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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NOX1 (CAeditome ID:27035)

Gene summary for NOX1

check button Gene summary
Gene informationGene symbol

NOX1

Gene ID

27035

Gene nameNADPH oxidase 1
SynonymsGP91-2|MOX1|NOH-1|NOH1
Cytomap

Xq22.1

Type of geneprotein-coding
DescriptionNADPH oxidase 1NADH/NADPH mitogenic oxidase subunit P65-MOXNADPH oxidase homolog-1mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)mitogenic oxidase 1
Modification date20210518
UniProtAcc

Q9Y5S8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NOX1

GO:0008284

NADPH oxidase 1

10485709

NOX1

GO:0042554

NADPH oxidase 1

10485709

NOX1

GO:0042743

NADPH oxidase 1

11331784

NOX1

GO:0051454

NADPH oxidase 1

10615049

NOX1

GO:1990451

NADPH oxidase 1

10615049

NOX1

GO:0005769

NADPH oxidase 1

17673675

NOX1

GO:0043020

NADPH oxidase 1

16636067


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RNA A-to-I events for NOX1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000007952.16

check button RNA A-to-I editing events in Cancer.
CAediting_1516407(100844456, -), CAediting_1516408(100844464, -), CAediting_1516409(100844509, -), CAediting_1516410(100844557, -), CAediting_1516411(100844571, -), CAediting_1516412(100844626, -), CAediting_1516413(100844634, -), CAediting_1516414(100845678, -), CAediting_1516415(100845712, -), CAediting_1516416(100845876, -), CAediting_1516417(100845922, -), CAediting_1516418(100846193, -), CAediting_1516419(100847067, -), CAediting_1516420(100847077, -), CAediting_1516421(100847167, -), CAediting_1516422(100847530, -), CAediting_1516423(100847548, -), CAediting_1516424(100847567, -), CAediting_1516425(100847568, -), CAediting_1516426(100847719, -), CAediting_1516427(100848325, -), CAediting_1516428(100848354, -), CAediting_1516429(100848376, -), CAediting_1516430(100848387, -), CAediting_1516431(100848396, -), CAediting_1516432(100848471, -), CAediting_1516433(100848488, -), CAediting_1516434(100848524, -), CAediting_1516435(100848565, -), CAediting_1516436(100849016, -), CAediting_1516437(100851721, -), CAediting_1516438(100851789, -), CAediting_1516439(100851792, -), CAediting_1516440(100853497, -), CAediting_1516441(100853498, -), CAediting_1516442(100853512, -), CAediting_1516443(100853539, -), CAediting_1516444(100853561, -), CAediting_1516445(100853568, -), CAediting_1516446(100853569, -), CAediting_1516447(100853570, -), CAediting_1516448(100853571, -), CAediting_1516449(100853576, -), CAediting_1516450(100853583, -), CAediting_1516451(100853589, -), CAediting_1516452(100853595, -), CAediting_1516453(100853605, -), CAediting_1516454(100853628, -), CAediting_1516455(100853633, -), CAediting_1516456(100853647, -), CAediting_1516457(100853664, -), CAediting_1516458(100853674, -), CAediting_1516459(100853682, -), CAediting_1516460(100853696, -), CAediting_1516461(100853703, -), CAediting_1516462(100853704, -), CAediting_1516463(100853705, -), CAediting_1516464(100853706, -), CAediting_1516465(100853724, -), CAediting_1516466(100853737, -), CAediting_1516467(100853740, -), CAediting_1516468(100853749, -), CAediting_1516469(100853763, -), CAediting_1516470(100853768, -), CAediting_1516471(100853782, -), CAediting_1516472(100853803, -), CAediting_1516473(100853808, -), CAediting_1516474(100853809, -), CAediting_1516475(100853926, -), CAediting_1516476(100853977, -), CAediting_1516477(100853995, -), CAediting_1516478(100854019, -), CAediting_1516479(100854021, -), CAediting_1516480(100854031, -), CAediting_1516481(100854034, -), CAediting_1516482(100854043, -), CAediting_1516483(100854060, -), CAediting_1516484(100854061, -), CAediting_1516485(100864028, -), CAediting_1516486(100864082, -), CAediting_1516487(100864128, -), CAediting_1516488(100864186, -), CAediting_1516489(100864236, -), CAediting_1516490(100864239, -), CAediting_1516491(100865976, -), CAediting_1516492(100865977, -), CAediting_1516493(100866114, -), CAediting_1516494(100866122, -), CAediting_1516495(100867655, -),

