_17956592_-ncRNA_intronic
CAediting_1407877chr20_17957177_-ncRNA_intronic
CAediting_1407878chr20_17957179_-ncRNA_intronic
CAediting_1407879chr20_17957191_-ncRNA_intronic
CAediting_1407880chr20_17957192_-ncRNA_intronic
CAediting_1407881chr20_17957193_-ncRNA_intronic
CAediting_1407882chr20_17957210_-ncRNA_intronic
CAediting_1407883chr20_17957246_-ncRNA_intronic
CAediting_1407884chr20_17957271_-ncRNA_intronic
CAediting_1407885chr20_17957313_-ncRNA_intronic
CAediting_1407886chr20_17957323_-ncRNA_intronic
CAediting_1407887chr20_17957404_-ncRNA_intronic
CAediting_1407888chr20_17960295_-ncRNA_intronic
CAediting_1407889chr20_17960339_-ncRNA_intronic
CAediting_1407890chr20_17960428_-ncRNA_intronic
CAediting_1407891chr20_17960499_-ncRNA_intronic
CAediting_1407892chr20_17960593_-ncRNA_intronic
CAediting_1407893chr20_17960594_-ncRNA_intronic
CAediting_1407894chr20_17960665_-ncRNA_intronic
CAediting_1407895chr20_17962251_-ncRNA_intronic
CAediting_1407896chr20_17962266_-ncRNA_intronic
CAediting_1407897chr20_17962271_-ncRNA_intronic
CAediting_1407898chr20_17962295_-ncRNA_intronic
CAediting_1407899chr20_17962296_-ncRNA_intronic
CAediting_1407900chr20_17962329_-ncRNA_intronic
CAediting_1407901chr20_17962333_-ncRNA_intronic
CAediting_1407902chr20_17962337_-ncRNA_intronic
CAediting_1407903chr20_17962342_-ncRNA_intronic
CAediting_1407904chr20_17962369_-ncRNA_intronic
CAediting_1407905chr20_17962372_-ncRNA_intronic
CAediting_1407906chr20_17962373_-ncRNA_intronic
CAediting_1407907chr20_17962374_-ncRNA_intronic
CAediting_1407908chr20_17962375_-ncRNA_intronic
CAediting_1407909chr20_17962378_-ncRNA_intronic
CAediting_1407910chr20_17962380_-ncRNA_intronic
CAediting_1407911chr20_17962381_-ncRNA_intronic
CAediting_1407912chr20_17962382_-ncRNA_intronic
CAediting_1407913chr20_17962383_-ncRNA_intronic
CAediting_1407914chr20_17962398_-ncRNA_intronic
CAediting_1407915chr20_17962399_-ncRNA_intronic
CAediting_1407916chr20_17962408_-ncRNA_intronic
CAediting_1407917chr20_17962409_-ncRNA_intronic
CAediting_1407918chr20_17962423_-ncRNA_intronic
CAediting_1407919chr20_17962425_-ncRNA_intronic
CAediting_1407920chr20_17962432_-ncRNA_intronic
CAediting_1407921chr20_17962445_-ncRNA_intronic
CAediting_1407922chr20_17962453_-ncRNA_intronic
CAediting_1407923chr20_17962459_-ncRNA_intronic
CAediting_1407924chr20_17962470_-ncRNA_intronic
CAediting_1407925chr20_17962475_-ncRNA_intronic
CAediting_1407926chr20_17962484_-ncRNA_intronic
CAediting_1407927chr20_17962512_-ncRNA_intronic
CAediting_1407928chr20_17962784_-ncRNA_exonic
CAediting_1407929chr20_17962796_-ncRNA_exonic
CAediting_1407930chr20_17963322_-ncRNA_intronic
CAediting_1407931chr20_17963336_-ncRNA_intronic
CAediting_1407932chr20_17963338_-ncRNA_intronic
CAediting_1407933chr20_17963342_-ncRNA_intronic
CAediting_1407934chr20_17963350_-ncRNA_intronic
CAediting_1407935chr20_17963389_-ncRNA_intronic
CAediting_1407936chr20_17963467_-ncRNA_intronic
CAediting_1407937chr20_17965558_-ncRNA_intronic
CAediting_1407938chr20_17966263_-ncRNA_intronic
CAediting_1407939chr20_17966273_-ncRNA_intronic
CAediting_1407940chr20_17966323_-ncRNA_intronic
CAediting_1407941chr20_17966333_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1407855chr20_17942866_-SINEAluAluSx
CAediting_1407856chr20_17942875_-SINEAluAluSx
CAediting_1407857chr20_17944579_-SINEAluAluY
CAediting_1407858chr20_17944583_-SINEAluAluY
CAediting_1407859chr20_17944817_-SINEAluAluY
CAediting_1407860chr20_17944818_-SINEAluAluY
CAediting_1407861chr20_17944826_-SINEAluAluY
CAediting_1407862chr20_17944834_-SINEAluAluY