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RNA editing positional annotations for NOX1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1516407chrX_100844456_-intronic
CAediting_1516408chrX_100844464_-intronic
CAediting_1516409chrX_100844509_-intronic
CAediting_1516410chrX_100844557_-intronic
CAediting_1516411chrX_100844571_-intronic
CAediting_1516412chrX_100844626_-intronic
CAediting_1516413chrX_100844634_-intronic
CAediting_1516414chrX_100845678_-intronic
CAediting_1516415chrX_100845712_-intronic
CAediting_1516416chrX_100845876_-intronic
CAediting_1516417chrX_100845922_-intronic
CAediting_1516418chrX_100846193_-intronic
CAediting_1516419chrX_100847067_-intronic
CAediting_1516420chrX_100847077_-intronic
CAediting_1516421chrX_100847167_-intronic
CAediting_1516422chrX_100847530_-intronic
CAediting_1516423chrX_100847548_-intronic
CAediting_1516424chrX_100847567_-intronic
CAediting_1516425chrX_100847568_-intronic
CAediting_1516426chrX_100847719_-intronic
CAediting_1516427chrX_100848325_-intronic
CAediting_1516428chrX_100848354_-intronic
CAediting_1516429chrX_100848376_-intronic
CAediting_1516430chrX_100848387_-intronic
CAediting_1516431chrX_100848396_-intronic
CAediting_1516432chrX_100848471_-intronic
CAediting_1516433chrX_100848488_-intronic
CAediting_1516434chrX_100848524_-intronic
CAediting_1516435chrX_100848565_-intronic
CAediting_1516436chrX_100849016_-intronic
CAediting_1516437chrX_100851721_-intronic
CAediting_1516438chrX_100851789_-intronic
CAediting_1516439chrX_100851792_-intronic
CAediting_1516440chrX_100853497_-intronic
CAediting_1516441chrX_100853498_-intronic
CAediting_1516442chrX_100853512_-intronic
CAediting_1516443chrX_100853539_-intronic
CAediting_1516444chrX_100853561_-intronic
CAediting_1516445chrX_100853568_-intronic
CAediting_1516446chrX_100853569_-intronic
CAediting_1516447chrX_100853570_-intronic
CAediting_1516448chrX_100853571_-intronic
CAediting_1516449chrX_100853576_-intronic
CAediting_1516450chrX_100853583_-intronic
CAediting_1516451chrX_100853589_-intronic
CAediting_1516452chrX_100853595_-intronic
CAediting_1516453chrX_100853605_-intronic
CAediting_1516454chrX_100853628_-intronic
CAediting_1516455chrX_100853633_-intronic
CAediting_1516456chrX_100853647_-intronic
CAediting_1516457chrX_100853664_-intronic
CAediting_1516458chrX_100853674_-intronic
CAediting_1516459chrX_100853682_-intronic
CAediting_1516460chrX_100853696_-intronic
CAediting_1516461chrX_100853703_-intronic
CAediting_1516462chrX_100853704_-intronic
CAediting_1516463chrX_100853705_-intronic
CAediting_1516464chrX_100853706_-intronic
CAediting_1516465chrX_100853724_-intronic
CAediting_1516466chrX_100853737_-intronic
CAediting_1516467chrX_100853740_-intronic
CAediting_1516468chrX_100853749_-intronic
CAediting_1516469chrX_100853763_-intronic
CAediting_1516470chrX_100853768_-intronic
CAediting_1516471chrX_100853782_-intronic
CAediting_1516472chrX_100853803_-intronic
CAediting_1516473chrX_100853808_-intronic
CAediting_1516474chrX_100853809_-intronic
CAediting_1516475chrX_100853926_-intronic
CAediting_1516476chrX_100853977_-intronic
CAediting_1516477chrX_100853995_-intronic
CAediting_1516478chrX_100854019_-intronic
CAediting_1516479chrX_100854021_-intronic
CAediting_1516480chrX_100854031_-intronic
CAediting_1516481chrX_100854034_-intronic
CAediting_1516482chrX_100854043_-intronic
CAediting_1516483chrX_100854060_-intronic
CAediting_1516484chrX_100854061_-intronic
CAediting_1516485chrX_100864028_-intronic
CAediting_1516486chrX_100864082_-intronic
CAediting_1516487chrX_100864128_-intronic
CAediting_1516488chrX_100864186_-intronic
CAediting_1516489chrX_100864236_-intronic
CAediting_1516490chrX_100864239_-intronic
CAediting_1516491chrX_100865976_-intronic
CAediting_1516492chrX_100865977_-intronic
CAediting_1516493chrX_100866114_-intronic
CAediting_1516494chrX_100866122_-intronic
CAediting_1516495chrX_100867655_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1516407chrX_100844456_-SINEAluAluSz
CAediting_1516408chrX_100844464_-SINEAluAluSz
CAediting_1516409chrX_100844509_-SINEAluAluSz
CAediting_1516410chrX_100844557_-SINEAluAluSz
CAediting_1516411chrX_100844571_-SINEAluAluSz
CAediting_1516412chrX_100844626_-SINEAluAluSz
CAediting_1516413chrX_100844634_-SINEAluAluSz
CAediting_1516414chrX_100845678_-SINEAluAluSx3
CAediting_1516415chrX_100845712_-SINEAluAluSx3
CAediting_1516416chrX_100845876_-SINEAluAluY
CAediting_1516417chrX_100845922_-SINEAluAluY
CAediting_1516418chrX_100846193_-SINEAluAluSx3
CAediting_1516419chrX_100847067_-SINEAluAluSx1
CAediting_1516420chrX_100847077_-SINEAluAluSx1
CAediting_1516421chrX_100847167_-SINEAluAluSx1
CAediting_1516422chrX_100847530_-SINEAluAluSq2
CAediting_1516423chrX_100847548_-SINEAluAluSq2
CAediting_1516424chrX_100847567_-SINEAluAluSq2
CAediting_1516425chrX_100847568_-SINEAluAluSq2
CAediting_1516426chrX_100847719_-SINEAluAluSq2
CAediting_1516427chrX_100848325_-SINEAluAluSq2
CAediting_1516428chrX_100848354_-SINEAluAluSq2
CAediting_1516429chrX_100848376_-SINEAluAluSq2
CAediting_1516430chrX_100848387_-SINEAluAluSq2
CAediting_1516431chrX_100848396_-SINEAluAluSq2
CAediting_1516432chrX_100848471_-SINEAluAluSq2
CAediting_1516433chrX_100848488_-SINEAluAluSq2
CAediting_1516434chrX_100848524_-SINEAluAluSq2
CAediting_1516435chrX_100848565_-SINEAluAluSq2
CAediting_1516436chrX_100849016_-SINEAluAluSp
CAediting_1516437chrX_100851721_-SINEAluAluSx
CAediting_1516438chrX_100851789_-SINEAluAluSx
CAediting_1516439chrX_100851792_-SINEAluAluSx
CAediting_1516440chrX_100853497_-SINEAluAluSz
CAediting_1516441chrX_100853498_-SINEAluAluSz
CAediting_1516442chrX_100853512_-SINEAluAluSz
CAediting_1516443chrX_100853539_-SINEAluAluSz
CAediting_1516444chrX_100853561_-SINEAluAluSz
CAediting_1516445chrX_100853568_-SINEAluAluSz
CAediting_1516446chrX_100853569_-SINEAluAluSz
CAediting_1516447chrX_100853570_-SINEAluAluSz
CAediting_1516448chrX_100853571_-SINEAluAluSz
CAediting_1516449chrX_100853576_-SINEAluAluSz
CAediting_1516450chrX_100853583_-SINEAluAluSz
CAediting_1516451chrX_100853589_-SINEAluAluSz
CAediting_1516452chrX_100853595_-SINEAluAluSz
CAediting_1516453chrX_100853605_-SINEAluAluSz
CAediting_1516454chrX_100853628_-SINEAluAluSz
CAediting_1516455chrX_100853633_-SINEAluAluSz
CAediting_1516456chrX_100853647_-SINEAluAluSz
CAediting_1516457chrX_100853664_-SINEAluAluSz
CAediting_1516458chrX_100853674_-SINEAluAluSz
CAediting_1516459chrX_100853682_-SINEAluAluSz
CAediting_1516460chrX_100853696_-SINEAluAluSz
CAediting_1516461chrX_100853703_-SINEAluAluSq10
CAediting_1516462chrX_100853704_-SINEAluAluSq10
CAediting_1516463chrX_100853705_-SINEAluAluSq10