CAediting_1407863chr20_17951979_-SINEAluAluY
CAediting_1407864chr20_17954784_-SINEAluAluSx3
CAediting_1407865chr20_17954839_-SINEAluAluSx3
CAediting_1407866chr20_17954849_-SINEAluAluSx3
CAediting_1407867chr20_17954878_-SINEAluAluSx3
CAediting_1407868chr20_17955883_-SINEAluAluSz6
CAediting_1407869chr20_17955891_-SINEAluAluSz6
CAediting_1407870chr20_17955920_-SINEAluAluSz6
CAediting_1407871chr20_17955934_-SINEAluAluSz6
CAediting_1407872chr20_17955947_-SINEAluAluSz6
CAediting_1407873chr20_17955989_-SINEAluAluSz6
CAediting_1407874chr20_17955991_-SINEAluAluSz6
CAediting_1407875chr20_17956056_-SINEAluAluSz6
CAediting_1407876chr20_17956592_-SINEAluAluSx
CAediting_1407877chr20_17957177_-SINEAluAluY
CAediting_1407878chr20_17957179_-SINEAluAluY
CAediting_1407879chr20_17957191_-SINEAluAluY
CAediting_1407880chr20_17957192_-SINEAluAluY
CAediting_1407881chr20_17957193_-SINEAluAluY
CAediting_1407882chr20_17957210_-SINEAluAluY
CAediting_1407883chr20_17957246_-SINEAluAluY
CAediting_1407884chr20_17957271_-SINEAluAluY
CAediting_1407885chr20_17957313_-SINEAluAluY
CAediting_1407886chr20_17957323_-SINEAluAluY
CAediting_1407887chr20_17957404_-SINEAluAluY
CAediting_1407888chr20_17960295_-SINEAluAluSz
CAediting_1407889chr20_17960339_-SINEAluAluSg
CAediting_1407890chr20_17960428_-SINEAluAluSg
CAediting_1407891chr20_17960499_-SINEAluAluSg
CAediting_1407892chr20_17960593_-SINEAluAluSg
CAediting_1407893chr20_17960594_-SINEAluAluSg
CAediting_1407894chr20_17960665_-SINEAluAluSz
CAediting_1407895chr20_17962251_-SINEAluAluSg
CAediting_1407896chr20_17962266_-SINEAluAluSg
CAediting_1407897chr20_17962271_-SINEAluAluSg
CAediting_1407898chr20_17962295_-SINEAluAluSg
CAediting_1407899chr20_17962296_-SINEAluAluSg
CAediting_1407900chr20_17962329_-SINEAluAluSg
CAediting_1407901chr20_17962333_-SINEAluAluSg
CAediting_1407902chr20_17962337_-SINEAluAluSg
CAediting_1407903chr20_17962342_-SINEAluAluSg
CAediting_1407904chr20_17962369_-SINEAluAluSg
CAediting_1407905chr20_17962372_-SINEAluAluSg
CAediting_1407906chr20_17962373_-SINEAluAluSg
CAediting_1407907chr20_17962374_-SINEAluAluSg
CAediting_1407908chr20_17962375_-SINEAluAluSg
CAediting_1407909chr20_17962378_-SINEAluAluSg
CAediting_1407910chr20_17962380_-SINEAluAluSg
CAediting_1407911chr20_17962381_-SINEAluAluSg
CAediting_1407912chr20_17962382_-SINEAluAluSg
CAediting_1407913chr20_17962383_-SINEAluAluSg
CAediting_1407914chr20_17962398_-SINEAluAluSg
CAediting_1407915chr20_17962399_-SINEAluAluSg
CAediting_1407916chr20_17962408_-SINEAluAluSg
CAediting_1407917chr20_17962409_-SINEAluAluSg
CAediting_1407918chr20_17962423_-SINEAluAluSg
CAediting_1407919chr20_17962425_-SINEAluAluSg
CAediting_1407920chr20_17962432_-SINEAluAluSg
CAediting_1407921chr20_17962445_-SINEAluAluSg
CAediting_1407922chr20_17962453_-SINEAluAluSg
CAediting_1407923chr20_17962459_-SINEAluAluSg
CAediting_1407924chr20_17962470_-SINEAluAluSg
CAediting_1407925chr20_17962475_-SINEAluAluSg
CAediting_1407926chr20_17962484_-SINEAluAluSg
CAediting_1407930chr20_17963322_-SINEAluAluJr
CAediting_1407931chr20_17963336_-SINEAluAluJr
CAediting_1407932chr20_17963338_-SINEAluAluJr
CAediting_1407933chr20_17963342_-SINEAluAluJr
CAediting_1407934chr20_17963350_-SINEAluAluJr
CAediting_1407935chr20_17963389_-SINEAluAluJr
CAediting_1407936chr20_17963467_-SINEAluAluJr
CAediting_1407937chr20_17965558_-SINEAluAluYc
CAediting_1407938chr20_17966263_-SINEAluAluSx1
CAediting_1407939chr20_17966273_-SINEAluAluSx1
CAediting_1407940chr20_17966323_-SINEAluAluSx1
CAediting_1407941chr20_17966333_-SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for SNX5