CAediting_1516464chrX_100853706_-SINEAluAluSq10
CAediting_1516465chrX_100853724_-SINEAluAluSq10
CAediting_1516466chrX_100853737_-SINEAluAluSq10
CAediting_1516467chrX_100853740_-SINEAluAluSq10
CAediting_1516468chrX_100853749_-SINEAluAluSq10
CAediting_1516469chrX_100853763_-SINEAluAluSq10
CAediting_1516470chrX_100853768_-SINEAluAluSq10
CAediting_1516471chrX_100853782_-SINEAluAluSq10
CAediting_1516472chrX_100853803_-SINEAluAluSq10
CAediting_1516473chrX_100853808_-SINEAluAluSq10
CAediting_1516474chrX_100853809_-SINEAluAluSq10
CAediting_1516475chrX_100853926_-SINEAluAluSx
CAediting_1516476chrX_100853977_-SINEAluAluSx
CAediting_1516477chrX_100853995_-SINEAluAluSx
CAediting_1516478chrX_100854019_-SINEAluAluSx
CAediting_1516479chrX_100854021_-SINEAluAluSx
CAediting_1516480chrX_100854031_-SINEAluAluSx
CAediting_1516481chrX_100854034_-SINEAluAluSx
CAediting_1516482chrX_100854043_-SINEAluAluSx
CAediting_1516483chrX_100854060_-SINEAluAluSx
CAediting_1516484chrX_100854061_-SINEAluAluSx
CAediting_1516485chrX_100864028_-SINEAluAluJb
CAediting_1516486chrX_100864082_-SINEAluAluJb
CAediting_1516487chrX_100864128_-SINEAluAluJb
CAediting_1516488chrX_100864186_-SINEAluAluJb
CAediting_1516489chrX_100864236_-SINEAluAluJb
CAediting_1516490chrX_100864239_-SINEAluAluJb
CAediting_1516491chrX_100865976_-SINEAluAluSz
CAediting_1516492chrX_100865977_-SINEAluAluSz
CAediting_1516493chrX_100866114_-SINEAluAluSz
CAediting_1516494chrX_100866122_-SINEAluAluSz
CAediting_1516495chrX_100867655_-SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for NOX1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000007952.16.NOX1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000007952.16.NOX1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOX1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NOX1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NOX1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229414chr17_67471546_+ENSG00000007952.16ENST00000372960hsa-miR-548aa1008433931008434008mer-1a100843393100843417146-9.64
CAediting_1229414chr17_67471546_+ENSG00000007952.16ENST00000372966hsa-miR-548aa1008433931008434008mer-1a100843393100843417146-9.64

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NOX1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for NOX1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
COADCAediting_1516458chrX_100853674_-0.04461985070554550.262460606507237....

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Relation with cancer stages for NOX1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for NOX1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for NOX1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
NOX1Q9Y5S8DB09140OxygenNADPH oxidase 1 SmallMoleculeDrugapproved|vet_approved

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RelatedDiseases for NOX1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
NOX1C0007102Malignant tumor of colon1CTD_human
NOX1C0009375Colonic Neoplasms1CTD_human
NOX1C0018801Heart failure1CTD_human
NOX1C0018802Congestive heart failure1CTD_human
NOX1C0020443Hypercholesterolemia1CTD_human
NOX1C0023212Left-Sided Heart Failure1CTD_human
NOX1C0235527Heart Failure, Right-Sided1CTD_human
NOX1C1959583Myocardial Failure1CTD_human
NOX1C1961112Heart Decompensation1CTD_human