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000089006.15.SNX5.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000089006.15.SNX5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SNX5

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SNX5

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SNX5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_688081chr9_63819627_+ENSG00000089006.15ENST00000377768hsa-miR-4477b17941688179416947mer-m81794168717941711142-13.05
CAediting_1229415chr17_67471547_+ENSG00000089006.15ENST00000463050hsa-miR-548aa17947322179473287mer-m81794732117947347150-11.76
CAediting_1229414chr17_67471546_+ENSG00000089006.15ENST00000481323hsa-miR-548aa17968217179682237mer-m81796821617968240140-14.18
CAediting_1368054chr19_46709310_-ENSG00000089006.15ENST00000481323hsa-miR-320e17968130179681378mer-1a1796813017968148153-21.26
CAediting_1229414chr17_67471546_+ENSG00000089006.15ENST00000486039hsa-miR-548aa17968217179682237mer-m81796821617968240140-14.18
CAediting_1368054chr19_46709310_-ENSG00000089006.15ENST00000486039hsa-miR-320e17968130179681378mer-1a1796813017968148153-21.26

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229415chr17_67471547_+ENSG00000089006.15ENST00000463050hsa-miR-548aa17947291179472977mer-m81794729017947317145-10.07
CAediting_1229413chr17_67471544_+ENSG00000089006.15ENST00000463050hsa-miR-548aa17947291179472977mer-m81794729017947317145-10.07

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SNX5

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SNX5

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LUSCCAediting_1407901chr20_17962333_-0.000327622545696880.368347689491635....
LUSCCAediting_1407903chr20_17962342_-0.008642745811976750.243820251001902....
STADCAediting_1407903chr20_17962342_-..0.01479002905946430.164153698648642..
SKCMCAediting_1407903chr20_17962342_-..0.03146695259044370.237783115904925..
STADCAediting_1407925chr20_17962475_-..0.04326806096124360.226585318607731..

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Relation with cancer stages for SNX5

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
ESCApathologic_stageCAediting_1407903chr20_17962342_-0.0470159129624833-0.185624964178516
LUSCpathologic_stageCAediting_1407901chr20_17962333_-0.0246152816626243-0.235521396823578

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Relation with survival for SNX5

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LUSCCAediting_1407901chr20_17962333_-0.008066447281794060.001092091469.83

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RelatedDrugs for SNX5

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX5

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SNX5C0024623Malignant neoplasm of stomach1CTD_human
SNX5C0038356Stomach Neoplasms1CTD_human
SNX5C0235874Disease Exacerbation1CTD_human
SNX5C1708349Hereditary Diffuse Gastric Cancer1CTD_human